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Nicole Varble, Vincent M Tutino, Jihnhee Yu, Ashish Sonig, Adnan H Siddiqui, Jason M Davies, Hui Meng
BACKGROUND AND PURPOSE: Many ruptured intracranial aneurysms (IAs) are small. Clinical presentations suggest that small and large IAs could have different phenotypes. It is unknown if small and large IAs have different characteristics that discriminate rupture. METHODS: We analyzed morphological, hemodynamic, and clinical parameters of 413 retrospectively collected IAs (training cohort; 102 ruptured IAs). Hierarchal cluster analysis was performed to determine a size cutoff to dichotomize the IA population into small and large IAs...
March 13, 2018: Stroke; a Journal of Cerebral Circulation
Torbjørn Øygard Skodvin, Øyvind Evju, Angelika Sorteberg, Jørgen Gjernes Isaksen
BACKGROUND: Maximal size and other morphological parameters of intracranial aneurysms (IAs) are used when deciding if an IA should be treated prophylactically. These parameters are derived from postrupture morphology. As time and rupture may alter the aneurysm geometry, possible morphological predictors of a rupture should be established in prerupture aneurysms. OBJECTIVE: To identify morphological parameters of unruptured IAs associated with later rupture. METHODS: Nationwide matched case-control study...
February 26, 2018: Neurosurgery
Yongchun Deng, Hua Xu, XiaoHua Zeng
Different epidemiological studies have indicated conflicting information about the association of induced abortion (IA) with breast cancer risk. A recent meta-analysis with prospective evidences did not support the positive association between IA and breast cancer risk. Thus, we in our meta-analysis study have tried to analyze this specific association.We searched all relevant articles from an English-language literature using Pubmed, Embase, and Cochrane databases, until December 10, 2016. All the statistical analyses were performed on case-control studies, using Review Manager Software 5...
January 2018: Medicine (Baltimore)
Thomas Evans, Philine Zu Ermgassen, Tatsuya Amano, Kelvin S-H Peh
Invasive alien species (IAS) constitute a major threat to global biological diversity. In order to control their spread, a detailed understanding of the factors influencing their distribution is essential. Although international trade is regarded as a major force structuring spatial patterns of IAS, the role of other social factors remains unclear. Despite studies highlighting the importance of strong governance in slowing drivers of biodiversity loss such as logging, deforestation, and agricultural intensification, no study has yet analyzed its contribution to the issue of IAS...
February 2018: Ecology and Evolution
Seth C Inzaule, Raph L Hamers, Marc Noguera-Julian, Maria Casadellà, Mariona Parera, Tobias F Rinke de Wit, Roger Paredes
Objectives: To investigate the prevalence and patterns of major and accessory resistance mutations associated with integrase strand transfer inhibitors (INSTIs), across diverse HIV-1 subtypes in sub-Saharan Africa. Methods: pol gene sequences were obtained using Illumina next-generation sequencing from 425 INSTI-naive HIV-infected adults from Kenya (21.2%), Nigeria (7.3%), South Africa (22.8%), Uganda (25.2%) and Zambia (23.5%). Drug resistance interpretation was based on the IAS 2017 mutation list and accessory mutations from Stanford HIVdb with resistance penalty scores of ≥10 to at least 1 INSTI...
February 14, 2018: Journal of Antimicrobial Chemotherapy
H-L Zhang, L Li, C-J Cheng, X-C Sun
OBJECTIVE: The study aims to detect the association of miR-146a-5p with intracranial aneurysms (IAs). PATIENTS AND METHODS: The expression of miR-146a-5p was compared from plasma samples between 72 patients with intracranial aneurysms (IAs) and 40 healthy volunteers by quantitative Real-time polymerase chain reaction (qRT-PCR). Statistical analysis was performed to analyze the relationship between miR-146a-5p expression and clinical data and overall survival (OS) time of IAs patients...
February 2018: European Review for Medical and Pharmacological Sciences
Kagan Kircaburun, Mark D Griffiths
Background and aims Recent research has suggested that social networking site use can be addictive. Although extensive research has been carried out on potential addiction to social networking sites, such as Facebook, Twitter, YouTube, and Tinder, only one very small study has previously examined potential addiction to Instagram. Consequently, the objectives of this study were to examine the relationships between personality, self-liking, daily Internet use, and Instagram addiction, as well as exploring the mediating role of self-liking between personality and Instagram addiction using path analysis...
February 20, 2018: Journal of Behavioral Addictions
Chris Kay, Jennifer A Collins, Galen E B Wright, Fiona Baine, Zosia Miedzybrodzka, Folefac Aminkeng, Alicia J Semaka, Cassandra McDonald, Mark Davidson, Steven J Madore, Erynn S Gordon, Norman P Gerry, Mario Cornejo-Olivas, Ferdinando Squitieri, Sarah Tishkoff, Jacquie L Greenberg, Amanda Krause, Michael R Hayden
Huntington disease (HD) is the most common monogenic neurodegenerative disorder in populations of European ancestry, but occurs at lower prevalence in populations of East Asian or black African descent. New mutations for HD result from CAG repeat expansions of intermediate alleles (IAs), usually of paternal origin. The differing prevalence of HD may be related to the rate of new mutations in a population, but no comparative estimates of IA frequency or the HD new mutation rate are available. In this study, we characterize IA frequency and the CAG repeat distribution in fifteen populations of diverse ethnic origin...
February 20, 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Brenda Gamboa-Loira, César Hernández-Alcaraz, A Jay Gandolfi, Mariano E Cebrián, Ana Burguete-García, Angélica García-Martínez, Lizbeth López-Carrillo
BACKGROUND: Nutrients and genetic polymorphisms participating in one-carbon metabolism may explain interindividual differences in inorganic arsenic (iAs) methylation capacity, which in turn may account for variations in susceptibility to iAs-induced diseases. OBJECTIVES: 1) To evaluate the association between polymorphisms in five one-carbon metabolism genes (FOLH1 c.223 T > C, MTHFD1 c.1958 G > A, MTHFR c.665 C > T, MTR c.2756 A > G, and MTRR c...
February 17, 2018: Environmental Research
Roxane Guillod-Magnin, Beat J Brüschweiler, Rafael Aubert, Max Haldimann
Inorganic arsenic (iAs) is a contaminant present in food, especially in rice and rice-based products. Toxicity of arsenic compounds (As) depends on species and oxidative state. Inorganic arsenic species, such as arsenite (As(III)) and arsenate (As(V)), are more bioactive and toxic than organic arsenic species, like methylarsonic acid (MMA(V)) and dimethylarsinic acid (DMA(V)) or arsenosugars and arsenobetaine. An ion chromatography-inductively coupled plasma-mass spectroscopy (IC-ICP-MS) method was developed to separate the four following arsenic anions: As(III), As(V), MMA(V) and DMA(V)...
February 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Vicent Yusà, Rosa Pérez, Alfredo Sánchez, Olga Pardo, Marta Roca
We present a new approach to arsenic (As) risk assessment using biomonitoring. In this pilot study we determined the levels of total and speciated urinary arsenicin 109 Spanish school children aged between 6 and 11 years, and interpreted these concentrations in a risk assessment context. The geometric mean (GM) for total As (TAs) was 33.82 μ/L. The order of occurrence and average concentrations of the different species was arsenobetaine (AsB) (100%, 15 μg/L), dimethylarsinic (DMA) (97%, 8.32 μg/L), monomethylarsonic (MMA) (26%, 0...
February 11, 2018: Science of the Total Environment
Guang-Xian Wang, Jun Liu, You-Qiang Chen, Li Wen, Ming-Guang Yang, Ming-Fu Gong, Dong Zhang
OBJECTIVE: Patient related clinical factors and intracranial aneurysms (IAs) at different locations may lead to statistical bias when investigating the rupture risk of IAs. Thus the purpose of this study was to identify the morphological parameters that are related to the rupture of mirror posterior communicating artery aneurysms (PComAAs). METHODS: Between August 2011 and July 2017, 68 patients with mirror PComAAs and aneurysmal subarachnoid hemorrhage were diagnosed by CT angiography at three medical centers...
February 2, 2018: Journal of Neurointerventional Surgery
Bing Li, Xining Zhang, Tingting Wu
Recently, Instantaneous Angular Speed (IAS) measurement is successfully established and prevalently applied to a wide variety of machines due to the hypothesis that the speed fluctuation of rotating machinery carries plentiful dynamic responses. Nevertheless, exploration and application based on angular signal are still insufficient. Under the same hypothesis, in this paper, we introduced an extended algorithm named Instantaneous Angular Phase Demodulation (IAPD), together with the selection of optimal sideband family to extract the Instantaneous Angular Displacement Fluctuation (IADF) signal...
February 8, 2018: ISA Transactions
Fabrizio Minichilli, Fabrizio Bianchi, Anna Maria Ronchi, Francesca Gorini, Elisa Bustaffa
Arsenic is ubiquitous and has a potentially adverse impact on human health. We compared the distribution of concentrations of urinary inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian areas with other international studies, and we assessed the relationship between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human biomonitoring study on 271 subjects (132 men) aged 20-44, randomly sampled and stratified by area, gender, and age. Data on environmental and occupational exposure and dietary habits were collected through a questionnaire...
February 9, 2018: International Journal of Environmental Research and Public Health
Yoshito Hirata, Kai Morino, Koichiro Akakura, Celestia S Higano, Kazuyuki Aihara
Using a dataset of 150 patients treated with intermittent androgen suppression (IAS) through a fixed treatment schedule, we retrospectively designed a personalized treatment schedule mathematically for each patient. We estimated 100 sets of parameter values for each patient by randomly resampling each patient's time points to take into account the uncertainty for observations of prostate specific antigen (PSA). Then, we identified 3 types and classified patients accordingly: in type (i), the relapse, namely the divergence of PSA, can be prevented by IAS; in type (ii), the relapse can be delayed by IAS later than by continuous androgen suppression (CAS); in type (iii) IAS was not beneficial and therefore CAS would have been more appropriate in the long run...
February 8, 2018: Scientific Reports
Valeria Famiglini, Romano Silvestri
Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by Merck AG have been analysed with focus on introduction of the 3',5'-dimethyl groups at the 3-phenylsulfonyl moiety, the 2-hydroxyethyl tail at the indole-2-carboxamide nitrogen, coupling of the carboxamide nitrogen with one or two glycinamide and alaninamide units, a fluorine atom at position 4 of the indole ring and correlation between configuration of the asymmetric centre and linker length...
January 2018: Antiviral Chemistry & Chemotherapy
Lisa Smeester, Rebecca C Fry
PURPOSE OF REVIEW: Exposure to inorganic arsenic (iAs) via drinking water represents a significant global public health threat with chronic exposure associated with cancer, skin lesions, neurological impairment, and cardiovascular diseases. Particularly susceptible populations include the developing fetus and young children. This review summarizes some of the critical studies of the long-term health effects and underlying biological mechanisms related to developmental exposure to arsenic...
February 6, 2018: Current Environmental Health Reports
Noam Tau, Udi Sadeh-Gonik, Gilles Aulagner, Francis Turjman, Benjamin Gory, Xavier Armoiry
OBJECTIVES: Endovascular treatment of wide-neck intracranial aneurysms (IAs) is challenging, especially in bifurcation location. The intra-saccular flow-disruptor Woven EndoBridge (WEB) offers a new concept of endovascular therapy for wide-neck IAs. We performed an update of a systematic review aimed to report the feasibility, effectiveness and safety of WEB device therapy. PATIENTS AND METHODS: A systematic review was conducted using several electronic databases (including PUBMED and EMBASE), searching for studies published between October 2015 and December 2017 (those published between January 2010 and September 2015 were included in our initial systematic review)...
March 2018: Clinical Neurology and Neurosurgery
Oluwadamilare A Adebambo, Damian Shea, Rebecca C Fry
Epidemiologic studies indicate an association between exposure to cadmium (Cd) and placental-related pregnancy disorders. While a precise mechanism is unknown, oxidative imbalance and dysregulation of the hypoxia inducible factor (HIF) and transforming growth factor beta (TGF-β) pathways have been implicated in placental disease pathogenesis. Here we investigated key oxidative and placentation pathways in JEG-3 placental trophoblast cells treated with Cd alone, environmental water samples predominated by Cd with low concentrations of other metals (e...
February 2, 2018: Toxicology and Applied Pharmacology
Carolina Camacho, A Cristina Rocha, Vera L Barbosa, Patrícia Anacleto, M Luísa Carvalho, Rie R Rasmussen, Jens J Sloth, C Marisa Almeida, António Marques, M Leonor Nunes
Sea urchin represents one of the most valuable seafood product being harvested and explored for their edible part, the gonads or roe. This species is generally considered a sentinel organism for ecotoxicological studies being widely used in monitoring programs to assess coastal aquatic environments quality, because is directly exposed to anthropogenic contaminants in their habitat. In this context, the aim of this study is to evaluate the concentrations of macro (Cl, K, P, Ca, S) and trace (Zn, Br, Fe, Sr, I, Se, Rb, Cu, Cr, Ni, As, iAs, Cd, Pb, Hg) elements in Paracentrotus lividus gonads from three South West Atlantic production areas subjected to distinct environmental and anthropogenic pressures...
January 29, 2018: Environmental Research
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