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https://www.readbyqxmd.com/read/28648641/glypican-based-drug-releasing-titania-implants-to-regulate-bmp2-bioactivity-as-a-potential-approach-for-craniosynostosis-therapy
#1
Manpreet Bariana, Prem Dwivedi, Sarbin Ranjitkar, John A Kaidonis, Dusan Losic, Peter J Anderson
Advances in molecular biology and nanomedicine based therapies hold promise to obviate the need of multiple surgical interventions (associated with current management) in craniosynostosis by preventing bone re-ossification. One such adjunctive therapy involves application of glypicans 1 and 3 (GPC1 and GPC3) that are BMP inhibitors implicated in downregulating the BMP2 activity in prematurely fusing sutures. Electrochemically anodized Titania nanotube (TNT) arrays have been recognized as a promising localized, long-term drug delivery platform for bone-related therapies...
June 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28578101/nanoengineered-silica-properties-applications-and-toxicity
#2
Andrea M Mebert, Carolyn J Baglole, Martin F Desimone, Dusica Maysinger
Silica nanoparticles are widely used for biomedical purposes, but also in cosmetic products, food, the car industry, paints, etc. Considering their mega production, one should not ignore their potential hazardous effects on humans, flora and fauna. Human exposure to nanosilica can occur unintentionally in daily life and in industrial settings. Here, we review the common methods of silica nanoparticle production and its applications in biomedical investigations and nanotoxicology. The use of silica nanoparticles in biomedicine is discussed in terms of drug delivery, their responsiveness to different stimuli, theranostic applications and their uses in the food and cosmetic industries...
May 31, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28574242/nanoengineered-stent-surface-to-reduce-in-stent-restenosis-in-vivo
#3
Harald Nuhn, Cesar E Blanco, Tejal A Desai
In-stent restenosis (ISR) is the leading cause of stent failure and is a direct result of a dysfunctional vascular endothelium and subsequent overgrowth of vascular smooth muscle tissue. TiO2 nanotubular (NT) arrays have been shown to affect vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) in vitro by accelerating VEC cell proliferation and migration while suppressing VSMCs. This study investigates for the first time the potentially beneficial effects of TiO2 NT arrays on vascular tissue in vivo...
June 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28452385/nanoengineering-of-aggregation-free-and-thermally-stable-gold-nanoparticles-in-mesoporous-frameworks
#4
Ben Liu, Ting Jiang, Haoquan Zheng, Shanka Dissanayke, Wenqiao Song, Anthony Federico, Steven L Suib, Jie He
Loading catalytically active, aggregation-free and thermally stable metal nanoparticles (NPs) on a high surface area support represents a major interest in heterogeneous catalysis. Current synthetic approaches to these hybrid catalysts, however, still lack controllability in the thermal stability of metal NPs, particularly at high temperatures in the absence of organic ligands. We herein report a facile "co-assembly" methodology to prepare aggregation-free, ligand-free and thermally stable mesoporous hybrid nanocatalysts of metal-oxides and metal-carbons...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447416/microfluidics-in-flow-cytometry-and-related-techniques
#5
REVIEW
M C Béné
Technological advances in laboratory automation are now well understood and applied as they considerably improved the speed and robustness of haematological laboratory data, in the companion fields of blood analyzers and flow cytometry. Still rather confidential is the field of microfluidics, mostly confined so far to academic settings and research laboratories. The literature in the field of microfluidics is growing and applications in hematology range from cell counting to flow cytometry, cell sorting, or ex vivo testing...
May 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28414902/tuning-chemistry-and-topography-of-nanoengineered-surfaces-to-manipulate-immune-response-for-bone-regeneration-applications
#6
Zetao Chen, Akash Bachhuka, Shengwei Han, Fei Wei, Shifeier Lu, Rahul Madathiparambil Visalakshan, Krasimir Vasilev, Yin Xiao
Osteoimmunomodulation has informed the importance of modulating a favorable osteoimmune environment for successful materials-mediated bone regeneration. Nanotopography is regarded as a valuable strategy for developing advanced bone materials, due to its positive effects on enhancing osteogenic differentiation. In addition to this direct effect on osteoblastic lineage cells, nanotopography also plays a vital role in regulating immune responses, which makes it possible to utilize its immunomodulatory properties to create a favorable osteoimmune environment...
April 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28378362/conjugated-polymer-nanoparticles-to-augment-photosynthesis-of-chloroplasts
#7
Yunxia Wang, Shengliang Li, Libing Liu, Fengting Lv, Shu Wang
By coating chloroplasts with conjugated polymer nanoparticles (CPNs), a new bio-optical hybrid photosynthesis system (chloroplast/CPNs) is developed. Since CPNs possess unique light harvesting ability, including the ultraviolet part that chloroplasts absorb less, chloroplast/CPN complexes can capture broader range of light to accelerate the electron transport rates in photosystem II (PS II), the critical protein complex in chloroplasts, and augment photosynthesis beyond natural chloroplasts. The degree of spectral overlay between emission of CPNs and absorption of chloroplasts is critical for the enhanced photosynthesis...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28371447/nanoparticles-for-bone-tissue-engineering
#8
REVIEW
Sílvia Vieira, Stephanie Vial, Rui L Reis, J Miguel Oliveira
Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone...
April 3, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28335249/plasma-nanoengineering-and-nanofabrication
#9
EDITORIAL
Krasimir Vasilev, Melanie Macgregor Ramiasa
With the recent advances in nanotechnology, plasma nanofabrication has become an exciting new niche because plasma-based approaches can deliver unique structures at the nanoscale that cannot be achieved by other techniques and/or in a more economical and environmentally friendly manner.[...].
June 23, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28301732/nanoengineering-heterogeneous-catalysts-by-atomic-layer-deposition
#10
Joseph A Singh, Nuoya Yang, Stacey F Bent
A new generation of catalysts is needed to meet society's energy and resource requirements. Current catalyst synthesis does not fully achieve optimum control of composition, size, and structure. Atomic layer deposition (ALD) is an emerging technique that allows synthesizing of highly controlled catalysts in the forms of films, nanoparticles, and single sites. The addition of ALD coatings can also be used to introduce promoters and improve the stability of traditional catalysts. Evolving research shows promise for applying ALD to understand catalytically active sites and create next-generation catalysts using advanced 3D nanostructures...
February 27, 2017: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/28291321/nanoengineered-superhydrophobic-surfaces-of-aluminum-with-extremely-low-bacterial-adhesivity
#11
Ferdi Hizal, Natthakan Rungraeng, Junghoon Lee, Soojin Jun, Henk J Busscher, Henny C van der Mei, Chang-Hwan Choi
Bacterial adhesion and biofilm formation on surfaces are troublesome in many industrial processes. Here, nanoporous and nanopillared aluminum surfaces were engineered by anodizing and postetching processes and made hydrophilic (using the inherent oxide layer) or hydrophobic (applying a Teflon coating) with the aim of discouraging bacterial adhesion. Adhesion of Staphylococcus aureus ATCC 12600 (Gram-positive, spherically shaped) and Escherichia coli K-12 (Gram-negative, rod-shaped) was evaluated to the nanoengineered surfaces under both static and flow conditions (fluid shear rate of 37 s(-1))...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28277651/nanoengineering-of-core-shell-magnetic-mesoporous-microspheres-with-tunable-surface-roughness
#12
Qin Yue, Yu Zhang, Yongjian Jiang, Jialuo Li, Hongwei Zhang, Chengzhong Yu, Ahmed A Elzatahry, Abdulaziz Alghamdi, Yonghui Deng, Dongyuan Zhao
Functional core-shell mesoporous microspheres with integrated functions, controlled structure, and surface properties and morphologies have received increasing attention due to their excellent physicochemical properties. Herein, core-shell magnetic mesoporous materials with cauliflower-like morphology and tunable surface roughness have been synthesized through a kinetics-controlled interface co-assembly and deposition of mesostructured nanocomposites on Fe3O4@RF microspheres (RF refers to resorcinol formaldehyde resin)...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28247441/2d-chalcogenide-nanoplate-assemblies-for-thermoelectric-applications
#13
Chaochao Dun, Corey A Hewitt, Qi Li, Junwei Xu, Drew C Schall, Hyunsu Lee, Qike Jiang, David L Carroll
Engineered atomic dislocations have been used to create a novel, Sb2 Te3 nanoplate-like architecture that exhibits a unique antisymmetric chirality. High-resolution transmission electron microscopy (HRTEM) coupled with atomic force microscopy and X-ray photoelectron spectroscopy reveals the architectures to be extremely well ordered with little residual strain. Surface modification of these topologically complex macrostructures (≈3 µm) has been achieved by direct growth of metallic Ag nanoparticles onto the edge sites of the Sb2 Te3 ...
June 2017: Advanced Materials
https://www.readbyqxmd.com/read/28230203/water-insoluble-photosensitizer-nanocolloids-stabilized-by-supramolecular-interfacial-assembly-towards-photodynamic-therapy
#14
Yamei Liu, Kai Ma, Tifeng Jiao, Ruirui Xing, Guizhi Shen, Xuehai Yan
Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6)...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28195299/nanoengineering-of-an-si-mnge-quantum-dot-superlattice-for-high-curie-temperature-ferromagnetism
#15
Tianxiao Nie, Xufeng Kou, Jianshi Tang, Yabin Fan, Shengwei Lee, Qinglin He, Li-Te Chang, Koichi Murata, Yin Gen, Kang L Wang
The realization and application of spintronic devices would be dramatically advanced if room-temperature ferromagnetism could be integrated into semiconductor nanostructures, especially when compatible with mature silicon technology. Herein, we report the observation of such a system - an Si/MnGe superlattice with quantum dots well aligned in the vertical direction successfully grown by molecular beam epitaxy. Such a unique system could take full advantage of the type-II energy band structure of the Si/Ge heterostructure, which could trap the holes inside MnGe QDs, significantly enhancing the hole-mediated ferromagnetism...
February 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28138241/nanoengineered-implant-as-a-new-platform-for-regenerative-nanomedicine-using-3d-well-organized-human-cell-spheroids
#16
Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Sandy Eap, David Brasse, Pascale Schwinté, Manuel Arruebo, Nadia Benkirane-Jessel
In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28124594/strategies-of-engineering-nanoparticles-for-treating-neurodegenerative-disorders
#17
Khanh Tu Nguyen, Minh Nguyet Pham, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran, Tran Truong-Dinh Thao
Neurodegenerative disorders (NDs) are typically referred to Alzheimer's disease, Parkinson's diseases, amyotrophic lateral sclerosis and prion disease. These are commonly debilitating and, unfortunately, have few therapeutic options. One of the main difficulties in fighting against NDs is to overcome the shielding of blood-brain barrier (BBB), which greatly limits the penetration of various therapeutic drugs, which sometimes leads to severe side effects. Nanotechnology, by engineering materials of a size scale usually within 1-100 nm, fortunately offers an alternative approach for novel, promising and innovative solutions...
January 25, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28073276/interlaced-nanostructured-interface-with-graphene-buffer-layer-reduces-thermal-boundary-resistance-in-nano-microelectronic-systems
#18
Lei Tao, Sreeprasad Theruvakkattil Sreenivasan, Rouzbeh Shahsavari
Improving heat transfer in hybrid nano/microelectronic systems is a challenge, mainly due to the high thermal boundary resistance (TBR) across the interface. Herein, we focus on gallium nitride (GaN)/diamond interface-as a model system with various high power, high temperature, and optoelectronic applications-and perform extensive reverse nonequilibrium molecular dynamics simulations, decoding the interplay between the pillar length, size, shape, hierarchy, density, arrangement, system size, and the interfacial heat transfer mechanisms to substantially reduce TBR in GaN-on-diamond devices...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050890/nanoengineered-strategies-for-sirna-delivery-from-target-assessment-to-cancer-therapeutic-efficacy
#19
REVIEW
Dinesh Kumar Mishra, Neelam Balekar, Pradyumna Kumar Mishra
The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barriers of the circulatory system. Therefore, the development and validation of safe, stable, and efficient nanoengineered delivery systems are highly essential for effective delivery of siRNA into cancer cells...
April 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28026152/harnessing-three-dimensional-anatomy-of-graphene-foam-to-induce-superior-damping-in-hierarchical-polyimide-nanostructures
#20
Pranjal Nautiyal, Benjamin Boesl, Arvind Agarwal
Graphene foam-based hierarchical polyimide composites with nanoengineered interface are fabricated in this study. Damping behavior of graphene foam is probed for the first time. Multiscale mechanisms contribute to highly impressive damping in graphene foam. Rippling, spring-like interlayer van der Waals interactions and flexing of graphene foam branches are believed to be responsible for damping at the intrinsic, interlayer and anatomical scales, respectively. Merely 1.5 wt% graphene foam addition to the polyimide matrix leads to as high as ≈300% improvement in loss tangent...
December 27, 2016: Small
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