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Electroconvulsive therapy cognitive impairment

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https://www.readbyqxmd.com/read/27828927/effect-of-low-dose-of-ketamine-on-learning-memory-function-in-patients-undergoing-electroconvulsive-therapy-a-randomized-double-blind-controlled-clinical-study
#1
Qibin Chen, Su Min, Xuechao Hao, Lihua Peng, Huaqing Meng, Qinghua Luo, Jianmei Chen, Xiao Li
OBJECTIVES: Converging evidence suggests that low doses of ketamine have antidepressant effects. The feasibility and safety of administering low doses of ketamine as adjunctive medication during electroconvulsive therapy (ECT) to enhance ECT efficacy and mitigate cognitive impairment has attracted much attention. This study investigated the effects of low doses of ketamine on learning and memory in patients undergoing ECT under propofol anesthesia. METHODS: This randomized, placebo-controlled, double-blind study recruited patients with moderate to severe depressive disorders who failed to respond to antidepressants and were scheduled to receive ECT...
November 3, 2016: Journal of ECT
https://www.readbyqxmd.com/read/27771245/early-and-late-onset-depression-in-late-life-a-prospective-study-on-clinical-and-structural-brain-characteristics-and-response-to-electroconvulsive-therapy
#2
Annemiek Dols, Filip Bouckaert, Pascal Sienaert, Didi Rhebergen, Kristof Vansteelandt, Mara Ten Kate, Francois-Laurent de Winter, Hannie C Comijs, Louise Emsell, Mardien L Oudega, Eric van Exel, Sigfried Schouws, Jasmien Obbels, Mike Wattjes, Frederik Barkhof, Piet Eikelenboom, Mathieu Vanderbulcke, Max L Stek
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study...
September 22, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27721186/the-properties-and-utility-of-the-core-measure-of-melancholia
#3
REVIEW
Gordon Parker, Stacey McCraw
BACKGROUND: The CORE measure was designed to assess a central feature of melancholia - signs of psychomotor disturbance (PMD) - and so provide an alternate non-symptom based measure of melancholia or of its probability. This review evaluates development and application studies undertaken over the last 25 years to consider how well it has met its original objectives. METHODS: All studies published using the CORE measure as either the only or an adjunctive measure of melancholia were obtained and are considered in this review...
January 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27663585/the-change-in-facial-emotion-recognition-ability-in-inpatients-with-treatment-resistant-schizophrenia-after-electroconvulsive-therapy
#4
Mihriban Dalkıran, Akif Tasdemir, Tamer Salihoglu, Murat Emul, Alaattin Duran, Mufit Ugur, Ruhi Yavuz
People with schizophrenia have impairments in emotion recognition along with other social cognitive deficits. In the current study, we aimed to investigate the immediate benefits of ECT on facial emotion recognition ability. Thirty-two treatment resistant patients with schizophrenia who have been indicated for ECT enrolled in the study. Facial emotion stimuli were a set of 56 photographs that depicted seven basic emotions: sadness, anger, happiness, disgust, surprise, fear, and neutral faces. The average age of the participants was 33...
September 23, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27658720/improvement-in-verbal-memory-performance-in-depressed-in-patients-after-treatment-with-electroconvulsive-therapy
#5
S V Biedermann, J M Bumb, T Demirakca, G Ende, A Sartorius
OBJECTIVE: Electroconvulsive therapy (ECT) is a highly effective and well-tolerated therapy for severe and treatment-resistant depression. Cognitive side-effects are still feared by some patients and clinicians. Importantly, cognitive impairments are among the most disabling symptoms of depression itself. METHODS: Patients suffering from a severe episode of depression were treated with either ECT or treatment as usual (TAU) in an in-patient setting. Matched healthy participants served as controls (HC)...
December 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27629598/major-depressive-disorder
#6
Christian Otte, Stefan M Gold, Brenda W Penninx, Carmine M Pariante, Amit Etkin, Maurizio Fava, David C Mohr, Alan F Schatzberg
Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite. MDD occurs about twice as often in women than it does in men and affects one in six adults in their lifetime. The aetiology of MDD is multifactorial and its heritability is estimated to be approximately 35%. In addition, environmental factors, such as sexual, physical or emotional abuse during childhood, are strongly associated with the risk of developing MDD...
2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27455425/dexmedetomidine-protects-against-learning-and-memory-impairments-caused-by-electroconvulsive-shock-in-depressed-rats-involvement-of-the-nmda-receptor-subunit-2b-nr2b-erk-signaling-pathway
#7
Xin Gao, Fu-Zhi Zhuang, Shou-Jun Qin, Li Zhou, Yun Wang, Qing-Feng Shen, Mei Li, Michelle Villarreal, Lauren Benefield, Shu-Ling Gu, Teng-Fei Ma
Cognitive impairment is a common adverse effect of electroconvulsive therapy (ECT) during treatment for severe depression. Dexmedetomidine (DEX), a sedative-anesthetic drug, is used to treat post-ECT agitation. However, it is not known if DEX can protect against ECT-induced cognitive impairments. To address this, we used chronic unpredictable mild stress (CUMS) to establish a model of depression for ECT treatment. Our Morris water maze and sucrose preference test results suggest that DEX alleviates ECT-induced learning and memory impairments without altering the antidepressant efficacy of ECT...
September 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27322602/efficacy-and-safety-of-combining-clozapine-with-electrical-or-magnetic-brain-stimulation-in-treatment-refractory-schizophrenia
#8
Shyam Sundar Arumugham, Jagadisha Thirthalli, Chittaranjan Andrade
INTRODUCTION: A substantial proportion (40-70%) of patients with treatment-resistant schizophrenia experience persistent symptoms despite an adequate clozapine trial. Brain stimulation techniques (BST) such as electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) have shown promise in medication-refractory schizophrenia. However, their co-administration with clozapine raises some safety concerns. AREAS COVERED: We conducted a systematic literature search through Pubmed and cross-references for relevant publications evaluating the safety and efficacy of combining BST with clozapine...
September 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27295463/a-brief-measure-for-assessing-patient-perceptions-of-cognitive-side-effects-after-electroconvulsive-therapy-the-subjective-assessment-of-memory-impairment
#9
Divya Rani Kumar, Hank Ke Han, John Tiller, Colleen K Loo, Donel M Martin
OBJECTIVES: Directly inquiring about patient experiences of memory problems after ECT may alert clinicians to the existence of treatment side effects and provide an impression of their intrusiveness. In this study, we examined use of a novel and brief patient-reported measure to assess perceptions of memory side effects and their functional consequences before and after an acute ECT treatment course. These outcomes were compared with objective cognitive and subjective quality of life measures...
December 2016: Journal of ECT
https://www.readbyqxmd.com/read/27208499/mood-and-neuropsychological-effects-of-different-doses-of-ketamine-in-electroconvulsive-therapy-for-treatment-resistant-depression
#10
Xiaomei Zhong, Hongbo He, Chunping Zhang, Zhijie Wang, Miaoling Jiang, Qirong Li, Minling Zhang, Xiong Huang
BACKGROUND: Treatment-resistant depression (TRD) is a growing clinical challenge. Electroconvulsive therapy (ECT) is an effective tool for TRD treatment. However, there remains a subset of patients who do not respond to this treatment with common anesthetic agent. Ketamine, a noteworthy anesthetic agent, has emerged as an augmentation to enhance the antidepressant efficacy of ECT. Trials of i.v. ketamine in TRD indicated dose-related mood enhancing efficacy. We aimed to explore anesthetic and subanesthetic concentrations of ketamine in ECT for TRD with respect to their impact on mood and neuropsychological effects...
September 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27104927/propofol-ameliorates-electroconvulsive-shock-induced-learning-and-memory-impairment-by-regulation-of-synaptic-metaplasticity-via-autophosphorylation-of-camkiia-at-thr-305-in-stressed-rats
#11
Li Ren, Fan Zhang, Su Min, Xuechao Hao, Peipei Qin, Xianlin Zhu
Electroconvulsive therapy (ECT) is an effective treatment for depression, but it can induce learning and memory impairment. Our previous study found propofol (γ-aminobutyric acid (GABA) receptor agonist) could ameliorate electroconvulsive shock (ECS, an analog of ECT to animals)-induced cognitive impairment, however, the underlying molecular mechanisms remain unclear. This study aimed to investigate the effects of propofol on metaplasticity and autophosphorylation of CaMKIIa in stressed rats receiving ECS...
June 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27017958/propofol-alleviates-electroconvulsive-shock-induced-memory-impairment-by-modulating-probdnf-mbdnf-ratio-in-depressive-rats
#12
Fan Zhang, Jie Luo, Su Min, Li Ren, Peipei Qin
This study investigated the effects of propofol and electroconvulsive shock (ECS), the analogue of electroconvulsive therapy (ECT) in animals, on tissue plasminogen activator (tPA) and its inhibitor (PAI-1) as well as the precursor of brain-derived neurotrophic factor (proBDNF)/mature BDNF (mBDNF) ratio in depressive rats. ECT is an effective treatment for depression, but can cause cognitive deficit. Some studies have indicated that propofol can ameliorate cognitive decline induced by ECT, but the underlying molecular mechanism is still unclear...
March 23, 2016: Brain Research
https://www.readbyqxmd.com/read/26756319/reversal-of-cerebral-glucose-hypometabolism-on-positron-emission-tomography-with-electroconvulsive-therapy-in-an-elderly-patient-with-a-psychotic-episode
#13
Sameer Hassamal, Paul Jolles, Ananda Pandurangi
AB, a 74-year-old Caucasian woman, was admitted for acute onset of psychosis, anxiety, and cognitive impairment. Pharmacotherapy was unsuccessful and the patient was referred for electroconvulsive therapy (ECT). Pre-ECT, (18) F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography showed extensive frontal, parietal, and temporal cortical hypometabolism suggestive of a neurodegenerative disease. After eight ECT sessions, the psychotic and anxiety symptoms as well as the cognitive impairment resolved...
January 12, 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/26664715/cognitive-impairment-and-electroconvulsive-therapy-in-geriatric-depression-what-could-be-the-role-of-rivastigmine-a-case-series
#14
Audrey Monica van Schaik, Didi Rhebergen, Marieke Jantien Henstra, Daniel J Kadouch, Eric van Exel, Maximilianus Lourentius Stek
Electroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to premature termination of ECT. Treatment of this cognitive impairment is of utmost importance. In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on cognitive impairment in three older, severely depressed patients during or after a course of ECT...
September 28, 2015: Clinics and Practice
https://www.readbyqxmd.com/read/26549957/efficacy-and-safety-of-treating-patients-with-refractory-schizophrenia-with-antipsychotic-medication-and-adjunctive-electroconvulsive-therapy-a-systematic-review-and-meta-analysis
#15
REVIEW
Wenzheng Wang, Chengcheng Pu, Jiangling Jiang, Xinyi Cao, Jijun Wang, Min Zhao, Chunbo Li
BACKGROUND: The efficacy and safety of the combined treatment of refractory schizophrenia with antipsychotic medications and electroconvulsive therapy (ECT) remain uncertain. AIMS: Conduct systematic review and meta-analysis of available literature in English and Chinese about ECT in the treatment of refractory schizophrenia. METHODS: English and Chinese databases were searched for studies published prior to May 20, 2015 regarding the efficacy and safety of the combined treatment of refractory schizophrenia with antipsychotic medications and ECT...
August 25, 2015: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/26536019/effect-of-memantine-on-cognitive-performance-in-patients-under-electroconvulsive-therapy-a-double-blind-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Narges Shams Alizadeh, Azad Maroufi, Mehnoosh Jamshidi, Kambiz Hassanzadeh, Fardin Gharibi, Ebrahim Ghaderi
OBJECTIVES: Various strategies such as adding cholinesterase inhibitors are used to reduce cognitive impairments during electroconvulsive therapy. In this study, we aimed to assess the effectiveness and safety of memantine as an N-methyl-D-aspartate receptor antagonist in the prevention of cognitive deficits due to ECT. METHODS: Thirty-eight adult patients with various mental disorders were randomized to memantine (10 mg/day initially and 20 mg/day at the end of the first week) or placebo during the ECT period...
November 2015: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/26493090/the-acute-and-medium-term-effects-of-treatment-with-electroconvulsive-therapy-on-memory-in-patients-with-major-depressive-disorder
#17
N P Maric, Z Stojanovic, S Andric, I Soldatovic, M Dolic, Z Spiric
BACKGROUND: Current literature provides insufficient information on the degree of cognitive impairment during and after electroconvulsive therapy (ECT), mostly due to the fact that applied tests lacked sensitivity and flexibility. Our goal was to evaluate cognitive functioning in adult depressed patients treated with bi-temporal ECT, using tests sensitive for detection of possible acute and medium-term memory changes. METHOD: Thirty adult patients with major depressive disorder, treated with a course of bi-temporal ECT, underwent clinical and cognitive measurements three times: at baseline, immediately after a course of ECT, and 1 month later...
March 2016: Psychological Medicine
https://www.readbyqxmd.com/read/26489663/study-protocol-for-the-randomised-controlled-trial-ketamine-augmentation-of-ect-to-improve-outcomes-in-depression-ketamine-ect-study
#18
RANDOMIZED CONTROLLED TRIAL
Liam Trevithick, R Hamish McAllister-Williams, Andrew Blamire, Tim Branton, Ross Clark, Darragh Downey, Graham Dunn, Andrew Easton, Rebecca Elliott, Clare Ellwell, Katherine Hayden, Fiona Holland, Salman Karim, Jo Lowe, Colleen Loo, Rajesh Nair, Timothy Oakley, Antony Prakash, Parveen K Sharma, Stephen R Williams, Ian M Anderson
BACKGROUND: There is a robust empirical evidence base supporting the acute efficacy of electroconvulsive therapy (ECT) for severe and treatment resistant depression. However, a major limitation, probably contributing to its declining use, is that ECT is associated with impairment in cognition, notably in anterograde and retrograde memory and executive function. Preclinical and preliminary human data suggests that ketamine, used either as the sole anaesthetic agent or in addition to other anaesthetics, may reduce or prevent cognitive impairment following ECT...
October 21, 2015: BMC Psychiatry
https://www.readbyqxmd.com/read/26381183/pba-regulates-neurogenesis-and-cognition-dysfunction-after-repeated-electroconvulsive-shock-in-a-rat-model
#19
Zhao-Hui Yao, Xiang Kang, Liu Yang, Yi Niu, Ye Lu, Li Nie
Electroconvulsive therapy (ECT) was widely used to treat the refractory depression. But ECT led to the cognitive deficits plaguing the depression patients. The underlying mechanisms of the cognitive deficits remain elusive. Repeated electroconvulsive shock (rECS) was used to simulate ECT and explore the mechanisms of ECT during the animal studies. Previous studies showed rECS could lead to neurogenesis and cognitive impairment. But it was well known that neurogenesis could improve the cognition. So these suggested that the mechanism of the cognitive deficit after rECS was very complex...
December 15, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26341690/-non-invasive-brain-stimulation-for-treatment-of-schizophrenic-psychoses
#20
REVIEW
A Hasan, T Wobrock, U Palm, W Strube, F Padberg, P Falkai, A Fallgatter, C Plewnia
Despite many different available pharmacological and psychosocial treatment options, an optimal control of symptoms is only partly possible for most schizophrenia patients. Especially, persistent auditory hallucinations, negative symptoms and cognitive impairment are difficult to treat symptoms. Several non-invasive brain stimulation techniques are increasingly being considered as new therapeutic add on options for the management of schizophrenia, targeting these symptom domains. The technique which has been available for the longest time and that is best established in clinical care is electroconvulsive therapy (ECT)...
December 2015: Der Nervenarzt
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