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https://www.readbyqxmd.com/read/27898069/clozapine-modifies-the-differentiation-program-of-human-adipocytes-inducing-browning
#1
E Kristóf, Q-M Doan-Xuan, A K Sárvári, Á Klusóczki, P Fischer-Posovszky, M Wabitsch, Z Bacso, P Bai, Z Balajthy, L Fésüs
Administration of second-generation antipsychotic drugs (SGAs) often leads to weight gain and consequent cardio-metabolic side effects. We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA than in the untreated white adipocytes. Laser scanning cytometry showed that up to 40% of the differentiating single primary and Simpson-Golabi-Behmel syndrome (SGBS) adipocytes had the characteristic morphological features of browning cells...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27847515/the-ambu%C3%A2-aura-i%C3%A2-laryngeal-mask-and-lma-supreme%C3%A2-a-randomized-trial-of-clinical-performance-and-fibreoptic-positioning-in-unparalysed-anaesthetised-patients-by-novices
#2
Zanahriah Yahaya, Wendy H Teoh, Nora A Dintan, Ravi Agrawal
Introduction. Manikin studies' data cannot accurately be extrapolated to real-life scenarios and inherent differences in design and materials of newer products may affect their clinical performance. Methods. Hence, we compared the AMBU® Aura-i™ and LMA Supreme™ in this randomized trial involving 100 ASA 1-2 unparalysed anaesthetised patients undergoing minor gynaecological surgery. Investigators had <20 Aura-i insertions. Primary outcome was time to achieve effective ventilation and secondarily insertion parameters, oropharyngeal leak pressures (OLP), fibreoptic positioning, and pharyngeal morbidity...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27812636/gel-pillow-designed-specifically-for-obstructive-sleep-apnea-treatment-with-continuous-positive-airway-pressure
#3
Adriana Salvaggio, Anna Lo Bue, Serena Iacono Isidoro, Salvatore Romano, Oreste Marrone, Giuseppe Insalaco
Objective: To determine whether the use of a gel pillow with side cutouts designed to accommodate a continuous positive airway pressure (CPAP) mask and reduce head temperature improves the efficacy of and adherence to auto-CPAP therapy. Methods: Twenty-three consecutive CPAP-naïve patients with obstructive sleep apnea were enrolled in the study. Patients were given an auto-CPAP machine with an appropriate CPAP mask and were instructed to use CPAP for 15 nights...
September 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27761035/a-randomised-trial-to-compare-i-gel-and-proseal%C3%A2-laryngeal-mask-airway-for-airway-management-in-paediatric-patients
#4
R Nirupa, Satinder Gombar, Vanita Ahuja, Preeti Sharma
BACKGROUND AND AIMS: i-gel™ is a newer supraglottic airway device with a unique non-inflatable cuff. We aimed to compare i-gel™ with ProSeal™ laryngeal mask airway (PLMA™) in children scheduled for surgery under general anaesthesia (GA) with controlled ventilation. METHODS: This prospective, randomised controlled study was conducted in 100 surgical patients, aged 2-6 years of American Society of Anesthesiologists Physical Status I-II scheduled under GA. Patients were randomly allocated to receive either size 2 i-gel™ or PLMA™ as an airway device...
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27755181/sore-throat-following-three-adult-supraglottic-airway-devices-a-randomised-controlled-trial
#5
Joël L'Hermite, Elisabeth Dubout, Sophie Bouvet, Laure-Hélène Bracoud, Philippe Cuvillon, Jean-Emmanuel de La Coussaye, Jacques Ripart
BACKGROUND: Sore throat is a common complaint after surgery. It affects patient satisfaction and can affect activity after discharge. The supraglottic airway device (SAD) offers an alternative to traditional tracheal intubation with potential benefit in preventing sore throat. OBJECTIVE: The aim of this study was to compare the incidence of sore throat following three different SADs, the laryngeal mask airway Unique (LMA-U) and the more recent LMA Supreme (LMA-S) and the I-gel...
October 15, 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27754781/quantification-of-leakage-of-sub-micron-aerosols-through-surgical-masks-and-facemasks-for-pediatric-use
#6
Suvajyoti Guha, Brady McCaffrey, Prasanna Hariharan, Matthew R Myers
Surgical respirators, surgical masks (SMs) and facemasks for pediatric use (FPUs) are routinely used in the US healthcare industry as personal protective equipment (PPE) against infectious diseases. While N95s including surgical respirators have been routinely studied, SMs and FPUs have not received as much attention, particularly in the context of aerosolized threats. This is because SMs and PFUs are not designed to protect against sub-micron aerosols. However, with the possibility of new or re-emerging airborne diseases or bio-aerosol weapons lingering, combined with the limited availability of respirators and logistical issues associated with fit-testing millions, the general adult and pediatric populations may elect to wear SMs and FPUs, respectively, in the case of a pandemic or a bio-terrorist attack...
October 18, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27621860/use-of-laryngeal-mask-airway-for-non-endotracheal-intubated-anesthesia-for-patients-with-pectus-excavatum-undergoing-thoracoscopic-nuss-procedure
#7
Xiaojun Du, Songsong Mao, Jianxiu Cui, Jue Ma, Guangyan Zhang, Yong Zheng, Haiyu Zhou, Liang Xie, Dongkun Zhang, Ruiqing Shi, Gang Chen
BACKGROUND: The aim of the present study was to determine the safety and feasibility of the use of laryngeal mask airway (LMA) for non-endotracheal intubated anesthesia for patients with pectus excavatum (PE) undergoing thoracoscopic Nuss procedure. METHODS: Between July 2015 and December 2015, 30 selected patients with PE were planned to undergo a thoracoscopic Nuss procedure using LMA for non-endotracheal intubated anesthesia in the Guangdong General Hospital...
August 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27608342/optimal-flexible-laryngeal-mask-airway-size-in-children-weighing-10-to-20-kg
#8
K Z Chen, T J Liu, W X Li, X Shen
This prospective, randomised study was conducted to assess the effect of flexible laryngeal mask airway (FLMA) size on oropharyngeal leak pressure (OLP) in children at the recommended intracuff pressure. A total of 120 children undergoing elective ophthalmic surgery were randomly assigned to the size 2 FLMA group or size 2.5 FLMA group. The primary measurement was OLP at an intracuff pressure of 40 cmH2O. Secondary outcomes included the incidence of OLP <10 cmH2O, insufficient ventilation, gastric insufflation, insertion time, successful first-attempt insertion rate, fibreoptic view grade and pharyngolaryngeal adverse events...
September 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27607153/oronasal-mask-may-compromise-the-efficacy-of-continuous-positive-airway-pressure-on-osa-treatment-is-there-evidence-for-avoiding-the-oronasal-route
#9
Rafaela Garcia Santos Andrade, Fernanda Madeiro, Pedro Rodrigues Genta, Geraldo Lorenzi-Filho
PURPOSE OF REVIEW: Continuous positive airway pressure (CPAP) delivered by nasal mask is the gold standard treatment for obstructive sleep apnea (OSA). However, oral and oronasal masks are also available. We considered experimental evidence and reviewed clinical trials that evaluated the impact of oral and oronasal mask on OSA treatment. RECENT FINDINGS: One recent study in 18 OSA patients that slept with a customized oronasal mask with two sealed compartments showed that the change of CPAP flow from nasal to oronasal and oral caused upper airway obstruction because of posterior displacement of the tongue demonstrated by nasoendoscopy...
November 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27573519/neonatal-ventilation-with-a-manikin-model-and-two-novel-peep-valves-without-an-external-gas-source
#10
Monica Thallinger, Hege Langli Ersdal, Colin Morley, Carolyn Purington, Øystein Gomo, Estomih Mduma, Joar Eilevstjønn, Ketil Størdal
OBJECTIVE: Positive end expiratory pressure (PEEP) is beneficial when ventilating preterm newborns. The aim was to study whether inexperienced providers were able to generate PEEP during simulated neonatal ventilation, using two novel prototype PEEP valves, on a self-inflating bag without an external gas source. DESIGN: Forty-six nursing students in Tanzania were trained in ventilation with a new Laerdal Upright resuscitator and mask on a NeoNatalie manikin with a newborn resuscitation monitor...
August 29, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27555181/laryngeal-mask-airway-proseal-provides-higher-oropharyngeal-leak-pressure-than-i-gel-in-adult-patients-under-general-anesthesia-a-meta-analysis
#11
Souvik Maitra, Dalim K Baidya, Mahesh K Arora, Sulagna Bhattacharjee, Puneet Khanna
STUDY OBJECTIVE: i-gel is a single-use supraglottic airway device that has a gastric drain tube similar to laryngeal mask airway (LMA) ProSeal. Randomized trials, when compared i-gel with LMA ProSeal, reported a differing results. Primary objective of this study is to compare LMA ProSeal and i-gel in terms of oropharyngeal leak pressure. DESIGN: Meta-analysis of randomized controlled trials where i-gel has been compared to LMA ProSeal in adult airway management during general anesthesia...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27542098/precautionary-practices-for-administering-anesthetic-gases-a-survey-of-physician-anesthesiologists-nurse-anesthetists-and-anesthesiologist-assistants
#12
James M Boiano, Andrea L Steege
Scavenging systems and administrative and work practice controls for minimizing occupational exposure to waste anesthetic gases have been recommended for many years. Anesthetic gases and vapors that are released or leak out during medical procedures are considered waste anesthetic gases. To better understand the extent recommended practices are used, the NIOSH Health and Safety Practices Survey of Healthcare Workers was conducted in 2011 among members of professional practice organizations representing anesthesia care providers including physician anesthesiologists, nurse anesthetists, and anesthesiologist assistants...
October 2, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27532916/association-of-noninvasive-ventilation-strategies-with-mortality-and-bronchopulmonary-dysplasia-among-preterm-infants-a-systematic-review-and-meta-analysis
#13
REVIEW
Tetsuya Isayama, Hiroko Iwami, Sarah McDonald, Joseph Beyene
IMPORTANCE: Various noninvasive ventilation strategies are used to prevent bronchopulmonary dysplasia (BPD) of preterm infants; however, the best mode is uncertain. OBJECTIVE: To compare 7 ventilation strategies for preterm infants including nasal continuous positive airway pressure (CPAP) alone, intubation and surfactant administration followed by immediate extubation (INSURE), less invasive surfactant administration (LISA), noninvasive intermittent positive pressure ventilation, nebulized surfactant administration, surfactant administration via laryngeal mask airway, and mechanical ventilation...
August 9, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27492428/observation-of-ventilation-effects-of-i-gel%C3%A2-supreme%C3%A2-and-ambu-auraonce%C3%A2-with-respiratory-dynamics-monitoring-in-small-children
#14
Zhiqing Gu, Quanying Jin, Junjun Liu, Lianhua Chen
The shortcomings of laryngeal mask airway (LMA™), such as upper airway obstruction and gastric distension or airway leakage, may limit its application in small children. The I-gel™ (I-gel), LMA-Supreme™ (LMA-S), and Ambu AuraOnce™ (Ambu) are three improvements upon these shortcomings. This study adopted respiratory dynamic monitoring to observe the ventilation parameters of the three laryngeal masks in small children. A total of 105 children were randomized into Ambu (n = 35), I-gel (n = 35), and LMA-S (n = 35) groups...
August 4, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27409643/comparison-of-proseal-laryngeal-mask-airway-plma-with-cuffed-and-uncuffed-endotracheal-tubes-in-infants
#15
Eyyup Sabri Ozden, Basak Ceyda Meco, Zekeriyya Alanoglu, Neslihan Alkıs
We aimed to compare cuffed and uncuffed endotracheal tubes (ETTs) with ProSealTM laryngeal mask airway (PLMA) in terms of airway security and extubation, starting out from the hypothesis that PLMA will provide alternative airway safety to the endotracheal tubes, and that airway complications will be less observed. After obtaining approval from the local Ethics Committee and parental informed consent, 120 pediatric patients 1-24 months old, American Society of Anesthesiologists physical status I-II, requiring general anesthesia for elective lower abdominal surgery, were randomized into PLMA (Group P, n = 40), cuffed ETT (Group C, n = 40), and uncuffed ETT (Group UC, n = 40) groups...
November 10, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27384245/sustained-versus-intermittent-lung-inflation-for-resuscitation-of-preterm-infants-a-randomized-controlled-trial
#16
Mohamed S El-Chimi, Hisham A Awad, Tarek M El-Gammasy, Ola G El-Farghali, Mohamed T Sallam, Dina M Shinkar
AIM: To evaluate efficacy and safety of delivery room (DR) sustained lung inflation (SLI) in resuscitation of preterm neonates. METHODS: Randomized Controlled Trial including 112 preterm infants randomized to either SLI (n = 57) using T-piece resuscitator [maximum three inflations with maximum pressure of 30 cmH2O for 15 s followed by continuous positive airway pressure (CPAP) of 5-7 cmH2O] or conventional bag/mask inflation (CBMI) (n = 55) using traditional self-inflating bag (maximum pressure of 40 cmH2O at a rate of 40-60 per min)...
August 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27380049/randomized-crossover-study-assessing-oropharyngeal-leak-pressure-and-fiber-optic-positioning-laryngeal-mask-airway-supreme%C3%A2-versus-laryngeal-tube-lts-ii%C3%A2-size-2-in-non-paralyzed-anesthetized-children
#17
L Gasteiger, S Ofner, B Stögermüller, B Ziegler, J Brimacombe, C Keller
BACKGROUND: As there are currently no data available comparing the practicability of the laryngeal mask airway (LMA) Supreme™ size 2 versus the laryngeal tube LTS II™ size 2 in children, this trial was conducted to quantify the differences between these two airway devices concerning leak pressure and fiber optic-controlled positioning in non-paralyzed, anesthetized pediatric patients. METHODS: A total of 56 children aged 1-6 years and weighing between 11 and 23 kg were enrolled in the study...
August 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27366552/comparison-of-laryngeal-mask-airway-supreme-tm-versus-unique-tm-in-edentulous-geriatric-patients
#18
Tangül Beydeş, Semih Küçükgüçlü, Şule Özbilgin, Bahar Kuvaki, Meltem Ademoğlu, Melek Sarı
OBJECTIVE: It is more difficult to perform bag-mask ventilation in edentulous patients than in patients with intact dentition. The laryngeal mask airway (LMA) provides a better alternative to the standard face mask if the facial contours of the patient are not suited for the standard face mask. We aimed to compare these two different LMAs in edentulous geriatric patients. METHODS: Edentulous patients aged ≥65 years of American Society of Anesthesiologists physical status I-III were included in the study...
February 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27366518/comparison-of-i-gel-with-classic-laryngeal-mask-airway-regarding-the-ease-of-use-and-clinical-performance
#19
Dilek Erdoğan Arı, Arzu Yıldırım Ar, Ceren Şanlı Karip, İncifer Siyahkoç, Ahmet Hakan Arslan, Fatma Nur Akgün
OBJECTIVE: I-gel is a new supraglottic airway device without an inflatable cuff. We aimed to compare I-gel and the classic laryngeal mask airway (LMA) regarding the ease of use and clinical performance in Turkish population. METHODS: Fifty American Society of Anesthesiologists (ASA) I-II patients were randomly allocated into two groups: Group I-gel and Group LMA. Insertion time and success in first attempt were recorded. Peak, plato and mean airway pressures, EtCO2, airway compliance and leak volume were periodically recorded during the operation...
October 2015: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27329901/neonatal-endotracheal-intubation-how-to-make-it-more-baby-friendly
#20
REVIEW
Rajesh Maheshwari, Mark Tracy, Nadia Badawi, Murray Hinder
Neonatal endotracheal intubation is commonly accompanied by significant disturbances in physiological parameters. The procedure is often poorly tolerated, and multiple attempts are commonly required before the airway is secured. Adverse physiological effects include hypoxemia, bradycardia, hypertension, elevation in intracranial pressure and possibly increase in pulmonary vascular resistance. Use of premedications to facilitate intubation has been shown to reduce but not eliminate these effects. Other important preventative factors include adequate training of the operators and guidelines to limit the duration of attempts...
May 2016: Journal of Paediatrics and Child Health
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