keyword
https://read.qxmd.com/read/35668748/construction-of-nanocarriers-based-on-nucleic-acids-and-their-applications-in-nanobiology-delivery-systems
#21
JOURNAL ARTICLE
Yingshu Guo, Xiuping Cao, Xiaofei Zheng, S K Jahir Abbas, Juan Li, Weihong Tan
In recent years, nanocarriers based on nucleic acids have emerged as powerful and novel nanocarriers that are able to meet the demand for cancer-cell-specific targeting. Functional dynamics analysis revealed good biocompatibility, low toxicity and programmable structures, and their advantages include controllable size and modifiability. The development of novel hybrids has focused on the distinct roles of biosensing, drug and gene delivery, vaccine transport, photosensitization, counteracting drug resistance and functioning as carriers and logic gates...
May 2022: National Science Review
https://read.qxmd.com/read/35600663/exosomes-derived-from-olfactory-ensheathing-cells-provided-neuroprotection-for-spinal-cord-injury-by-switching-the-phenotype-of-macrophages-microglia
#22
JOURNAL ARTICLE
Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Xiao-Hui Wang, Da-Geng Huang, Shi-Chang Liu, Xun Chen, Hao Yang, Dingjun Hao
Transplantation of olfactory ensheathing cells (OECs) has been demonstrated to be beneficial for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival and promoting angiogenesis. Besides OECs, the conditioned medium (CM) from OECs has also been proved to have therapeutic effects for SCI, indicating that the bioactive substances secreted by OECs are essential for its protective effects. Nevertheless, there is still little information regarding the underlying mechanisms. Considering that exosomes are crucial for intercellular communication and could be secreted by different types of cells, we speculated that the therapeutic potential of OECs for SCI might be partially based on their exosomes...
May 2022: Bioengineering & Translational Medicine
https://read.qxmd.com/read/35559896/intracellular-reactive-oxygen-species-trigger-mitochondrial-dysfunction-and-apoptosis-in-cadmium-telluride-quantum-dots-induced-liver-damage
#23
JOURNAL ARTICLE
Qing Liu, Daming Wu, Ying Ma, Yuna Cao, Yanting Pang, Meng Tang, Yuepu Pu, Ting Zhang
Quantum dots (QDs), also known as semiconductor QDs, have specific photoelectricproperties which find application in bioimaging, solar cells, and light-emitting diodes (LEDs). However, the application of QDs is often limited by issues related to health risks and potential toxicity. The purpose of this study was to provide evidence regarding the safety of cadmium telluride (CdTe) QDs by exploring the detailed mechanisms involved in its hepatotoxicity. This study showed that CdTe QDs can increase reactive oxygen species (ROS) in hepatocytes after being taken up by hepatocytes, which triggers a significant mitochondrial-dependent apoptotic pathway, leading to hepatocyte apoptosis...
January 2022: NanoImpact
https://read.qxmd.com/read/35334669/high-resolution-separation-of-nanoparticles-using-a-negative-magnetophoretic-microfluidic-system
#24
JOURNAL ARTICLE
Lin Zeng, Xi Chen, Rongrong Zhang, Shi Hu, Hongpeng Zhang, Yi Zhang, Hui Yang
The separation and purification of a sample of interest is essential for subsequent detection and analysis procedures, but there is a lack of effective separation methods with which to purify nano-sized particles from the sample media. In this paper, a microfluidic system based on negative magnetophoresis is presented for the high-resolution separation of nanoparticles. The system includes on-chip magnetic pole arrays and permalloys that symmetrically distribute on both sides of the separation channel and four permanent magnets that provide strong magnetic fields...
February 26, 2022: Micromachines
https://read.qxmd.com/read/34813642/rearrangement-of-protein-structures-on-a-gold-nanoparticle-surface-is-regulated-by-ligand-adsorption-modes
#25
JOURNAL ARTICLE
Xiaofeng Wang, Rong Lei, Limei Li, Xinyu Fei, Rui Ju, Xiwen Sun, Huiying Cao, Qingfang Zhang, Chunying Chen, Xinyi Wang
With development of the nanomedicine field and increasing hazards of exposure to nanobiological materials, research on the protein corona is urgently required. In particular, the understanding of the mechanism of structural changes of protein on a nanosurface should be improved. Herein, we focus on exploring the role of ligand adsorption modes (physiosorbed citrates or chemisorbed GSH) in the regulation of conformational rearrangement of three blood proteins (serum albumin, globulin, and fibrinogen) on the surface of gold nanoparticles...
November 23, 2021: Nanoscale
https://read.qxmd.com/read/34759355/the-ancillary-effects-of-nanoparticles-and-their-implications-for-nanomedicine
#26
REVIEW
Evan P Stater, Ali Y Sonay, Cassidy Hart, Jan Grimm
Nanoparticles are often engineered as a scaffolding system to combine targeting, imaging and/or therapeutic moieties into a unitary agent. However, mostly overlooked, the nanomaterial itself interacts with biological systems exclusive of application-specific particle functionalization. This nanoparticle biointerface has been found to elicit specific biological effects, which we term 'ancillary effects'. In this Review, we describe the current state of knowledge of nanobiology gleaned from existing studies of ancillary effects with the objectives to describe the potential of nanoparticles to modulate biological effects independently of any engineered function; evaluate how these effects might be relevant for nanomedicine design and functional considerations, particularly how they might be useful to inform clinical decision-making; identify potential clinical harm that arises from adverse nanoparticle interactions with biology; and, finally, highlight the current lack of knowledge in this area as both a barrier and an incentive to the further development of nanomedicine...
November 2021: Nature Nanotechnology
https://read.qxmd.com/read/34679230/strong-penetration-induced-effective-photothermal-therapy-by-exosome-mediated-black-phosphorus-quantum-dots
#27
JOURNAL ARTICLE
Jing Liu, Kezhen Yi, Qi Zhang, Hang Xu, Xingang Zhang, Dong He, Fubing Wang, Xiangheng Xiao
Nanocancer medicine, such as photothermal therapy (PTT), as a promising way to solve cancer without side effects, faces a huge biological barrier during the circulation of nanoparticles in the body, including nanobiological interactions in the blood, isolation of nanoparticles in the macrophage system, tumor spillover effect, and especially uneven intratumoral distribution of nanoparticles, which cast a shadow over the hope. To address the problem of intratumoral distribution, an effective photothermal agent is introduced by packaging the black phosphorus quantum dots (BPQDs) into exosome vector (EXO) through electroporation method...
October 22, 2021: Small
https://read.qxmd.com/read/34309242/the-action-networks-of-nanosilver-bridging-the-gap-between-material-and-biology
#28
REVIEW
Huiliang Cao, Hui Qin, Yongsheng Li, Klaus D Jandt
The emergence of nanosilver (silver in nanoscale shapes and their assemblies) benefits the landscape of modern healthcare; however, this brings about concerns over its safety issues associated with an ultrasmall size and high mobility. By reviewing previous reporting details about the synthesis and characterization of nanosilver and its biological responses, a gap between materials synthesis and their biomedical uses is characterized by the insufficient understanding of the interacting and interplaying nanoscale actions of silver...
July 26, 2021: Advanced Healthcare Materials
https://read.qxmd.com/read/34027090/a-review-of-biomarkers-in-the-context-of-type-1-diabetes-biological-sensing-for-enhanced-glucose-control
#29
REVIEW
Kelilah L Wolkowicz, Eleonora M Aiello, Eva Vargas, Hazhir Teymourian, Farshad Tehrani, Joseph Wang, Jordan E Pinsker, Francis J Doyle, Mary-Elizabeth Patti, Lori M Laffel, Eyal Dassau
As wearable healthcare monitoring systems advance, there is immense potential for biological sensing to enhance the management of type 1 diabetes (T1D). The aim of this work is to describe the ongoing development of biomarker analytes in the context of T1D. Technological advances in transdermal biosensing offer remarkable opportunities to move from research laboratories to clinical point-of-care applications. In this review, a range of analytes, including glucose, insulin, glucagon, cortisol, lactate, epinephrine, and alcohol, as well as ketones such as beta-hydroxybutyrate, will be evaluated to determine the current status and research direction of those analytes specifically relevant to T1D management, using both in-vitro and on-body detection...
May 2021: Bioengineering & Translational Medicine
https://read.qxmd.com/read/33940715/review-of-gut-nanotoxicology-in-mammals-exposure-transformation-distribution-and-toxicity
#30
REVIEW
Xiaoquan Huang, Meng Tang
Nanomaterials are increasingly used in food processing, daily necessities and other fields due to their excellent properties, and increase the environmental contamination. Human beings will inevitably come into contact with these nanomaterials through multiple exposure routes especially oral exposure. The intestine is an important organ for nutrient absorption and physiologic barrier, which may be the main target of nanoparticles (NPs) exposure. However, for a long time, research on the toxicity of NPs has mainly focused on organs such as liver, kidney and brain...
June 15, 2021: Science of the Total Environment
https://read.qxmd.com/read/33924735/engineering-the-interface-between-inorganic-nanoparticles-and-biological-systems-through-ligand-design
#31
REVIEW
Rui Huang, David C Luther, Xianzhi Zhang, Aarohi Gupta, Samantha A Tufts, Vincent M Rotello
Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with "small" organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.
April 13, 2021: Nanomaterials
https://read.qxmd.com/read/33882685/targeting-trained-innate-immunity-with-nanobiologics-to-treat-cardiovascular-disease
#32
JOURNAL ARTICLE
Abraham J P Teunissen, Mandy M T van Leent, Geoffrey Prevot, Eliane E S Brechbuhl, Carlos Pérez-Medina, Raphaël Duivenvoorden, Zahi A Fayad, Willem J M Mulder
The innate immune system plays a key role in atherosclerosis progression and the pathogenesis of cardiovascular disease. Trained immunity, an epigenetically regulated hyperresponsive state of myeloid cells, is a driving force underlying chronic inflammation in atherosclerosis. Therapeutically targeting innate trained immunity therefore may mature into a compelling new paradigm for the effective treatment of cardiovascular patients, which would require effective engagement of myeloid cells. For over a decade, we have worked on apolipoprotein A1-based nanomaterials, referred to as nanobiologics, which we have utilized for myeloid cell-directed immunotherapy...
April 22, 2021: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/33707549/aptes-monolayer-coverage-on-self-assembled-magnetic-nanospheres-for-controlled-release-of-anticancer-drug-nintedanib
#33
JOURNAL ARTICLE
V C Karade, A Sharma, R P Dhavale, R P Dhavale, S R Shingte, P S Patil, J H Kim, D R T Zahn, A D Chougale, G Salvan, P B Patil
The use of an appropriate delivery system capable of protecting, translocating, and selectively releasing therapeutic moieties to desired sites can promote the efficacy of an active compound. In this work, we have developed a nanoformulation which preserves its magnetization to load a model anticancerous drug and to explore the controlled release of the drug in a cancerous environment. For the preparation of the nanoformulation, self-assembled magnetic nanospheres (MNS) made of superparamagnetic iron oxide nanoparticles were grafted with a monolayer of (3-aminopropyl)triethoxysilane (APTES)...
March 11, 2021: Scientific Reports
https://read.qxmd.com/read/33692130/prosaposin-mediates-inflammation-in-atherosclerosis
#34
JOURNAL ARTICLE
Mandy M T van Leent, Thijs J Beldman, Yohana C Toner, Marnix A Lameijer, Nils Rother, Siroon Bekkering, Abraham J P Teunissen, Xianxiao Zhou, Roy van der Meel, Joost Malkus, Sheqouia A Nauta, Emma D Klein, Francois Fay, Brenda L Sanchez-Gaytan, Carlos Pérez-Medina, Ewelina Kluza, Yu-Xiang Ye, Gregory Wojtkiewicz, Edward A Fisher, Filip K Swirski, Matthias Nahrendorf, Bin Zhang, Yang Li, Bowen Zhang, Leo A B Joosten, Gerard Pasterkamp, Arjan Boltjes, Zahi A Fayad, Esther Lutgens, Mihai G Netea, Niels P Riksen, Willem J M Mulder, Raphaël Duivenvoorden
Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties of these cells are dictated by their metabolism, of which the mechanistic target of rapamycin (mTOR) signaling pathway is a key regulator. Using myeloid cell-specific nanobiologics in apolipoprotein E-deficient ( Apoe -/- ) mice, we found that targeting the mTOR and ribosomal protein S6 kinase-1 (S6K1) signaling pathways rapidly diminished plaque macrophages' inflammatory activity. By investigating transcriptome modifications, we identified Psap , a gene encoding the lysosomal protein prosaposin, as closely related with mTOR signaling...
March 10, 2021: Science Translational Medicine
https://read.qxmd.com/read/33674313/a-modular-approach-toward-producing-nanotherapeutics-targeting-the-innate-immune-system
#35
JOURNAL ARTICLE
Mandy M T van Leent, Anu E Meerwaldt, Alexandre Berchouchi, Yohana C Toner, Marianne E Burnett, Emma D Klein, Anna Vera D Verschuur, Sheqouia A Nauta, Jazz Munitz, Geoffrey Prévot, Esther M van Leeuwen, Farideh Ordikhani, Vera P Mourits, Claudia Calcagno, Philip M Robson, George Soultanidis, Thomas Reiner, Rick R M Joosten, Heiner Friedrich, Joren C Madsen, Ewelina Kluza, Roy van der Meel, Leo A B Joosten, Mihai G Netea, Jordi Ochando, Zahi A Fayad, Carlos Pérez-Medina, Willem J M Mulder, Abraham J P Teunissen
Immunotherapies controlling the adaptive immune system are firmly established, but regulating the innate immune system remains much less explored. The intrinsic interactions between nanoparticles and phagocytic myeloid cells make these materials especially suited for engaging the innate immune system. However, developing nanotherapeutics is an elaborate process. Here, we demonstrate a modular approach that facilitates efficiently incorporating a broad variety of drugs in a nanobiologic platform. Using a microfluidic formulation strategy, we produced apolipoprotein A1-based nanobiologics with favorable innate immune system-engaging properties as evaluated by in vivo screening...
March 2021: Science Advances
https://read.qxmd.com/read/33268903/nanobiologic-trains-innate-immunity-for-anticancer-responses
#36
Alexandra Flemming
No abstract text is available yet for this article.
January 2021: Nature Reviews. Drug Discovery
https://read.qxmd.com/read/33173162/nanobiologic-trains-innate-immunity-for-anticancer-responses
#37
COMMENT
Alexandra Flemming
No abstract text is available yet for this article.
December 2020: Nature Reviews. Immunology
https://read.qxmd.com/read/33125893/trained-immunity-promoting-nanobiologic-therapy-suppresses-tumor-growth-and-potentiates-checkpoint-inhibition
#38
JOURNAL ARTICLE
Bram Priem, Mandy M T van Leent, Abraham J P Teunissen, Alexandros Marios Sofias, Vera P Mourits, Lisa Willemsen, Emma D Klein, Roderick S Oosterwijk, Anu E Meerwaldt, Jazz Munitz, Geoffrey Prévot, Anna Vera Verschuur, Sheqouia A Nauta, Esther M van Leeuwen, Elizabeth L Fisher, Karen A M de Jong, Yiming Zhao, Yohana C Toner, Georgios Soultanidis, Claudia Calcagno, Paul H H Bomans, Heiner Friedrich, Nico Sommerdijk, Thomas Reiner, Raphaël Duivenvoorden, Eva Zupančič, Julie S Di Martino, Ewelina Kluza, Mohammad Rashidian, Hidde L Ploegh, Rick M Dijkhuizen, Sjoerd Hak, Carlos Pérez-Medina, Jose Javier Bravo-Cordero, Menno P J de Winther, Leo A B Joosten, Andrea van Elsas, Zahi A Fayad, Alexander Rialdi, Denis Torre, Ernesto Guccione, Jordi Ochando, Mihai G Netea, Arjan W Griffioen, Willem J M Mulder
Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a bone marrow-avid nanobiologic platform designed specifically to induce trained immunity. We established the potent anti-tumor capabilities of our lead candidate MTP10 -HDL in a B16F10 mouse melanoma model. These anti-tumor effects result from trained immunity-induced myelopoiesis caused by epigenetic rewiring of multipotent progenitors in the bone marrow, which overcomes the immunosuppressive tumor microenvironment...
October 29, 2020: Cell
https://read.qxmd.com/read/33053152/nitric-oxide-no-signalling-in-plant-nanobiology-current-status-and-perspectives
#39
JOURNAL ARTICLE
Zsuzsanna Kolbert, Réka Szőllősi, Gábor Feigl, Zoltán Kónya, Andrea Rónavári
Plant nanobiology as a novel research field provides scientific basis for the agricultural use of nanoparticles (NPs). Plants respond to the presence of nanomaterials by synthesizing signal molecules, such as the multifunctional gaseous nitric oxide (NO). Several reports have described the effects of different nanomaterials (primarily chitosan NPs, metal oxide NPs and carbon nanotubes) on endogenous NO synthesis and signalling in different plant species. Other works have demonstrated the ameliorating effect of exogenous NO donor (primarily sodium nitroprusside) treatments on NP-induced stress...
October 14, 2020: Journal of Experimental Botany
https://read.qxmd.com/read/32986047/ultrasmall-au-nanoclusters-for-bioanalytical-and-biomedical-applications-the-undisclosed-and-neglected-roles-of-ligands-in-determining-the-nanoclusters-catalytic-activities
#40
JOURNAL ARTICLE
Da Chen, Jinghong Li
Significantly different from conventional Au nanoparticles, ultrasmall Au nanoclusters (NCs) consisting of several to about a hundred Au atoms with a size below 2 nm exhibit a strong quantum confinement effect, and possess an intriguing molecular-like highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) transition, quantized charging, intrinsic chirality, and special fluorescence properties, as well as high catalytic activities. In virtue of their unique molecular-like electronic structure, remarkable physicochemical properties, mild preparation conditions and good biocompatibility, Au NCs have been having a profound impact on bioanalytical and biomedical applications, such as biosensing, biological imaging, cell markers, drug delivery, photodynamic/photothermal therapy, and biomedical toxicology...
October 1, 2020: Nanoscale Horizons: the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy
keyword
keyword
92459
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.