keyword
https://read.qxmd.com/read/38467368/a-dynamic-model-of-inorganic-arsenic-induced-carcinogenesis-reveals-an-epigenetic-mechanism-for-epithelial-mesenchymal-plasticity
#21
JOURNAL ARTICLE
Matthew Rea, Greg Kimmerer, Shania Mittendorf, Xiaopeng Xiong, Meghan Green, Darrell Chandler, Wesley Saintilnord, Jessica Blackburn, Tianyan Gao, Yvonne N Fondufe-Mittendorf
Inorganic arsenic (iAs) causes cancer by initiating dynamic transitions between epithelial and mesenchymal cell phenotypes. These transitions transform normal cells into cancerous cells, and cancerous cells into metastatic cells. Most in vitro models assume that transitions between states are binary and complete, and do not consider the possibility that intermediate, stable cellular states might exist. In this paper, we describe a new, two-hit in vitro model of iAs-induced carcinogenesis that extends to 28 weeks of iAs exposure...
March 9, 2024: Environmental Pollution
https://read.qxmd.com/read/38462721/subcutaneous-air-entrapment-after-subcutaneous-implantable-cardioverter-defibrillator-implantation-evaluated-by-computed-tomography
#22
JOURNAL ARTICLE
Yuka Taguchi, Toshiyuki Ishikawa, Katsumi Matsumoto, Masatoshi Narikawa, Yoshinori Okazaki, Shuichi Miyagawa, Akira Horigome, Junya Hosoda
BACKGROUND: Inappropriate shock (IAS) caused by subcutaneous air entrapment (AE) in an early period after subcutaneous implantable cardioverter defibrillator (S-ICD) implantation has been reported, however, no detailed data on air volume are available. We evaluated the subcutaneous air volume after implantation and its absorption rate one week after implantation. METHODS: Patients who underwent S-ICD implantation in our hospital received chest CT scans immediately after implantation and followed up 1 week later...
March 10, 2024: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/38451269/safety-and-efficacy-of-lvis-jr-stent-assisted-coiling-of-intracranial-aneurysms-in-small-diameter-parent-arteries-a%C3%A2-single-center-experience
#23
JOURNAL ARTICLE
Shuailong Shi, Shuhai Long, Fangfang Hui, Qi Tian, Zhuangzhuang Wei, Ji Ma, Jie Yang, Ye Wang, Xinwei Han, Tengfei Li
OBJECTIVE: To investigate the safety and efficacy of LVIS Jr stent-assisted coiling (SAC) of intracranial aneurysms (IAs) in small-diameter parent arteries and determine the factors influencing incomplete aneurysm occlusion. MATERIAL AND METHODS: Clinical and imaging data of 130 patients with IAs in small-diameter parent arteries that were treated with LVIS Jr SAC were retrospectively analyzed. Stent apposition was evaluated by high-resolution flat detector CT, and aneurysm embolization density was evaluated using 2D-DSA...
March 7, 2024: Clinical Neuroradiology
https://read.qxmd.com/read/38446164/sustained-effects-of-developmental-exposure-to-inorganic-arsenic-on-hepatic-gsto2-expression-and-mating-success-in-zebrafish
#24
JOURNAL ARTICLE
Abigail Ama Koomson, Patrice Delaney, Nouf Khan, Kirsten C Sadler
The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on human and fish health are well characterized and several lines of evidence suggest that some impacts can manifest years after exposure cessation. Using a developmental exposure protocol whereby zebrafish embryos were exposed to 0.5 and 1.5 mM iAs from 4-120 hours post fertilization (hpf) and then removed, we investigated the sustained effects of iAs on gene expression in the liver, survival, reproductive success, and susceptibility to iAs toxicity in the subsequent generation...
March 1, 2024: Biology Open
https://read.qxmd.com/read/38443187/clinical-and-angiographic-characteristics-of-ruptured-and-unruptured-distal-cerebral-aneurysms-a-review-of-a-large-series-of-cases-in-a-high-volume-center
#25
JOURNAL ARTICLE
Roberta Cao, Adonis Mattar, Esteban Torche, Roberto Riva, Morgane Laubacher, Ricardo Moreno-Gomez, Francis Turjman, Andrea Falini, Pietro Panni, Omer F Eker
OBJECTIVE: To evaluate clinical, angiographic features, and endovascular approach of ruptured and unruptured distal intracranial aneurysms (DIAs). METHODS: From January 2013 to February 2022, details of all consecutive intracranial aneurysms (IAs) treated endovascularly in our center were collected and retrospectively reviewed. IAs involving the anterior cerebral artery, middle cerebral artery, and posterior cerebral artery (distal to anterior communicating artery, limen insula, and P1 segment, respectively), and those distal to superior cerebellar artery, anterior-inferior cerebellar artery, and posterior inferior cerebellar artery's first segment were classified based on their etiology, location, size, and shape...
March 5, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38442695/longitudinal-trends-in-hiv-1-subtypes-and-drug-resistance-in-children-from-argentina-over-a-15-year-period-2006-2021
#26
JOURNAL ARTICLE
Natalia J López, Solange Arazi-Caillaud, Rosa M Bologna, Andrea M Mangano, Cristina P Aulicino
Background: Human immunodeficiency virus (HIV) drug resistance is a major cause of treatment failure in children and adolescents infected with the virus. Objectives: The objectives of the study are to investigate HIV drug resistance (HIVDR) in patients who attended a referral care center in Argentina over a 15-year period and to compare mutational patterns between HIV-1 polsequences characterized as B or BF recombinants. Methods: Individual resistance-associated mutations (RAMs) (to protease and reverse transcriptase inhibitors) were identified according to IAS-USA guidelines in 374 HIV-1-infected children and adolescents...
2024: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38433967/incorporating-mesopelagic-fish-into-the-evaluation-of-conservation-areas-for-marine-living-resources-under-climate-change-scenarios
#27
JOURNAL ARTICLE
Shuhao Liu, Yang Liu, Katharina Teschke, Mark A Hindell, Rachel Downey, Briannyn Woods, Bin Kang, Shuyang Ma, Chi Zhang, Jianchao Li, Zhenjiang Ye, Peng Sun, Jianfeng He, Yongjun Tian
UNLABELLED: Mesopelagic fish (meso-fish) are central species within the Southern Ocean (SO). However, their ecosystem role and adaptive capacity to climate change are rarely integrated into protected areas assessments. This is a pity given their importance as crucial prey and predators in food webs, coupled with the impacts of climate change. Here, we estimate the habitat distribution of nine meso-fish using an ensemble model approach (MAXENT, random forest, and boosted regression tree)...
February 2024: Marine life science & technology
https://read.qxmd.com/read/38433266/somatic-cag-repeat-instability-in-intermediate-alleles-of-the-htt-gene-and-its-potential-association-with-a-clinical-phenotype
#28
JOURNAL ARTICLE
Ainara Ruiz de Sabando, Marc Ciosi, Arkaitz Galbete, Sarah A Cumming, Darren G Monckton, Maria A Ramos-Arroyo
Huntington disease (HD) is a neurodegenerative disorder caused by ≥36 CAGs in the HTT gene. Intermediate alleles (IAs) (27-35 CAGs) are not considered HD-causing, but their potential association with neurocognitive symptoms remains controversial. As HTT somatic CAG expansion influences HD onset, we hypothesised that IAs are somatically unstable, and that somatic CAG expansion may drive phenotypic presentation in some IA carriers. We quantified HTT somatic CAG expansions by MiSeq sequencing in the blood DNA of 164 HD subjects and 191 IA (symptomatic and control) carriers, and in the brain DNA of a symptomatic 33 CAG carrier...
March 4, 2024: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/38432438/evaluation-of-biotoxins-and-toxic-metal-risks-in-mussels-from-the-sea-of-marmara-following-marine-mucilage
#29
JOURNAL ARTICLE
Hande Doğruyol, Şafak Ulusoy, Nuray Erkan, Sühendan Mol, Özkan Özden, İdil Can Tunçelli, Şehnaz Yasemin Tosun, Didem Üçok, Eda Dağsuyu, Refiye Yanardağ
The mucilage phenomenon observed in the Sea of Marmara in 2021, has raised public concern about seafood safety. Mediterranean mussels serve as a vehicle in food chain, enabling the transfer of pollutants. Farmed and wild mussels were collected from 4 different stations throughout the fishing season. Biotoxins causing amnesic, paralytic, or diarrhetic shellfish poisonings (ASP, PSP, or DSP) were examined during monthly samplings. Potential health risks posed by cadmium, lead and arsenic were assessed. All health risks were evaluated considering 150 g/week mussel consumption considering different age groups of consumers (50, 60, 70 kg)...
March 1, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38430670/pro-vegetarian-dietary-patterns-and-essential-and-heavy-metal-exposure-in-children-of-4-5-years-from-the-infancia-y-medio-ambiente-cohort-inma
#30
JOURNAL ARTICLE
Alejandro Oncina-Cánovas, Jesús Vioque, Gabriel Riutort-Mayol, Raquel Soler-Blasco, Amaia Irizar, Ziortza Barroeta, Ana Fernández-Somoano, Adonina Tardón, Martine Vrijheid, Mònica Guxens, Manus Carey, Caroline Meharg, Kathryn Ralphs, Coalain McCreanor, Andrew Meharg, Antonio J Signes-Pastor
Dietary patterns provide a comprehensive assessment of food consumption, including essential nutrients and potential exposure to environmental contaminants. While pro-vegetarian (PVG) dietary patterns have shown health benefits in adults, their effects on children are less well studied. This study aims to explore the association between children's adherence to the most common PVG dietary patterns and their exposure to metals, assessed through urine concentration. In our study, we included a population of 723 children aged 4-5-years from the INfancia y Medio Ambiente (INMA) cohort in Spain...
March 1, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38428138/insulin-autoimmunity-associated-with-vitiligo-a-rare-case-presentation
#31
JOURNAL ARTICLE
Presoon Kuruvilla, Angel John, Ashith Murali
SUMMARY: Insulin autoantibody syndrome (IAS) or Hirata's disease is a rare condition characterized by recurrent fasting hypoglycaemic and postprandial hyperglycaemic episodes. Insulin autoantibodies are diagnostic for the condition. Hirata's disease has been seen to be associated with other autoimmune conditions. Vitiligo is a common depigmentation disorder whose exact cause is unknown but thought to have an autoimmune aetiology. Although autoimmunity plays a role in the pathogenesis of both the diseases, association between the two has not been reported till date...
January 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/38427337/updated-treatment-recommendation-on-use-of-cabotegravir-and-rilpivirine-for-people-with-hiv-from-the-ias-usa-guidelines-panel
#32
JOURNAL ARTICLE
Paul E Sax, Melanie A Thompson, Michael S Saag
No abstract text is available yet for this article.
March 1, 2024: JAMA
https://read.qxmd.com/read/38425424/inducing-mitochondriopathy-like-damages-by-transformable-nucleopeptide-nanoparticles-for-targeted-therapy-of-bladder-cancer
#33
JOURNAL ARTICLE
Da-Yong Hou, Ni-Yuan Zhang, Lu Wang, Mei-Yu Lv, Xiang-Peng Li, Peng Zhang, Yue-Ze Wang, Lei Shen, Xiu-Hai Wu, Bo Fu, Peng-Yu Guo, Zi-Qi Wang, Dong-Bing Cheng, Hao Wang, Wanhai Xu
Mitochondriopathy inspired adenosine triphosphate (ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration (IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites, leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like damages...
April 2024: National Science Review
https://read.qxmd.com/read/38419712/causal-association-between-depression-and-intracranial-aneurysms-a-bidirectional-two-sample-mendelian-randomization-study
#34
JOURNAL ARTICLE
Jujiang Wu, Hao Sun, Junqiang Ma
BACKGROUND: Although observational studies have suggested a bidirectional relation between depression and intracranial aneurysms (IAs), their causal relations remain unclear. Thus we aimed to assess the causal association between depression and IAs. METHODS: We conducted a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from publicly available genome-wide association studies of depression ( n  = 500,199), IAs ( n  = 79,429), unruptured intracranial aneurysm (uIA) ( n  = 74,004), and subarachnoid hemorrhage (SAH) ( n  = 77,074)...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38417634/low-shear-stress-induces-macrophage-infiltration-and-aggravates-aneurysm-wall-inflammation-via-ccl7-ccr1-tak1-nf-%C3%AE%C2%BAb-axis
#35
JOURNAL ARTICLE
Heng Wei, Guijun Wang, Qi Tian, Chengli Liu, Wenrui Han, Jianfeng Wang, Peibang He, Mingchang Li
BACKGROUND: This study aimed to elucidate the mechanism by which wall shear stress (WSS) influences vascular walls, accounting for the susceptibility of intracranial aneurysms (IAs) to rupture. METHOD: We collected blood samples from the sacs of 24 ruptured and 28 unruptured IAs and analyzed the expression of chemokine CCL7 using enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression analyses were employed to assess clinical data, aneurysm morphology, and hemodynamics in both groups...
February 26, 2024: Cellular Signalling
https://read.qxmd.com/read/38416142/effect-of-siphon-morphology-on-the-risk-of-c7-segment-aneurysm-formation-a%C3%A2-case-control-cfd-study
#36
JOURNAL ARTICLE
Ying Wang, Bo Chen, Laixin Song, Yuzhe Li, Ming Xu, Tianxiang Huang, Feiyue Zeng
PURPOSE: Tortuosity of the internal carotid artery (ICA) is associated with intracranial aneurysms (IAs). The siphon is the most curved segment of the ICA, but its morphology has controversial effects on IAs. This study aimed to explore the morphometric features of the siphon and the potential hemodynamic mechanisms that may affect C7 aneurysm formation. METHODS: In this study 32 patients with C7 aneurysms diagnosed at Xiangya Hospital between 2019 and 2021 and 32 control subjects were enrolled after propensity score matching...
February 28, 2024: Clinical Neuroradiology
https://read.qxmd.com/read/38415120/accuracy-of-solid-portion-size-measured-on-multiplanar-volume-rendering-images-for-assessing-invasiveness-in-lung-adenocarcinoma-manifesting-as-subsolid-nodules
#37
JOURNAL ARTICLE
Wang-Jia Li, Zhi-Gang Chu, Dan Li, Wei-Wei Jing, Qiu-Ling Shi, Fa-Jin Lv
BACKGROUND: The solid component of subsolid nodules (SSNs) is closely associated with the invasiveness of lung adenocarcinoma, and its accurate assessment is crucial for selecting treatment method. Therefore, this study aimed to evaluate the accuracy of solid component size within SSNs measured on multiplanar volume rendering (MPVR) and compare it with the dimensions of invasive components on pathology. METHODS: A pilot study was conducted using a chest phantom to determine the optimal MPVR threshold for the solid component within SSN, and then clinical validation was carried out by retrospective inclusion of patients with pathologically confirmed solitary SSN from October 2020 to October 2021...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38411387/optimizing-screening-cutoffs-for-drugs-of-abuse-in-hair-using-immunoassay-for-forensic-applications
#38
JOURNAL ARTICLE
Arianna Giorgetti, Jennifer P Pascali, Guido Pelletti, Marco Garagnani, Raffaella Roffi, Marialuisa Grech, Paolo Fais
BACKGROUND: In forensic toxicology, positive immunoassay (IA) test results do not hold forensic validity and need to be confirmed with mass spectrometry (MS). On the other hand, a negative result is a strong indication that the drug and/or the drug metabolites are not present in the sample and that confirmatory analyses are not necessary. Consequently, a negative IA result must have forensic validity since it can be admitted in court during a trial. OBJECTIVES: Screening cutoffs for the analysis of hair samples using immunoassays (IAs) were retrospectively optimized based on the Society of Hair Testing (SoHT) confirmation cutoffs and the utility of the test for forensic applications was discussed...
February 27, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38408001/a-bioimpedance-spectroscopy-interface-for-eim-based-on-if-sampling-and-pseudo-2-path-sc-bandpass-%C3%AE-%C3%AE-adc
#39
JOURNAL ARTICLE
Alejandro D Fernandez Schrunder, Yu-Kai Huang, Saul Rodriguez, Ana Rusu
This paper presents a low-noise bioimpedance (bio-Z) spectroscopy interface for electrical impedance myography (EIM) over the 1 kHz to 2 MHz frequency range. The proposed interface employs a sinusoidal signal generator based on direct-digital-synthesis (DDS) to improve the accuracy of the bio-Z reading, and a quadrature low-intermediate frequency (IF) readout to achieve a good noise-to-power efficiency and the required data throughput to detect muscle contractions. The readout is able to measure baseline and time-varying bio-Z by employing robust and power-efficient low-gain IAs and sixth-order single-bit bandpass (BP) ΔΣ ADCs...
February 26, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38407801/arsenic-as-accumulation-in-different-genotypes-of-indica-rice-oryza-sativa-l-and-health-risk-assessment-based-on-inorganic-as
#40
JOURNAL ARTICLE
Chunle Chen, Yanhang Yu, Tian Tian, Bo Xu, Hongyan Wu, Guo Wang, Yanhui Chen
To reveal differences in arsenic (As) accumulation among indica rice cultivars and assess the human health risks arising from inorganic arsenic (iAs) intake via rice consumption, a total of 320 field indica rice samples and corresponding soil samples were collected from Fujian Province in China. The results showed that available soil As (0.03 to 3.83 mg/kg) showed a statistically significant positive correlation with total soil As (0.10 to 19.45 mg/kg). The inorganic As content in brown rice was between 0...
February 26, 2024: Environmental Monitoring and Assessment
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