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https://www.readbyqxmd.com/read/28709971/epigenetic-mechanisms-underlying-the-toxic-effects-associated-with-arsenic-exposure-and-the-development-of-diabetes
#1
REVIEW
Fazlullah Khan, Saeideh Momtaz, Kamal Niaz, Fatima Ismail Hassan, Mohammad Abdollahi
BACKGROUND: Exposure to inorganic arsenic (iAs) is a major threat to the human health worldwide. The consumption of arsenic in drinking water and other food products is associated with the risk of development of type-2 diabetes mellitus (T2DM). The available experimental evidence indicates that epigenetic alterations may play an important role in the development of diseases that are linked with exposure to environmental toxicants. iAs seems to be associated with the epigenetic modifications such as alterations in DNA methylation, histone modifications, and micro RNA (miRNA) abundance...
July 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28689257/fluid-attenuated-inversion-recovery-vascular-hyperintensities-in-predicting-cerebral-hyperperfusion-after-intracranial-arterial-stenting
#2
Chih-Cheng Wan, David Yen-Ting Chen, Ying-Chi Tseng, Feng-Xian Yan, Kun-Yu Lee, Chen-Hua Chiang, Chi-Jen Chen
PURPOSE: No reliable imaging sign predicting cerebral hyperperfusion after intracranial arterial stenting (IAS) had been described in the literature. This study evaluated the effect of fluid-attenuated inversion recovery vascular hyperintensities (FVHs), also called hyperintense vessel sign on T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) MR images, in predicting significant increase in cerebral blood flow (CBF) defined by arterial spin labeling (ASL) after IAS. METHODS: We reviewed ASL CBF images and T2-FLAIR MR images before (D0), 1 day after (D1), and 3 days after (D3) IAS of 16 patients...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28688302/effects-of-gait-speed-on-the-body-s-center-of-mass-motion-relative-to-the-center-of-pressure-during-over-ground-walking
#3
Hsuan-Lun Lu, Mei-Ying Kuo, Chu-Fen Chang, Tung-Wu Lu, Shih-Wun Hong
Preferred walking speed (PWS) reflects the integrated performance of the relevant physiological sub-systems, including energy expenditure. It remains unclear whether the PWS during over-ground walking is chosen to optimize one's balance control because studies on the effects of speed on the body's balance control have been limited. The current study aimed to bridge the gap by quantifying the effects of the walking speed on the body's center of mass (COM) motion relative to the center of pressure (COP) in terms of the changes and directness of the COM-COP inclination angle (IA) and its rate of change (RCIA)...
July 5, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28682783/looks-can-be-deceiving-body-image-dissatisfaction-relates-to-social-anxiety-through-fear-of-negative-evaluation
#4
Yada Pawijit, Watcharaphon Likhitsuwan, Jason Ludington, Kullaya Pisitsungkagarn
Introduction Emerging adults are particularly vulnerable to body image dissatisfaction and social anxiety. These bring about a host of negative outcomes, including compromised social adjustment and well-being. Fear of negative evaluation has been shown to be a core element of social anxiety, but it is rarely considered in studies of body image and its effects on social anxiety. This study aimed to bridge this gap by examining the role of fear of negative evaluation in the association between body image dissatisfaction and social anxiety...
July 6, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28681739/molecular-mechanisms-of-the-intracranial-aneurysms-and-their-association-with-the-long-noncoding-ribonucleic-acid-anril-a-review-of-literature
#5
REVIEW
Jiang Che
Long noncoding ribonucleic acids (RNAs) are important regulators of gene expression. Antisense noncoding RNA in the INK4 locus (ANRIL), which was coded on the Chr9p21.3 loci, participates in the pathogenesis of tumor, coronary artery disease, type 2 diabetes mellitus, and other diseases. A genome-wide association study indicated ANRIL to be a candidate gene that may lead to the development of an intracranial aneurysm (IA) formation. However, the detailed molecular mechanisms are unknown and have not been studied...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28681496/transcutaneous-sacral-nerve-stimulation-for-intraoperative-verification-of-internal-anal-sphincter-innervation
#6
D W Kauff, T Moszkowski, C Wegner, A Heimann, K-P Hoffmann, T B Krüger, H Lang, W Kneist
BACKGROUND: The current standard for pelvic intraoperative neuromonitoring (pIONM) is based on intermittent direct nerve stimulation. This study investigated the potential use of transcutaneous sacral nerve stimulation for non-invasive verification of pelvic autonomic nerves. METHODS: A consecutive series of six pigs underwent low anterior rectal resection. For transcutaneous sacral nerve stimulation, an array of ten electrodes (cathodes) was placed over the sacral foramina (S2 to S4)...
July 6, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28678378/successful-treatment-of-passive-fecal-incontinence-in-an-animal-model-using-engineered-biosphincters-a-3-month-follow-up-study
#7
Jaime L Bohl, Elie Zakhem, Khalil N Bitar
Fecal incontinence (FI) is the involuntary passage of fecal material. Current treatments have limited successful outcomes. The objective of this study was to develop a large animal model of passive FI and to demonstrate sustained restoration of fecal continence using anorectal manometry in this model after implantation of engineered autologous internal anal sphincter (IAS) biosphincters. Twenty female rabbits were used in this study. The animals were divided into three groups: (a) Non-treated group: Rabbits underwent IAS injury by hemi-sphincterectomy without treatment...
July 5, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28673027/pretreatment-hiv-drug-resistance-results-in-virological-failure-and-accumulation-of-additional-resistance-mutations-in-ugandan-children
#8
Cissy Kityo, Ragna S Boerma, Kim C E Sigaloff, Elizabeth Kaudha, Job C J Calis, Victor Musiime, Sheila Balinda, Rita Nakanjako, T Sonia Boender, Peter N Mugyenyi, Tobias F Rinke de Wit
Background: Pretreatment HIV drug resistance (PDR) can impair virological response to ART, jeopardizing effective treatment for children. Methods: Children aged ≤12 years initiated first-line ART in Uganda during 2010-11. Baseline and 6 monthly viral load (VL) and genotypic resistance testing if VL >1000 copies/mL was done. The 2015 IAS-USA mutation list and Stanford algorithm were used to score drug resistance mutations (DRMs) and susceptibility. Virological failure (VF) was defined as two consecutive VLs >1000 copies/mL or death after 6 months of ART...
June 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28672730/analytical-and-clinical-performance-of-thyroglobulin-autoantibody-assays-in-thyroid-cancer-follow-up
#9
Waddah Katrangi, Stephan K G Grebe, Alicia Algeciras-Schimnich
BACKGROUND: While thyroglobulin autoantibodies (TgAb) can result in false low serum thyroglobulin (Tg) immunoassay (IA) measurements, they might also be indicators of disease persistence/recurrence. Hence, accurate TgAb measurement, in addition to Tg quantification, is crucial for thyroid cancer monitoring. We compared the analytical and clinical performance of four commonly used TgAb IAs. METHODS: We measured Tg by mass spectrometry (Tg-MS) and by four pairs of Tg and TgAb IAs (Beckman, Roche, Siemens, Thermo) in 576 samples...
June 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28665763/overall-and-specific-migration-from-multilayer-high-barrier-food-contact-materials-kinetic-study-of-cyclic-polyester-oligomers-migration
#10
Sara Úbeda, Margarita Aznar, Paula Vera, Cristina Nerín, Luis Henríquez, Laura Taborda, Claudia Restrepo
Most multilayer high barrier materials used in food packaging have a polyurethane adhesive layer in their structures. In order to assess the safety of these materials, it is important to determine the compounds intentionally added to the adhesives (IAS) as well as those non-intentionally added substances (NIAS). During the manufacture of polyurethane adhesives, some by-products can be formed, such as cyclic polyester oligomers coming from the reaction between dicarboxylic acids and glycols. Since these compounds are not listed in the Regulation 10/2011/EU, they should not be found in migration above 0...
June 30, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28659246/discovery-of-novel-dapy-ias-hybrid-derivatives-as-potential-hiv-1-inhibitors-using-molecular-hybridization-based-on-crystallographic-overlays
#11
Boshi Huang, Xueshun Wang, Xinhao Liu, Zihui Chen, Wanzhuo Li, Songkai Sun, Huiqing Liu, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Crystallographic overlap studies and pharmacophoric analysis indicated that diarylpyrimidine (DAPY)-based HIV-1 NNRTIs showed a similar binding mode and pharmacophoric features as indolylarylsulfones (IASs), another class of potent NNRTIs. Thus, a novel series of DAPY-IAS hybrid derivatives were identified as newer NNRTIs using structure-based molecular hybridization. Some target compounds exhibited moderate activities against HIV-1 IIIB strain, among which the two most potent inhibitors possessed EC50 values of 1...
June 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28652115/longitudinal-trends-of-hiv-drug-resistance-in-a-large-canadian-cohort-1996-2016
#12
Genevieve Rocheleau, Chanson J Brumme, Jeannie Shoveller, Viviane Lima, Richard Harrigan
OBJECTIVES: We aim to identify long-term trends in HIV drug resistance before and after combined antiretroviral therapy (cART) initiation. METHODS: IAS-USA (2015) mutations were identified in 23,271 HIV protease-reverse transcriptase sequences from 6543 treatment naïve British Columbia adults. Participants that started cART between 1996-2014 were followed until April 2016. Equality of proportions test compared the percentage of participants with acquired drug resistance (ADR) or transmitted drug resistance (TDR) in 1996, to those in 2014...
June 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28650453/regional-intra-arterial-steroid-treatment-in-120-patients-with-steroid-resistant-or-dependent-gvhd
#13
M Y Shapira, A Klimov, S Vipul, S Grisariu, B R Avni, R Or, A I Bloom
GvHD results in death in the majority of steroid-resistant patients. This report assesses the safety and efficacy of two regional intra-arterial steroid (IAS) treatment protocols in the largest published cohort of patients with resistant/dependent hepatic and/or gastrointestinal GvHD, as well as identification of predictors of response to IAS and survival. One hundred and twenty patients with hepatic, gastrointestinal GvHD or both were given IAS. Gastrointestinal initial response (IR) and complete response (CR) were documented in 67...
June 26, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28640505/associations-between-arsenic-3-oxidation-state-methyltransferase-as3mt-and-n-6-adenine-specific-dna-methyltransferase-1-n6amt1-polymorphisms-arsenic-metabolism-and-cancer-risk-in-a-chilean-population
#14
Rosemarie de la Rosa, Craig Steinmaus, Nicholas K Akers, Lucia Conde, Catterina Ferreccio, David Kalman, Kevin R Zhang, Christine F Skibola, Allan H Smith, Luoping Zhang, Martyn T Smith
Inter-individual differences in arsenic metabolism have been linked to arsenic-related disease risks. Arsenic (+3) methyltransferase (AS3MT) is the primary enzyme involved in arsenic metabolism, and we previously demonstrated in vitro that N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) also methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic dimethylarsonic acid (DMA). Here, we evaluated whether AS3MT and N6AMT1 gene polymorphisms alter arsenic methylation and impact iAs-related cancer risks...
July 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28638230/role-of-three-dimensional-endoanal-ultrasound-in-assessing-the-anal-sphincter-morphology-of-female-patients-with-chronic-proctalgia
#15
Ya-Hong Xue, Shu-Qing Ding, Yi-Jiang Ding, Li-Qun Pan
AIM: To assess the role of three-dimensional endoanal ultrasound (3D-EAUS) for morphological assessment of the anal sphincter of female patients with chronic proctalgia (CP). METHODS: In this unmatched case control study, 30 consecutive female patients with CP and 25 normal women (control group) were enrolled. 3D-EAUS was performed in all subjects. Thickness and length of internal anal sphincter (IAS), thickness of puborectalis muscle (PR), length of the external anal sphincter (EAS) plus PR, and puborectalis angle were measured and compared between the two groups...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28630262/dipeptidyl-peptidase-4-inhibitor-anagliptin-prevents-intracranial-aneurysm-growth-by-suppressing-macrophage-infiltration-and-activation
#16
Taichi Ikedo, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Manabu Nagata, Risako Fujikawa, Sei Higuchi, Mika Yasui, Tomohiro Aoki, Miyuki Fukuda, Masayuki Yokode, Susumu Miyamoto
BACKGROUND: Chronic inflammation plays a key role in the pathogenesis of intracranial aneurysms (IAs). DPP-4 (dipeptidyl peptidase-4) inhibitors have anti-inflammatory effects, including suppressing macrophage infiltration, in various inflammatory models. We examined whether a DPP-4 inhibitor, anagliptin, could suppress the growth of IAs in a rodent aneurysm model. METHODS AND RESULTS: IAs were surgically induced in 7-week-old male Sprague Dawley rats, followed by oral administration of 300 mg/kg anagliptin...
June 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28628334/chiral-indolylarylsulfone-non-nucleoside-reverse-transcriptase-inhibitors-as-new-potent-and-broad-spectrum-anti-hiv-1-agents
#17
Valeria Famiglini, Giuseppe La Regina, Antonio Coluccia, Domiziana Masci, Andrea Brancale, Roger Badia, Eva Riveira Muñoz, Jose A Este, Emmanuele Crespan, Alessandro Brambilla, Giovanni Maga, Myriam Catalano, Cristina Limatola, Francesca Romana Romana Formica, Roberto Cirilli, Ettore Novellino, Romano Silvestri
We designed and synthesized a series of chiral indolyarylsulfones (IASs) as new HIV-1 NNRTIs. The new IASs 8-37 showed potent inhibition of the HIV-1 WT NL4-3 strain and of the mutant K103N, Y181C, Y188L and K103N-Y181C HIV-1 strains. Six racemic mixtures, 8, 23-25, 31 and 33, were separated at semipreparative level into their pure enantiomers. The (R)-8 enantiomer bearing the chiral (α-methylbenzyl) was superior to the (S)-counterpart. IAS derivatives bearing the (S) alanine unit, (S)-23, (S,R)-25, (S)-31 and (S)-33, were remarkably more potent than the corresponding (R)-enantiomers...
June 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28625818/quantitative-assessment-of-lung-and-bladder-cancer-risk-and-oral-exposure-to-inorganic-arsenic-meta-regression-analyses-of-epidemiological-data
#18
Heather N Lynch, Ke Zu, Erin M Kennedy, Thuy Lam, Xiaobin Liu, Daniella M Pizzurro, Christine T Loftus, Lorenz R Rhomberg
Inorganic arsenic (iAs) in drinking water varies geographically and is prevalent worldwide. While exposures in the US are generally low, there are some areas with higher levels of naturally occurring iAs (potentially >100μg/L) where residents rely on unregulated drinking water wells. Much of the evidence on the association between iAs and cancer comes from epidemiological studies conducted in South American and Asian populations. These populations have generally been exposed to much higher levels of iAs and have differing underlying characteristics, both of which make comparing them to Western populations difficult...
June 16, 2017: Environment International
https://www.readbyqxmd.com/read/28625634/imaging-features-of-tsct-predict-the-classification-of-pulmonary-preinvasive-lesion-minimally-and-invasive-adenocarcinoma-presented-as-ground-glass-nodules
#19
Yinan Liu, Hui Sun, Fei Zhou, Chunxia Su, Guanghui Gao, Shengxiang Ren, Caicun Zhou, Zhemin Zhang, Jingyun Shi
OBJECTIVES: To comprehensively investigate the role of thin section computed tomography(TSCT) features to distinguish invasive adenocarcinoma(IA) from preinvasive or minimally invasive adenocarcinoma(MIA) appearing as pure or mixed ground glass nodules (pGGNs, mGGNs), and to distinguish adenocarcinoma in situ (AIS) from atypical adenomatous hyperplasia (AAH) in pGGNs. MATERIALS AND METHODS: Three hundred thirteen patients with 334 pathologically diagnosed GGNs according to the 2011 IASLC/ATS/ERS classification were included into this study...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28619494/role-of-hemodynamics-forces-in-unruptured-intracranial-aneurysms-an-overview-of-a-complex-scenario
#20
REVIEW
Marcello Longo, Francesca Granata, Sergio Racchiusa, Enricomaria Mormina, Grasso Giovanni, Giuseppe Maria Longo, Giada Garufi, Francesco M Salpietro, Concetta Alafaci
BACKGROUND: The understanding of unruptured intracranial aneurysms (IAs) natural history has always played a critical role in pre-surgical or endovascular planning, in order to avoid possible fatal events. Size, shape, morphology and location are known risk factors for aneurysm's rupture, but morphologic parameters alone, may not be sufficient in order to perform a proper rupture risk stratification. METHODS: We performed a systematic PUBMED search and focused on hemodynamics forces which may influence aneurysmal initiation, growth and rupture...
June 12, 2017: World Neurosurgery
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