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https://www.readbyqxmd.com/read/28732432/intradermal-skin-testing-in-allergic-rhinitis-and-asthma-with-negative-skin-prick-tests
#1
Fuat Erel, Nurhan Sarioglu, Mehmet Kose, Mustafa Kaymakci, Mucahide Gokcen, Ahmet Hamdi Kepekci, Mehmet Arslan
Taking medical history, physical examination, and performing some in vivo and in vitro tests are necessary for the diagnosis of allergy. Skin prick test (SPT) is considered as the standard method and first-line approach for the detection of allergic sensitization. Although mainly SPT is used for the detection of allergic sensitization, intradermal skin test (IDST) may be necessary, especially in patients with a negative SPT result. IDST is quite safe; however, is nowadays seldom used for detection of inhalant allergy and its value remains controversial...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28729647/neural-determinants-of-human-goal-directed-vs-habitual-action-control-and-their-relation-to-trait-motivation
#2
Hamdi Eryilmaz, Anais Rodriguez-Thompson, Alexandra S Tanner, Madeline Giegold, Franklin C Huntington, Joshua L Roffman
Instrumental learning is mediated by goal-directed and habit systems in the brain. While rodent studies implicate distinct prefrontal/striatal regions in goal-directed and habit learning, neural systems underpinning these two processes in humans remain poorly understood. Here, using a validated discrimination learning task that distinguishes goal-directed learning from habit learning in 72 subjects in fMRI, we investigated the corticostriatal correlates of goal-directed learning and tested whether brain activation during learning is associated with trait motivation and behavioral performance in the post-learning test phase...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28707035/cerebellar-ataxia-and-obstructive-hydrocephalus-rare-neurologic-presentations-in-patients-with-systemic-lupus-erythematosus
#3
REVIEW
Hamdy Mohamed Abdelaziz Ahmed, Rasmia El-Gohary, Fatema Fayed, Hala El-Gendy
The first cases of systemic lupus erythematosus (SLE) with effects on the nervous system were reported more than 100 years ago. Cerebellar involvement and obstructive hydrocephalus are rarely encountered in patients with SLE. We report two patients with SLE who developed cerebellar ataxia. The first patient presented with significant headache at time of SLE diagnosis and negative brain imaging studies on initial evaluation. The headache recurred with findings of cerebellar ataxia and obstructive hydrocephalus...
July 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28698967/endogenous-expression-of-odn-related-peptides-in-astrocytes-contributes-to-cell-protection-against-oxidative-stress-astrocyte-neuron-crosstalk-relevance-for-neuronal-survival
#4
Ikram Ghouili, Seyma Bahdoudi, Fabrice Morin, Fatma Amri, Yosra Hamdi, Pierre Michael Coly, Marie-Laure Walet-Balieu, Jérôme Leprince, Sami Zekri, Hubert Vaudry, David Vaudry, Hélène Castel, Mohamed Amri, Marie-Christine Tonon, Olfa Masmoudi-Kouki
Astroglial cells are important actors in the defense of brain against oxidative stress injuries. Glial cells synthesize and release the octadecaneuropeptide ODN, a diazepam-binding inhibitor (DBI)-related peptide, which acts through its metabotropic receptor to protect neurons and astrocytes from oxidative stress-induced apoptosis. The purpose of the present study is to examine the contribution of the endogenous ODN in the protection of astrocytes and neurons from moderate oxidative stress. The administration of H2O2 (50 μM, 6 h) induced a moderate oxidative stress in cultured astrocytes, i...
July 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28690724/imaging-of-complicated-frontal-sinusitis
#5
Naourez Kolsi, Ahmed Zrig, Hamdi Chouchène, Rachida Bouatay, Khaled Harrathi, Jamel Koubaa
Complications occur in 3% of the cases of frontal sinusitis. These are mainly oculo-orbital, intracranial and osteomyelitis. Our aim is to describe the contribution of different imaging modalities in the diagnosis of these complications and their post-treatment monitoring. within a 15 years period (2000-2014), 10 patients with complicated frontal sinusitis were included into this retrospective study. 10 patients (9 males) aged 9 to 70 year old (mean 28). Two of these patients (20%) had a history of craniofacial trauma...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28688944/enhancement-of-extracellular-polymeric-substances-eps-production-in-spirulina-arthrospira-sp-by-two-step-cultivation-process-and-partial-characterization-of-their-polysaccharidic-moiety
#6
Imene Chentir, Marwa Hamdi, Amel Doumandji, Abdelkadder Hadj Sadok, Hatem Ben Ouada, Moncef Nasri, Mourad Jridi
The interactive effects of light intensity and NaCl concentration were investigated for Spirulina two-step cultivation process using Full Factorial Design. In the experiment interval, light intensity had no effect while the NaCl concentration had significant effect on extracellular polymeric substances enhancement. Interestingly, results revealed a significant negative interaction between light and NaCl indicating that high NaCl concentration (40g.L(-1)) and low light intensity (10μmol photons m(-2)s(-1)) enhanced the EPS production...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28688573/comparison-between-selective-and-routine-intensive-care-unit-admission-post-supraglottoplasty
#7
Timothy Cooper, Bree Harris, Ahmed Mourad, Daniel Garros, Hamdy El-Hakim
OBJECTIVE: To compare major post-operative respiratory complications, post-operative disposition and duration of hospital admission before and after adopting a selective intensive care unit (ICU) admission care plan following supraglottoplasty (SGP). METHODS: Retrospective case series set in a tertiary pediatric referral center. Eligible patients undergoing SGP between October 2003 and July 2015 were identified through a prospectively kept surgical database. Historical cohorts with routine admission to ICU and selective admission to ICU were identified based on a shift in surgeon practice...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28688566/dysphagia-in-healthy-children-characteristics-and-management-of-a-consecutive-cohort-at-a-tertiary-centre
#8
Orysya Svystun, Wendy Johannsen, Rabin Persad, Justine M Turner, Carina Majaesic, Hamdy El-Hakim
OBJECTIVE: Whereas the literature is replete with reports on complex children with dysphagia (DP), the parameters characterizing non-neurologically impaired (NNI) children have been underreported, leaving a substantial knowledge gap. We set to characterize a consecutive cohort of NNI children, their management, and outcomes. METHODS: We undertook a retrospective case series. Children (<18 years old) attending a tertiary multidisciplinary swallowing clinic were eligible...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28686109/%C3%AE-adducin-gene-promoter-dna-methylation-and-the-risk-of-essential-hypertension
#9
Nervana M K Bayoumy, Mohamed M El-Shabrawi, Ola Farouk Leheta, Hamdy Hassan Omar
This study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (CpG) dinucleotides on ADD1 promoter were measured employing bisulfite pyrosequencing technology. Our results showed that females have a higher ADD1 DNA methylation than males and a significantly lower CpG1 methylation level is associated with increased risk of EH among them...
July 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28686004/bioglass%C3%A2-45s5-based-composites-for-bone-tissue-engineering-and-functional-applications
#10
REVIEW
M Rizwan, M Hamdi, W J Basirun
Bioglass® 45S5 (BG) has an outstanding ability to bond with bones and soft tissues, but its application as a load-bearing scaffold material is restricted due to its inherent brittleness. BG-based composites combine the amazing biological and bioactive characteristics of BG with structural and functional features of other materials. This paper reviews the composites of Bioglass(®) in combination with metals, ceramics and polymers for a wide range of potential applications from bone scaffolds to nerve regeneration...
July 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28685795/the-risk-of-acute-coronary-syndrome-in-ramadan
#11
Asma Sriha Belguith, Houda Baccouche, Mohamed Habib Grissa, Hamdi Boubaker, Wahid Bouida, Kaouthar Beltaief, Adel Sekma, Nizar Fredj, Nasri Bzeouiche, Zied Zina, Riadh Boukef, Mohamed Soltani, Semir Nouira
BACKGROUND: Data on the effect of fasting on coronary disease are rare and controversial. The aim of our study was to investigate the influence of Ramadan on the prevalence of acute coronary syndrome among chest pain patients in the emergency department of Monastir. METHODS: It was a prospective study, performed in the emergency department of Fattouma Bourguiba University Hospital of Monastir, during the 3 months before, during and after Ramadan from 2012 to 2014...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28685310/prognostic-significance-of-hematoma-thickness-to-midline-shift-ratio-in-patients-with-acute-intracranial-subdural-hematoma-a-retrospective-study
#12
Wael Mohamed Mohamed Moussa, Wael Mahmoud Khedr, Amr Hamdy Elwany
Acute intracranial subdural hematoma (ASDH) is commonly associated with a grave prognosis citing a high incidence of morbidity and mortality. The parameters to decide on surgical evacuation of the hematoma are sometimes controversial. In this study, we theorized that the ratio between maximal hematoma thickness and midline shift would be varied by associated intrinsic brain pathology emanating from the trauma and would thus objectively evaluates the prognosis in ASDH. The records of patients diagnosed with ASDH who were submitted to surgical evacuation through a craniotomy were revised...
July 6, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28678166/access-to-hiv-care-and-resilience-in-a-long-term-conflict-setting-a-qualitative-assessment-of-the-experiences-of-living-with-diagnosed-hiv-in-mogadishu-somali
#13
Asli Kulane, John O A Owuor, Douglas Sematimba, Sacdia Abdisamad Abdulahi, Hamdi Moalim Yusuf, Lul M Mohamed
BACKGROUND: Human Immunodeficiency Virus (HIV) continues to take a heavy toll on the lives of many people, with the worst impact on health and wellbeing for the affected individuals in fragile states. The HIV situation in Somalia is not clearly known and experiences of the people living with HIV in this war-torn region are often unexpressed. This pilot qualitative study sought to explore the experiences of people diagnosed with HIV living in Mogadishu, and their resilience in access to care and social support...
July 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28670882/circulating-hypermethylated-rassf1a-as-a-molecular-biomarker-for-diagnosis-of-hepatocellular-carcinoma
#14
Lamiaa A Mansour, Maissa El Raziky, Amal A Mohamed, Enas H Mahmoud, Sherif Hamdy, Enas H El Sayed
Background: Detection of circulating DNA can be applied for the diagnosis of many malignant neoplasms, including the hepatocellular carcinoma (HCC). The molecular pathogenesis of HCC is complex, involving different genetic and epigenetic alterations, chromosomal aberrations, gene mutations and altered molecular pathways. RASSF1A is a well-established tumor suppressor gene which suffers frequent inactivation due to promoter hypermethylation of CPG islands in multiple tumors including HCC, resulting in the reduction or loss of gene expression...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28669560/potential-of-rassf1a-promoter-methylation-as-biomarker-for-endometrial-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Noel Pabalan, Anthicha Kunjantarachot, Chetana Ruangpratheep, Hamdi Jarjanazi, Denise Maria Christofolini, Caio Parente Barbosa, Bianca Bianco
BACKGROUND: An epigenetic approach to explaining endometrial carcinogenesis necessitates good understanding of Ras association domain family 1 isoform A (RASSF1A) promoter methylation data from primary studies. AIMS: Differential magnitude of reported associations between RASSF1A promoter methylation and endometrial cancer (EC) prompted a meta-analysis to obtain more precise estimates. METHODS: Literature search yielded eight included articles...
June 29, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28665834/a-prospective-assessment-of-adverse-events-in-3-digestive-surgery-departments-from-central-tunisia
#16
Mondher Letaief, Sana El Mhamdi, Sameen Siddiqi, Rached Letaief, Abdelwaheb Morjane, Abdelaziz Hamdi
OBJECTIVE: The aim of the study was to prospectively assess the incidence, the preventability, and the factors contributing to adverse events (AEs) in surgical departments of Tunisian hospitals. METHODS: A prospective longitudinal study evaluated the incidence of AEs in surgical departments of three university hospitals in central Tunisia. The study followed 1687 admitted patients until their discharge from the hospitals based on a standard two-stage method that first included staff interviews and review of medical records based on 18 criteria and later was followed by an expert review to confirm or reject the presence of an AE...
June 29, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28657166/nmr-hs-spme-gc-ms-and-hplc-ms-n-analyses-of-phytoconstituents-and-aroma-profile-of-rosmarinus-eriocalyx-l
#17
Hamdi Bendif, Mohamed Djamel Miara, Gregorio Peron, Stefania Sut, Stefano Dall'Acqua, Guido Flamini, Filippo Maggi
In this work a comprehensive study on the chemical constituents of the aerial parts of Rosmarinus eriocalyx L. (Lamiaceae), an aromatic shrub traditionally consumed as a food and herbal remedy in Algeria, is presented. The aroma profile was analysed by headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS), whereas the crude extract constituents were analyzed by (1) H-NMR and by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS(n) )...
June 28, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28652668/prevalence-and-prognostic-significance-of-anemia-in-patients-presenting-for-st-elevation-myocardial-infarction-in-a-tunisian-center
#18
Walid Jomaa, Imen Ben Ali, Sonia Hamdi, Mohamed A Azaiez, Aymen El Hraïech, Khaldoun Ben Hamda, Faouzi Maatouk
BACKGROUND: Anemia on admission is a powerful predictor of major cardiovascular events in patients presenting for acute coronary syndromes. We sought to determine the prevalence and prognostic impact of anemia in patients presenting for ST-elevation myocardial infarction (STEMI). METHODS: We analyzed data from a Tunisian retrospective single center STEMI registry. Patients were enrolled between January 1998 and October 2014. Anemic and nonanemic patients were compared for clinical and prognostic features and according to four prespecified hemoglobin level subgroups...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28651172/simultaneous-determination-of-cis-permethrin-and-trans-permethrin-in-rat-plasma-and-brain-tissue-using-gas-chromatography-negative-chemical-ionization-mass-spectrometry
#19
Shirin Hooshfar, Darren R Gullick, Michael R Linzey, Tanzir Mortuza, Mona Hamdy Abdel Rahman, Clinton A Rogers, James V Bruckner, Catherine A White, Michael G Bartlett
A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100μL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for sample preparation and gas chromatography-negative chemical ionization mass spectrometry (GCNCI-MS) for detection. Quantitation of trace levels of the insecticide in small volumes of biological samples is essential to support toxicokinetic studies in small animals. There are currently no validated methods in the literature for determining cis-PERM and trans- PERM in volumes as low as 100μL of rat plasma or brain homogenate...
June 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28650485/neuroblastoma-is-composed-of-two-super-enhancer-associated-differentiation-states
#20
Tim van Groningen, Jan Koster, Linda J Valentijn, Danny A Zwijnenburg, Nurdan Akogul, Nancy E Hasselt, Marloes Broekmans, Franciska Haneveld, Natalia E Nowakowska, Johannes Bras, Carel J M van Noesel, Aldo Jongejan, Antoine H van Kampen, Linda Koster, Frank Baas, Lianne van Dijk-Kerkhoven, Margriet Huizer-Smit, Maria C Lecca, Alvin Chan, Arjan Lakeman, Piet Molenaar, Richard Volckmann, Ellen M Westerhout, Mohamed Hamdi, Peter G van Sluis, Marli E Ebus, Jan J Molenaar, Godelieve A Tytgat, Bart A Westerman, Johan van Nes, Rogier Versteeg
Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development stages. It has been proposed that super-enhancer-associated transcription factor (TF) networks underlie lineage identity, but the role of these enhancers in intratumoral heterogeneity is unknown. Here we show that most neuroblastomas include two types of tumor cells with divergent gene expression profiles...
June 26, 2017: Nature Genetics
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