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https://www.readbyqxmd.com/read/28418614/efficacy-and-safety-of-low-dose-heparin-in-hemodialysis
#1
Mariana Murea, Gregory B Russell, Pirouz Daeihagh, Anita M Saran, Karan Pandya, Mark Cabrera, John M Burkart, Barry I Freedman
INTRODUCTION: The dose of unfractionated heparin (UFH) administered during hemodialysis (HD) varies widely. This prospective study evaluated the safety and efficacy of UFH dose de-escalation. METHODS: Sixty-six prevalent patients on HD receiving UFH per standard-dose protocol (load dose [LD] 50-75 units/kg, maintenance dose [MD] 500-1000 units/hour) had heparin prescription converted to low-dose protocol (start LD 15 units/kg and MD 500 units/hour; dose adjusted in small increments based on assessments of extracorporeal blood circuit)...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28407309/cadmium-exposure-and-osteoporosis-a-population-based-study-and-benchmark-dose-estimation-in-southern-china
#2
Lv Yingjian, Wang Ping, Huang Rui, Liang Xuxia, Wang Peng, Tan Jianbin, Chen Zihui, Dun Zhongjun, Wang Jing, Jiang Qi, Wu Shixuan, Ling Haituan, Li Zhixue, Yang Xinfen
This study aimed to assess the association between osteoporosis and long-term environmental Cd exposure through diet in southern China. A total of 1116 subjects from a Cd-polluted area and a non-Cd-polluted area were investigated. All subjects met the criteria of having been living in the investigated area for more than 15 years and lived on a subsistence diet of rice and vegetables grown in that area. Besides bone mineral density, the levels of urinary markers of early renal impairment, such as urinary N-acetyl-β-D-glucosaminidase (NAG), α1 -microglobulin, β2 -microglobulin, and urinary albumin, were also determined...
April 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28384126/an-automated-method-for-accurate-vessel-segmentation
#3
Xin Yang, Chaoyue Liu, Hung Le Minh, Zhiwei Wang, Aichi Chien, Kwang-Ting Tim Cheng
Vessel segmentation is a critical task for various medical applications, such as diagnosis assistance of diabetic retinopathy, quantification of cerebral aneurysm's growth, and guiding surgery in neurosurgical procedures. Despite technology advances in image segmentation, existing methods still suffer from low accuracy for vessel segmentation in the two challenging while common scenarios in clinical usage: (1) regions with a low signal-to-noise-ratio (SNR), and (2) at vessel boundaries disturbed by adjacent non-vessel pixels...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28330106/enhanced-production-of-pectinase-by-aspergillus-terreus-ncft-4269-10-using-banana-peels-as-substrate
#4
Bijay Kumar Sethi, Prativa Kumari Nanda, Santilata Sahoo
Aspergillus terreus NCFT4269.10 was implemented in solid-state (SSF) and liquid static surface fermentation (LSSF) for biosynthesis of pectinase. Amongst various substrates, like, mustard oil cake, neem oil cake, groundnut oil cake, black gram peels, green gram peels, chickling vetch peels/grass pea peels wheat bran, pearl millet residues, finger millet waste, broken rice, banana peels (BP), apple pomace (AP) and orange peels, banana peel (Musa paradisiaca L.; Family: Musaceae) was most suitable for pectinase biosynthesis (LSSF: 400 ± 21...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28320025/-the-influence-of-caseload-on-continuous-treatment-with%C3%A2-antidementia-drugs
#5
Jens Bohlken, Karel Kostev
Objective The goal of this study is to investigate the impact of the number of dementia cases in general and specialist practices on the continuity of treatment with antidementia drugs. Methodology Period between 2004 and 2013: 1116 general practices, 200 specialist practices, 37 178 dementia cases; observation period: 36 months. Practice groups with 1 - 9, 10 - 20, 21-s49, and ≥ 50 dementia cases. Results The treatment continuity is higher in practices with an average of 150 dementia cases than in practices with five dementia cases (73...
March 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28195211/psychological-stress-and-risk-of-incident-atrial-fibrillation-in-men-and-women-with-known-atrial-fibrillation-genetic-risk-scores
#6
Thomas Svensson, Mariusz Kitlinski, Gunnar Engström, Olle Melander
Psychological stress has been reported as a possible trigger of atrial fibrillation (AF). No studies have investigated whether any association between stress and AF could be modified by genetic susceptibility to AF (AF-genetic risk score (AF-GRS)). 8765 men and 13,543 women from the Malmö Diet Cancer Study, a population-based cohort, were included in the analyses. A variable representing stress was constructed from questions measuring job strain, and from one question assessing non-occupational stress. Cox proportional hazards regression models were adjusted for known covariates of AF...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181202/long-term-outcome-of-acute-coronary-syndromes-in-young-patients
#7
Giacomo Tini, Giulia Proietti, Matteo Casenghi, Marzia Colopi, Katia Bontempi, Camillo Autore, Massimo Volpe, Beatrice Musumeci
INTRODUCTION: Acute coronary syndromes (ACS) in young patients are uncommon and their influence on morbidity and mortality in this population is still debated. AIM: We investigated clinical and angiographic characteristics, risk factors and outcome in young patients diagnosed with ACS, compared with those of older patients, evaluating survival free from death and/or nonfatal myocardial infarction (MI) and/or coronary revascularization (primary endpoint), and then with respect to each component of the primary endpoint...
February 8, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28145490/comparative-genomics-of-vibrio-campbellii-strains-and-core-species-of-the-vibrio-harveyi-clade
#8
Huei-Mien Ke, Anuphap Prachumwat, Chun-Ping Yu, Yi-Ting Yang, Sutitcha Promsri, Kuan-Fu Liu, Chu-Fang Lo, Mei-Yeh Jade Lu, Mei-Chin Lai, Isheng J Tsai, Wen-Hsiung Li
The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but misclassification has been common due to similarities in their rDNA sequences and phenotypes. To better understand their evolutionary relationships and functional features, we sequenced a shrimp pathogen strain V. harveyi 1114GL, reclassified it as V. campbellii and compared this and 47 other sequenced Vibrio genomes in the Harveryi clade...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28117013/gray-scale-and-power-doppler-ultrasonographic-findings-in-the-assessment-of-disease-activity-and-their-correlation-with-disease-activity-parameters-in-rheumatoid-arthritis
#9
Sandeep Jindal, Reshma Kaushik, Shailendra Raghuvanshi, Rajeev Mohan Kaushik, Rajesh Kakkar
OBJECTIVES: To study the utility of gray scale and power Doppler ultrasonography in assessing the disease activity and correlation of ultrasonographic findings with disease activity parameters in rheumatoid arthritis (RA). MATERIALS AND METHODS: This cross-sectional study was conducted on 100 RA patients diagnosed as per 2010 classification criteria. Rheumatoid factor (RF), serum anti-cyclic citrullinated peptide antibodies (ACPA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score with 28-joint counts and ESR (DAS28-ESR), visual analogue scale (VAS) for global disease activity and gray scale ultrasonography (GSUS) and power Doppler ultrsonography (PDUS) scores in hands and wrists were determined...
January 19, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28111236/prevalence-of-prediabetes-risk-in-offspring-born-to-mothers-with-hyperandrogenism
#10
Shen Tian, Xian-Hua Lin, Yi-Meng Xiong, Miao-E Liu, Tian-Tian Yu, Min Lv, Wei Zhao, Gu-Feng Xu, Guo-Lian Ding, Chen-Ming Xu, Min Jin, Chun Feng, Yan-Ting Wu, Ya-Jing Tan, Qian Gao, Jian Zhang, Cheng Li, Jun Ren, Lu-Yang Jin, Bin Chen, Hong Zhu, Xue-Ying Zhang, Song-Chang Chen, Xin-Mei Liu, Ye Liu, Jun-Yu Zhang, Li Wang, Ping Zhang, Xiao-Jun Chen, Li Jin, Xi Chen, Yi-Cong Meng, Dan-Dan Wu, Hui Lin, Qian Yang, Cheng-Liang Zhou, Xin-Zhu Li, Yi-Yu Wang, Yu-Qian Xiang, Zhi-Wei Liu, Ling Gao, Lu-Ting Chen, Hong-Jie Pan, Rong Li, Fang-Hong Zhang, Lan-Feng Xing, Yi-Min Zhu, Christian Klausen, Peter C K Leung, Ju-Xue Li, Fei Sun, Jian-Zhong Sheng, He-Feng Huang
BACKGROUND: Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. METHODS: Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28102896/impact-of-pre-transplant-depression-on-outcomes-of-allogeneic-and-autologous-hematopoietic-stem-cell-transplantation
#11
Areej El-Jawahri, Yi-Bin Chen, Ruta Brazauskas, Naya He, Stephanie J Lee, Jennifer M Knight, Navneet Majhail, David Buchbinder, Raquel M Schears, Baldeep M Wirk, William A Wood, Ibrahim Ahmed, Mahmoud Aljurf, Jeff Szer, Sara M Beattie, Minoo Battiwalla, Christopher Dandoy, Miguel-Angel Diaz, Anita D'Souza, Cesar O Freytes, James Gajewski, Usama Gergis, Shahrukh K Hashmi, Ann Jakubowski, Rammurti T Kamble, Tamila Kindwall-Keller, Hilard M Lazarus, Adriana K Malone, David I Marks, Kenneth Meehan, Bipin N Savani, Richard F Olsson, David Rizzieri, Amir Steinberg, Dawn Speckhart, David Szwajcer, Helene Schoemans, Sachiko Seo, Celalettin Ustun, Yoshiko Atsuta, Jignesh Dalal, Carmem Sales-Bonfim, Nandita Khera, Theresa Hahn, Wael Saber
BACKGROUND: To evaluate the impact of depression before autologous and allogeneic hematopoietic cell transplantation (HCT) on clinical outcomes post-transplantation. METHODS: We analyzed data from the Center for International Blood and Marrow Transplant Research to compare outcomes after autologous (n = 3786) or allogeneic (n = 7433) HCT for adult patients with hematologic malignancies with an existing diagnosis of pre-HCT depression requiring treatment versus those without pre-HCT depression...
January 19, 2017: Cancer
https://www.readbyqxmd.com/read/28047242/su-f-t-494-a-multi-institutional-study-of-independent-dose-verification-using-golden-beam-data
#12
M Itano, R Tachibana, M Yamashita, H Shimizu, Y Sugawara, K Kotabe, T Kamima, R Takahashi, S Ishibashi, Y Uchida, T Yamazaki, H Tachibana
PURPOSE: In general, beam data of individual linac is measured for independent dose verification software program and the verification is performed as a secondary check. In this study, independent dose verification using golden beam data was compared to that using individual linac's beam data. METHODS: Six institutions were participated and three different beam data were prepared. The one was individual measured data (Original Beam Data, OBD) .The others were generated by all measurements from same linac model (Model-GBD) and all linac models (All-GBD)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27977601/three-polymorphisms-of-tumor-necrosis-factor-alpha-and-hepatitis-b-virus-related-hepatocellular-carcinoma-a-meta-analysis
#13
Qi Xiao, BiQi Fu, Ping Chen, Zhong Zhong Liu, Wei Wang, QiFa Ye
BACKGROUND: To assess the association between tumor necrosis factor-alpha (TNF-α) G308A, G238A and C863T polymorphisms and hepatitis B virus related hepatocellular carcinoma (HBV-HCC) susceptibility. METHODS: We interrogated the databases of Pubmed, Sciencedirect and Viley online library up to March 8, 2016. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated in a fixed-effects model or a random-effects model when appropriate. RESULTS: In total, 12 case-control studies which containing 1580 HBV-HCC cases, 2033 HBV carrier controls, 395 HBV spontaneously recovered (SR) controls and 1116 healthy controls were included...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27951593/autofluorescence-lifetimes-in-patients-with-choroideremia-identify-photoreceptors-in-areas-with-retinal-pigment-epithelium-atrophy
#14
Chantal Dysli, Sebastian Wolf, Hoai Viet Tran, Martin S Zinkernagel
Purpose: The purpose of this study was to investigate fundus autofluorescence lifetimes in patients with choroideremia and to identify tissue-specific lifetime characteristics and potential prognostic markers. Methods: Autofluorescence lifetimes of the retina were measured in two spectral channels (498-560 nm and 560-720 nm) in patients with choroideremia and age-matched healthy controls. Furthermore, autofluorescence intensities and spectral-domain optical coherence tomography (OCT) data were acquired and compared to fundus autofluorescence lifetime data...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27938920/impact-of-different-hypopnea-definitions-on-obstructive-sleep-apnea-severity-and-cardiovascular-mortality-risk-in-women-and-elderly-individuals
#15
Francisco Campos-Rodriguez, Miguel A Martínez-García, Nuria Reyes-Nuñez, Maria J Selma-Ferrer, Naresh M Punjabi, Ramon Farre
OBJECTIVE: To assess the impact of three hypopnea definitions on the severity classification of obstructive sleep apnea (OSA) and its association with cardiovascular mortality risk in women and elderly individuals. METHODS: We analyzed two Spanish clinical cohorts (1116 women and 939 elderly individuals) who were studied for suspicion of OSA between 1998 and 2007. A calibration model was used to apply different definitions of hypopnea to our two cohorts. Hypopnea was defined as a 30-90% reduction in oronasal flow for ≥10 s followed by (1) ≥4% fall in oxyhemoglobin saturation-AHI4%; (2) ≥3% fall in oxyhemoglobin saturation-AHI3%; or (3) ≥3% fall in oxyhemoglobin saturation or an event-related arousal-AHI3%a...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27913975/clinical-impact-of-an-antibiotic-stewardship-program-at-a-children-s-hospital
#16
Brian R Lee, Jennifer L Goldman, Diana Yu, Angela L Myers, Leslie M Stach, Erin Hedican, Mary Anne Jackson, Jason G Newland
INTRODUCTION: Antibiotic stewardship programs (ASP) improve appropriate antibiotic use. Data are limited on the clinical benefit of ASPs in children's hospitals. This study's objective was to determine the impact of an ASP on length of stay (LOS) and readmission rate among patients admitted to children's hospitals. METHODS: Data from a prospective-audit-with-feedback ASP were used to examine the ASP review characteristics, including antibiotic(s) prescribed, clinical indication, recommendations made by the ASP, and agreement with recommendations...
March 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27890680/the-putative-role-of-maldi-msi-in-the-study-of-membranous-nephropathy
#17
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment. In secondary cases, the best strategy involves treating the underlying disease, whereas in primary forms, the identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27884146/demographic-and-clinical-profiles-of-plasmodium-falciparum-and-plasmodium-vivax-patients-at-a-tertiary-care-centre-in-southwestern-india
#18
Laura Chery, Jennifer N Maki, Anjali Mascarenhas, Jayashri T Walke, Pooja Gawas, Anvily Almeida, Mezia Fernandes, Marina Vaz, Rakesh Ramanan, Diksha Shirodkar, Maria Bernabeu, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Ambika Sharma, Riaz Basha Shaik, Rimi Chakrabarti, Prasad Babar, John White, Devaraja G Mudeppa, Shiva Kumar, Wenyun Zuo, Kristen M Skillman, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Ashwani Kumar, Neena Valecha, V N Jindal, Anar Khandeparkar, Pradeep Naik, Sunanda Amonkar, Manoj T Duraisingh, Shripad Tuljapurkar, Joseph D Smith, Nagesh Dubhashi, Roque G W Pinto, Maria Silveria, Edwin Gomes, Pradipsinh K Rathod
BACKGROUND: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. METHODS: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27856712/rates-of-performance-loss-and-neuromuscular-activity-in-men-and-women-during-cycling-evidence-for-a-common-metabolic-basis-of-muscle-fatigue
#19
Christopher W Sundberg, Sandra K Hunter, Matthew W Bundle
The durations that muscular force and power outputs can be sustained until failure fall predictably on an exponential decline between an individual's 3-s burst maximum to the maximum performance they can sustain aerobically. The exponential time constants describing these rates of performance loss are similar across individuals, suggesting that a common metabolically based mechanism governs muscle fatigue; however, these conclusions come from studies mainly on men. To test whether the same physiological understanding can be applied to women, we compared the performance-duration relationships and neuromuscular activity between seven men [23...
January 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27850753/1116-end-tidal-carbon-dioxide-monitoring-for-tracheal-intubation-a-prospective-multicenter-study
#20
Ilana Harwayne-Gidansky, Melissa Langhan, Sholeen Nett, Beth Emerson, Matthew Pinto, Akira Nishisaki
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
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