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Immobilization degeneration

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https://www.readbyqxmd.com/read/29571021/linalyl-acetate-prevents-olmesartan-induced-intestinal-hypermotility-mediated-by-interference-of-the-sympathetic-inhibitory-pathway-in-hypertensive-rat
#1
Soonho Kwon, Yu Shan Hsieh, You Kyoung Shin, Purum Kang, Geun Hee Seol
Olmesartan-associated enteropathy (OAE) is a life-threatening pathological condition, but its underlying mechanisms have not been elucidated. Although intestinal hypermotility is frequently accompanied by chronic diarrhea, there have been no studies of olmesartan-induced hypermotility. Intestinal motility should be well regulated by the enteric nervous system, but degeneration of enteric neurons has been reported in patients with chronic diarrheal diseases, such as irritable bowel syndrome, suggesting a connection between OAE and intestinal hypermotility...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29486771/mitochondrial-damage-and-plugging-of-transport-selectively-in-myelinated-small-diameter-axons-are-major-early-events-in-peripheral-neuroinflammation
#2
Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A Gregson, Michael R Duchen, Kenneth J Smith
BACKGROUND: Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known. METHODS: We used in vivo confocal microscopy to compare the effects of inflammation in experimental autoimmune neuritis (EAN), a model of Guillain-Barré syndrome (GBS), on mitochondrial function and transport in large- and small-diameter axons. We have compared mitochondrial function and transport in vivo in (i) healthy axons, (ii) axons affected by experimental autoimmune neuritis, and (iii) axons in which mitochondria were focally damaged by laser induced photo-toxicity...
February 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29426225/high-content-microfluidic-screening-platform-used-to-identify-%C3%AF-2r-tmem97-binding-ligands-that-reduce-age-dependent-neurodegeneration-in-c-elegans-sc_app-model
#3
Sudip Mondal, Evan Hegarty, James J Sahn, Luisa L Scott, Sertan Kutal Gökçe, Chris Martin, Navid Ghorashian, Praveen Navoda Satarasinghe, Sangeetha Iyer, Wisath Sae-Lee, Timothy R Hodges, Jonathan T Pierce, Stephen F Martin, Adela Ben-Yakar
The nematode Caenorhabditis elegans, with tractable genetics and a well-defined nervous system, provides a unique whole-animal model system to identify novel drug targets and therapies for neurodegenerative diseases. Large-scale drug or target screens in models that recapitulate the subtle age- and cell-specific aspects of neurodegenerative diseases are limited by a technological requirement for high-throughput analysis of neuronal morphology. Recently, we developed a single-copy model of amyloid precursor protein (SC_APP) induced neurodegeneration that exhibits progressive degeneration of select cholinergic neurons...
February 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29373812/journey-of-sperms-from-production-by-males-to-storage-by-queens-in-crematogaster-osakensis-hymenoptera-formicidae
#4
Ayako Gotoh, Koudai Furukawa
Ants show a unique reproductive system among insects. Males finish sperm production, and their testes degenerate at a young stage. After copulation, spermatozoa are transferred into the queens, who store the received sperm cells throughout their long lifespan without additional mating. In the present study, we investigated the reproductive biology of Crematogaster osakensis from male sexual maturation to sperm transfer, and sperm storage in queens. The sperm production was completed by eclosion and all produced spermatozoa had migrated to the seminal vesicle and the testes shrank until 10 days after eclosion...
February 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29345715/tendon-function-related-structure-simple-healing-process-and-mysterious-ageing
#5
Jan Zabrzyński, Łukasz Łapaj, Łukasz Paczesny, Agnieszka Zabrzyńska, Dariusz Grzanka
Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions. In this paper we summarize actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimized for the best performance of the tissue...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29189218/adjacent-level-degeneration-bryan-total-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion
#6
Justin Miller, Rick Sasso, Paul Anderson, K Daniel Riew, Austin McPhilamy, Thomas Gianaris
STUDY DESIGN: Prospective randomized, 2-center, clinical trial. OBJECTIVE: To prospectively compare adjacent level degeneration between the Bryan Cervical Disc Prosthesis and anterior cervical discectomy and fusion (ACDF), and assess the reliability of our measurements utilizing a method not previously described. SUMMARY OF BACKGROUND DATA: ACDF is a reliable and proven procedure for the treatment of radiculopathy and/or myelopathy. Despite a successful track record several limitations including adjacent segment degeneration/disease, loss of viscoelastic disc properties, perioperative immobilization, graft site morbidity, pseudarthrosis, and plating complications have been identified...
March 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29164801/improving-the-biological-function-of-decellularized-heart-valves-through-integration-of-protein-tethering-and-three-dimensional-cell-seeding-in-a-bioreactor
#7
Mehrnaz Namiri, Mohammad Kazemi Ashtiani, Saeed Abbasalizadeh, Zahra Mazidi, Elena Mahmoudi, Saman Nikeghbalian, Nasser Aghdami, Hossein Baharvand
Decellularized xenogeneic heart valves (DHVs) are promising products for valve replacement. However, the widespread clinical application of such products is limited due to the risk of immune reaction, progressive degeneration, inflammation, and calcification. Here, we have developed an optimized decellularization protocol for a xenogeneic heart valve. We improved the biological function of DHVs by protein tethering onto DHV and three-dimensional (3D) cell seeding in a bioreactor. Our results showed that heart valves treated with a Triton X-100 and sodium deoxycholate-based protocol were completely cell-free, with preserved biochemical and biomechanical properties...
November 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29145857/treatment-of-charcot-neuroarthropathy-and-osteomyelitis-of-the-same-foot-a-retrospective-cohort-study
#8
Martin Berli, Lazaros Vlachopoulos, Sabra Leupi, Thomas Böni, Charlotte Baltin
BACKGROUND: We evaluated treatment of osteomyelitis in the foot in the presence of Charcot neuroarthropathy, a devastating condition with progressive degeneration and joint destruction. We hypothesized that there was a difference in (1) amputation rate, (2) amputation level, (3) duration of antibiotic therapy, and (4) duration of immobilization for treatment of osteomyelitis within versus outside the Charcot zone. METHODS: Forty patients (43 ft) diagnosed with Charcot neuroarthropathy and osteomyelitis of the same foot were retrospectively analyzed...
November 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29107632/keratin-biomaterials-augment-anti-inflammatory-macrophage-phenotype-in-vitro
#9
Michele Waters, Pamela VandeVord, Mark Van Dyke
Tissue regeneration following injury is mediated by macrophage recruitment and differentiation in response to environmental signals. In general, macrophages adopt either a classically M1 (M[IFN-γ, LPS]) or alternatively activated M2 (M[IL-4, IL-13] or M[IL-10]) phenotype. Recent studies have highlighted the importance of alternatively activated macrophages in tissue remodeling and repair as well as the contribution of an imbalance of classically and alternatively activated macrophages to tissue degeneration and disease progression...
January 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29097664/high-frequency-recombination-between-members-of-an-ltr-retrotransposon-family-during-transposition-bursts
#10
Diego H Sanchez, Hervé Gaubert, Hajk-Georg Drost, Nicolae Radu Zabet, Jerzy Paszkowski
Retrotransposons containing long terminal repeats (LTRs) form a substantial fraction of eukaryotic genomes. The timing of past transposition can be estimated by quantifying the accumulation of mutations in initially identical LTRs. This way, retrotransposons are divided into young, potentially mobile elements, and old that moved thousands or even millions of years ago. Both types are found within a single retrotransposon family and it is assumed that the old members will remain immobile and degenerate further...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29051115/an-herbal-formula-consisting-of-schisandra-chinensis-turcz-baill-lycium-chinense-mill-and-eucommia-ulmoides-oliv-alleviates-disuse-muscle-atrophy-in-rats
#11
Seongguk Cho, Riwon Hong, Poorm Yim, Mijung Yeom, Bombi Lee, Woong Mo Yang, Jongki Hong, Hyang Sook Lee, Dae-Hyun Hahm
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (SC), Lycium chinense Mill (LC) and Eucommia ulmoides Oliv (EU) are representative tonic herbal medicines that help to strengthen body muscles and bones making them stronger according to the Donguibogam, a tradition medical book of the Joseon Dynasty in Korea. AIM OF THE STUDY: To evaluate effects of an herbal formula consisting of SC, LC and EU on muscle atrophy in C2C12 myotubes and in a rat model of immobilization-induced muscle atrophy...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28980991/crystal-structure-of-cobalt-hydroxide-carbonate-co-2-co-3-oh-2-density-functional-theory-and-x-ray-diffraction-investigation
#12
Jorge González-López, Jeremy K Cockcroft, Ángeles Fernández-González, Amalia Jimenez, Ricardo Grau-Crespo
The cobalt carbonate hydroxide Co2 CO3 (OH)2 is a technologically important solid which is used as a precursor for the synthesis of cobalt oxides in a wide range of applications. It also has relevance as a potential immobilizer of the toxic element cobalt in the natural environment, but its detailed crystal structure is so far unknown. The structure of Co2 CO3 (OH)2 has now been investigated using density functional theory (DFT) simulations and powder X-ray diffraction (PXRD) measurements on samples synthesized via deposition from aqueous solution...
October 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28974461/bone-replaces-articular-cartilage-in-the-rat-knee-joint-after-prolonged-immobilization
#13
T M Campbell, K Reilly, O Laneuville, H Uhthoff, G Trudel
BACKGROUND: Lost joint range of motion (ROM) is common in chronic osteoarthritis, alters regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and bone alterations. Limited data exist on the regional effects on joints subjected to chronic losses of ROM. OBJECTIVE: To characterize the regional replacement by bone as part of articular cartilage degeneration after prolonged immobilization. METHODS: Eleven rat knees were rigidly-immobilized in flexion for 32weeks with contralateral and sham-operated (n=6) knees as controls...
September 30, 2017: Bone
https://www.readbyqxmd.com/read/28937328/biomechanical-effects-of-hybrid-stabilization-on-the-risk-of-proximal-adjacent-segment-degeneration-following-lumbar-spinal-fusion-using-an-interspinous-device-or-a-pedicle-screw-based-dynamic-fixator
#14
Chang-Hyun Lee, Young Eun Kim, Hak Joong Lee, Dong Gyu Kim, Chi Heon Kim
OBJECTIVE Pedicle screw-rod-based hybrid stabilization (PH) and interspinous device-based hybrid stabilization (IH) have been proposed to prevent adjacent-segment degeneration (ASD) and their effectiveness has been reported. However, a comparative study based on sound biomechanical proof has not yet been reported. The aim of this study was to compare the biomechanical effects of IH and PH on the transition and adjacent segments. METHODS A validated finite element model of the normal lumbosacral spine was used...
December 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28885030/platelet-adhesion-and-activation-on-chiral-surfaces-the-influence-of-protein-adsorption
#15
Yonghong Fan, Rifang Luo, Honghong Han, Yajun Weng, Hong Wang, Jing'an Li, Ping Yang, Yunbing Wang, Nan Huang
Adsorbed proteins and their conformational change on blood-contacting biomaterials will determine their final hemocompatibility. It has frequently been reported that surface chirality of biomaterials may highly influence their protein adsorption behavior. Here, lysine and tartaric acid with different chirality were immobilized onto TiO2 films respectively, and the influence of surface chirality on protein adsorption, platelet adhesion, and activation was also investigated. It showed that the l- and d-molecule grafted samples had almost the same grafting density, surface topography, chemical components, and hydrophilicity in this study...
October 3, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28861345/possible-role-of-sialylation-of-retinal-protein-glycans-in-the-regulation-of-electroretinogram-response-in-mice
#16
Satpal Ahuja
AIM: To evaluate if the nature, degree and extent of Siaα2-3-/Siaα2-6-sialylation of retinal protein glycans plays a possible role in the development and regulation of electroretinogram response (ERG) in mice. METHODS: Proteins extracted, from retinae of postnatal day 2 (PN2), PN7, and PN14 wild type (wt) and retinal degeneration 1 (rd1) mice were quantified, labeled and used for lectin-microarray profiling with immobilized lectins which recognize a wide range of N-/O-glycans...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28822015/experimental-periodontitis-in-the-potentialization-of-the-effects-of-immobilism-in-the-skeletal-striated-muscle
#17
Marcela Aparecida Leite, Tatiane Morgenstern de Mattia, Camila Mayumi Martin Kakihata, Bruna Martinazzo Bortolini, Pedro Henrique de Carli Rodrigues, Gladson Ricardo Flor Bertolini, Rose Meire Costa Brancalhão, Lucinéia de Fátima Chasko Ribeiro, Carlos Augusto Nassar, Patrícia Oehlmeyer Nassar
This study aims to evaluate if ligature-induced periodontitis can potentiates the deleterious effects of immobilization in the skeletal striated muscle, contributing to the development of muscle atrophy due to disuse. Forty Wistar rats were divided into four groups: (1) Control Group (CG), (2) Periodontal Disease (PDG), (3) Immobilized (IG), and (4) Immobilized with Periodontal Disease (IPDG). Periodontal disease was induced for 30 days, with ligature method, and the immobilization was performed with cast bandage for 15 days...
December 2017: Inflammation
https://www.readbyqxmd.com/read/28793833/synergistic-therapeutic-effect-of-three-dimensional-stem-cell-clusters-and-angiopoietin-1-on-promoting-vascular-regeneration-in-ischemic-region
#18
Jung-Mi Kang, Jeong-Kee Yoon, Seong-Ja Oh, Byung-Soo Kim, Sang-Heon Kim
Peripheral artery disease (PAD) is an ischemic disease characterized by reduced blood flow to the legs, feet, and hands. Human mesenchymal stem cells are an attractive cell source to treat PAD in regenerative medicine. However, in clinical applications, the use of adult stem cells has several limitations, such as low cell viability and low therapeutic efficiency. In this study, we described an innovative method of culturing three-dimensional stem cell clusters (Angiocluster™ [AC]), demonstrated the potential for ACs to differentiate into vascular cells, and assessed the synergistic effects of ACs and angiopoietin-1 (Ang-1) on angiogenesis in ischemic animal models...
September 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28577071/isolation-of-a-methylated-mannose-binding-protein-from-terrestrial-worm-enchytraeus-japonensis
#19
Shigeru Ogawa, Mamoru Mizuno, Mayuko Suzuki, Kohtaro Goto, Yuriko Hirose, Akio Matsuda, Takuya Saito, Suguru Oguri, Kiyoshi Furukawa
To elucidate a biological role of the methylated mannose residues found in N-glycans of terrestrial worm Enchytraeus japonensis, we first synthesized 3-O-methyl mannose- and 4-O-methyl mannose-derivatives and immobilized them to Sepharose 4B beads in order to isolate the sugar-binding protein. When whole protein extracts from the worms was applied to a series of the columns immobilized with the modified and unmodified mannose-derivatives, respectively, a protein with a molecular weight of 25,000 was isolated by 4-O-methyl mannose-immobilized column chromatography, and termed as a methylated mannose-binding protein (mMBP)...
October 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28567222/comparison-of-the-extent-of-degeneration-among-the-normal-disc-immobilized-disc-and-immobilized-disc-with-an-endplate-fracture
#20
Wonki Choi, Sukkyun Song, Seungbum Chae, Sangbong Ko
BACKGROUND: This study attempts to prove a cause and effect relationship between spine immobilization following posterior fixation for unstable burst fractures and degeneration observed following hardware removal. METHODS: We enrolled 57 patients (259 intervertebral discs [IVDs]) who underwent only posterior instrumentation without fusion for thoracolumbar and lumbar unstable burst fractures. We arbitrarily named the IVD that has an endplate fracture after immobilization using pedicle screws as the fractured endplate and immobilized disc (FEID), the IVD that has no endplate fracture after immobilization using pedicle screws as the nonfractured endplate and immobilized disc (NFEID), and the IVD that has no endplate fracture and no immobilization instrumentation as the normal disc (ND)...
June 2017: Clinics in Orthopedic Surgery
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