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https://www.readbyqxmd.com/read/29351598/smooth-muscle-cells-of-intracranial-vessels-from-development-to-disease
#1
Juhana Frösen, Anne Joutel
Cerebrovascular diseases that cause ischemic or hemorrhagic stroke with subsequent loss of life or functional capacity due to damage of the brain tissue are among the leading causes of human suffering and economic burden inflicted by diseases in the developed world. Diseases affecting intracranial vessels are significant contributors to ischemic and hemorrhagic strokes. Brain arteriovenous malformations (bAVM), which are a collection of abnormal blood vessels connecting arteries to veins, are the most common cause of intracranial hemorrhage in children and young adults...
January 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29350772/arsenite-induced-histone-h3-modification-and-its-effects-on-egr1-and-fos-expression-in-hela-cells
#2
Toshihide Suzuki, Hiroshi Watanabe, Kayoko Kita, Taro Honma, Takafumi Ochi
It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes of arsenical carcinogenicity. Here we examined global histone H3 modification by trivalent inorganic arsenite (iAs(III)) and its contribution to gene expression in HeLa cells. iAs(III) induced histone H3K9 dimethylation (H3K9me2) and trimethylation (H3K9me3), histone H3S10 phosphorylation (H3S10p), histone H3T11 phosphorylation (H3T11p) and histone H3K9S10 trimethyl-phosphorylation (H3K9me3S10p)...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29347826/acceptability-of-hiv-cure-related-trials-the-challenges-for-physicians-and-people-living-with-hiv-anrs-apsec
#3
Marie Preau, Marjolaine Doumergue, Christel Protiere, Cécile Goujard, Marion Mora, Laurence Meyer, Jean-Daniel Lelievre, François Raffi, Bruno Spire, Olivier Lambotte, Marie Suzan-Monti
Essential HIV cure-related clinical trials (HCRCT) have a potentially high-risk profile in terms of participants' health, which could hinder enrollment by people living with HIV (PLWH) and healthcare professionals (HP). The ANRS-APSEC survey is part of the IAS "Towards an HIV cure" initiative, which promotes multidisciplinary research for a safe, affordable and scalable cure. The study objectives were to understand the psychosocial mechanisms underlying PLWH and HP viewpoints about future HCRCT. Six focus group discussions (three with PLWH (n = 21) and three with HP (n = 30)) were held in three French infectious disease units...
January 18, 2018: AIDS Care
https://www.readbyqxmd.com/read/29342509/the-influence-of-explanatory-images-on-risk-perceptions-and-treatment-preference
#4
Raluca Cozmuta, Evan Wilhelms, Diana Cornell, Julia Nolte, Valerie Reyna, Liana Fraenkel
OBJECTIVE: To examine whether providing patients a series of balance scales (BS) depicting a reciprocal relationship between achieving disease control and increasing the risk of infection influences treatment preference. METHODS: Participants were randomized to receive a description of a medication in which risk of infection was described using one of four formats: numbers only, numbers + icon array (IA), numbers + BS, or numbers + IA + BS (i.e. combination). We compared the likelihood of starting the medication across the four formats, and whether the influence of risk formats varied by numeracy and gist risk appraisals...
January 17, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29342213/circulating-neutrophil-transcriptome-may-reveal-intracranial-aneurysm-signature
#5
Vincent M Tutino, Kerry E Poppenberg, Kaiyu Jiang, James N Jarvis, Yijun Sun, Ashish Sonig, Adnan H Siddiqui, Kenneth V Snyder, Elad I Levy, John Kolega, Hui Meng
BACKGROUND: Unruptured intracranial aneurysms (IAs) are typically asymptomatic and undetected except for incidental discovery on imaging. Blood-based diagnostic biomarkers could lead to improvements in IA management. This exploratory study examined circulating neutrophils to determine whether they carry RNA expression signatures of IAs. METHODS: Blood samples were collected from patients receiving cerebral angiography. Eleven samples were collected from patients with IAs and 11 from patients without IAs as controls...
2018: PloS One
https://www.readbyqxmd.com/read/29334797/association-of-functional-mmp-2-gene-variant-with-intracranial-aneurysms-case-control-genetic-association-study-and-meta-analysis
#6
Varinder S Alg, Xiayi Ke, Joan Grieve, Stephen Bonner, Daniel C Walsh, Diederik Bulters, Neil Kitchen, Henry Houlden, David J Werring
INTRODUCTION: Abnormalities in Matrix Metalloproteinase (MMP) genes, which are important in extracellular matrix (ECM) maintenance and therefore arterial wall integrity are a plausible underlying mechanism of intracranial aneurysm (IA) formation, growth and subsequent rupture. We investigated whether the rs243865 C > T SNP (single nucleotide polymorphism) within the MMP-2 gene (which influences gene transcription) is associated with IA compared to matched controls. MATERIALS AND METHODS: We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured)...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334776/multiple-intracranial-aneurysms-in-a-patient-with-type-i-gaucher-disease-a-case-report-and-literature-review
#7
Matthew R Reynolds, Daniel M Heiferman, Andrew B Boucher, Brian M Howard, Daniel L Barrow, Jacques E Dion
Multiple intracranial aneurysms (IAs) have never been reported in a patient with Gaucher disease (GD). A 69-year-old-female with type I GD presented with a left sixth nerve palsy due to a large posterior inferior cerebellar artery (PICA) aneurysm. Cerebral angiography demonstrated fifteen unruptured IAs (UIAs).
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29313805/nationwide-genetic-surveillance-of-plasmodium-vivax-in-papua-new-guinea-reveals-heterogeneous-transmission-dynamics-and-routes-of-migration-amongst-subdivided-populations
#8
Abebe A Fola, Elma Nate, G L Abby Harrison, Céline Barnadas, Manuel W Hetzel, Jonah Iga, Peter Siba, Ivo Mueller, Alyssa E Barry
The Asia Pacific Leaders in Malaria Alliance (APLMA) have committed to eliminate malaria from the region by 2030. Papua New Guinea (PNG) has the highest malaria burden in the Asia-Pacific region but with the intensification of control efforts since 2005, transmission has been dramatically reduced and Plasmodium vivax is now the dominant malaria infection in some parts of the country. To gain a better understanding of the transmission dynamics and migration patterns of P. vivax in PNG, here we investigate population structure in eight geographically and ecologically distinct regions of the country...
December 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29304371/rare-coding-variants-in-angptl6-are-associated-with-familial-forms-of-intracranial-aneurysm
#9
Romain Bourcier, Solena Le Scouarnec, Stéphanie Bonnaud, Matilde Karakachoff, Emmanuelle Bourcereau, Sandrine Heurtebise-Chrétien, Céline Menguy, Christian Dina, Floriane Simonet, Alexis Moles, Cédric Lenoble, Pierre Lindenbaum, Stéphanie Chatel, Bertrand Isidor, Emmanuelle Génin, Jean-François Deleuze, Jean-Jacques Schott, Hervé Le Marec, Gervaise Loirand, Hubert Desal, Richard Redon
Intracranial aneurysms (IAs) are acquired cerebrovascular abnormalities characterized by localized dilation and wall thinning in intracranial arteries, possibly leading to subarachnoid hemorrhage and severe outcome in case of rupture. Here, we identified one rare nonsense variant (c.1378A>T) in the last exon of ANGPTL6 (Angiopoietin-Like 6)-which encodes a circulating pro-angiogenic factor mainly secreted from the liver-shared by the four tested affected members of a large pedigree with multiple IA-affected case subjects...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29301971/intracranial-aneurysm-associated-single-nucleotide-polymorphisms-alter-regulatory-dna-in-the-human-circle-of-willis
#10
Melanie D Laarman, Marit W Vermunt, Rachel Kleinloog, Jelkje J de Boer-Bergsma, Netherlands Brain Bank, Gabriël J E Rinkel, Menno P Creyghton, Michal Mokry, Jeroen Bakkers, Ynte M Ruigrok
BACKGROUND AND PURPOSE: Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in 6 genomic loci. To gain insight into the relevance of these IA-associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop. METHODS: We performed chromatin immunoprecipitation and sequencing for histone modifications H3K4me1 and H3K27ac to identify regulatory regions, including distal enhancers and active promoters, in postmortem specimens of the human CoW...
January 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29291518/in%C3%A2-vivo-bioconcentration-of-a-metal-mixture-by-danio-rerio-eleutheroembryos
#11
S Zarco-Fernández, A García-García, J Sanz-Landaluze, C Pecheyran, R Muñoz-Olivas
Exposure to heavy metals has represented one of the most serious health risks of environmental pollution over the last 50 years. Most of the bioconcentration studies that have been carried out to date explored only individual contaminants, unlike the real situations that occur in the environment. In this work, zebrafish eleutheroembryos were exposed to a mixture of CH3Hg(II), iAs(III), Ag(I) and Cd(II), and new BCFs were calculated and compared with those calculated from single metal exposures. In both cases, experimental conditions meet the OECD Test 305 conditions established for aquatic systems...
December 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29290046/post-surgical-fecal-incontinence
#12
Filippo Pucciani
The primary endpoint of this work was to understand the pathophysiology of fecal incontinence manifested after rectal and anal surgery. A retrospective cohort study with negative colonoscopy patients was created and 169 postoperative incontinent patients were analyzed (114 women and 55 men: mean age 58.9 ± 6.3): clinical evaluation, endoanal ultrasound and anorectal manometry reports were scanned. The duration of incontinence was very long, with a mean of 21.7 months. The mean number of bowel movements/week was 18...
December 30, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/29281188/health-care-worker-decompression-sickness-incidence-risk-and-mitigation
#13
Richard Clarke
Inadvertent exposure to radiation, chemical agents and biological factors are well recognized hazards associated with the health care delivery system. Less well appreciated yet no less harmful is risk of decompression sickness in those who accompany patients as inside attendants (IAs) during provision of hyperbaric oxygen therapy. Unlike the above hazards where avoidance is practiced, IA exposure to decompression sickness risk is unavoidable. While overall incidence is low, when calculated as number of cases over number of exposures or potential for a case during any given exposure, employee cumulative risk, defined here as number of cases over number of IAs, or risk that an IA may suffer a case, is not...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29233817/exogenous-insulin-antibody-syndrome-eias-a-clinical-syndrome-associated-with-insulin-antibodies-induced-by-exogenous-insulin-in-diabetic-patients
#14
Xiaolei Hu, Fengling Chen
Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS...
December 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29228923/cdkn2bas-gene-polymorphisms-and-the-risk-of-intracranial-aneurysm-in-the-chinese-population
#15
Yunchang Chen, Gancheng Li, Haiyan Fan, Shenquan Guo, Ran Li, Jian Yin, Xin Zhang, Xifeng Li, Xuying He, Chuanzhi Duan
BACKGROUND: CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whether CDKN2BAS gene polymorphisms associated with Chinese patients with IA. METHODS: We selected 200 patients(52.69 ± 11.50) with sporadic IA as experimental group, 200 participants(49.99 ± 13.00) over the same period to the hospital without cerebrovascular diseases as control group...
December 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29228677/copper-or-and-arsenic-induce-oxidative-stress-cascaded-nuclear-factor-kappa-b-dependent-inflammation-and-immune-imbalance-trigging-heat-shock-response-in-the-kidney-of-chicken
#16
Yu Wang, Hongjing Zhao, Yizhi Shao, Juanjuan Liu, Jinglun Li, Mingwei Xing
Excessive amount of copper (Cu) and inorganic arsenic (iAs) coexists in drinking water in many regions, this is associated with high risk of nephropathy, defined as chronic structural and functional disorders of the kidney. However, the underlying mechanisms are not well understood. In this study, a total of 72 day-old Hy-line chickens were exposed to 300 mg/kg copper sulphate or/and 30 mg/kg arsenic trioxide for 12 weeks. Indicators of oxidative stress, inflammation and heat shock proteins (HSPs) production were analyzed in kidney...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226782/patterns-of-source-monitoring-bias-in-incarcerated-youths-with-and-without-conduct-problems
#17
Larisa Morosan, Deborah Badoud, George Salaminios, Stephan Eliez, Martial Van der Linden, Patrick Heller, Martin Debbané
INTRODUCTION: Antisocial individuals present behaviours that violate the social norms and the rights of others. In the present study, we examine whether biases in monitoring the self-generated cognitive material might be linked to antisocial manifestations during adolescence. We further examine the association with psychopathic traits and conduct problems (CPs). METHODS: Sixty-five incarcerated adolescents (IAs; M age = 15.85, SD = 1.30) and 88 community adolescents (CAs; M age = 15...
December 10, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29216956/increased-pit1-and-pit2-expression-in-streptozotocin-stz-induced-diabetic-mice-contributes-to-uptake-of-ias-v
#18
Sha Li Yu, Ling Fei Xu, Jun Xia Wu, Chen Juan Yao, Qiao Yun Hu, Chun Xue Zhang, Xin Yuan Zhao, Hai Yan Wei, Xiao Ke Wang, Gang Chen
OBJECTIVE: This study aimed to investigate the susceptibility of mice with streptozotocin(STZ)-induced diabetes mellitus (TIDM) to the uptake of pentavalent inorganic arsenic (iAsV) and the possible molecular mechanism. METHODS: TIDM was induced in mice by STZ. TIDM and normal mice were treated with 15.0 mg/kg Na2HAsO4·12H2O by intragastric administration. Then, the concentrations of arsenic in various tissues were measured by atomic fluorescence spectrometry. The gene expression levels of Pit1 and Pit2 were quantified by real-time RT-PCR, and their protein levels were detected by Western blotting in mouse heart, kidney, and liver tissues...
November 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29212582/benefits-of-intraluminal-agarose-stents-during-end-to-end-intestinal-anastomosis-in-new-zealand-white-rabbits
#19
Wen-Yao Kuo, Hsiao-Chun Huang, Shih-Wei Huang, Kuan-Hua Yu, Feng-Pang Cheng, Jiann-Hsiung Wang, Jui-Te Wu
In the present study, we evaluated the utility of an intraluminal agarose stent (IAS) for end-to-end intestinal anastomoses in rabbits. Female New Zealand white rabbits (n = 14) underwent conventional sutured anastomosis (CSA) with or without an IAS. IAS were used to maintain the luminal diameter for more rapid and accurate suturing, and then was squeezed transluminally to crush it into fragments, which passed through the intestines and were eliminated. The rabbits were euthanized on postoperative day 21. At necropsy, the anastomoses were assessed for adhesion formation, stenosis, and bursting pressure and were examined histologically for collagen content and blood vessel formation...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29204679/gestational-exposure-to-inorganic-arsenic-ias3-alters-glutamate-disposition-in-the-mouse-hippocampus-and-ionotropic-glutamate-receptor-expression-leading-to-memory-impairment
#20
Janikua Nelson-Mora, Martha L Escobar, Luis Rodríguez-Durán, Lourdes Massieu, Teresa Montiel, Verónica M Rodríguez, Karina Hernández-Mercado, María E Gonsebatt
Early life exposure to environmental pollutants and toxic chemicals has been linked to learning and behavioral alterations in children. iAs exposure is associated with different types neurological disorders such as memory and learning impairment. iAs is methylated in the brain by the arsenic III-methyltransferase in a process that requires glutathione (GSH). The xCT-antiporter cell membrane transporter participates in the influx of cystine for GSH synthesis in exchange for glutamate in a 1:1 ratio. In CD-1 mice gestationally exposed to 20 ppm of sodium arsenite in drinking water, we have previously observed up-regulation of xCT in the male mouse hippocampus which caused glutamatergic synapse alterations affecting learning and memory processes...
December 4, 2017: Archives of Toxicology
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