Rodrigo Tozetto, Beatriz S Rocha, Evelyn A Andrade, Luiza S Cruz, Rosana L Rosa, Isadora Machinski, Evelin L Oliveira, Jéssica R B Monteiro, Adriana Y Koga, Leandro C Lipinski, Eduardo C Meurer, Rodrigo R Kitagawa, Flávio Luís Beltrame
Oreochromis niloticus (Nile tilapia) skin is a by-product of Brazilian fish farming, rich in collagen. The present study aims to evaluate the wound healing, antioxidant, and antimicrobial potential of the raw hydrolyzed extract of Nile tilapia skin, as well as the identification of the main compounds. The in vitro activity was performed using antioxidant, antimicrobial and scratch wound healing assays. An in vivo experiment was performed to evaluate the wound healing potential. On days 1, 7, 14 and 21, the lesions were photographed to assess wound retraction and on the 7th, 14th and 21st days the skins were removed for histological evaluation and the blood of the animals was collected for glutamic oxaloacetic transaminase and glutamic pyruvic transaminase determination...
September 25, 2023: Chemistry & Biodiversity