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https://www.readbyqxmd.com/read/27915676/dietary-exposure-to-trace-elements-and-health-risk-assessment-in-the-region-of-valencia-spain-a-total-diet-study
#1
Silvia Marín, Olga Pardo, Rosario Báguena, Guillermina Font, Vicent Yusà
Dietary exposure of the Valencian Region population to lead, cadmium, inorganic arsenic (iAs), chromium, copper, tin and methylmercury (meHg) was assessed in a Total Diet Study carried out in the Region of Valencia in 2010-2011. A total of 8100 food samples were collected and analysed. Occurrence data were combined with consumption data to estimate dietary exposure in adults (>15 years of age) and young children (6-15 years of age). The estimated intake was calculated by a probabilistic approach. Average intake levels (optimistic scenario) for lead, inorganic arsenic (iAs), chromium and tin were 0...
December 5, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27914647/human-exposure-to-dietary-inorganic-arsenic-and-other-arsenic-species-state-of-knowledge-gaps-and-uncertainties
#2
Francesco Cubadda, Brian P Jackson, Kathryn L Cottingham, Yoshira Ornelas Van Horne, Margaret Kurzius-Spencer
Inorganic arsenic (iAs) is ubiquitous in the environment as arsenite (AsIII) and arsenate (AsV) compounds and biotransformation of these toxic chemicals leads to the extraordinary variety of organoarsenic species found in nature. Despite classification as a human carcinogen based on data from populations exposed through contaminated drinking water, only recently has a need for regulatory limits on iAs in food been recognized. The delay was due to the difficulty in risk assessment of dietary iAs, which critically relies on speciation analysis providing occurrence data for iAs in food - and not simply for total arsenic...
November 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27892527/abnormal-hypermethylation-of-the-vdac2-promoter-is-a-potential-cause-of-idiopathic-asthenospermia-in-men
#3
Aiming Xu, Yibo Hua, Jianzhong Zhang, Wei Chen, Kai Zhao, Wei Xi, Hainan Wang, Jianzheng Fang, Shifeng Su, Min Tang, Bianjiang Liu, Zengjun Wang
This study aimed to explore the association between the methylation status of the VDAC2 gene promoter region and idiopathic asthenospermia (IAS). Twenty-five IAS patients and 27 fertile normozoospermia (NZ) were involved. GC-2spd cells were treated with different concentrations of 5-aza-2'-deoxycytidine (5-Aza-CdR) for 24 h and 48 h. qRT-PCR was conducted to reveal whether or not VDAC2 expression was regulated by methylated modification. A dual-luciferase activity detection was used to verify VDAC2 promoter activity in GC-2spd cells...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892449/otorrhagia-and-nosebleed-as-first-signs-of-intravascular-absorption-syndrome-during-hysteroscopy-from-bench-to-bedside
#4
V Giacobbe, D Rossetti, S G Vitale, A M C Rapisarda, F Padula, A S Laganà, V I Palmara
Hysteroscopic surgery is indicated for the treatment of several intrauterine diseases. The surgeon needs to be aware of, and know how to prevent, possible complications related to these procedures. In the case of operative hysteroscopy, the systemic effects of low-viscosity fluid uptake must be considered in order to prevent the complications in the patient. We report on two unusual clinical signs of intravascular absorption syndrome (IAS) that developed during an operative hysteroscopy with glycine 1.5% as the fluid of distension...
January 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27891172/vortex-analysis-of-intra-aneurismal-flow-in-cerebral-aneurysms
#5
Kevin Sunderland, Christopher Haferman, Gouthami Chintalapani, Jingfeng Jiang
This study aims to develop an alternative vortex analysis method by measuring structure ofIntracranial aneurysm (IA) flow vortexes across the cardiac cycle, to quantify temporal stability of aneurismal flow. Hemodynamics were modeled in "patient-specific" geometries, using computational fluid dynamics (CFD) simulations. Modified versions of known λ2 and Q-criterion methods identified vortex regions; then regions were segmented out using the classical marching cube algorithm. Temporal stability was measured by the degree of vortex overlap (DVO) at each step of a cardiac cycle against a cycle-averaged vortex and by the change in number of cores over the cycle...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27889806/a-comparative-assessment-of-arsenic-risks-and-the-nutritional-benefits-of-fish-consumption-in-kuwait-arsenic-versus-omega-3-fatty-acids
#6
Adnan Husain, Kurunthachalam Kannan, Hing Man Chan, Brian Laird, Hanan Al-Amiri, Basma Dashti, Anwar Sultan, Amani Al-Othman, Bedraya Mandekar
Inorganic and organic forms of arsenic (As), as well as omega-3 fatty acids were measured in 578 fish/seafood samples that belong to 15 species of commonly consumed seafood in Kuwait. Arsenic speciation data, with the toxicological profile of inorganic arsenic (iAs) and fish consumption rates were applied in a probabilistic risk assessment to estimate the risk from exposure to iAs. The nutritional benefits of omega-3-fatty acid levels in various species of fish were taken into consideration. Results showed that the mean daily intake of iAs through fish consumption among the Kuwaiti population was 0...
November 26, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27889539/pharmacodynamics-of-s-dimethylarsino-glutathione-a-putative-metabolic-intermediate-of-inorganic-arsenic-in-mice
#7
Ayaka Kato, Yayoi Kobayashi, Osamu Udagawa, Seishiro Hirano
Inorganic arsenicals are well-known carcinogens, whereas arsenite (iAs(III)) compounds are now recognized as potent therapeutic agents for several leukemias, and arsenic trioxide has been used for the treatment of recurrent acute promyelocytic leukemia (APL). However, recent clinical trials revealed that arsenite is not always effective for non-APL malignancies. Another arsenical, S-dimethylarsino-glutathione ([DMA(III)(GS)]), which is a putative metabolic intermediate in the hepatic metabolism of iAs(III), shows promise for treating several types of lymphoma...
November 23, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27888225/use-of-the-pipeline-embolization-device-for-recurrent-and-residual-cerebral-aneurysms-a-safety-and-efficacy-analysis-with-short-term-follow-up
#8
Anna Luisa Kühn, Katyucia de Macedo Rodrigues, J Diego Lozano, David E Rex, Francesco Massari, Takamitsu Tamura, Mary Howk, Christopher Brooks, Jenna L'Heureux, Matthew J Gounis, Ajay K Wakhloo, Ajit S Puri
OBJECTIVE: Evaluation of the safety and efficacy of the Pipeline embolization device (PED) when used as second-line treatment for recurrent or residual, pretreated ruptured and unruptured intracranial aneurysms (IAs). METHODS: Retrospective review of our database to include all patients who were treated with a PED for recurrent or residual IAs following surgical clipping or coiling. We evaluated neurological outcome and angiograms at discharge, 6- and 12-months' follow-up and assessed intimal hyperplasia at follow-up...
November 25, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27887747/the-rise-of-invasive-species-denialism
#9
James C Russell, Tim M Blackburn
Scientific consensus on the negative impacts of invasive alien species (IAS) is increasingly being challenged. Whereas informed scepticism of impacts is important, science denialism is counterproductive. Such denialism arises when uncertainty on impacts is confounded by differences in values. Debates on impacts must take into account both the evidence presented and motivations.
November 22, 2016: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/27884419/a-novel-deep-inspiration-maneuver-for-difficult-transseptal-puncture
#10
Tolga Aksu, Tumer Erdem Guler, Kivanc Yalin, Sukriye Ebru Golcuk, Kazim Serhan Ozcan, Niyazi Guler
Transseptal puncture (TSP) may not be possible in cases of an elastic, aneurysmal, or thickened interatrial septum (IAS). During deep inspiration (DI), the chest wall expands and the diaphragm descends. This makes intrapleural pressure to become more negative, which leads to movement of the IAS to the right side. The aim of this study was to verify prospectively the feasibility, safety, and outcome of DI associated with conventional TSP technique in patients with challenging IAS anatomy. From September 2012 to May 2016, 224 patients underwent TSP due to different indications...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27882163/insulin-induced-autoimmune-syndrome-a-case-report
#11
Jian-Ping Chu, Xiao-Wei Zheng, Jie Lu, Jin-Yan Zhong, Jia-Lin Li, Miao Xu, Fang Lin
Insulin autoimmune syndrome (IAS) is a disease characterized by hyperinsulinemic hypoglycemia associated with autoantibodies against endogenous insulin. A 56-year-old man was admitted to Ningbo First Hospital for the treatment of spontaneous hypoglycemia. He was found to have elevated fasting insulin level (>1,000 mIU/l) and presence of insulin autoantibodies, and after appropriate workup, was diagnosed with IAS. After treating with prednisone for 2 months, his insulin level started decreasing. In patients with repeated hypoglycemia, IAS should be considered in the differential diagnosis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881288/internal-anal-sphincter-clinical-perspective
#12
REVIEW
Lalit Kumar, Anton Emmanuel
OBJECTIVE: To summarise current knowledge of Internal anal sphincter. BACKGROUND: The internal anal sphincter (IAS) is the involuntary ring of smooth muscle in the anal canal and is the major contributor to the resting pressure in the anus. Structural injury or functional weakness of the muscle results in passive incontinence of faeces and flatus. With advent of new assessment and treatment modalities IAS has become an important topic for surgeons. This review was undertaken to summarise our current knowledge of internal anal sphincter and highlight the areas that need further research...
November 20, 2016: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/27855237/insulin-autoimmune-syndrome-a-rare-cause-of-postprandial-hypoglycemia
#13
Pooja Sahni, Nitin Trivedi, Abdulkadir Omer
: A 65-year-old obese Caucasian woman presented with symptomatic postprandial hypoglycemic episodes, resolution of symptoms with carbohydrate intake and significantly elevated anti-insulin antibody levels. She did not have any evidence for the use of oral antidiabetic medications, insulin, herbal substances, performing strenuous exercise or history of bariatric surgery. Fingerstick blood glucose readings revealed blood sugar of 35 mg/dL and 48 mg/dL, when she had these symptoms. Her medical history was significant for morbid obesity, hypothyroidism and gastro esophageal reflux disease...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27847981/knockout-of-arsenic-3-oxidation-state-methyltransferase-is-associated-with-adverse-metabolic-phenotype-in-mice-the-role-of-sex-and-arsenic-exposure
#14
Christelle Douillet, Madelyn C Huang, R Jesse Saunders, Ellen N Dover, Chongben Zhang, Miroslav Stýblo
Susceptibility to toxic effects of inorganic arsenic (iAs) depends, in part, on efficiency of iAs methylation by arsenic (+3 oxidation state) methyltransferase (AS3MT). As3mt-knockout (KO) mice that cannot efficiently methylate iAs represent an ideal model to study the association between iAs metabolism and adverse effects of iAs exposure, including effects on metabolic phenotype. The present study compared measures of glucose metabolism, insulin resistance and obesity in male and female wild-type (WT) and As3mt-KO mice during a 24-week exposure to iAs in drinking water (0...
November 15, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27847713/effect-of-intra-articular-hyaluronic-acid-injection-on-hemiplegic-shoulder-pain-after-stroke
#15
Myung Hun Jang, Chang-Hyung Lee, Yong-Il Shin, Soo-Yeon Kim, Sung Chul Huh
OBJECTIVE: To evaluate the efficacy of intra-articular hyaluronic acid (IAHA) injection for hemiplegic shoulder pain (HSP) after stroke. METHODS: Thirty-one patients with HSP and limited range of motion (ROM) without spasticity of upper extremity were recruited. All subjects were randomly allocated to group A (n=15) for three weekly IAHA injection or group B (n=16) for a single intra-articular steroid (IAS) injection. All injections were administered by an expert physician until the 8th week using a posterior ultrasonography-guided approach...
October 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27847544/effects-of-reynolds-and-womersley-numbers-on-the-hemodynamics-of-intracranial-aneurysms
#16
Hafez Asgharzadeh, Iman Borazjani
The effects of Reynolds and Womersley numbers on the hemodynamics of two simplified intracranial aneurysms (IAs), that is, sidewall and bifurcation IAs, and a patient-specific IA are investigated using computational fluid dynamics. For this purpose, we carried out three numerical experiments for each IA with various Reynolds (Re = 145.45 to 378.79) and Womersley (Wo = 7.4 to 9.96) numbers. Although the dominant flow feature, which is the vortex ring formation, is similar for all test cases here, the propagation of the vortex ring is controlled by both Re and Wo in both simplified IAs (bifurcation and sidewall) and the patient-specific IA...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27836361/ultrasound-guided-intrasphincteric-botulinum-toxin-injection-relieves-obstructive-defecation-due-to-hirschsprung-s-disease-and-internal-anal-sphincter-achalasia
#17
Joseph T Church, Samir K Gadepalli, Toghrul Talishinsky, Daniel H Teitelbaum, Marcus D Jarboe
PURPOSE: Chronic obstructive defecation can occur in patients with Hirschsprung Disease (HD) and internal anal sphincter (IAS) achalasia. Injection of Botulinum Toxin (BoTox) into the IAS can temporarily relieve obstructive defecation, but can be challenging when performed by tactile sense alone. We compared results of BoTox injections with and without ultrasound (US) guidance. METHODS: We retrospectively reviewed BoTox injections into the IAS for obstructive defecation over 5years...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27836272/dietary-arsenic-exposure-in-brazil-the-contribution-of-rice-and-beans
#18
Virginia S T Ciminelli, Massimo Gasparon, Jack C Ng, Gabriela C Silva, Claudia L Caldeira
The human health risk associated with arsenic in food in Southeast Brazil was quantified. Based on the most commonly consumed food types in the Brazilian diet, the maximum inorganic As (iAs) daily intake from food (0.255 μg kg(-1) body weight per day) is approximately 9% of the Benchmark Dose Lower Limit (BMDL0.5) of 3 μg kg(-1) body weight per day set by the World Health Organization (WHO) and Food and Agriculture Organization (FAO) Joint Expert Committee in Food Additives (JECFA). When water is included, the contribution of food to the total intake varies from 96...
November 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27835000/identification-of-the-lowest-t-2-j-%C3%AF-0-isobaric-analog-state-in-52-co-and-its-impact-on-the-understanding-of-%C3%AE-decay-properties-of-52-ni
#19
X Xu, P Zhang, P Shuai, R J Chen, X L Yan, Y H Zhang, M Wang, Yu A Litvinov, H S Xu, T Bao, X C Chen, H Chen, C Y Fu, S Kubono, Y H Lam, D W Liu, R S Mao, X W Ma, M Z Sun, X L Tu, Y M Xing, J C Yang, Y J Yuan, Q Zeng, X Zhou, X H Zhou, W L Zhan, S Litvinov, K Blaum, G Audi, T Uesaka, Y Yamaguchi, T Yamaguchi, A Ozawa, B H Sun, Y Sun, A C Dai, F R Xu
Masses of ^{52g,52m}Co were measured for the first time with an accuracy of ∼10  keV, an unprecedented precision reached for short-lived nuclei in the isochronous mass spectrometry. Combining our results with the previous β-γ measurements of ^{52}Ni, the T=2, J^{π}=0^{+} isobaric analog state (IAS) in ^{52}Co was newly assigned, questioning the conventional identification of IASs from the β-delayed proton emissions. Using our energy of the IAS in ^{52}Co, the masses of the T=2 multiplet fit well into the isobaric multiplet mass equation...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27810988/the-association-of-arsenic-exposure-and-metabolism-with-type-1-and-type-2-diabetes-in-youth-the-search-case-control-study
#20
Maria Grau-Pérez, Chin-Chi Kuo, Miranda Spratlen, Kristina A Thayer, Michelle A Mendez, Richard F Hamman, Dana Dabelea, John L Adgate, William C Knowler, Ronny A Bell, Frederick W Miller, Angela D Liese, Chongben Zhang, Christelle Douillet, Zuzana Drobná, Elizabeth J Mayer-Davis, Miroslav Styblo, Ana Navas-Acien
OBJECTIVE: Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes. RESEARCH DESIGN AND METHODS: Six hundred eighty-eight participants <22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated...
November 3, 2016: Diabetes Care
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