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Georgios Sahsamanis, Georgios Vourliotakis, Konstantinos Maltezos, Georgios Plakas, Vasileios Tzilalis
Isolated abdominal aortic dissection (IAAD) is a rare form of aortic dissection involving usually the infrarenal part of the abdominal aorta. A 45-year-old male presented with lumbar pain and claudication. Computed tomography angiography (CTA) revealed an infrarenal IAAD extending to the left external iliac artery (EIA), causing ≥90% narrowing of the lumen. An endovascular approach was decided, with deployment of an aortic stent-graft and two balloon expandable stents in both common iliac arteries (IAs), applying the kissing stents technique...
September 25, 2017: Annals of Vascular Diseases
Min Kyung Kang, Jae Myung Yu, Kwang Jin Chun, Jaehuk Choi, Seonghoon Choi, Namho Lee, Jung Rae Cho
OBJECTIVE: This study aimed to evaluate the factors associated with increased arterial stiffness (IAS) measured by pulse wave velocity (PWV) and its clinical implications in patients with type 2 diabetes mellitus (DM). METHODS: This was an observational, cross-sectional study. The ankle-brachial PWV was used to measure arterial stiffness, and 310 patients (mean age, 49±9 years; 180 men) with type 2 DM were divided into two groups according to the results of PWV: Group 1 (IAS; n=214) and Group 2 (normal arterial stiffness; n=96)...
November 2017: Anatolian Journal of Cardiology
Erkki Lathouwers, Eric Y Wong, Donghan Luo, Sareh Seyedkazemi, Sandra De Meyer, Kimberley Brown
BACKGROUND: Darunavir 800 mg once daily (QD) is indicated for HIV-1-infected treatment-naïve and treatment-experienced (without darunavir resistance-associated mutations [RAMs]) individuals, and has been evaluated in phase 2/3 studies with durations between 48 and 192 weeks. OBJECTIVE: To summarize the development (or identification) of post-baseline resistance (RAMs and antiretroviral phenotypic susceptibility) among subjects receiving darunavir QD dosing. METHODS: Seven phase 2/3 studies with available genotypes/phenotypes for subjects treated with ritonavir- or cobicistat-boosted darunavir 800 mg QD regimens were assessed: ARTEMIS (NCT00258557; n = 343), GS-US-299-0102 (NCT01565850; n = 153), GS-US-216-0130 (NCT01440569; n = 313), ODIN (NCT00524368; n = 294), INROADS (NCT01199939; n = 54), MONET (NCT00458302; n = 256), and PROTEA (NCT01448707; n = 273)...
November 16, 2017: HIV Clinical Trials
Isadora Olivé, Maria Densmore, Sherain Harricharan, Jean Théberge, Margaret C McKinnon, Ruth Lanius
OBJECTIVES: The innate alarm system (IAS) models the neurocircuitry involved in threat processing in posttraumatic stress disorder (PTSD). Here, we investigate a primary subcortical structure of the IAS model, the superior colliculus (SC), where the SC is thought to contribute to the mechanisms underlying threat-detection in PTSD. Critically, the functional connectivity between the SC and other nodes of the IAS remains unexplored. EXPERIMENTAL DESIGN: We conducted a resting-state fMRI study to investigate the functional architecture of the IAS, focusing on connectivity of the SC in PTSD (n = 67), its dissociative subtype (n = 41), and healthy controls (n = 50) using region-of-interest seed-based analysis...
November 13, 2017: Human Brain Mapping
Guang-Xian Wang, Li Wen, Liu Yang, Qi-Chuang Zhang, Jin-Bo Yin, Chun-Mei Duan, Dong Zhang
PURPOSE: To study the clinical and morphological characteristics associated with risk factors for the rupture of intracranial aneurysms (IAs). METHODS: A total of 1115 consecutive patients with 1282 IAs were reviewed from August 2011 to February 2016. The patients and IAs were divided into ruptured and unruptured groups. Based on the clinical and morphologic findings, the risk factors for IA rupture were assessed using statistical methods. RESULTS: Age, hypertension, diabetes mellitus and cerebral atherosclerosis were associated with ruptured IAs...
November 9, 2017: World Neurosurgery
Chao-Bao Luo, Feng-Chi Chang, Chung-Jung Lin, Wan-Yuo Guo
BACKGROUND: Endovascular coil embolization is an accepted treatment option for intracranial aneurysms. However, the coiling of aneurysms with an incorporated artery (IA) poses a high risk of IA occlusion. Here we report our experience of endovascular coil placement using a technique that avoids IA occlusion in aneurysms with IAs. METHODS: Over a 6-year period, 185 patients harboring 206 intracranial aneurysms underwent endosaccular coiling. Forty-two of these patients with 45 aneurysms were treated by coil placement to avoid IAs occlusion...
November 6, 2017: Journal of the Chinese Medical Association: JCMA
Christoph Hasslacher, Justo Lorenzo Bermejo
Background: A lower incidence of cardiovascular events has been reported in type 2 diabetes patients treated with insulin analogs (IAs). Corresponding data on people affected by type 1 diabetes are not available yet. Methodology: We investigated demographic and clinical data from 509 type 1 diabetics, who were treated in an outpatient clinic from 2006 to 2012. Multiple logistic regression was used to investigate the relationship between the type of insulin treatment and the prevalence of cardiovascular (CV) complications, that is, presence of coronary heart, cerebrovascular and peripheral arterial diseases, adjusting for potential confounders...
November 2017: Therapeutic Advances in Endocrinology and Metabolism
Taichi Ikedo, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Manabu Nagata, Risako Fujikawa, Fumiyoshi Yamazaki, Mitsutoshi Setou, Masayuki Yokode, Susumu Miyamoto
OBJECT: The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA. MATERIAL AND METHODS: IAs were surgically induced in 7-week-old male rats and analyzed by IMS in negative-ion mode...
October 27, 2017: Biochemical and Biophysical Research Communications
Guang-Xian Wang, Lan-Lan Liu, Li Wen, Yun-Xing Cao, Yu-Chun Pei, Dong Zhang
OBJECTIVE: To identify the morphological parameters that are related to intracranial aneurysms (IAs) rupture using a case-control model. METHODS: A total of 107 patients with multiple IAs and aneurysmal subarachnoid hemorrhage between August 2011 and February 2017 were enrolled in this study. Characteristics of IAs location, shape, neck width, perpendicular height, depth, maximum size, flow angle, parent vessel diameter (PVD), aspect ratio (AR) and size ratio (SR) were evaluated using CT angiography...
October 2017: Asian Pacific Journal of Tropical Medicine
Céline Bellard, Jean-François Rysman, Boris Leroy, Chantal Claud, Georgina M Mace
Biological invasions are among the main drivers of biodiversity losses. As threats from biological invasions increase, one of the most urgent tasks is to identify areas of high vulnerability. However, the lack of comprehensive information on the impacts of invasive alien species (IAS) is a problem especially on islands, where most of the recorded extinctions associated with IAS have occurred. Here we provide a global, network-oriented analysis of IAS on islands. Using network analysis, we structured 27,081 islands and 437 threatened vertebrates into 21 clusters, based on their profiles in term of invasiveness and shared vulnerabilities...
November 6, 2017: Nature ecology & evolution
Huihui Wang, Jiayu Zhu, Lu Li, Yongfang Li, Hang Lv, Yuanyuan Xu, Guifan Sun, Jingbo Pi
Inorganic arsenic (iAs) is a known toxicant and carcinogen. Worldwide arsenic exposure has become a threat to human health. The severity of arsenic toxicity is strongly correlated with the speed of arsenic metabolism (methylation) and clearance. Furthermore, oxidative stress is recognized as a major mechanism for arsenic-induced toxicity. Nuclear factor-E2-related factor 2 (Nrf2), a key regulator in cellular adaptive antioxidant response, is clearly involved in alleviation of arsenic-induced oxidative damage...
December 15, 2017: Toxicology and Applied Pharmacology
YaQiu Wu, Zhili Li, Yi Shi, Longyi Chen, Haibin Tan, Zhenyu Wang, Cheng Yin, Ling Liu, Junting Hu
BACKGROUND: Genetic risk factors can contribute to the etiology of intracranial aneurysms (IAs) and the genetic predisposition of IAs is largely unknown. Our study is aimed to explore the role of rare variation in IA susceptibility. METHODS: Whole exome sequencing (WES) was performed in a representative family with history of multiple cases of IAs. WES variants were prioritized by various filtering strategies, including frequency, predicted pathogenicity and functional prediction...
October 26, 2017: World Neurosurgery
Torbjørn Øygard Skodvin, Øyvind Evju, Christian A Helland, Jørgen Gjernes Isaksen
OBJECTIVE Hemodynamic rupture predictors in intracranial aneurysms (IAs) must be investigated in prerupture aneurysms, because rupture might significantly alter aneurysm hemodynamics. Both clinical and aneurysmal factors influence hemodynamics, possibly confounding results in unmatched patient materials. The authors aimed to identify hemodynamic variables at the time of diagnosis that could be associated with IA rupture. METHODS A nationwide matched case-control study of IA hemodynamics at the time of diagnosis was performed...
November 3, 2017: Journal of Neurosurgery
Tim Davis, Eric Loudermilk, Michael DePalma, Corey Hunter, David Lindley, Nilesh Patel, Daniel Choi, Marc Soloman, Anita Gupta, Mehul Desai, Asokumar Buvanendran, Leonardo Kapural
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. METHODS: This is a prospective, multicenter, randomized trial with 151 subjects with chronic (≥6 months) knee pain that was unresponsive to conservative modalities...
November 1, 2017: Regional Anesthesia and Pain Medicine
E K Alidjinou, J Deldalle, C Hallaert, O Robineau, F Ajana, P Choisy, D Hober, L Bocket
Background: Sanger sequencing of plasma RNA is the standard method for HIV-1 drug resistance testing in treatment-naive patients, but is limited by the non-detection of resistance-associated mutations (RAMs) with prevalence below approximately 20%. Objectives: We compared RNA and DNA Sanger sequencing (RSS and DSS) with RNA next-generation sequencing (NGS) for RAM detection in HIV-1 reverse transcriptase (RT), protease (PR) and integrase (IN) genes. Methods: Sanger sequencing was performed on RNA and DNA, following the recommendations of the French Agency for AIDS Research (ANRS)...
October 1, 2017: Journal of Antimicrobial Chemotherapy
Marine Perrier, Benoit Visseaux, Roland Landman, Véronique Joly, Eve Todesco, Yazdan Yazdanpanah, Vincent Calvez, Anne-Geneviève Marcelin, Diane Descamps, Charlotte Charpentier
Objectives: To evaluate, in a clinical cohort of HIV-1-infected patients, the prevalence of PI minority resistant variants (MRV) at ART baseline and their impact on the virological response to a first-line PI-based regimen. Patients and methods: In an observational single-centre cohort, we assessed all ART-naive patients initiating a first-line regimen including two NRTI and one boosted PI, darunavir/ritonavir or atazanavir/ritonavir, between January 2012 and March 2015...
October 25, 2017: Journal of Antimicrobial Chemotherapy
Yue Yin, Junfeng Wan, Shaozhen Li, Hongli Li, Christophe Dagot, Yan Wang
In order to evaluate the influence of roxarsone (ROX) on the livestock wastewater treatment, a lab-scale pilot employing an anoxic-oxic (A-O) process was investigated by adding different concentrations of ROX at different periods. The mass balance of arsenic (As) in the A-O system was established through the analysis of As speciation and As migration in the gas, liquid and solid phases. The results showed that around 80% of total ROX (initial concentration was 50mgROXL(-1)) was eliminated in the anoxic reactor (R1) in which at least about 11% of total ROX was transformed to inorganic As(v) (iAs(v)) due to the direct breaking of the C-As bond of ROX...
October 23, 2017: Science of the Total Environment
Kate V Meriwether, Mark E Lockhart, Isuzu Meyer, Holly E Richter
OBJECTIVES: The authors used 2-dimensional images from pelvic 3 T magnetic resonance imaging (MRI) to characterize changes in the internal anal sphincter (IAS) and external anal sphincter (EAS) from prepregnancy to postdelivery in the same cohort. METHODS: This secondary analysis studied a prospective cohort of women undergoing 3 T MRI before their first pregnancy and 6 or more months after delivery. Radial thickness was measured at 12, 3, 9, and 6 o'clock from axial proximal and mid views and oblique distal views of the IAS, and at 3 and 9 o'clock from oblique views of the EAS...
October 24, 2017: Female Pelvic Medicine & Reconstructive Surgery
S Stelzner, M Böttner, J Kupsch, W Kneist, P Quirke, N P West, H Witzigmann, T Wedel
BACKGROUND: The internal anal sphincter (IAS) contributes substantially to anorectal functions. While its autonomic nerve supply has been studied at the microscopic level, little information is available concerning the macroscopic topography of extrinsic nerve fibres. This study was designed to identify neural connections between the pelvic plexus and the IAS, provide a detailed topographical description, and give histological proof of autonomic nerve tissue. METHODS: Macroscopic dissection of pelvic autonomic nerves was performed under magnification in seven (5 males, 2 females) hemipelvises obtained from body donors (67-92 years)...
October 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Tetiana B Oleshko, Olha A Obukhova, Tetiana M Oleshko, Olha I Matlai, Dmitriy D Sotnikov, Viktoriia Yu Harbuzova
INTRODUCTION: Endothelial dysfunction is the basic pathogenic development mechanism of ischemic atherothrombotic stroke (IAS). One of the reasons for changes of endothelin structure and properties and its receptor can be genetic polymorphism of their genes. AIM: Study of C+70G polymorphic variant associations of endothelin receptor A gene (EDNRA) with IAS development became the goal of research. MATERIAL AND METHODS: Venous blood of 170 patients with IAS and 124 persons without cerebrovascular pathology was used for the research...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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