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https://www.readbyqxmd.com/read/29784450/physician-assessed-and-patient-reported-urinary-morbidity-after-radio-chemotherapy-and-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#1
Lars Fokdal, Richard Pötter, Kathrin Kirchheiner, Jacob Chr Lindegaard, Nina Boje Kibsgaard Jensen, Christian Kirisits, Cyrus Chargari, Umesh Mahantshetty, Ina Maria Jürgenliemk-Schulz, Barbara Segedin, Peter Hoskin, Kari Tanderup
BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29780413/experience-with-renal-autotransplantation-typical-and-atypical-indications
#2
Ali Bourgi, Rana Aoun, Elias Ayoub, Maroun Moukarzel
Introduction and Objectives: Renal autotransplantation is a kidney-saving surgical procedure used in selected patients. The purpose of this report is to review nine typical and atypical indications for kidney autotransplantation and evaluate its effectiveness in maintaining kidney function and avoiding cancer recurrence. Materials and Methods: From 1999 till 2014, nine renal autotransplantations were performed in our center. A retrospective case review was done...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29775417/targeting-histone-methyltransferase-enhancer-of-zeste-homolog-2-inhibits-renal-epithelial-mesenchymal-transition-and-attenuates-renal-fibrosis
#3
Xiaoxu Zhou, Chongxiang Xiong, Evelyn Tolbert, Ting C Zhao, George Bayliss, Shougang Zhuang
Enhancer of zeste homolog-2 (EZH2) is a methyltransferase that induces histone H3 lysine 27 trimethylation (H3K27me3) and functions as an oncogenic factor in many cancer types. Its role in renal epithelial-mesenchymal transition (EMT) remains unknown. In this study, we found that EZH2 and H3K27me3 were highly expressed in mouse kidney with unilateral ureteral obstruction and cultured mouse kidney proximal tubular (TKPT) cells undergoing EMT. Inhibition of EZH2 with 3-deazaneplanocin A (3-DZNeP) attenuated renal fibrosis, which was associated with preserving E-cadherin expression and inhibiting Vimentin up-regulation in the obstructed kidney...
May 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29748098/multi-institutional-evaluation-of-the-prognostic-significance-of-ezh2-expression-in-high-grade-upper-tract-urothelial-carcinoma
#4
Nirmish Singla, Laura-Maria Krabbe, Ahmet M Aydin, Vandana Panwar, Solomon L Woldu, Yuval Freifeld, Christopher G Wood, Jose A Karam, Alon Z Weizer, Jay D Raman, Mesut Remzi, Nathalie Rioux-Leclercq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim Bensalah, Arthur I Sagalowsky, Shahrokh F Shariat, Yair Lotan, Aditya Bagrodia, Payal Kapur, Vitaly Margulis
PURPOSE: Enhancer of zeste homolog 2 is a methyltransferase encoded by the EZH2 gene, whose role in upper tract urothelial carcinoma (UTUC) is poorly understood. We sought to evaluate the prognostic value of EZH2 expression in UTUC. METHODS: We reviewed a multi-institutional cohort of patients who underwent radical nephroureterectomy for high-grade UTUC from 1990 to 2008. Immunohistochemistry for EZH2 was performed on tissue microarrays. Percentage of staining was evaluated, and the discriminative value of EZH2 was tested, with EZH2 positivity defined as>20% staining present...
May 7, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29739370/gastrointestinal-cancer-and-bilateral-hydronephrosis-resulted-in-a-high-risk-of-ureteral-stent-failure
#5
Mari Ohtaka, Takashi Kawahara, Daiji Takamoto, Taku Mochizuki, Yusuke Hattori, Jun-Ichi Teranishi, Kazuhide Makiyama, Yasuhide Miyoshi, Yasushi Yumura, Masahiro Yao, Hiroji Uemura
BACKGROUND: Urologists frequently encounter malignant ureteral obstruction (MUO) caused by advanced urological or non-urological malignant disease, but the treatment policy is unclear. The present study examined the risk factors for predicting ureteral stent failure in patients with MUO after ureteral stent insertion and the change in the renal function after retrograde ureteral stent insertion in cases of bilateral hydronephrosis. METHODS: A total of 39 patients who required ureteral stent placement for MUO at Yokohama City University Medical Center (Yokohama, Japan) between February 2007 and May 2016 were included in this study...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29737959/risk-factors-for-bladder-cancer-recurrence-survival-in-patients-with-upper-tract-urothelial-carcinoma
#6
Yu-Peng Wu, Yun-Zhi Lin, Min-Yi Lin, Ting-Ting Lin, Shao-Hao Chen, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu
Purpose The aim of this work was to investigate the predictive factors for bladder cancer recurrence survival (BCRS) in patients with upper-tract urothelial carcinoma (UTUC). Methods We selected patients with UTUC who underwent segmental ureterectomy (Su) or nephroureterectomy (Nu) from 2004 to 2013 from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with a history of intravesical therapy for bladder cancer and bladder cancer prior to the diagnosis of UTUC were excluded. We used Kaplan-Meier analysis, log-rank tests, and Cox proportional hazards model to compare overall survival, cancer-specific survival, and BCRS...
December 1, 2017: Tumori
https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#7
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29730917/-laparoscopic-type-c1-hysterectomy-based-on-the-anatomic-landmark-of-the-uterus-deep-vein-and-its-branches-for-cervical-cancer
#8
M R Liang, D X Han, W Jiang, H Liu, L Li, M L Zhong, L Luo, S Y Zeng
Objective: To introduce the laparoscopic type C1 hysterectomy based on the anatomic landmark of the uterus deep vein and its branched and to evaluate its feasibility and safety for cervical cancer and its effect to bladder function and to provide some reference to simplify the surgical procedures of laparoscopic type C1 hysterectomy. Methods: The clinicopathologic data of the patients with stage ⅠA2~ⅡB cervical cancer and who underwent the laparoscopic C1 hysterectomy based on anatomic landmark of the uterus deep vein and its branches between March 2010 and December 2015 was retrospectively analysed...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29721162/does-perioperative-chemotherapy-improve-survival-in-upper-tract-urothelial-carcinoma-a-population-based-analysis
#9
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Rashid Sayyid, Girish S Kulkarni, Robert J Hamilton, Neil E Fleshner
Objectives: To evaluate the utilization and outcomes of perioperative chemotherapy in non-metastatic UTUC patients over the past decade using a large national database. Methods: All patients aged 18 and older diagnosed with non-metastatic UTUC between 2004 and 2013 were identified within the Surveillance, Epidemiology and End Results (SEER) database. Relevant clinical data was collected and predictors of cancer specific mortality (CSM) and other cause mortality (OCM) were analyzed...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29693458/segmental-ureterectomy-is-acceptable-for-high-risk-ureteral-carcinoma-comparing-to-radical-nephroureterectomy
#10
Zixiong Huang, Xiaowei Zhang, Xiaopeng Zhang, Qing Li, Shijun Liu, Luping Yu, Tao Xu
PURPOSE: To determine if segmental ureterectomy (SU) could be chosen for wider oncological indications than low-risk ureteral carcinoma, given the difficulties in accurate preoperative risk stratification determination and kidney-sparing needs for successive therapy. METHODS: Data from ureteral carcinoma patients who underwent open SU or laparoscopic radical nephroureterectomy (RNU) between 2011 and 2016 were retrospectively reviewed. Kaplan-Meier survival analysis and Cox regression model with patients' baseline characteristics (age, bladder cancer history, hydronephrosis), procedure type, and tumor characteristics (site, size, pathological features) as covariates were used to evaluate oncological outcomes...
April 25, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29681815/the-use-of-a-metal-stent-in-the-treatment-of-ureteral-stricture-in-a-patient-who-had-undergone-radical-cystectomy-with-the-creation-of-an-ileal-conduit
#11
Taku Mochizuki, Takashi Kawahara, Genta Iwamoto, Shinnosuke Kuroda, Masahiro Yao, Hiroji Uemura
Approximately 9.2% of patients who undergo radical cystectomy are reported to develop ureteral stricture as a result of both benign and malignant conditions. A metallic stent is a continuous, unfenestrated all-metal double-pigtail ureteric stent with no end or side holes. The patient was a 74-year-old man who underwent radial cystectomy with the creation of an ileal conduit due to advanced bladder cancer 7 years previously. Although he had no radiographic recurrence, he developed bilateral hydronephrosis. We herein report the first case of a patient with ureteral stricture after radial cystectomy with the creation of an ileal conduit who was successfully treated by the insertion of a metal stent by a combined antegrade and retrograde approach...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29664839/a-population-based-assessment-of-urologic-procedures-and-operations-after-surgery-or-pelvic-radiation-for-cervical-cancer
#12
Blayne Welk, Christopher Wallis, David DʼSouza, Jacob McGee, Robert K Nam
OBJECTIVE: The treatment of cervical cancer can result in genitourinary morbidity. We measured selected urologic procedures after the treatment of cervical cancer with either surgery or radiation. METHODS: We used administrative data from the province of Ontario Canada to identify adult women who had nonmetastatic cervical cancer and were treated with surgery or radiation between 1994 and 2014. Study outcomes were surgical or procedure codes representing ureteric repair or fistula repair...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29648512/malignant-ureteric-obstruction-decompression-how-much-gain-for-how-much-pain-a-narrative-review
#13
Joanna Prentice, Tarik Amer, Ali Tasleem, Omar Aboumarzouk
Over the last thirty years, the management of Malignant Ureteric Obstruction (MUO) has evolved from a single disciplinary decision to a multi-disciplinary approach. Careful consideration must be given to the risks and benefits of decompression of hydronephrosis for an individual patient. There is a lack of consensus of opinion as well as strong evidence to support the decision process. Outcomes that were identified amongst patients undergoing treatment for MUO included prognosis, quality of life (QOL), complications, morbidity and prognostication tools...
April 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29624505/impact-of-concomitant-urologic-intervention-on-clinical-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Akshat Saxena, Winston Liauw, Sohaib A Virk, David L Morris
INTRODUCTION: The impact of concomitant urologic procedures (UPs) on perioperative and long-term outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is uncertain. METHODS: In total, 935 consecutive CRS/HIPEC procedures were performed between 1996 and 2016 in Sydney, Australia. Among these, 73 (7.8%) involved concomitant UP. The association of concomitant UP with 21 perioperative outcomes and overall survival was assessed using univariate and multivariate analyses...
April 5, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29595646/urological-complications-after-radical-hysterectomy-with-postoperative-radiotherapy-and-radiotherapy-alone-for-cervical-cancer
#15
Faping Li, Hui Guo, Heping Qiu, Shukun Liu, Kaixuan Wang, Chao Yang, Chao Tang, Qi Zheng, Yuchuan Hou
Radiotherapy is a reliable method to cure cervical cancer patients, but it could cause serious urological complications after the treatment due to the anatomical location of the cervix. The main purpose of this retrospective analysis is to study the incidence, latency, and therapeutic efficacy of urological complications caused by radical hysterectomy with postoperative radiotherapy or radiotherapy alone in patients with cervical cancer.A retrospective analysis was conducted on patients with cervical cancer who received radical hysterectomy with postoperative radiotherapy or radiotherapy alone at the First Hospital of Jilin University between January 2010 and May 2016...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29587736/comparison-of-clinicopathologic-characteristics-epigenetic-biomarkers-and-prognosis-between-renal-pelvic-and-ureteral-tumors-in-upper-tract-urothelial-carcinoma
#16
Dong Fang, Shiming He, Gengyan Xiong, Nirmish Singla, Zhenpeng Cao, Lei Zhang, Xuesong Li, Liqun Zhou
BACKGROUND: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis. METHODS: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared...
March 27, 2018: BMC Urology
https://www.readbyqxmd.com/read/29546601/management-of-urinary-tract-fistulas-using-reversible-balloon-nephrostomy-a-single-center-retrospective-analysis-of-56-patients
#17
Jérôme Gas, François-Xavier Nouhaud, Mathieu Roumiguié, Séverine Lagarde, Marie-Charlotte Delchier, Éric Huyghe, Michel Soulié, Xavier Gamé, Jean-Baptiste Beauval
PURPOSE: To evaluate the effectiveness of balloon nephrostomy (BN) for treating urinary tract fistulas. MATERIALS AND METHODS: In a single-center retrospective analysis, 56 patients were treated using BN between 2003 and 2014. All causes of urinary tract fistula were included. We assessed the effectiveness of drainage, complications, and the types of reconstruction surgery used. Success was defined as fistula closure without surgery. RESULTS: The cohort consisted of 25 males (54%) and 31 females (55%) with a median age of 63 years who underwent BN for a urinary fistula secondary to surgery, i...
March 15, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29475412/urological-approach-for-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-a-clinical-care-center
#18
Carlos Gustavo Trujillo, Cristina Domínguez, Daniela Robledo, Juan Ignacio Caicedo, Alejandra Bravo-Balado, Juan Guillermo Cataño, Natalia Cortés, Lina Parra, Wilson Riaño, Eduardo Londoño-Schimmer, Jorge Otero, Gabriel Herrera, Fernando Arias, Mauricio Plata
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is associated with significant manipulation of the urinary tract (UT). We aim to describe the urological events and their management in patients who underwent CRS-HIPEC. METHODS: Clinical records of patients who underwent treatment between 2007 and 2015 were reviewed. Urological events and their multidisciplinary management were analyzed. Descriptive statistics were calculated...
February 23, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29471598/-ureteral-cancer-developing-in-retrocaval-ureter-a-case-report
#19
Yoshiaki Matsumura, Yusuke Iemura, Shinji Fukui, Yoriaki Kagebayashi, Shoji Samma, Shigehiro Tsujimoto, Takashi Okada, Toru Kanno
Ureteral cancer in the retrocaval ureter is rare. We herein report a patient with this condition laparoscopically treated. A 69-year-old man was referred to us because of right ureteral cancer diagnosed during ureteroscopic surgery for a ureteral calculus. Histological diagnosis of the ureteroscopically biopsied material was non-invasive papillary urothelial carcinoma, low grade (G2). Computed tomography (CT) demonstrated a retrocaval ureter : a double J stent placed during ureteroscopy assisted the diagnosis...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29468200/robot-assisted-perineal-radical-prostatectomy-in-a-post-kidney-transplant-recipient
#20
Volkan Tugcu, Abdulmuttalip Simsek, Ismail Yigitbasi, Mustafa Gurkan Yenice, Selcuk Sahin, Ali Ihsan Tasci
Background: After almost two decades, transabdominal robotic radical prostatectomy techniques have been fully developed and are widely practiced by many robotic urologists. Recently, a transperineal robotic radical prostatectomy, a technique not yet popular to many, was introduced as an alternative approach in patients with previous abdominal surgery. Here, we present our unique experience with robotic perineal radical prostatectomy (r-PRP) on a kidney transplant recipient. Case Presentation: A 71-year-old man who had a kidney transplant 4 months previously was diagnosed with prostate cancer (PCa) and underwent r-PRP using the da Vinci Xi robotic system...
2018: Journal of Endourology Case Reports
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