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https://www.readbyqxmd.com/read/28340150/severe-conduction-defects-requiring-permanent-pacemaker-implantation-in-patients-with-a-new-onset-left-bundle-branch-block-after-transcatheter-aortic-valve-implantation
#1
V J Nijenhuis, V F Van Dijk, S M Chaldoupi, J C Balt, J M Ten Berg
Aims: Transcatheter aortic valve implantation (TAVI) is frequently associated with cardiac conduction defects (CCD) requiring permanent pacemaker implantation (PPI). Although new-onset left bundle branch block (LBBB) is often seen, the rate of progression to severe CCD is unclear. We aimed to find clinical and electrocardiographic (ECG) parameters associated with severe CCD requiring PPI in patients with a new-onset LBBB after TAVI and assess its effect on clinical outcome. Methods and results: All consecutive patients undergoing TAVI who developed a new-onset LBBB were retrospectively analysed...
March 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28238508/using-a-multidimensional-prognostic-index-mpi-based-on-comprehensive-geriatric-assessment-cga-to-predict-mortality-in-elderly-undergoing-transcatheter-aortic-valve-implantation
#2
Marie-Laure Bureau, Evelyne Liuu, Luc Christiaens, Alberto Pilotto, Jean Mergy, Fabienne Bellarbre, Pierre Ingrand, Marc Paccalin
BACKGROUND: Selection of appropriate elderly who can benefit from transcatheter aortic valve implantation (TAVI) is challenging. We evaluated the prognosis of this procedure according to the comprehensive geriatric assessment (CGA) based on the multidimensional prognostic index (MPI). METHODS: Prospective observational monocentric study from January 2013 to December 2015. Consecutive patients aged ≥75 who underwent TAVI and a complete CGA were included. Baseline demographic, geriatric and cardiologic data were collected...
February 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28173819/cardiovascular-magnetic-resonance-evaluation-of-symptomatic-severe-aortic-stenosis-association-of-circumferential-myocardial-strain-and-mortality
#3
Tarique Al Musa, Akhlaque Uddin, Peter P Swoboda, Timothy A Fairbairn, Laura E Dobson, Anvesha Singh, Pankaj Garg, Christopher D Steadman, Bara Erhayiem, Ananth Kidambi, David P Ripley, Adam K McDiarmid, Philip Haaf, Daniel J Blackman, Sven Plein, Gerald P McCann, John P Greenwood
BACKGROUND: It is unknown whether circumferential strain is associated with prognosis after treatment of aortic stenosis (AS). We aimed to characterise strain in severe AS, using myocardial tagging cardiovascular magnetic resonance (CMR), prior to and following Transcatheter Aortic Valve Implantation (TAVI) and Surgical Aortic Valve Replacement (SAVR), and determine whether abnormalities in strain were associated with outcome. METHODS: CMR was performed pre- and 6 m post-intervention in 98 patients (52 TAVI, 46 SAVR; 77 ± 8 years) with severe AS...
February 8, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28104807/transcatheter-aortic-valve-implantation-new-hope-in-the-management-of-valvular-heart-disease
#4
REVIEW
Sofia Metaxa, Adam Ioannou, Constantinos G Missouris
Severe calcific aortic stenosis is relatively common, and unless treated with valve replacement it carries an adverse prognosis. A large number of patients, however, are denied surgery due to their advanced age or coexistent medical conditions that increase perioperative cardiovascular risks. Transcatheter aortic valve implantation (TAVI), a technique in which a bioprosthetic valve is inserted via a catheter and implanted within the diseased native aortic valve, is a new therapeutic modality for treatment of older patients with severe symptomatic aortic stenosis and other comorbidities, who have an inherently high surgical risk...
January 19, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28100340/-outcome-comparison-of-different-therapy-procedures-in-surgical-high-risk-elderly-patients-with-severe-aortic-stenosis
#5
Y Q Ye, Y T Wang, Z Li, M Y Wang, H Y Xu, W J Zhang, Q R Liu, G N Niu, Y J Wu
Objective: To compare the outcome of surgical high-risk elderly patients with severe aortic stenosis(SAS) treated by different therapy procedures, including transcatheter aortic valve implantation(TAVI), surgical aortic valve replacement(SAVR), and drug therapy. Methods: We retrospectively analyzed the clinical data of 242 surgical high-risk elderly (age ≥65 years old) SAS patients hospitalized in Fuwai Hospital between September 2012 and June 2015. According to the treatment method, patients were divided into TAVI group (81 cases), SAVR group (59 cases) and drug therapy group (102 cases)...
January 25, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28089155/prognostic-value-of-body-mass-index-in-transcatheter-aortic-valve-implantation-a-j-shaped-curve
#6
Rocío González-Ferreiro, Antonio J Muñoz-García, Diego López-Otero, Pablo Avanzas, Isaac Pascual, Juan H Alonso-Briales, Ramiro Trillo-Nouche, Federico Pun, Manuel F Jiménez-Navarro, José M Hernández-García, César Morís, José R González Juanatey
OBJECTIVES: We aimed to determine whether body mass index (BMI) is a prognostic indicator for long-term, all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI). BACKGROUND: Obesity in patients with established cardiovascular disease has previously been identified as an indicator of good prognosis, a phenomenon known as the "obesity paradox". The prognostic significance of BMI in patients with severe aortic stenosis (AoS) undergoing TAVI is a matter of current debate, as published studies are scarce and their results conflicting...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28017301/prognostic-value-of-hypoalbuminemia-after-transcatheter-aortic-valve-implantation-from-the-japanese-multicenter-ocean-tavi-registry
#7
Masanori Yamamoto, Tetsuro Shimura, Seiji Kano, Ai Kagase, Atsuko Kodama, Mitsuru Sago, Tatsuya Tsunaki, Yutaka Koyama, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
Hypoalbuminemia, a frailty criterion, belongs to a group of co-morbidities not captured as a traditional risk factor. We assessed its prognostic value in patients who underwent transcatheter aortic valve implantation (TAVI). The study included 1,215 consecutive patients from the Optimized Catheter Valvular Intervention -TAVI Japanese multicenter registry. Hypoalbuminemia was defined as serum albumin level <3.5 g/dl. Baseline characteristics, procedural outcomes, and all-cause, cardiovascular and noncardiovascular mortality rates after TAVI were compared between patients with albumin level <3...
December 2, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27989054/contribution-of-dobutamine-stress-echocardiography-to-the-diagnosis-and-prognosis-of-low-flow-low-gradient-aortic-stenosis
#8
Sílvia Aguiar Rosa, Luísa Moura Branco, Ana Galrinho, Guilherme Portugal, Joäo Abreu, Duarte Cacela, José Fragata, Rui Cruz Ferreira
BACKGROUND: Aortic valve replacement (AVR) is the treatment of choice in patients with severe symptomatic aortic stenosis (AS). Patients with a low left ventricular ejection fraction (LVEF) represent a challenge for evaluation and therapeutic decision. Dobutamine stress echocardiography (DSE) allows the distinction to be made between fixed low-flow/low-gradient (LF/LG) AS and pseudosevere AS. METHODS: Between 2001 and 2014 a retrospective analysis was conducted of patients who underwent DSE to investigate severe AS...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27931726/meta-analysis-of-impact-of-diabetes-mellitus-on-outcomes-after-transcatheter-aortic-valve-implantation
#9
Yinghao Sun, Xianbao Liu, Yuxin He, Mengyao Tang, Qifeng Zhu, Xiaobin Xu, Dongyu Guo, Keda Shi, Po Hu, Lihan Wang, Huijia Kong, Jubo Jiang, Xiaoping Lin, Qiyuan Xu, Feng Gao, Jian'an Wang
To date, the impact of diabetes mellitus (DM) on prognosis after transcatheter aortic valve implantation (TAVI) is still contradictory and thus merits further investigation. The purpose of this meta-analysis was to evaluate the impact of DM on outcomes after TAVI. A systematic search of the PubMed database was performed. Primary end points were 30-day and 1-year all-cause mortality after TAVI. Risk ratios (RRs) and 95% CIs were calculated using the random-effect or fixed-effect model, depending on heterogeneity between studies, and p values <0...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27892889/the-impact-of-functional-vs-degenerative-mitral-regurgitation-on-clinical-outcomes-among-patients-undergoing-transcatheter-aortic-valve-implantation
#10
René Vollenbroich, Stefan Stortecky, Fabien Praz, Jonas Lanz, Anna Franzone, Katarzyna Zuk, Dik Heg, Marco Valgimigli, Crochan John O'Sullivan, Corinna Heinisch, Eva Roost, Peter Wenaweser, Stephan Windecker, Thomas Pilgrim
BACKGROUND: Among patients undergoing transcatheter aortic valve implantation (TAVI), concomitant mitral regurgitation (MR) has been associated with adverse prognosis. We aimed to assess long-term clinical outcomes according to MR etiology. METHODS: In a single-center registry of consecutive patients undergoing TAVI, we investigated the impact of functional (FMR) vs degenerative (DMR) MR on cardiovascular (CV) mortality throughout 2years of follow-up. RESULTS: Among 603 patients (mean age 82...
October 28, 2016: American Heart Journal
https://www.readbyqxmd.com/read/27862874/outcomes-of-patients-with-low-pressure-aortic-gradient-undergoing-transcatheter-aortic-valve-implantation-a-meta-analysis
#11
Federico Conrotto, Fabrizio D'Ascenzo, Maurizio D'Amico, Claudio Moretti, Marco Pavani, Paolo Scacciatella, Pierluigi Omedè, Antonio Montefusco, Giuseppe Biondi-Zoccai, Fiorenzo Gaita, Francesco Maisano, Fabian Nietlispach
BACKGROUND: The risk/benefit balance of transcatheter aortic valve implantation (TAVI) in patients with low-gradient aortic stenosis (LGAS) remains to be well defined. Aim of the study was to investigate the impact of LGAS in patients undergoing TAVI. METHODS: Medline, Cochrane Library, and Scopus were searched for articles reporting outcome of patients with LGAS undergoing TAVI. The primary endpoint was 12-months all-cause mortality and the secondary endpoint was 30-day all-cause mortality...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27797979/prognosis-assessment-of-persistent-left-bundle-branch-block-after-tavi-by-an-electrophysiological-and-remote-monitoring-risk-adapted-algorithm-rationale-and-design-of-the-multicentre-lbbb-tavi-study
#12
Grégoire Massoullié, Pierre Bordachar, Didier Irles, Christophe Caussin, Antoine Da Costa, Pascal Defaye, Frédéric Jean, Alexis Mechulan, Pierre Mondoly, Géraud Souteyrand, Bruno Pereira, Sylvain Ploux, Romain Eschalier
INTRODUCTION: Percutaneous aortic valve replacement (transcatheter aortic valve implantation (TAVI)) notably increases the likelihood of the appearance of a complete left bundle branch block (LBBB) by direct lesion of the LBB of His. This block can lead to high-grade atrioventricular conduction disturbances responsible for a poorer prognosis. The management of this complication remains controversial. METHOD AND ANALYSIS: The screening of LBBB after TAVI persisting for more than 24 hours will be conducted by surface ECG...
October 26, 2016: BMJ Open
https://www.readbyqxmd.com/read/27753605/impact-of-permanent-pacemaker-on-mortality-after-transcatheter-aortic-valve-implantation-the-pragmatic-pooled-rotterdam-milan-toulouse-in-collaboration-pacemaker-substudy
#13
Gennaro Giustino, Robert M A Van der Boon, Javier Molina-Martin de Nicolas, Nicolas Dumonteil, Alaide Chieffo, Peter P T de Jaegere, Didier Tchetche, Bertrand Marcheix, Damien Millischer, Romain Cassagneau, Didier Carrié, Nicolas M Van Mieghem, Antonio Colombo
AIMS: We sought to evaluate the impact of permanent pacemaker (PPM) implantation on two-year mortality and one-year left ventricular ejection fraction recovery (∆LVEFR=one-year LVEF-baseline LVEF) after transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: We pooled patient-level data from four European institutions with significant TAVI volume. Outcomes were compared between patients without PPM (no-PPM), patients with PPM prior to TAVI (old-PPM) and patients with PPM implanted after TAVI (new-PPM)...
October 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27744287/atrial-fibrillation-in-patients-undergoing-transcatheter-aortic-valve-implantation-epidemiology-timing-predictors-and-outcome
#14
REVIEW
Giuseppe Tarantini, Marco Mojoli, Marina Urena, Alec Vahanian
Atrial fibrillation (AF) is a common arrhythmia in patients with aortic stenosis. When these patients are treated medically or by surgical aortic valve replacement, AF is associated with increased risk of adverse events including death. Growing evidence suggests a significant impact of AF on outcomes also in patients with aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI). Conversely, limited evidence is available regarding the optimal management of this condition. This review aims to summarize prevalence, pathophysiology, prognosis, and treatment of AF in patients undergoing TAVI...
October 15, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27636535/renal-dysfunction-and-transcatheter-aortic-valve-implantation-outcomes
#15
REVIEW
Marco Barbanti, Giuseppe Gargiulo, Corrado Tamburino
Transcatheter aortic valve implantation (TAVI) underwent progressive improvements until it became the default therapy for inoperable patients, and a recommended therapy in high-risk operable patients with symptomatic severe aortic stenosis. Recent evidence will further support TAVI as treatment for a growing number of patients. Areas covered: This review will discuss on the current knowledge about the role of both pre-procedural chronic kidney disease (CKD) and post-procedural acute kidney injury (AKI) in adult patients with severe aortic stenosis undergoing TAVI...
December 2016: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/27623490/improvement-in-risk-stratification-in-transcatheter-aortic-valve-implantation-using-a-combination-of-the-tumor-marker-ca125-and-the-logistic-euroscore
#16
Oliver Husser, Julio Núñez, Christof Burgdorf, Andreas Holzamer, Christian Templin, Thorsten Kessler, Vicente Bodi, Juan Sanchis, Costanza Pellegrini, Andreas Luchner, Lars S Maier, Christof Schmid, Thomas F Lüscher, Heribert Schunkert, Adnan Kastrati, Michael Hilker, Christian Hengstenberg
INTRODUCTION AND OBJECTIVES: Conventional risk scores have not been accurate in predicting peri- and postprocedural risk of patients undergoing transcatheter aortic valve implantation (TAVI). Elevated levels of the tumor marker carbohydrate antigen 125 (CA125) have been linked to adverse outcomes after TAVI. We studied the additional value of CA125 to that of the EuroSCORE in predicting long-term mortality after TAVI. METHODS AND RESULTS: During a median follow-up of 59 weeks, 115 of 422 patients (27%) died after TAVI...
September 9, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27518151/-aortic-valve-replacement-in-the-elderly
#17
F Vogt, S Wicklein, K Singler, S Pfeiffer, T Fischlein, J Schwab, M Pauschinger, J Jessl
The treatment of severe symptomatic aortic valve stenosis by conventional aortic valve replacement (AVR) or by transcatheter aortic valve implantation (TAVI) has a good perinterventional prognosis even for patients of advanced age. Having a heart team select the best management strategies based on current guidelines for each individual patient is essential for success. Especially in elderly and increasingly multimorbid patients with sometimes severe preconditions, the detection of functional deficits is relevant not only for the mortality but also for perioperative and postoperative complications as well as the functional outcome...
October 2016: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/27431592/the-prognostic-impact-of-new-onset-persistent-left-bundle-branch-block-following-transcatheter-aortic-valve-implantation-a-meta-analysis
#18
REVIEW
Tomo Ando, Hisato Takagi
New-onset persistent left bundle branch block (NOP-LBBB) is one of the most common conduction disturbances after transcatheter aortic valve implantation (TAVI). We hypothesized that NOP-LBBB may have a clinically negative impact after TAVI. To find out, we conducted a systematic literature search of the MEDLINE/PubMed and Embase databases. Observational studies that reported clinical outcomes of NOP-LBBB patients after TAVI were included. The random-effects model was used to combine odds ratios, risk ratios, or hazard ratios (HRs) with 95% confidence intervals...
September 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27396630/percutaneous-closure-of-paravalvular-regurgitation-after-transcatheter-aortic-valve-implantation-a-systematic-review
#19
REVIEW
Tomo Ando, Hisato Takagi
Paravalvular regurgitation (PVR) remains one of the drawbacks of transcatheter aortic valve implantation (TAVI). Details of percutaneous closure (PCC) of PVR after TAVI remain obscure. We aimed to explore the patient characteristics, procedural details, closure devices used, and outcomes of PCC after TAVI. A systematic search of the MEDLINE/PubMed and Embase databases from January 2002 to September 2015 was conducted. Reports considered to include same patient were excluded and only the studies with largest cohorts were included...
October 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27239021/comparison-of-1-year-outcome-in-patients-with-severe-aorta-stenosis-treated-conservatively-or-by-aortic-valve-replacement-or-by-percutaneous-transcatheter-aortic-valve-implantation-data-from-a-multicenter-spanish-registry
#20
Hugo González-Saldivar, Carlos Rodriguez-Pascual, Gonzalo de la Morena, Covadonga Fernández-Golfín, Carmen Amorós, Mario Baquero Alonso, Luis Martínez Dolz, Albert Ariza Solé, Gabriela Guzmán-Martínez, Juan José Gómez-Doblas, Antonio Arribas Jiménez, María Eugenia Fuentes, Laura Galian Gay, Martin Ruiz Ortiz, Pablo Avanzas, Emad Abu-Assi, Tomás Ripoll-Vera, Oscar Díaz-Castro, Eduardo P Osinalde, Manuel Martínez-Sellés
The factors that influence decision making in severe aortic stenosis (AS) are unknown. Our aim was to assess, in patients with severe AS, the determinants of management and prognosis in a multicenter registry that enrolled all consecutive adults with severe AS during a 1-month period. One-year follow-up was obtained in all patients and included vital status and aortic valve intervention (aortic valve replacement [AVR] and transcatheter aortic valve implantation [TAVI]). A total of 726 patients were included, mean age was 77...
July 15, 2016: American Journal of Cardiology
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