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Chronic ulcerative colitis in children

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https://www.readbyqxmd.com/read/27890312/variables-associated-with-loss-of-ileoanal-pouches-constructed-in-childhood
#1
Khaled Abdelaal, Bruce Jaffray
AIMS: To quantify the incidence of loss of an ileoanal pouch in children and to identify variables associated this event. METHODS: Logistic regression of possible explanatory variables: age, sex, indication for procto-colectomy, pre-operative continence status, use of immunosuppressive drugs, open or laparoscopic surgery, number of stages, anastomotic leak, operative complication excluding anastomotic leak, performance of revisional surgery, albumin concentration and platelet count at time of surgery, rank order in series...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27862714/de-novo-inflammatory-bowel-disease-after-pediatric-kidney-or-liver-transplant
#2
Melissa A Fernandes, Hillary J Braun, Kim Evason, Sue Rhee, Emily R Perito
A subset of children who receive a liver and/or kidney transplant develop de novo inflammatory bowel disease-like chronic intestinal inflammation, not explained by infection or medications, following transplant. We have conducted a single-center, retrospective case series describing the unique clinical and histologic features of this IBD-like chronic intestinal inflammation following solid organ transplant. At our center, nine of 327 kidney or liver recipients developed de novo IBD following transplant (six liver, two kidney, one liver-kidney)...
November 11, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27622899/comparison-of-cytokine-and-efflux-transporter-expression-in-pediatric-vs-adult-onset-ulcerative-colitis
#3
Ana Savić Mlakar, Iva Hojsak, Mladen Jergović, Valerija Vojvoda Parčina, Žarko Babić, Branko Troskot, Željko Mihaljević, Krešo Bendelja
OBJECTIVES: Ulcerative colitis (UC), a chronic inflammation of the colon, is often more severe in children than adults. Identification of altered expression of efflux transporters, cytokines and suppressor of cytokine signalling (SOCS) molecules in pediatric vs. adult patients could provide insight to the differential molecular patterns related to the age and disease pathology. METHODS: Mucosal samples from terminal ileum and colon in pediatric (9 UC-New; 4 UC-Remission) and adult (9 UC-New; 8 UC-Remission) patients were compared to healthy subjects (15 children and 10 adults) for mRNA expressions of several efflux transporters, cytokines and SOCS molecules...
September 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27559471/improving-clinical-remission-rates-in-pediatric-inflammatory-bowel-disease-with-previsit-planning
#4
Jeffrey R Savarino, Jess L Kaplan, Harland S Winter, Christopher J Moran, Esther J Israel
Inflammatory Bowel Disease (IBD) is a chronic autoimmune inflammatory disease of the intestine which can lead to malnutrition, poor quality of life, and colon cancer.(1-4) Although there is no cure for the disease, clinical remission is the primary goal.(5) The Center for Inflammatory Bowel Disease at MassGeneral Hospital for Children (MGHfC) adopted a Previsit Planning (PVP) model to identify and discuss symptomatic patients prior to their appointments to identify specific issues that impact disease management...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27412739/-clinical-analysis-of-enteral-nutrition-in-47-children
#5
R D Zhuang, L J Tang, Y H Fang, K R Peng, J Chen
OBJECTIVE: To explore the efficacy and safety of the application of enteral nutrition (EN) in gastrointestinal disease in children, and to explore the possibility of the implementation of family EN. METHOD: Retrospective analysis of disease spectrum, EN approach, preparation, speed and time as well as adverse reactions and outcomes in 47 pediatric patients with gastrointestinal disease underwent EN therapy during July 2014 to March 2015. The nutrition indicators before and after EN therapy were compared by paired t-test...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27408437/gelatinous-transformation-of-bone-marrow-a-prospective-tertiary-center-study-indicating-varying-trends-in-epidemiology-and-pathogenesis
#6
Sneh Singh, Monica Gupta, Gajender Singh, Ashima Batra, Pratibha Dhiman, Abhinav, Sonia Chhabra, Rajeev Sen
Gelatinous bone marrow transformation (GTBM) also known as serous atrophy is a degenerative change in the hematopoietic bone marrow and is a rare well recognized pathological entity. It was earlier described mainly in association with anorexia nervosa and psychiatric eating disorders, but recently it has been reported in ulcerative colitis, tuberculosis, chronic renal diseases, immuno suppressed states (mainly HIV infection), malignancies and Kala azar. Treatment is based on treating the underlying disease...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27243421/predictors-of-pouchitis-after-ileal-pouch-anal-anastomosis-in-children
#7
Rajmohan Dharmaraj, Mahua Dasgupta, Pippa Simpson, Joshua Noe
OBJECTIVES: Predictive factors for the development of pouchitis after ileal pouch-anal anastomosis (IPAA) in children have not been well studied. In this retrospective study, the incidence and risk factors that predict pouchitis in children with IPAA will be identified. METHODS: The records of patients who underwent IPAA surgery at Children's Hospital of Wisconsin between January 2000 and December 2013 were reviewed retrospectively. Patients with clinical, endoscopic, and histological findings consistent with pouchitis were identified...
October 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27168239/mechanisms-of-pediatric-inflammatory-bowel-disease
#8
Joanna M Peloquin, Gautam Goel, Eduardo J Villablanca, Ramnik J Xavier
Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is characterized by chronic intestinal inflammation due to a complex interaction of genetic determinants, disruption of mucosal barriers, aberrant inflammatory signals, loss of tolerance, and environmental triggers. Importantly, the incidence of pediatric IBD is rising, particularly in children younger than 10 years. In this review, we discuss the clinical presentation of these patients and highlight environmental exposures that may affect disease risk, particularly among people with a background genetic risk...
May 20, 2016: Annual Review of Immunology
https://www.readbyqxmd.com/read/27130833/value-of-histopathology-for-predicting-the-post-operative-complications-of-ileo-anal-anastomosis-j-pouch-procedure-in-children-with-refractory-ulcerative-colitis
#9
Dina El Demellawy, Soufiane El Hallani, Joseph de Nanassy, James Young Lee, Emily Chan, Katrina Sullivan, Juan Bass, David Mack, Ahmed Nasr
The J-pouch is a surgical procedure offered to children with refractory ulcerative colitis (UC) who have undergone subtotal colectomy to reconstruct a reservoir function with ileo-anal anastomosis. Unfortunately, post-operative complications may occur and can compromise the pouch function. We assessed rectal histopathology to determine whether severity of inflammation in the rectum prior to the creation of the J-Pouch was associated with post-operative complications. We retrospectively reviewed the histopathology of all J-pouch procedure specimens from paediatric patients during the period 2000-2013 using an objective grading system that assesses the chronicity and activity of the UC disease...
June 2016: Pathology
https://www.readbyqxmd.com/read/27124970/-hormonal-changes-in-inflammatory-bowel-disease
#10
Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn's disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease. In the article we analyze correlation of IBD with gonadal hormone production and fertility, with adrenal function, with the function and morphology of the thyroid, with growth hormone production and growth disorders in children, and with bone mineral density reduction...
December 2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27117378/inflammatory-bowel-diseases-and-reproductive-health
#11
REVIEW
Agnieszka Kokoszko-Bilska, Slawomir Sobkiewicz, Jakub Fichna
Inflammatory bowel diseases (IBD) constitute a group of chronic intestinal diseases, including Crohn's disease and ulcerative colitis, which typically involve patients of reproductive age and may influence several features of human reproduction. There are many concerns regarding the interactions between the course of IBD, applied treatment (pharmacological or surgical), and fertility, reproductive outcomes, and also neonatal outcomes. To review the literature describing fertility in IBD patients (separately for female and male), and possible infertility treatment in this group of patients, a PubMed search for English only publications (articles and/or abstracts) was conducted...
August 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27110305/demographic-characteristics-of-children-with-early-clinical-manifestation-of-inflammatory-bowel-disease
#12
Edyta Szymańska, Sylwia Szymańska, Michał Szczepański, Piotr Landowski, Grażyna Czaja-Bulsa, Elżbieta Jarocka-Cyrta, Bartosz Korczowski, Elżbieta Krzesiek, Jarosław Kierkuś
INTRODUCTION: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition of the colon and small intestine. The disease is common in young people (children and young adults), but it is rare in children younger than five years of age. Therefore, IBD developing during the first years of life (under the age of 5) is known as an early-onset IBD (EO-IBD), and it is considered to be a specific entity with a distinct phenotype. However, the available data on that issue are still insufficient...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27108229/crohn-s-disease-and-gynecologic-manifestations-in-young-females
#13
C N Davis-Kankanamge, J L Bercaw-Pratt, X M Santos, J E Dietrich
STUDY OBJECTIVE: The purpose of this study was to describe the reproductive and gynecological concerns of young females with Crohn's disease. DESIGN, SETTING, PARTICIPANTS: Retrospective chart review of young females with Crohn's disease and gynecologic concerns at a large, urban tertiary children's hospital. INTERVENTIONS: none MAIN OUTCOME MEASURES: Documentation of abnormal bleeding, pelvic pain, genital fistula, ulcer, or abscess. RESULTS: The majority (85...
April 20, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26921580/quality-of-life-in-adolescents-with-inflammatory-bowel-disease-and-their-parents-comparison-with-healthy-controls
#14
COMPARATIVE STUDY
Daniela Jelenova, Jan Prasko, Marie Ociskova, Eva Karaskova, Martina Hunkova, Jana Kolarova, David Vydra, Michaela Holubova, Radovan Hruby, Klara Latalova, Vladimir Mihal
OBJECTIVE: Inflammatory bowel diseases (IBD) are chronic diseases with a significant impact on quality of life (QoL). The aim of the study was to examine the QoL in children with IBD and their families, depression and anxiety for both the children and their parents. METHODS: Participants were 29 adolescents with IBD (19 individuals suffered from the Crohn disease, another ten had ulcerative colitis) and 40 healthy controls of the same age (13-16 years). The probands and their parents completed questionnaires measuring the quality of life (KidScreen-10, PedsQL), depression (CDI, BDI-II), and anxiety (SAD, BAI)...
2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/26891438/-coexistence-of-coeliac-disease-and-inflammatory-bowel-disease-in-children
#15
REVIEW
Paulina Krawiec, Agnieszka Pawłowska-Kamieniak, Elżbieta Pac-Kożuchowska, Agnieszka Mroczkowska-Juchkiewcz, Katarzyna Kominek
Coeliac disease and inflammatory bowel disease are chronic inflammatory conditions of gastrointestinal tract with complex aetiology with genetic, environmental and immunological factors contributing to its pathogenesis. It was noted that immune-mediated disorders often coexist. There is well-known association between coeliac disease and type 1 diabetes and ulcerative colitis and primary sclerosing cholangitis. However, growing body of literature suggests the association between coeliac disease and inflammatory bowel disease, particularly ulcerative colitis...
January 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26891431/-ulcerative-colitis-in-a-6-year-old-boy-with-severe-coeliac-disease-a-case-report
#16
Agnieszka Pawłowska-Kamieniak, Paulina Krawiec, Elżbieta Pac-Kożuchowska, Agnieszka Mroczkowska-Juchkiewcz, Katarzyna Kominek
Coeliac disease is a chronic immune-mediated inflammation of the small intestine elicited by the gluten ingestion in genetically susceptible people. In coeliac patients there is higher incidence of other autoimmune disorders like type 1 diabetes or Hashimoto's thyroiditis. The coexistence of coeliac disease and inflammatory bowel disease is rare. The spectrum of presentation of coeliac disease and inflammatory bowel disease may be similar. However, those disorders require various therapeutic approaches. Thus, early recognition of the overlap between coeliac disease and inflammatory bowel disease is crucial to apply appropriate treatment and to prevent possible complications...
January 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26841224/controversies-revisited-a-systematic-review-of-the-comorbidity-of-depression-and-anxiety-with-inflammatory-bowel-diseases
#17
Antonina Mikocka-Walus, Simon R Knowles, Laurie Keefer, Lesley Graff
BACKGROUND: Although mental health concerns are known to occur commonly for those with inflammatory bowel diseases (IBD), the nature of this comorbid relationship has not been systematically reviewed to date. A review in 2007 identified 5 controversies regarding anxiety/depression rates and various comparators between and within IBD. We aimed to systematically analyze and critique the current evidence regarding this comorbidity, providing an update to the 5 controversies. METHODS: Ebscohost Medline, CINAHL, Embase, and PsychINFO were searched between 2005 and 2014 using systematic review methodology...
March 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26800471/-hormonal-changes-in-inflammatory-bowel-disease
#18
Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
UNLABELLED: Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn´s disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease...
2015: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/26582737/review-article-the-natural-history-of-paediatric-onset-ulcerative-colitis-in-population-based-studies
#19
REVIEW
M Fumery, D Duricova, C Gower-Rousseau, V Annese, L Peyrin-Biroulet, P L Lakatos
BACKGROUND: A better knowledge of the natural history of disabling chronic diseases is essential to improve patient management, evaluate the impact of treatment strategies and provide predictors for disabling disease and comprehensive information for patients. AIM: To summarise our current knowledge issued from population-based studies of the natural history of ulcerative colitis (UC) in children. METHODS: We searched MEDLINE (source PubMed) and international conference abstracts, and included all population-based studies that evaluated long-term outcome of paediatric-onset (<17 years at diagnosis) UC...
February 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/26414706/inflammatory-bowel-disease-in-children-and-adolescents
#20
REVIEW
Michael J Rosen, Ashish Dhawan, Shehzad A Saeed
The inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn disease, are chronic inflammatory disorders of the gastrointestinal tract most often diagnosed in adolescence and young adulthood, with a rising incidence in pediatric populations. These disorders are common enough in children that most pediatricians and other pediatric clinicians will encounter children with IBD in their general practice. Inflammatory bowel disease is caused by a dysregulated mucosal immune response to the intestinal microflora in genetically predisposed hosts...
November 2015: JAMA Pediatrics
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