keyword
https://read.qxmd.com/read/38384224/-research-status-of-nanomaterial-medical-device-and-discussion-on-biological-evaluation
#1
JOURNAL ARTICLE
Lingxiao Sun, Min Wan, Xiaoxia Sun, Jia Liu, Xiaoxiao Gai, Guowei Wang, Wenting Ruan, Yang Qin, Chenghu Liu
In recent years, China has made great progress in basic nanomedicine, nanotoxicology and nanobiology research. Nanotechnology has been continuously applied in biomaterial and medical device, more and more medical devices applying nanomaterials are developed and manufactured. In order to gain more comprehension and accurate understanding of the research and industrial development in nanobiomaterial medical devices, this study reviewed the common nanomaterial in medical devices and the regulatory situation of nanomaterial medical devices at home and abroad, and discussed the current challenges in biological evaluation of nanomaterial medical devices, with a view to providing ideas for the safety evaluation and research of related products...
January 30, 2024: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
https://read.qxmd.com/read/38261544/enantioselective-glutamic-acid-discrimination-and-nanobiological-imaging-by-chiral-fluorescent-silicon-nanoparticles
#2
JOURNAL ARTICLE
Yangxia Han, Manchang Kou, Kaijun Quan, Juanjuan Wang, Haixia Zhang, Hirotaka Ihara, Makoto Takafuji, Hongdeng Qiu
Enantioselective discrimination of chiral molecules is essential in chemistry, biology, and medical science due to the configuration-dependent activities of enantiomers. Therefore, identifying a specific amino acid and distinguishing it from its enantiomer by using nanomaterials with outstanding performance are of great significance. Herein, blue- and green-emitting chiral silicon nanoparticles named bSiNPs and gSiNPs, respectively, with excellent water solubility, salt resistance, pH stability, photobleaching resistance, biocompatibility, and ability to promote soybean germination, were fabricated in a facile one-step method...
January 23, 2024: Analytical Chemistry
https://read.qxmd.com/read/38113693/metal-organic-framework-integrated-hydrogel-bioreactor-for-smart-detection-of-metal-ions
#3
JOURNAL ARTICLE
Xiaoxia Mao, Mengqin Shi, Chen Chen, Jingkang Guo, Shaowei Liu, Hongquan Gou, Xiaoli Zhu, Wenxing Li, Dongsheng Mao
Bioreactors with environment responsiveness for smart detection has attracted widespread interest. Bioreactors that operate in liquid have excellent reaction speed and sensitivity, and those that operate at a solid interface have unique portability and stability. However, bioreactors that can simultaneously take advantage of both properties are still limited. Here, we developed a metal-organic framework (MOF) integrated hydrogel bioreactor that can accommodate both solid and liquid properties by using a hydrogel as a quasi-liquid medium...
December 9, 2023: Biosensors & Bioelectronics
https://read.qxmd.com/read/38059477/morphological-effects-and-in-vitro-biological-mechanisms-of-radiation-induced-cell-killing-by-gold-nanomaterials
#4
JOURNAL ARTICLE
Samir V Jenkins, Seunghyun Jung, Azemat Jamshidi-Parsian, Michael J Borrelli, Ruud P M Dings, Robert J Griffin
Gold nanomaterials have been shown to augment radiation therapy both in vitro and in vivo. However, studies on these materials are mostly phenomenological due to nanoparticle heterogeneity and the complexity of biological systems. Even accurate quantification of the particle dose still results in bulk average biases; the effect on individual cells is not measured but rather the effect on the overall population. To perform quantitative nanobiology, we coated glass coverslips uniformly at varying densities with Au nanoparticle preparations with different morphologies (45 nm cages, 25 nm spheres, and 30 nm rods)...
December 7, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/37997213/chiral-nanomaterials-for-cancer-vaccines
#5
REVIEW
Aihua Qu, Maozhong Sun, Liguang Xu, Liqiang Liu, Lingling Guo, Panpan Chen, Qing Wang, Zhiyong Du, Zhimeng Wu, Chuanlai Xu, Hua Kuang
Chirality is a fundamental characteristic of living organisms and is commonly observed at the biomolecule, cellular, and tissue levels. Chiral nanomaterials play an irreplaceable role in nanomedicine and nanobiology because of their unique enantioselectivity with biological components. Here, research progress relating to chiral nanomaterials in the field of vaccines is reviewed, including antigen presenting systems, immune adjuvants, and cancer vaccines. First, the common synthesis methods are outlined for different types of chiral nanomaterials, as well as their chiral sources, optical properties, and potential biological applications...
November 23, 2023: Small Methods
https://read.qxmd.com/read/37995184/acid-ceramidase-regulates-innate-immune-memory
#6
JOURNAL ARTICLE
Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M T van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A Fayad, Niels P Riksen, Luuk B Hilbrands, Rik G H Lindeboom, Joost H A Martens, Michiel Vermeulen, Leo A B Joosten, Mihai G Netea, Willem J M Mulder, Johan van der Vlag, Abraham J P Teunissen, Raphaël Duivenvoorden
Innate immune memory, also called "trained immunity," is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate trained immunity. In particular, we reveal that acid ceramidase, an enzyme that converts ceramide to sphingosine, is a potent regulator of trained immunity. We show that acid ceramidase regulates the transcription of histone-modifying enzymes, resulting in profound changes in histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation...
December 26, 2023: Cell Reports
https://read.qxmd.com/read/37803483/exosome-bearing-hydrogels-and-cardiac-tissue-regeneration
#7
REVIEW
Hassan Amini, Atieh Rezaei Namjoo, Maryam Taghavi Narmi, Narges Mardi, Samaneh Narimani, Ozra Naturi, Nafiseh Didar Khosrowshahi, Reza Rahbarghazi, Solmaz Saghebasl, Shahriar Hashemzadeh, Mohammad Nouri
BACKGROUND: In recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and restore the function of infarcted sites is a challenging issue after the occurrence of MI. The application of stem cells and byproducts such as exosomes (Exos) has paved the way for the alleviation of cardiac tissue injury along with conventional medications in clinics...
October 6, 2023: Biomaterials Research
https://read.qxmd.com/read/37693054/covid-severity-test-cost-sensor-an-electrochemical-immunosensing-approach-to-stratify-disease-severity
#8
JOURNAL ARTICLE
Sasya Madhurantakam, Jayanth Babu Karnam, Sriram Muthukumar, Shalini Prasad
With the evolution of the COVID-19 pandemic, there is now a need for point-of-care devices for the quantification of disease biomarkers toward disease severity assessment. Disease progression has been determined as a multifactor phenomenon and can be treated based on the host immune response within each individual. CoST is an electrochemical immunosensor point-of-care device that can determine disease severity through multiplex measurement and quantification of spike protein, nucleocapsid protein, D-dimer, and IL-2R from 100 μL of plasma samples within a few minutes...
September 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/37557061/current-knowledge-and-clinical-perspectives-for-a-unique-new-phylum-nanaorchaeota
#9
REVIEW
Yasmine Hassani, Gérard Aboudharam, Michel Drancourt, Ghiles Grine
Nanoarchaea measuring less than 500 nm and encasing an average 600-kb compact genome have been studied for twenty years, after an estimated 4193-million-year evolution. Comprising only four co-cultured representatives, these symbiotic organisms initially detected in deep-sea hydrothermal vents and geothermal springs, have been further distributed in various environmental ecosystems worldwide. Recent isolation by co-culture of Nanopusillus massiliensis from the unique ecosystem of the human oral cavity, prompted us to review the evolutionary diversity of nanaorchaea resulting in a rapidly evolving taxonomiy...
July 26, 2023: Microbiological Research
https://read.qxmd.com/read/37207419/enhanced-lysosomal-escape-of-cell-penetrating-peptide-functionalized-metal-organic-frameworks-for-co-delivery-of-survivin-sirna-and-oridonin
#10
JOURNAL ARTICLE
Mengru Cai, Yu Yao, Dongge Yin, Rongyue Zhu, Tingting Fu, Jiahui Kong, Kaixin Wang, Jing Liu, Aina Yao, Yidan Ruan, Wenjuan Shi, Qian Zhu, Jian Ni, Xingbin Yin
In recent years, small interfering RNA (siRNA) has been widely used in the treatment of human diseases, especially tumors, and has shown great appeal. However, the clinical application of siRNA faces several challenges. Insufficient efficacy, poor bioavailability, poor stability, and lack of responsiveness to a single therapy are the main problems affecting tumor therapy. Here, we designed a cell-penetrating peptide (CPP)-modified metal organic framework nanoplatform (named PEG-CPP33@ORI@survivin siRNA@ZIF-90, PEG-CPP33@NPs) for targeted co-delivery of oridonin (ORI), a natural anti-tumor active ingredient) and survivin siRNA in vivo...
April 28, 2023: Journal of Colloid and Interface Science
https://read.qxmd.com/read/37096860/antiviral-nanobiologic-therapy-remodulates-innate-immune-responses-to-highly-pathogenic-coronavirus
#11
JOURNAL ARTICLE
Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia
Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR-MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system...
April 25, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/36929288/silicon-nanowire-array-overcomes-chemotherapeutic-resistance-by-inducing-the-differentiation-of-breast-cancer-stem-cells
#12
JOURNAL ARTICLE
Xiaotong Wang, Sisi Liu, Wei Zhang, Haotong Peng, Miao Zhang, Yaping Li, Qi Guo, Wenjing Wang, Na Huang, LiYan Liu, Dandan Liu
Currently, traditional cancer treatment strategies are greatly challenged by the existence of cancer stem cells (CSCs), which are root cause of chemotherapy resistance. Differentiation therapy presents a novel therapeutic strategy for CSC-targeted therapy. However, there are very few studies on the induction of CSCs differentiation so far. Silicon nanowire array (SiNWA) with many unique properties is considered to be an excellent material for various applications ranging from biotechnology to biomedical applications...
March 16, 2023: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/36718371/graphene-nano-electromechanical-mass-sensor-with-high-resolution-at-room-temperature
#13
JOURNAL ARTICLE
Dong Hoon Shin, Hakseong Kim, Sung Hyun Kim, Hyeonsik Cheong, Peter G Steeneken, Chirlmin Joo, Sang Wook Lee
The inherent properties of 2D materials-light mass, high out-of-plane flexibility, and large surface area-promise great potential for precise and accurate nanomechanical mass sensing, but their application is often hampered by surface contamination. Here we demonstrate a tri-layer graphene nanomechanical resonant mass sensor with sub-attogram resolution at room temperature, fabricated by a bottom-up process. We found that Joule-heating is effective in cleaning the graphene membrane surface, which results in a large improvement in the stability of the resonance frequency...
February 17, 2023: IScience
https://read.qxmd.com/read/36327773/enzyme-mimic-nanomaterials-as-nanozymes-with-catalytic-attributes
#14
REVIEW
Muhammad Bilal, Nida Khaliq, Mubeen Ashraf, Nazim Hussain, Zulqarnain Baqar, Jakub Zdarta, Teofil Jesionowski, Hafiz M N Iqbal
Nanozymes are super-efficient nanomaterials with enzyme-like characteristics, as the name suggests. In the last decade, efforts have been made to develop "artificial enzymes," which are alternatives to natural enzymes. As nanoscience and nanotechnology advance, nanozymes, which are catalytic nanomaterials having enzyme-like properties, have fascinated researchers' attention. Nanozymes with unique physicochemical properties and nanomaterials that mimic catalytic activity have gained a special interest in the industrial sectors...
October 20, 2022: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/36317933/chiral-nanomaterials-for-biosensing-bioimaging-and-disease-therapies
#15
REVIEW
Aihua Qu, Liguang Xu, Chuanlai Xu, Hua Kuang
Chirality exists in every corner of nature and is closely associated with the phenomenon of life. The unique optical properties and enhanced enantioselectivity of chiral nanomaterials mean that they excel in many applications in nanobiology and nanomedicine. Here, we comprehensively review the progress that has been made toward the use of chiral nanomaterials in biosensing, bioimaging, and disease therapies. The construction strategies for three different types of chiral nanomaterials and their chirality-generating mechanisms are first generalized...
November 1, 2022: Chemical Communications: Chem Comm
https://read.qxmd.com/read/36083800/time-resolved-thickness-and-shape-change-quantification-using-a-dual-band-nanoplasmonic-ruler-with-sub-nanometer-resolution
#16
JOURNAL ARTICLE
Ferry Anggoro Ardy Nugroho, Dominika Świtlik, Antonius Armanious, Padraic O'Reilly, Iwan Darmadi, Sara Nilsson, Vladimir P Zhdanov, Fredrik Höök, Tomasz J Antosiewicz, Christoph Langhammer
Time-resolved measurements of changes in the size and shape of nanobiological objects and layers are crucial to understand their properties and optimize their performance. Optical sensing is particularly attractive with high throughput and sensitivity, and label-free operation. However, most state-of-the-art solutions require intricate modeling or multiparameter measurements to disentangle conformational or thickness changes of biomolecular layers from complex interfacial refractive index variations. Here, we present a dual-band nanoplasmonic ruler comprising mixed arrays of plasmonic nanoparticles with spectrally separated resonance peaks...
September 9, 2022: ACS Nano
https://read.qxmd.com/read/36067968/intravital-microscopy-for-real-time-monitoring-of-drug-delivery-and-nanobiological-processes
#17
REVIEW
Jeffrey Momoh, Dimitrios Kapsokalyvas, Michael Vogt, Sjoerd Hak, Fabian Kiessling, Marc van Zandvoort, Twan Lammers, Alexandros Marios Sofias
Intravital microscopy (IVM) expands our understanding of cellular and molecular processes, with applications ranging from fundamental biology to (patho)physiology and immunology, as well as from drug delivery to drug processing and drug efficacy testing. In this review, we highlight modalities, methods and model organisms that make up today's IVM landscape, and we present how IVM - via its high spatiotemporal resolution - enables analysis of metabolites, small molecules, nanoparticles, immune cells, and the (tumor) tissue microenvironment...
September 3, 2022: Advanced Drug Delivery Reviews
https://read.qxmd.com/read/35980131/amphiphilic-nanointerface-inducing-the-interfacial-activation-for-lipase
#18
JOURNAL ARTICLE
Jihang Zhang, Zhaoxin Wang, Wei Zhuang, Hesamoddin Rabiee, Chenjie Zhu, Jiawei Deng, Lei Ge, Hanjie Ying
Graphene-based materials are widely used in the field of immobilized enzymes due to their easily tunable interfacial properties. We designed amphiphilic nanobiological interfaces between graphene oxide (GO) and lipase TL ( Thermomyces lanuginosus ) with tunable reduction degrees through molecular dynamics simulations and a facile chemical modulation, thus revealing the optimal interface for the interfacial activation of lipase TL and addressing the weakness of lipase TL, which exhibits weak catalytic activity due to an inconspicuous active site lid...
August 31, 2022: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/35910802/turmeric-derived-nanovesicles-as-novel-nanobiologics-for-targeted-therapy-of-ulcerative-colitis
#19
JOURNAL ARTICLE
Caifang Gao, Yangyang Zhou, Zhejie Chen, Hongyi Li, Yaqin Xiao, Wei Hao, Ying Zhu, Chi Teng Vong, Mohamed A Farag, Yitao Wang, Shengpeng Wang
Rationale : Ulcerative colitis (UC), a typical kind of inflammatory bowel disease (IBD), is an idiopathic chronic intestinal inflammation. Conventional therapeutic strategies mainly focus on the rebalance of pro-inflammation and anti-inflammation cytokines, whereas targeting damaged intestinal barriers, imbalanced intestinal microbiota and dysregulated mucosal immune responses in UC remain a big challenge. The objective of this study was to develop turmeric-derived nanovesicles (TNVs) for alleviation of colitis and explore the underlying mechanisms...
2022: Theranostics
https://read.qxmd.com/read/35801691/high-efficiency-treatment-for-osteoarthritis-via-self-assembled-dual-functionalized-nanobiologics
#20
JOURNAL ARTICLE
Chenyu Wang, Jinrui Zhang, Bo Li, Jianlin Zuo, Yuanxin Li, Yao Sun, Fan Wang, Kai Liu, Jingjing Li
Osteoarthritis (OA) is a progressive joint disease that has a complex pathogenesis and lacks effective drugs. OA develops with cartilage degeneration and inflammation, thus synthesizing a drug with both anti-inflammatory properties and cartilage-repair capacity provides a promising treatment strategy. Therefore, in this study, we report self-assembled nanobiologics composed of an engineered recombinant IL-1 receptor antagonist (IL-1Ra) chimeric protein with chondroitin sulfate (CS). The nanobiologics, termed ICN, exhibit extraordinary biocompatibility, low immunogenicity, and good bioefficacy...
July 8, 2022: ACS Biomaterials Science & Engineering
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