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https://www.readbyqxmd.com/read/29317827/optimal-management-of-cogan-s-syndrome-a-multidisciplinary-approach
#1
REVIEW
Vittorio D'Aguanno, Massimo Ralli, Marco de Vincentiis, Antonio Greco
Cogan's syndrome (CS) is a rare disorder characterized by nonsyphilitic interstitial keratitis (IK) and audio-vestibular symptoms. CS affects mainly young Caucasian adults, mostly during their first three decades of age, and may develop into typical and atypical variants. Typical CS manifests primarily with IK and hearing loss, whereas atypical CS usually presents with inflammatory ocular manifestations in association with audio-vestibular symptoms but mostly different Ménière-like symptoms and, more frequently, with systemic inflammation (70%), of which vasculitis is the pathogenic mechanism...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29315188/relationship-between-the-extent-of-endolymphatic-hydrops-and-the-severity-and-fluctuation-of-audiovestibular-symptoms-in-patients-with-meni%C3%A3-re-s-disease-and-mri-evidence-of-hydrops
#2
Claudia Jerin, Sonja Floerke, Rebecca Maxwell, Robert Gürkov
OBJECTIVE: To characterize the short-, middle-, and long-term occurrence of vertigo attacks in a large population of Menière's disease (MD) and to investigate the relationship between the extent of endolymphatic hydrops (ELH) and the severity of audiovestibular symptoms. STUDY DESIGN: Prospective observational study. METHODS: One hundred ninety-two patients with clinically definite MD participated in this study. The degree of ELH was visualized by locally enhanced inner ear magnetic resonance imaging...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29315186/the-progressive-nature-of-meni%C3%A3-re-s-disease-stress-projections-and-lesion-analysis
#3
Daniel J Pender
HYPOTHESIS: An engineering model of the labyrinth can provide a mechanism that accounts for the pattern of lesion development observed in Menière's disease. BACKGROUND: Membrane lesions in Menière's disease can occur in virtually every part of the membranous labyrinth. How these lesions are induced is unclear and their mode of distribution uncertain. Pressure induced stress in the membranous labyrinth may play a mechanistic role in lesion formation and distribution...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29301160/-pharmacotherapy-of-vestibular-disorders-nystagmus-and-cerebellar-disorders
#4
K Feil, N Böttcher, O Kremmyda, C Muth, J Teufel, A Zwergal, T Brandt, M Strupp
There are currently different groups of drugs for the pharmacotherapy of vertigo, nystagmus and cerebellar disorders: antiemetics; anti-inflammatories, antimenieres, and antimigraineous medications and antidepressants, anticonvulsants, aminopyridines as well as acetyl-DL-leucine. In acute unilateral vestibulopathy, corticosteroids improve the recovery of peripheral vestibular function, but currently there is not sufficient evidence for a general recommendation. There is insufficient evidence to support the view that 16 mg t...
January 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29299506/longitudinal-up-regulation-of-endolymphatic-hydrops-in-patients-with-meniere-s-disease-during-medical-treatment
#5
Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda
Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29298210/electrophysiology-of-cranial-nerve-testing-auditory-nerve
#6
Alan D Legatt
The electrocochleogram and brainstem auditory evoked potentials (BAEPs) are electrophysiologic signals used to assess the auditory nerve. The electrocohleogram includes the cochlear microphonic, the cochlear summating potential, and the eighth nerve compound action potential. It is used predominantly for hearing assessment and for diagnosis of Ménière disease and auditory neuropathy. Brainstem auditory evoked potentials are used for hearing assessment, diagnosis of dysfunction within the cochlea, the auditory nerve, and the brainstem auditory pathways up to the level of the mesencephalon, and intraoperative monitoring of these structures...
January 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29296830/cd4-t-cells-specific-for-factor-viii-are-present-at-high-frequency-in-healthy-donors-and-comprise-na%C3%A3-ve-and-memory-cells
#7
Sylvain Meunier, Catherine Menier, Elodie Marcon, Sébastien Lacroix-Desmazes, Bernard Maillère
We investigated the frequency and subset origin of circulating factor VIII (FVIII)-specific CD4 T cells in healthy donors. Total CD4 T cells and purified CD4 T-cell subsets were stimulated with FVIII-loaded autologous dendritic cells and challenged for specificity in interferon-γ enzyme-linked immunospots. The number of specific T-cell lines allowed estimation of the frequency of T cells circulating in the blood of the donors. All the 16 healthy donors generated strong in vitro T-cell responses, leading to the generation of 154 FVIII-specific T-cell lines...
September 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29287768/autoimmune-arthritis-in-m%C3%A3-ni%C3%A3-re-s-disease-a-systematic-review-of-the-literature
#8
REVIEW
Lisa Caulley, Alexandra Quimby, Jacob Karsh, Azin Ahrari, Darren Tse, Georgios Kontorinis
INTRODUCTION: Successful management of patients with Ménière's disease (MD) involves understanding the pathophysiology of the disease and its comorbidities. The role of autoimmune diseases (AD) in MD remains unclear. The aim of this study was to further investigate the association between MD and AD. Specific goals were to characterize the prevalence, distribution, clinical and laboratory findings, and outcomes of autoimmune arthritis (AA) in MD. EVIDENCE REVIEW: This systematic review was conducted according to PRISMA guidelines...
November 29, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29287037/correlations-between-the-degree-of-endolymphatic-hydrops-and-symptoms-and-audiological-test-results-in-patients-with-meni%C3%A3-re-s-disease-a-reevaluation
#9
Shiyin Yang, Huaming Zhu, Bijun Zhu, Hui Wang, Zhengnong Chen, Yaqin Wu, Bin Chen, Haibo Shi, Yuehua Li, Jing Zou, Shankai Yin
OBJECTIVE: This study was performed to reevaluate the diagnostic significance of clinically well-accepted audiological tests in indicating endolymphatic hydrops (EH) in Menière's disease (MD). STUDY DESIGN: Retrospective case review. SETTINGS: Hospital. PATIENTS: Fifty patients (52 affected ears) diagnosed with MD were enrolled. INTERVENTION: Diagnostic. MAIN OUTCOME MEASURE: To analyze the correlations between endolymphatic hydrops and results of audiological test including the pure-tone audiometry threshold, suprathreshold function tests, electrocochleogram, and glycerol test...
December 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29283101/the-reliability-and-validity-of-dokuz-eyl%C3%A3-l-university-meniere-s-disease-disability-scale
#10
Başak Mutlu, Günay Kırkım, Serpil Mungan Durankaya, Selhan Gürkan, Tahsin Oğuz Başokçu, Enis Alpin Güneri
OBJECTIVE: Ménière's Disease (MD) is a chronic, non-life threatening inner ear disease, with attacks of disabling vertigo, progressive hearing loss, and tinnitus as the major symptoms. All three symptoms, separately or in combination, cause great distress and have a considerable impact on the quality of life of the patients. The aims of this study were to develop a disease-specific quality of life survey for patients with MD and to analyze the relationships between the audiovestibular findings and the survey...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29282702/treatment-of-dizziness-an-interdisciplinary-update
#11
Rainer Spiegel, Heiko Rust, Thomas Baumann, Hergen Friedrich, Raoul Sutter, Martina Göldlin, Christiane Rosin, René Müri, Georgios Mantokoudis, Roland Bingisser, Michael Strupp, Roger Kalla
This review provides an update on interdisciplinary treatment for dizziness. Dizziness can have various causes and the treatment offered should depend on the cause. After reading this article, the clinician will have an overview of current treatment recommendations. Recommendations are made for the most prevalent causes of dizziness including acute and chronic vestibular syndromes, vestibular neuritis, benign paroxysmal positional vertigo, endolymphatic hydrops and Menière's disease, vestibular paroxysmia and vestibular migraine, cardiac causes, transient ischaemic attacks and strokes, episodic ataxia type 2, persistent postural-perceptual dizziness, bilateral vestibulopathy, degenerative, autoimmune and neoplastic diseases, upbeat- and downbeat nystagmus...
December 28, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29282350/assessment-tools-for-use-in-patients-with-m%C3%A3-ni%C3%A3-re-disease-an-update
#12
Andrea Ciorba, Piotr Henryk Skarżyński, Virginia Corazzi, Chiara Bianchini, Claudia Aimoni, Stavros Hatzopoulos
A number of electrophysiological tests have been proposed for the initial diagnostic assessment or for the follow-up phase of patients affected by Ménière disease. The most common are: (i) vestibular evoked myogenic potentials (VEMPs); (ii) electrocochleography (ECochG); and (iii) otoacoustic emissions (OAEs). This paper presents the latest clinical developments with these 3 testing modalities. The PubMed, Embase, and Cinahl databases were searched from 2006 to December 2016. Full-text articles were obtained in cases where the title, abstract, or key words suggested that the study may be eligible for this review...
December 28, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29279722/current-diagnostic-procedures-for-diagnosing-vertigo-and-dizziness
#13
REVIEW
Leif Erik Walther
Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e.g. positional vertigo, vestibular neuritis, Menière's disease), vertigo may occur as main or accompanying symptom of a multitude of ENT-related diseases involving the inner ear...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29279721/recent-surgical-options-for-vestibular-vertigo
#14
REVIEW
Stefan Volkenstein, Stefan Dazert
Vertigo is not a well-defined disease but a symptom that can occur in heterogeneous entities diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine, and primary care physicians. Most vertigo syndromes have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe and discuss different surgical therapy options for hydropic inner ear diseases, Menière's disease, dehiscence syndromes, perilymph fistulas, and benign paroxysmal positional vertigo...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29274769/comparison-of-video-head-impulse-test-and-caloric-reflex-test-in-advanced-unilateral-definite-meni%C3%A3-re-s-disease
#15
F Rubin, F Simon, B Verillaud, P Herman, R Kania, C Hautefort
AIMS: There have been very few studies of the Video Head Impulse Test (VHIT) in patients with Menière's Disease (MD). Some reported 100% normal VHIT results, others not. These discrepancies may be due to differences in severity. The present study compared VHIT and caloric reflex test results in advanced unilateral definite MD. MATERIAL AND METHOD: A prospective study included 37 consecutive patients, with a mean age of 56±12 years. Mean hearing loss was 59±18dB HL; 12 patients were subject to Tumarkin's otolithic crises...
December 20, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29248204/intestinal-permeability-and-m%C3%A3-ni%C3%A3-re-s-disease
#16
F Di Berardino, D Zanetti, E Ciusani, C Caccia, V Leoni, U De Grazia, E Filipponi, L Elli
PURPOSE: Ménière disease (MD) is a multifactorial chronic disabling condition characterized by episodic vertigo, ear fullness, and hearing loss. MD patients often complain of aspecific gastrointestinal symptoms associated with autonomic dysregulation, frequently outweighed by the otological manifestations. Dietary modifications have been reported to improve the typical MD symptoms in some cases. Our purpose was to test the urinary levels of lactulose and mannitol (double sugar test) and the fecal calprotectin, both markers of altered intestinal permeability, in subjects with definite MD in an active and inactive stage...
December 5, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29238692/migraine-related-vertigo
#17
Vithal D Udagatti, Rajendran Dinesh Kumar
Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Ear, Nose and Throat examination was normal...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29235232/signs-of-electrocochleography-on-endolymphatic-sac-decompression-for-patients-with-m%C3%A3-ni%C3%A3-re-s-disease-our-experience-in-12-patients
#18
Wei Li, Yan Lei, Jiang Zhu, Yi Qian, Guo-Ting Ma, Tao Lu, Guo-Hua Hu, Hou-Yong Kang
Endolymphatic hydrops (ELH) is a well-established histological marker of Ménière's Disease (MD). The diagnosis of MD still depends on clinical symptoms complemented with inner ear function tests. Thus far, definitive diagnosis remains difficult. It is necessary for clinicians to explore an objective examination to diagnose MD and to monitor patients' ELH. This article is protected by copyright. All rights reserved.
December 13, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29231089/erratum
#19
(no author information available yet)
Lambert PR, Silverstein H, LeBel C, Bishop K. OTO-104 in Ménière's disease patients: phase 3 results. Otolaryngol Head Neck Surg. 2017;157:P122-P123. (Original doi: 10.1177/0194599817717251f) This Oral Presentation abstract should have included a note indicating that it was withdrawn during production of the issue. The online version has been updated to include this note.
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29227452/high-resolution-three-dimensional-delayed-contrast-mri-detects-endolymphatic-hydrops-in-patients-with-vertigo-and-vestibular-schwannoma
#20
Roxana Moayer, Gail P Ishiyama, Stellios Karnezis, Ali R Sepahdari, Akira Ishiyama
OBJECTIVE: Advances in high resolution magnetic resonance imaging (MRI) have enabled the detection of endolymphatic hydrops (EH), a pathological ballooning of the endolymphatic fluid system, known to be associated with Menière's disease. When a patient has a known diagnosis of vestibular schwannoma and develops recurrent episodic vertigo spells, many surgeons recommend surgical intervention, attributing the vestibular symptoms to the vestibular schwannoma. The aim of this study is to evaluate the clinical outcome in patients with vestibular schwannoma and EH, treated medically, for recurrent spells of vertigo...
January 2018: Otology & Neurotology
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