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https://www.readbyqxmd.com/read/28538387/prognostic-significance-of-urothelial-carcinoma-with-divergent-differentiation-in-upper-urinary-tract-after-radical-nephroureterectomy-without-metastatic-diseases-a-retrospective-cohort-study
#1
Chuan Qin, En-Li Liang, Zhi-Yong Du, Xiao-Yu Qiu, Gang Tang, Fei-Ran Chen, Bo Zhang, Da-Wei Tian, Hai-Long Hu, Chang-Li Wu
To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28435034/cytoreductive-prostatectomy-for-metastatic-prostate-cancer-first-lessons-learned-from-the-multicentric-prospective-lomp-trial
#2
Filip Poelaert, Caroline Verbaeys, Bernard Rappe, Bart Kimpe, Ignace Billiet, Hendrik Plancke, Karel Decaestecker, Valérie Fonteyne, Sarah Buelens, Nicolaas Lumen
OBJECTIVE: To prospectively evaluate patients with newly diagnosed metastatic prostate cancer (mPCa) in the context of the LoMP trial (which investigates the role of cytoreductive radical prostatectomy [cRP] in addition to standard of care [SoC]). To provide a preliminary analysis of patient's characteristics, safety of cRP and early local symptoms. PATIENTS AND METHODS: cRP was performed in asymptomatic patients with a resectable tumor and fit to undergo surgery (group A, n=17)...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28428106/gata3-immunohistochemistry-in-urothelial-carcinoma-of-the-upper-urinary-tract-as-a-urothelial-marker-as-well-as-a-prognosticator
#3
Satoshi Inoue, Taichi Mizushima, Kazutoshi Fujita, Abdelrazak Meliti, Hiroki Ide, Seiji Yamaguchi, Hiroaki Fushimi, George J Netto, Norio Nonomura, Hiroshi Miyamoto
Immunohistochemistry of a transcription factor, GATA3, has been widely used as a promising urothelial marker in diagnostic surgical pathology practice. However, the expression status of GATA3 in upper urinary tract urothelial carcinomas (UUTUCs) and its prognostic significance have not been fully investigated. We immunohistochemically stained for GATA3 in 99 UUTUC samples and paired non-neoplastic urothelial tissues. GATA3 was positive in 51 [51.5%; 32 (32.3%) weak, 11 (11.1%) moderate, 8 (8.1%) strong] of 99 UUTUCs, which was significantly lower than in benign urothelium [79 (96...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28422039/-urinary-tract-lymphoepithelial-carcinoma-report-of-two-cases-and-bibliographic-review
#4
Sebastian Valverde Martínez, Waleska Salcedo Mercado, Isabel Rodríguez Cruz, Sara Belén Prieto Nogal, Mario Martín Hernández, Luis Miguel Gómez Tejeda
OBJECTIVE: We report two cases of patients diagnosed with lymphoepithelioma-like carcinomas of the urinary tract. We review the literature of this rare entity. The objective is to clarify the clinical and therapeutic characteristics. METHODS: We present a retrospective review of medical records of two patients diagnosed with lymphoepithelioma-like carcinomas, one in the renal pelvis and the other in the bladder. We review the epidemiology, diagnosis and therapeutic alternatives...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28409437/prognostic-significance-of-pd-l1-expression-on-tumor-cells-and-tumor-infiltrating-mononuclear-cells-in-upper-tract-urothelial-carcinoma
#5
Bo Zhang, Wei Yu, Xueru Feng, Zheng Zhao, Yu Fan, Yisen Meng, Shuai Hu, Yun Cui, Qun He, Hong Zhang, Dong Li, Zhisong He, Liqun Zhou, Jie Jin, Wenke Han
Immunotherapy targeting the programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) pathway has shown promising results in several malignancies. However, the prognostic significance of PD-L1 expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study aimed to evaluate PD-L1 expression and its association with clinicopathological characteristics and oncological outcomes in UTUC patients. PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells (TIMCs), and E-cadherin and N-cadherin expression on tumor cells were assessed by immunohistochemistry in a cohort of 162 patients with UTUC...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28398494/impact-of-lymph-node-dissection-on-clinical-outcomes-during-nephroureterectomy-in-patients-with-clinically-node-negative-upper-urinary-tract-urothelial-cancer-subanalysis-of-a-multi-institutional-nationwide-case-series-of-the-japanese-urological-association
#6
Junichi Inokuchi, Masatoshi Eto, Tomohiko Hara, Hiroyuki Fujimoto, Hiroyuki Nishiyama, Jun Miyazaki, Eiji Kikuchi, Shiro Hinotsu, Takuya Koie, Chikara Ohyama
Objective: To evaluate the impact of lymph node dissection (LND) on the clinical outcomes during radical nephroureterectomy (RNU) in patients with clinically node-negative upper urinary tract urothelial cancer (UTUC). Methods: Within the nationwide case series of the Japanese Urological Association, which comprises 1509 patients with UTUC diagnosed in 2005, we identified 823 patients with clinically node-negative UTUC who underwent RNU. The extent of limited LND was defined as the renal hilar region only for renal pelvic cancer and as either the pelvic region or para-aortic/paracaval region only for ureteral cancer, while the extent of wider LND was defined as at least one perilesional LND region in addition to limited LND...
April 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28396695/a-new-patient-safety-smartphone-application-for-prevention-of-forgotten-ureteral-stents-results-from-a-clinical-pilot-study-in-194-patients
#7
Wilson R Molina, Rodrigo Pessoa, Rodrigo Donalisio da Silva, McCabe C Kenny, Diedra Gustafson, Leticia Nogueira, Mark E Leo, Michael K Yu, Fernando J Kim
BACKGROUND: Approximately 12% of all ureteral stents placed are retained or "forgotten." Forgotten stents are associated with significant safety concerns as well as increased costs and legal issues. Retained ureteral stents (RUS) often occur due to lack of clinical follow-up, communication or language barriers, and economic concerns. METHODS: We describe a multiplatform application that facilitates data collection to prevent RUS. The "Stent Tracker" application can be installed on mobile devices and computers...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28385045/long-term-outcomes-of-laparoscopic-nephro-ureterectomy-with-transurethral-circumferential-excision-of-the-ureteric-orifice-for-urothelial-carcinoma
#8
Aakash Pai, Muddassar Hussain, Richard G Hindley, Amr Emara, Neil Barber
Introduction When performing open or laparoscopic nephroureterectomy (LNU), the optimal way to excise the distal ureter remains controversial. There are concerns that primary endoscopic detachment of the intramural ureter is associated with adverse outcomes. Existing studies have limited patient numbers and inadequate oncologic follow up. We provide our institutions experience of this technique. Methods Data was collected prospectively on 59 patients (37 men) who underwent LNU over a 10 year period at a single centre using a standardized technique; initial endoscopic circumferential release of the distal ureter and bladder cuff followed by retroperitoneal en bloc LNU...
April 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28363728/pelvic-radiotherapy-in-the-setting-of-rheumatoid-arthritis-refining-the-paradigm
#9
T Felefly, R Mazeron, A Huertas, C H Canova, P Maroun, M Kordahi, P Morice, É Deutsch, C Haie-Méder, C Chargari
PURPOSE: Conflicting results concerning the toxicity of radiotherapy in the setting of rheumatoid arthritis were reported in literature. This work describes the toxicity profiles of patients with rheumatoid arthritis undergoing pelvic radiotherapy for gynecologic malignancies at our institution. PATIENTS AND METHODS: Charts of patients with rheumatoid arthritis who underwent pelvic radiotherapy for cervical or endometrial cancer in a curative intent at the Gustave-Roussy Cancer Campus between 1990 and 2015 were reviewed for treatment-related toxicities...
March 28, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28338493/surgery-for-recurrent-uterine-cancer-surgical-outcomes-and-implications-for-survival-a-case-series
#10
Lavinia Domenici, Katherine Nixon, Flavia Sorbi, Maria Kyrgiou, Joseph Yazbek, Marcia Hall, Jeremy Campbell, Norma Gibbons, Won-Ho Edward Park, Hani Gabra, Christina Fotopoulou
OBJECTIVE: The purpose of this study was to describe the patterns of relapse in uterine cancer (UC) and the role of surgery in the recurrent setting. METHODS: We describe surgical and clinical outcomes of all patients who underwent surgery for recurrent UC in a gynecological oncology tertiary referral center between May 1, 2013, and April 30, 2016. Progression-free survival and overall survival were estimated using Kaplan-Meier methods with the surgery at relapse being the starting point...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28327458/nfatc1-expression-as-a-prognosticator-in-urothelial-carcinoma-of-the-upper-urinary-tract
#11
Takashi Kawahara, Satoshi Inoue, Kazutoshi Fujita, Taichi Mizushima, Hiroki Ide, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression. In this study, we immunohistochemically stained for NFATc1 in upper urinary tract urothelial carcinoma (UUTUC) specimens and paired nonneoplastic urothelial tissues. NFATc1 was positive in 51 [52%; 40 (40%) weak (1+), 9 (9%) moderate (2+), and 2 (2%) strong (3+)] of 99 UUTUCs, which was significantly higher than in benign urothelium [30 (36%) of 83; 28 (34%) weak and 2 (2%) moderate] (0 vs 1+/2+/3+, P=...
June 2017: Translational Oncology
https://www.readbyqxmd.com/read/28264537/-locally-advanced-ureteral-cancer-seen-in-an-ectopic-kidney-a-case-report
#12
Koki Maeda, Yusaku Okada, Susumu Kageyama, Mitsuhiro Narita, Akihiro Kawauchi
An ectopic kidney is a common congenital anomaly of the urogenital system, but malignant tumor in an ectopic kidney has been rarely reported. We report a case of ureteral carcinoma arising from an ectopic kidney in an 83-year-old male. He visited a hospital complaining of gross hematuria. Computed tomography revealed right ectopic kidney, right ureteral tumor and bladder tumor around the right ureteral orifice. Transurethral resection of the bladder tumor was performed and histopathological diagnosis was urothelial carcinoma...
February 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28259810/robotic-ileal-interposition-for-radiation-induced-ureteral-stricture-disease
#13
Adam S Baumgarten, Bhavik B Shah, Trushar B Patel, Lucas R Wiegand
OBJECTIVE: To present a novel surgical concept using preoperative imaging to estimate length needed for ileal segment. This enables robotic ileal interposition to be completed with only 1 position change during surgery. MATERIALS AND METHODS: The index patient is a 69-year-old woman with a history of stage IIIB cervical cancer treated with chemotherapy and radiation 5 years prior to presentation. The patient subsequently developed a long segment stricture of the left ureter, which had been managed with ureteral stents...
March 1, 2017: Urology
https://www.readbyqxmd.com/read/28257819/in%C3%A2-vitro-and-ex%C3%A2-vivo-permeability-studies-of-paclitaxel-and-doxorubicin-from-drug-eluting-biodegradable-ureteral-stents
#14
Alexandre A Barros, Carlos Oliveira, Rui L Reis, Estevão Lima, Ana Rita C Duarte
A drug-eluting biodegradable ureteral stent (BUS) has been developed as a new approach for the treatment of urothelial tumors of upper urinary tract cancer. In a previous work, this system has proven to be a good carrier for anticancer drugs as a potential effective and sustainable intravesical drug delivery system. BUS has revealed to reduce in 75% the viability of human urothelial cancer cells (T24) after 72 h of contact and demonstrated minimal cytotoxic effect on human umbilical vein endothelial cells (HUVECs) which were used as a control...
February 28, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28247661/-internal-drainage-in-cancer-patients-optimizing-treatment-of-stent-related-symptoms
#15
A G Martov, D V Ergakov, A B Novikov, N G Muzhetskaya, G L Esen'yan
INTRODUCTION: The so-called stent-related symptoms caused mainly by detrusor overactivity due to distal ("cystic") curl of the internal stent are common among patients with this type of drainage. The need for long-term stenting makes the quality of life of cancer patients one of the challenging problems of modern urology. The aim of this study was to optimize treatment of stent-related symptoms in cancer patients with internal long-term stents by complementing the treatment regimen with m-anticholinergic solifenacin...
April 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28207528/idiopathic-retroperitoneal-fibrosis-causing-unilateral-ureteral-and-sigmoid-colon-obstruction-a-case-report
#16
Ting Yan, Yujuan Wang, Zhijun Liu, Xiaolei Zhang, Qian Wu, Mingrong Xi
OBJECTIVE: The present report aimed to present a unique case of idiopathic retroperitoneal fibrosis (RPF) presenting features of unilateral ureteral and sigmoid colon obstruction. RPF is a rare disorder with unclear etiology. CASE REPORT: A 43-year-old female had a 10-day history of lower right abdominal and lumbar pain. Gynecological examination, ultrasound, and computed tomography (CT) were all suggestive of right ovarian tumor. An enhanced CT showed right-sided hydronephrosis...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28198599/impact-of-a-bladder-cuff-excision-during-radical-nephroureterectomy-on-cancer-specific-survival-in-the-patients-with-upper-tract-urothelial-cancer-in-korea-a-retrospective-multi-institutional-study
#17
Yun-Sok Ha, Jae-Wook Chung, Seock H Choi, Jun N Lee, Bum S Kim, Tae-Hwan Kim, Eun S Yoo, Tae G Kwon, Seok-Soo Byun, Young D Choi, Ho W Kang, Seok J Yun, Wun-Jae Kim, Hyun T Kim
BACKGROUND: Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) is the surgical principle adopted for the treatment of upper tract urothelial cancers (UTUCs). However, not all RNUs are performed with BCE. We quantified the prognostic impact of RNU with BCE on cancer-specific survival (CSS) in a large patient population. METHODS: In total, 505 patients with UTUC were enrolled from four different institutions. The clinicopathological parameters of patients who underwent RNU with and without BCE were compared...
February 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#18
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
March 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28124532/the-burden-of-chronic-ureteral-stenting-in-cervical-cancer-survivors
#19
Robert A Goldfarb, Yunhua Fan, Stephanie Jarosek, Sean P Elliott
PURPOSE: Ureteral obstruction in cervical cancer occurs in up to 11% of patients, many of whom undergo ureteral stenting. Our aim was to describe the patient burden of chronic ureteral stenting in a population-based cohort by detailing two objectives: (1) the frequency of repeat procedures for ureteral obstruction; and, (2) the frequency of urinary adverse effects (UAEs) (e.g., lower urinary tract symptoms, flank pain). MATERIALS AND METHODS: From SEER-Medicare, we identified 202 women who underwent ureteral stent placement prior to or following cervical cancer treatment...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28119847/ureteral-rupture-caused-by-a-suprapubic-catheter-in-a-male-patient-with-spinal-cord-injury-a-case-report
#20
Hye Jung Choi, Chang Han Lee, Heesuk Shin
Spinal cord injury (SCI) may lead to urinary system disturbances. Patients with SCI usually have neurogenic bladder, and treatment optionss for this condition include clean intermittent catheterization and a permanent indwelling urethral or suprapubic catheter. Complications of catheterization include urinary tract infection, calculi, urinary tract injury, bladder contraction, bladder spasm, renal dysfunction, bladder cancer, and so forth. To the best of our knowledge, ureteral rupture is an unusual complication of catheterization, and ureteral rupture has been rarely reported in SCI patients...
December 2016: Annals of Rehabilitation Medicine
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