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Pediatric Heart Network

Meena Nathan, Marshall L Jacobs, J William Gaynor, Jane W Newburger, Carolyn Dunbar Masterson, Linda M Lambert, Danielle Hollenbeck-Pringle, Felicia L Trachtenberg, Owen White, Brett R Anderson, Margaret C Bell, Phillip T Burch, Eric M Graham, Jonathan R Kaltman, Kirk R Kanter, Carlos M Mery, Christian Pizarro, Marcus S Schamberger, Michael D Taylor, Jeffrey P Jacobs, Sara K Pasquali
BACKGROUND: Data routinely captured in clinical registries may be leveraged to enhance efficiency of prospective research. The quality of registry data for this purpose has not been studied, however. We evaluated the completeness and accuracy of perioperative data within congenital heart centers' local surgical registries. METHODS: Within 12 Pediatric Heart Network (PHN) sites, we evaluated 31 perioperative variables (and their subcategories, totaling 113 unique fields) collected via sites' local clinical registries for submission to The Society of Thoracic Surgeons Database, compared with chart review by PHN research coordinators...
October 7, 2016: Annals of Thoracic Surgery
Renee Margossian, Lynn A Sleeper, Gail D Pearson, Piers C Barker, Luc Mertens, Michael D Quartermain, Jason T Su, Girish Shirali, Shan Chen, Steven D Colan
BACKGROUND: Patients with functional single ventricles after the Fontan procedure have abnormal cardiac mechanics. The aims of this study were to determine factors that influence diastolic function and to describe associations of diastolic function with current clinical status. METHODS: Echocardiograms were obtained as part of the Pediatric Heart Network Fontan Cross-Sectional Study. Diastolic function grade (DFG) was assessed as normal (grade 0), impaired relaxation (grade 1), pseudonymization (grade 2), or restrictive (grade 3)...
September 10, 2016: Journal of the American Society of Echocardiography
Sukryool Kang, Robin Doroshow, James McConnaughey, Raj Shekhar
: Still's murmur is the most common innocent heart murmur in children. It is also the most commonly misdiagnosed murmur, resulting in a high number of unnecessary referrals to pediatric cardiologist. The purpose of this study was to develop a computer algorithm for automated identification of Still's murmur that may help reduce unnecessary referrals. METHODS: We first developed an accurate segmentation algorithm to locate the first and the second heart sounds. Once these sounds were identified, we extracted signal features specific to Still's murmur...
August 26, 2016: IEEE Transactions on Bio-medical Engineering
Asma M Khan, Robert S Green, Irene D Lytrivi, Raj Sahulee
BACKGROUND: Pediatric heart transplantations are limited by the supply of donor allografts. We sought to determine the cardiac allograft utilization rate for pediatric donors and identify donor factors that predict graft use for transplantation. METHODS: The United Network for Organ Sharing deceased donor database was queried from 4/30/2006 to 3/31/2014. Donor risk factors that might affect graft use for cardiac transplantation were evaluated. The pediatric cardiac graft utilization rate was calculated, and logistic regression modeling was performed to determine the risk factors relationship with graft use for transplantation...
August 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
William T Mahle, Susan C Nicolson, Danielle Hollenbeck-Pringle, Michael G Gaies, Madolin K Witte, Eva K Lee, Michelle Goldsworthy, Paul C Stark, Kristin M Burns, Mark A Scheurer, David S Cooper, Ravi Thiagarajan, V Ben Sivarajan, Steven D Colan, Marcus S Schamberger, Lara S Shekerdemian
OBJECTIVE: To determine whether a collaborative learning strategy-derived clinical practice guideline can reduce the duration of endotracheal intubation following infant heart surgery. DESIGN: Prospective and retrospective data collected from the Pediatric Heart Network in the 12 months pre- and post-clinical practice guideline implementation at the four sites participating in the collaborative (active sites) compared with data from five Pediatric Heart Network centers not participating in collaborative learning (control sites)...
October 2016: Pediatric Critical Care Medicine
Logan G Spector, Jeremiah S Menk, Jeffrey M Vinocur, Matthew E Oster, Brian A Harvey, James D St Louis, James Moller, Lazaros K Kochilas
BACKGROUND: The long-term outcomes of patients undergoing interventions for congenital heart disease (CHD) remain largely unknown. We linked the Pediatric Cardiac Care Consortium (PCCC) with the National Death Index (NDI) and the United Network for Organ Sharing Dataset (UNOS) registries to study mortality and transplant occurring up to 32 years postintervention. The objective of the current analysis was to determine the sensitivity of this linkage in identifying patients who are known to have died or undergone heart transplant...
2016: Journal of the American Heart Association
Ryan Butts, Melanie Davis, Andrew Savage, Ali Burnette, Minoo Kavarana, Scott Bradley, Andrew Atz, Paul J Nietert
BACKGROUND: The use of induction therapy in pediatric heart transplantation has increased. The aim of this study was to investigate the effects of induction therapy on graft survival. METHODS: The United Network for Organ Sharing database was queried for isolated pediatric heart transplants from January 1, 1994, to December 31, 2013. Propensity scores for induction treatment were calculated by estimating probability of induction using a logistic regression model...
June 29, 2016: Transplantation
Douglas Y Mah, Henry Cheng, Mark E Alexander, Lynn Sleeper, Jane W Newburger, Pedro J Del Nido, Ravi R Thiagarajan, Satish K Rajagopal
OBJECTIVES: Publicly available data from the Pediatric Heart Network's Single Ventricle Reconstruction Trial was analyzed to determine the prevalence, timing, risk factors for, and impact of second- and third-degree heart block (HB) on outcomes in patients who underwent stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS). METHODS: The presence and date of onset of post-S1P HB occurring within the first year of life, potential risk factors for HB, and factors known to predict poor outcomes after S1P were extracted...
July 2016: Journal of Thoracic and Cardiovascular Surgery
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Don Hayes, Allan R Glanville, David McGiffin, Joseph D Tobias, Dmitry Tumin
BACKGROUND: A survival advantage has been demonstrated for lung transplantation (LTx) in the cystic fibrosis (CF) population, but children may be at higher risk of post-transplant mortality than adults. METHODS: The registry of the International Society for Heart and Lung Transplantation (ISHLT) was queried for lung transplants performed during the period 1998 to 2014 in patients with CF. Period differences were assessed by dividing the sample into LTxs performed between 2006 and 2014 and those performed between 1998 and 2005...
September 2016: Journal of Heart and Lung Transplantation
Lyne Scott, Marilyn Li, Salima Thobani, Breck Nichols, Tricia Morphew, Kenny Yat-Choi Kwong
OBJECTIVE: To determine whether significant numbers of asthmatic children with initially rated intermittent asthma later suffer poor asthma control and require the addition of controller medications. METHODS: Inner-city Hispanic children were followed prospectively in an asthma-specific disease management system (Breathmobile) for a period of 2 years. Clinical asthma symptoms, morbidity treatment, and demographic data were collected at each visit. Treatment was based upon National Heart, Lung, and Blood Institute (NHLBI) Expert Panel Report 3 asthma guidelines...
August 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Sarah T Plummer, Christoph P Hornik, Hamilton Baker, Gregory A Fleming, Susan Foerster, M Eric Ferguson, Andrew C Glatz, Russel Hirsch, Jeffrey P Jacobs, Kyong-Jin Lee, Alan B Lewis, Jennifer S Li, Mary Martin, Diego Porras, Wolfgang A K Radtke, John F Rhodes, Julie A Vincent, Jeffrey D Zampi, Kevin D Hill
OBJECTIVES: Aortic arch reconstruction in children with single ventricle lesions may predispose to circulatory inefficiency and maladaptive physiology leading to increased myocardial workload. We sought to describe neoaortic anatomy and physiology, risk factors for abnormalities, and impact on right ventricular function in patients with single right ventricle lesions after arch reconstruction. METHODS: Prestage II aortic angiograms from the Pediatric Heart Network Single Ventricle Reconstruction trial were analyzed to define arch geometry (Romanesque [normal], crenel [elongated], or gothic [angular]), indexed neoaortic dimensions, and distensibility...
August 2016: Journal of Thoracic and Cardiovascular Surgery
Ryota Ochiai, Hitoshi Kato, Naomi Akiyama, Fukiko Ichida, Atsushi Yao, Ryo Inuzuka, Koichiro Niwa, Isao Shiraishi, Toshio Nakanishi
BACKGROUND: Current Japanese transfer practices for adult congenital heart disease (ACHD) patients in pediatric departments are elucidated in this study. The focus was on 149 facilities (from the Japanese Society of Pediatric Cardiology and Cardiac Surgery Subspecialty Board and the Japanese Association of Children's Hospitals and Related Institutions). One hundred and thirteen facilities were surveyed and the response rate was 75.8%. METHODS AND RESULTS: Twenty-six facilities (23...
April 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Michael J Wolf, Eva K Lee, Susan C Nicolson, Gail D Pearson, Madolin K Witte, Jeryl Huckaby, Michael Gaies, Lara S Shekerdemian, William T Mahle
BACKGROUND: Collaborative learning is a technique through which individuals or teams learn together by capitalizing on one another's knowledge, skills, resources, experience, and ideas. Clinicians providing congenital cardiac care may benefit from collaborative learning given the complexity of the patient population and team approach to patient care. RATIONALE AND DEVELOPMENT: Industrial system engineers first performed broad-based time-motion and process analyses of congenital cardiac care programs at 5 Pediatric Heart Network core centers...
April 2016: American Heart Journal
Norihide Fukushima
By renewal of Japanese Organ Transplantation Act on 17th July in 2010, organs can be donated after brain death with consent from their family, if he or she did not deny organ donation and brain dead organ donation increased from 10 to 50 cases in a year. Despite of an increase of heart transplantation (HTx), a waiting period for HTx has become longer because more candidates for HTx have been registered to Japan Organ Transplant Network. By renewal of the act, organ donation from brain dead children can be performed since then and pediatric left ventricular assist device, EXCOR was finally accepted to use in August 1st, 2015...
January 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Brody Wehman, Kristen A Stafford, Gregory J Bittle, Zachary N Kon, Charles F Evans, Keshava Rajagopal, Nicholas Pietris, Sunjay Kaushal, Bartley P Griffith
BACKGROUND: Pediatric patients awaiting orthotopic heart transplantation frequently require bridge to transplantation (BTT) with mechanical circulatory support. Posttransplant survival outcomes and predictors of mortality have not been thoroughly described in the modern era using a large-scale analysis. METHODS: The United Network for Organ Sharing database was reviewed to identify pediatric heart transplant recipients from 2005 through 2012. Patients were stratified into three groups: extracorporeal membrane oxygenation (ECMO), ventricular assist device (VAD), and direct transplantation (DTXP)...
June 2016: Annals of Thoracic Surgery
Simin Sadeghi-Bojd, Noor Mohammad Noori, Mehdi Mohammadi, Alireza Teimouri
BACKGROUND: Acute kidney injury (AKI) is characterized by a reversible increase in the blood concentration of creatinine and nitrogenous waste products and by the inability of the kidney to regulate fluid and electrolyte homeostasis appropriately. OBJECTIVE: AKI is a serious condition in critically ill patients. The aim of the study was to determine incidence rate, identify risk factors, and describe the clinical outcome of AKI in the Pediatric Intensive Care Unit (PICU)...
September 2015: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Matthew E Oster, Michael Kelleman, Courtney McCracken, Richard G Ohye, William T Mahle
BACKGROUND: Mortality for infants with single ventricle congenital heart disease remains as high as 8% to 12% during the interstage period, the time between discharge after the Norwood procedure and before the stage II palliation. The objective of our study was to determine the association between digoxin use and interstage mortality in these infants. METHODS AND RESULTS: We conducted a retrospective cohort study using the Pediatric Heart Network Single Ventricle Reconstruction Trial public use dataset, which includes data on infants with single right ventricle congenital heart disease randomized to receive either a Blalock-Taussig shunt or right ventricle-to-pulmonary artery shunt during the Norwood procedure at 15 institutions in North America from 2005 to 2008...
January 2016: Journal of the American Heart Association
Michael N Singh, Ronald V Lacro
Marfan syndrome is a genetic disorder of connective tissue with principal manifestations in the cardiovascular, ocular, and skeletal systems. Cardiovascular disease, mainly progressive aortic root dilation and aortic dissection, is the leading cause of morbidity and mortality. The primary aims of this report were to examine the evidence related to medical therapy for Marfan syndrome, including recently completed randomized clinical trials on the efficacy of β-blockers and angiotensin II receptor blockers for the prophylactic treatment of aortic enlargement in Marfan syndrome, and to provide recommendations for medical therapy on the basis of available evidence...
January 2016: Canadian Journal of Cardiology
David Ansari, Peter Höglund, Bodil Andersson, Johan Nilsson
BACKGROUND: Basiliximab and anti-thymocyte globulin are widely used drugs for induction therapy after pediatric heart transplantation. The aim of this study was to determine whether any differences could be observed between basiliximab and anti-thymocyte globulin, with respect to long-term mortality, in a population of pediatric cardiac transplant recipients. METHODS AND RESULTS: An analysis of pediatric heart transplant patients (aged <18 years) from the United Network for Organ Sharing database was conducted that compared patients receiving basiliximab with those that received anti-thymocyte globulin for the risk of all-cause mortality...
January 2016: Journal of the American Heart Association
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