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https://www.readbyqxmd.com/read/28809092/particle-targeting-in-complex-biological-media
#1
REVIEW
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Björnmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e...
August 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28777608/topological-control-on-the-structural-relaxation-of-atomic-networks-under-stress
#2
Mathieu Bauchy, Mengyi Wang, Yingtian Yu, Bu Wang, N M Anoop Krishnan, Enrico Masoero, Franz-Joseph Ulm, Roland Pellenq
Upon loading, atomic networks can feature delayed irreversible relaxation. However, the effect of composition and structure on relaxation remains poorly understood. Herein, relying on accelerated molecular dynamics simulations and topological constraint theory, we investigate the relationship between atomic topology and stress-induced structural relaxation, by taking the example of creep deformations in calcium silicate hydrates (C─S─H), the binding phase of concrete. Under constant shear stress, C─S─H is found to feature delayed logarithmic shear deformations...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28691100/nonvolatile-ferroelectric-domain-wall-memory
#3
Pankaj Sharma, Qi Zhang, Daniel Sando, Chi Hou Lei, Yunya Liu, Jiangyu Li, Valanoor Nagarajan, Jan Seidel
Ferroelectric domain walls are atomically sharp topological defects that separate regions of uniform polarization. The discovery of electrical conductivity in specific types of walls gave rise to "domain wall nanoelectronics," a technology in which the wall (rather than the domain) stores information. This paradigm shift critically hinges on precise nanoengineering of reconfigurable domain walls. Using specially designed nanofabricated electrodes and scanning probe techniques, we demonstrate a prototype nonvolatile ferroelectric domain wall memory, scalable to below 100 nm, whose binary state is defined by the existence or absence of conductive walls...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28691071/nanoengineered-ultralight-and-robust-all-metal-cathode-for-high-capacity-stable-lithium-oxygen-batteries
#4
Ji-Jing Xu, Zhi-Wen Chang, Yan-Bin Yin, Xin-Bo Zhang
The successful development of Li-O2 battery technology depends on resolving the issue of cathode corrosion by the discharge product (Li2O2) and/or by the intermediates (LiO2) generated during cell cycling. As an important step toward this goal, we report for the first time the nanoporous Ni with a nanoengineered AuNi alloy surface directly attached to Ni foam as a new all-metal cathode system. Compared with other noncarbonaceous cathodes, the Li-O2 cell with an all-metal cathode is capable of operation with ultrahigh specific capacity (22,551 mAh g(-1) at a current density of 1...
June 28, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28672204/nanoengineered-porous-chitosan-catio3-hybrid-scaffolds-for-accelerating-schwann-cells-growth-in-peripheral-nerve-regeneration
#5
Guicai Li, Qinzhi Xiao, Ryan McNaughton, Lei Han, Luzhong Zhang, Yaling Wang, Yumin Yang
To further improve the property of promoting peripheral nerve regeneration of chitosan materials, CaTiO3 nanoparticles with various concentrations were synthesized in chitosan (CS) solution and formed to porous CS/CaTiO3 hybrid scaffolds. The properties including morphology, wettability, porosity, crystallization intensity and surface charges were characterized, respectively. The influence of the porous CS/CaTiO3 hybrid scaffolds on Schwann cells growth was evaluated. The results showed that the CaTiO3 hybridized CS scaffolds possessed homogeneous nanoparticles distribution with concentration-dependent effect...
June 22, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28658956/protein-interactions-with-nanoengineered-polyoxazoline-surfaces-generated-via-plasma-deposition
#6
Laura E Gonzalez Garcia, Melanie MacGregor-Ramiasa, Rahul Madathiparambil Visalakshan, Krasimir Vasilev
Protein adsorption to biomaterials is critical in determining their suitability for specific applications, such as implants or biosensors. Here, we show that surface nanoroughness can be tailored to control the covalent binding of proteins to plasma-deposited polyoxazoline (PPOx). Nanoengineered surfaces were created by immobilizing gold nanoparticles varying in size and surface density on PPOx films. To keep the surface chemistry consistent while preserving the nanotopography, all substrates were overcoated with a nanothin PPOx film...
July 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28648641/glypican-based-drug-releasing-titania-implants-to-regulate-bmp2-bioactivity-as-a-potential-approach-for-craniosynostosis-therapy
#7
Manpreet Bariana, Prem Dwivedi, Sarbin Ranjitkar, John A Kaidonis, Dusan Losic, Peter J Anderson
Advances in molecular biology and nanomedicine based therapies hold promise to obviate the need of multiple surgical interventions (associated with current management) in craniosynostosis by preventing bone re-ossification. One such adjunctive therapy involves application of glypicans 1 and 3 (GPC1 and GPC3) that are BMP inhibitors implicated in downregulating the BMP2 activity in prematurely fusing sutures. Electrochemically anodized Titania nanotube (TNT) arrays have been recognized as a promising localized, long-term drug delivery platform for bone-related therapies...
June 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28578101/nanoengineered-silica-properties-applications-and-toxicity
#8
Andrea M Mebert, Carolyn J Baglole, Martin F Desimone, Dusica Maysinger
Silica nanoparticles are widely used for biomedical purposes, but also in cosmetic products, food, the car industry, paints, etc. Considering their mega production, one should not ignore their potential hazardous effects on humans, flora and fauna. Human exposure to nanosilica can occur unintentionally in daily life and in industrial settings. Here, we review the common methods of silica nanoparticle production and its applications in biomedical investigations and nanotoxicology. The use of silica nanoparticles in biomedicine is discussed in terms of drug delivery, their responsiveness to different stimuli, theranostic applications and their uses in the food and cosmetic industries...
May 31, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28574242/nanoengineered-stent-surface-to-reduce-in-stent-restenosis-in-vivo
#9
Harald Nuhn, Cesar E Blanco, Tejal A Desai
In-stent restenosis (ISR) is the leading cause of stent failure and is a direct result of a dysfunctional vascular endothelium and subsequent overgrowth of vascular smooth muscle tissue. TiO2 nanotubular (NT) arrays have been shown to affect vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) in vitro by accelerating VEC cell proliferation and migration while suppressing VSMCs. This study investigates for the first time the potentially beneficial effects of TiO2 NT arrays on vascular tissue in vivo...
June 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28452385/nanoengineering-of-aggregation-free-and-thermally-stable-gold-nanoparticles-in-mesoporous-frameworks
#10
Ben Liu, Ting Jiang, Haoquan Zheng, Shanka Dissanayke, Wenqiao Song, Anthony Federico, Steven L Suib, Jie He
Loading catalytically active, aggregation-free and thermally stable metal nanoparticles (NPs) on a high surface area support represents a major interest in heterogeneous catalysis. Current synthetic approaches to these hybrid catalysts, however, still lack controllability in the thermal stability of metal NPs, particularly at high temperatures in the absence of organic ligands. We herein report a facile "co-assembly" methodology to prepare aggregation-free, ligand-free and thermally stable mesoporous hybrid nanocatalysts of metal-oxides and metal-carbons...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447416/microfluidics-in-flow-cytometry-and-related-techniques
#11
REVIEW
M C Béné
Technological advances in laboratory automation are now well understood and applied as they considerably improved the speed and robustness of haematological laboratory data, in the companion fields of blood analyzers and flow cytometry. Still rather confidential is the field of microfluidics, mostly confined so far to academic settings and research laboratories. The literature in the field of microfluidics is growing and applications in hematology range from cell counting to flow cytometry, cell sorting, or ex vivo testing...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28414902/tuning-chemistry-and-topography-of-nanoengineered-surfaces-to-manipulate-immune-response-for-bone-regeneration-applications
#12
Zetao Chen, Akash Bachhuka, Shengwei Han, Fei Wei, Shifeier Lu, Rahul Madathiparambil Visalakshan, Krasimir Vasilev, Yin Xiao
Osteoimmunomodulation has informed the importance of modulating a favorable osteoimmune environment for successful materials-mediated bone regeneration. Nanotopography is regarded as a valuable strategy for developing advanced bone materials, due to its positive effects on enhancing osteogenic differentiation. In addition to this direct effect on osteoblastic lineage cells, nanotopography also plays a vital role in regulating immune responses, which makes it possible to utilize its immunomodulatory properties to create a favorable osteoimmune environment...
April 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28378362/conjugated-polymer-nanoparticles-to-augment-photosynthesis-of-chloroplasts
#13
Yunxia Wang, Shengliang Li, Libing Liu, Fengting Lv, Shu Wang
By coating chloroplasts with conjugated polymer nanoparticles (CPNs), a new bio-optical hybrid photosynthesis system (chloroplast/CPNs) is developed. Since CPNs possess unique light harvesting ability, including the ultraviolet part that chloroplasts absorb less, chloroplast/CPN complexes can capture broader range of light to accelerate the electron transport rates in photosystem II (PS II), the critical protein complex in chloroplasts, and augment photosynthesis beyond natural chloroplasts. The degree of spectral overlay between emission of CPNs and absorption of chloroplasts is critical for the enhanced photosynthesis...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28371447/nanoparticles-for-bone-tissue-engineering
#14
REVIEW
Sílvia Vieira, Stephanie Vial, Rui L Reis, J Miguel Oliveira
Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28335249/plasma-nanoengineering-and-nanofabrication
#15
EDITORIAL
Krasimir Vasilev, Melanie Macgregor Ramiasa
With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[...].
June 23, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28301732/nanoengineering-heterogeneous-catalysts-by-atomic-layer-deposition
#16
REVIEW
Joseph A Singh, Nuoya Yang, Stacey F Bent
A new generation of catalysts is needed to meet society's energy and resource requirements. Current catalyst synthesis does not fully achieve optimum control of composition, size, and structure. Atomic layer deposition (ALD) is an emerging technique that allows for synthesis of highly controlled catalysts in the form of films, nanoparticles, and single sites. The addition of ALD coatings can also be used to introduce promoters and improve the stability of traditional catalysts. Evolving research shows promise for applying ALD to understand catalytically active sites and create next-generation catalysts using advanced 3D nanostructures...
June 7, 2017: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/28291321/nanoengineered-superhydrophobic-surfaces-of-aluminum-with-extremely-low-bacterial-adhesivity
#17
Ferdi Hizal, Natthakan Rungraeng, Junghoon Lee, Soojin Jun, Henk J Busscher, Henny C van der Mei, Chang-Hwan Choi
Bacterial adhesion and biofilm formation on surfaces are troublesome in many industrial processes. Here, nanoporous and nanopillared aluminum surfaces were engineered by anodizing and postetching processes and made hydrophilic (using the inherent oxide layer) or hydrophobic (applying a Teflon coating) with the aim of discouraging bacterial adhesion. Adhesion of Staphylococcus aureus ATCC 12600 (Gram-positive, spherically shaped) and Escherichia coli K-12 (Gram-negative, rod-shaped) was evaluated to the nanoengineered surfaces under both static and flow conditions (fluid shear rate of 37 s(-1))...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28277651/nanoengineering-of-core-shell-magnetic-mesoporous-microspheres-with-tunable-surface-roughness
#18
Qin Yue, Yu Zhang, Yongjian Jiang, Jialuo Li, Hongwei Zhang, Chengzhong Yu, Ahmed A Elzatahry, Abdulaziz Alghamdi, Yonghui Deng, Dongyuan Zhao
Functional core-shell mesoporous microspheres with integrated functions, controlled structure, and surface properties and morphologies have received increasing attention due to their excellent physicochemical properties. Herein, core-shell magnetic mesoporous materials with cauliflower-like morphology and tunable surface roughness have been synthesized through a kinetics-controlled interface co-assembly and deposition of mesostructured nanocomposites on Fe3O4@RF microspheres (RF refers to resorcinol formaldehyde resin)...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28247441/2d-chalcogenide-nanoplate-assemblies-for-thermoelectric-applications
#19
Chaochao Dun, Corey A Hewitt, Qi Li, Junwei Xu, Drew C Schall, Hyunsu Lee, Qike Jiang, David L Carroll
Engineered atomic dislocations have been used to create a novel, Sb2 Te3 nanoplate-like architecture that exhibits a unique antisymmetric chirality. High-resolution transmission electron microscopy (HRTEM) coupled with atomic force microscopy and X-ray photoelectron spectroscopy reveals the architectures to be extremely well ordered with little residual strain. Surface modification of these topologically complex macrostructures (≈3 µm) has been achieved by direct growth of metallic Ag nanoparticles onto the edge sites of the Sb2 Te3 ...
June 2017: Advanced Materials
https://www.readbyqxmd.com/read/28230203/water-insoluble-photosensitizer-nanocolloids-stabilized-by-supramolecular-interfacial-assembly-towards-photodynamic-therapy
#20
Yamei Liu, Kai Ma, Tifeng Jiao, Ruirui Xing, Guizhi Shen, Xuehai Yan
Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6)...
February 23, 2017: Scientific Reports
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