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Brian R Lee, Jennifer L Goldman, Diana Yu, Angela L Myers, Leslie M Stach, Erin Hedican, Mary Anne Jackson, Jason G Newland
INTRODUCTION: Antibiotic stewardship programs (ASP) improve appropriate antibiotic use. Data are limited on the clinical benefit of ASPs in children's hospitals. This study's objective was to determine the impact of an ASP on length of stay (LOS) and readmission rate among patients admitted to children's hospitals. METHODS: Data from a prospective-audit-with-feedback ASP were used to examine the ASP review characteristics, including antibiotic(s) prescribed, clinical indication, recommendations made by the ASP, and agreement with recommendations...
December 2, 2016: Infectious Diseases and Therapy
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents the leading cause of nephrotic syndrome in adults and is one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate management of patients. In secondary cases, the best strategy consists in treating the underlying disease whereas in primary forms, the possible identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 23, 2016: Biochimica et Biophysica Acta
Laura Chery, Jennifer N Maki, Anjali Mascarenhas, Jayashri T Walke, Pooja Gawas, Anvily Almeida, Mezia Fernandes, Marina Vaz, Rakesh Ramanan, Diksha Shirodkar, Maria Bernabeu, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Ambika Sharma, Riaz Basha Shaik, Rimi Chakrabarti, Prasad Babar, John White, Devaraja G Mudeppa, Shiva Kumar, Wenyun Zuo, Kristen M Skillman, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Ashwani Kumar, Neena Valecha, V N Jindal, Anar Khandeparkar, Pradeep Naik, Sunanda Amonkar, Manoj T Duraisingh, Shripad Tuljapurkar, Joseph D Smith, Nagesh Dubhashi, Roque G W Pinto, Maria Silveria, Edwin Gomes, Pradipsinh K Rathod
BACKGROUND: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. METHODS: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P...
November 25, 2016: Malaria Journal
Christopher W Sundberg, Sandra K Hunter, Matthew W Bundle
The durations that muscular force and power outputs can be sustained until failure fall predictably on an exponential decline between an individual's 3-s burst maximum to the maximum performance they can sustain aerobically. The exponential time constants describing these rates of performance loss are similar across individuals suggesting that a common metabolically-based mechanism governs muscle fatigue; however, these conclusions come from studies mainly on men. To test whether the same physiological understanding can be applied to women, we compared the performance-duration relationships and neuromuscular activity between 7 men (23...
November 17, 2016: Journal of Applied Physiology
Ilana Harwayne-Gidansky, Melissa Langhan, Sholeen Nett, Beth Emerson, Matthew Pinto, Akira Nishisaki
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
In Kyu Moon, Seonno Yoon, Jungwoo Oh
To achieve high energy storage on three-dimensional (3D) structures at low cost, materials with high power and long cycle life characteristics have to be developed. We synthesized ZnCo2 O4 /reduced graphene oxide (rGO) binary composites in commercial sponges. ZnCo2 O4 nanosheets were grown on the surface of GO/sponge through a hydrothermal reaction. The resulting flexible, free-standing ZnCo2 O4 /rGO/sponge electrodes were used as the electrodes in a symmetric supercapacitor. ZnCo2 O4 /rGO/sponge electrodes have a large specific capacitance of 1116...
November 2, 2016: Chemistry: a European Journal
Peter J Na, Kim B Kim, Su Yeon Lee-Tauler, Hae-Ra Han, Miyong T Kim, Hochang B Lee
OBJECTIVE: Our aim is to investigate the prevalence and predictors of suicidal ideation among Korean American older adults and assess the self-rated mental health of Korean American older adults with suicidal ideation with or without depressive syndrome. METHODS: The Memory and Aging Study of Koreans is a cross-sectional, epidemiologic study of a community-representative sample of Korean American older adults (N = 1116) residing in the Baltimore-Washington area...
October 25, 2016: International Journal of Geriatric Psychiatry
Sofian Berrouiguet, Maria Luisa Barrigón, Sara A Brandt, Santiago Ovejero-García, Raquel Álvarez-García, Juan Jose Carballo, Philippe Lenca, Philippe Courtet, Enrique Baca-García
PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose CDSS. METHOD: A web application ( was developed to assess patients and collect data regarding gender, age, diagnosis and treatment. We analyzed antipsychotic prescriptions in 4345 patients attended in five Psychiatric Community Mental Health Centers from June 2014 to October 2014...
2016: PloS One
Hao Li, Wen Wang, Lu Zhang, Qing Lan, Jiangfei Wang, Yong Cao, Jizong Zhao
BACKGROUND: Intracranial aneurysm (IA) is a cerebrovascular disorder characterized by an abnormally bulged artery in the brain and subarachnoid hemorrhage caused by IA rupture with a high ratio of fatality and morbidity. However, the genetic cause of IA remains largely unknown. METHODS: A dysregulated long noncoding RNA (lncRNA) -associated competing endogenous RNA (ceRNA) network was constructed by using sample-matched microRNA (miRNA), lncRNA, and messenger (mRNA) expression profiles in 12 saccular IA samples and paired control arteries...
October 15, 2016: World Neurosurgery
Jan Franko, Qian Shi, Jeffrey P Meyers, Timothy S Maughan, Richard A Adams, Matthew T Seymour, Leonard Saltz, Cornelis J A Punt, Miriam Koopman, Christophe Tournigand, Niall C Tebbutt, Eduardo Diaz-Rubio, John Souglakos, Alfredo Falcone, Benoist Chibaudel, Volker Heinemann, Joseph Moen, Aimery De Gramont, Daniel J Sargent, Axel Grothey
BACKGROUND: Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer without peritoneal involvement. Here we further investigated the effect of the number and location of metastases in patients receiving first-line systemic chemotherapy. METHODS: We analysed individual patient data for previously untreated patients enrolled in 14 phase 3 randomised trials done between 1997 and 2008...
October 12, 2016: Lancet Oncology
Mary Brolin, Maria Torres, Dominic Hodgkin, Constance Horgan, Margaret Lee, Elizabeth Merrick, Grant Ritter, Lee Panas, Natasha DeMarco, Jonna Hopwood, Andrea Gewirtz, John Straus, Janice Harrington, Nancy Lane
OBJECTIVE: Multiple detoxification admissions among clients with substance use disorders (SUD) are costly to the health care system. This study explored the impact on behavior and cost outcomes of recovery support navigator (RSN) services delivered with and without a contingent incentive intervention. METHODS: New intakes at four detoxification programs were offered RSN-only (N=1116) or RSN plus incentive (RSN+I; N=1551) services. The study used a group-level cross-over design with the intervention in place at each clinic reversed halfway through the enrollment period...
September 12, 2016: Journal of Substance Abuse Treatment
K Kobayashi, S Hirota, Y Kako, S Yamamoto, H Takaki, K Yamakado
PURPOSE: This study was conducted to evaluate changes in liver stiffness, volume, and function before and after occlusion of spontaneous portosystemic shunt. MATERIALS & METHODS: Twenty-four patients (13 men and 11 women) with a mean age of 68.2 years±10.1 (SD) (age range, 49-82 years) underwent percutaneous occlusion of spontaneous portosystemic shunt because of gastric varices (n=17) or hepatic encephalopathy (n=7) from March 2011 to June 2013. The liver fibrosis index indicating liver stiffness was calculated by using ultrasound elastography before and after shunt occlusion...
September 20, 2016: Diagnostic and Interventional Imaging
Qingzhou Guan, Rou Chen, Haidan Yan, Hao Cai, You Guo, Mengyao Li, Xiangyu Li, Mengsha Tong, Lu Ao, Hongdong Li, Guini Hong, Zheng Guo
The highly stable within-sample relative expression orderings (REOs) of gene pairs in a particular type of human normal tissue are widely reversed in the cancer condition. Based on this finding, we have recently proposed an algorithm named RankComp to detect differentially expressed genes (DEGs) for individual disease samples measured by a particular platform. In this paper, with 461 normal lung tissue samples separately measured by four commonly used platforms, we demonstrated that tens of millions of gene pairs with significantly stable REOs in normal lung tissue can be consistently detected in samples measured by different platforms...
September 13, 2016: Oncotarget
Chris G Adigun, Tracey C Vlahovic, Michael B McClellan, Kailas D Thakker, Ryan R Klein, Tuan A Elstrom, Daniel B Ward
BACKGROUND: Poly-ureaurethane has been previously described for the management of dry, brittle, and in general, dystrophic nails. The polymer yields a waterproof, breathable barrier to protect the nail plate and prevent further damage to the nail, while regulating transonychial water loss (TOWL). Because nail dystrophy and dessication are contributing factors to onychomycosis, a barrier that protects the nail but also allows a topical antifungal to permeate its shield is potentially an advantageous combination...
September 1, 2016: Journal of Drugs in Dermatology: JDD
David M Fothergill, Allison R Loiselle, Anthony R Reinhold
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Hongnian Sun, Dongdong Zhao, Bin Xiong, Chunzhi Zhang, Changhao Bi
BACKGROUND: Corynebacterium glutamicum was used as a metabolic engineering chassis for production of crude violacein (mixture of violacein and deoxyviolacein) due to Corynebacterium's GRAS status and advantages in tryptophan fermentation. The violacein is a commercially potential compound with various applications derived from L-tryptophan. RESULTS: Corynebacterium glutamicum ATCC 21850 that could produce 162.98 mg L(-1) tryptophan was employed as a novel host for metabolic engineering chassis...
2016: Microbial Cell Factories
Yuanyuan Li, Qifa Cai, Lei Wang, Qingwei Li, Xiang Peng, Biao Gao, Kaifu Huo, Paul K Chu
Rechargeable lithium-sulfur (Li-S) batteries are promising in high-energy storage due to the large specific energy density of about 2600 W h kg(-1). However, the low conductivity of sulfur and discharge products as well as polysulfide-shuttle effect between the cathode and anode hamper applications of Li-S batteries. Herein, we describe a novel and efficient S host material consisting of mesoporous TiO2 nanocrystals (NCs) fabricated in situ on reduced graphene oxide (rGO) for Li-S batteries. The TiO2@rGO hybrid can be loaded with 72 wt % sulfur...
September 14, 2016: ACS Applied Materials & Interfaces
N J Robinson, R S Dean, M Cobb, M L Brennan
It is currently unclear how frequently a diagnosis is made during small-animal consultations or how much of a role making a diagnosis plays in veterinary decision-making. Understanding more about the diagnostic process will help direct future research towards areas relevant to practicing veterinary surgeons. The aim of this study was to determine the frequency with which a diagnosis was made, classify the types of diagnosis made (and the factors influencing these) and determine which specific diagnoses were made for health problems discussed during small-animal consultations...
September 1, 2016: Preventive Veterinary Medicine
Denise A Rokitka, Colleen Curtin, Jennifer E Heffler, Michael A Zevon, Kris Attwood, Martin C Mahoney
PURPOSE: Surveillance for long-term complications related to previous cancer therapy can help diagnose/manage chronic health conditions in childhood cancer survivors and improve survivor quality of life. However, a challenge to delivering long-term care to childhood cancer survivors is loss to follow-up; many patients discontinue care at specialized survivor care centers. The purpose of this study was to examine patterns of loss to follow-up among a cohort of childhood cancer survivors...
August 16, 2016: Journal of Adolescent and Young Adult Oncology
Sardar Sindhu, Areej Al-Roub, Merin Koshy, Reeby Thomas, Rasheed Ahmad
BACKGROUND/AIMS: Obese individuals are known to have increased Matrix metalloproteinase (MMP)-9 plasma levels and MMP-9 is reported to play an important role in obesity-associated adipose tissue inflammation. Since in obesity, the levels of circulatory saturated free fatty acid (FFA) palmitate (palimitic acid) are increased and modulate the expression of inflammatory mediators, the role of palmitate in the regulation of MMP-9 remains unclear. METHODS: Human monocytic cell line THP-1 and primary monocytes were stimulated with palmitate and TNF-α (positive control)...
2016: Cellular Physiology and Biochemistry
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