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A F Silva, J Vercruysse, C Vervaet, J P Remon, J A Lopes, T De Beer, M C Sarraguça
The present study aims at acquiring an in-depth process knowledge about a twin-screw granulation and fluid bed drying process performed on the commercially available continuous line. Batch Statistical Process Monitoring (BSPM) principles are used to describe and monitor the variables with a relevant time-related trajectory. The continuous granulator operates in a truly continuous manner and variables logged by this unit do not present time-relevant features. On the other hand, the fluid bed dryer is divided in six identical cells, which are sequentially filled and discharged, ensuring a continuous flow of material...
April 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Lynn M Rose, Fiona Wills, Connie Bourassa-Shaw, Terri L Butler, Jeanette Griscavage Ennis, Kim Emmons, Patrick Shelby, Meher Antia, Kim Folger Bruce
Introduction: The Institute of Translational Health Sciences (ITHS), a Clinical and Translational Science Award (CTSA)-funded program at the University of Washington (UW), established the Drug and Device Advisory Committee (DDAC) to provide product-specific scientific and regulatory mentoring to investigators seeking to translate their discoveries into medical products. An 8-year retrospective analysis was undertaken to evaluate the impact of the DDAC programs on commercialization metrics...
August 2017: Journal of Clinical and Translational Science
Xudong Ge, Prosper Adangwa, Ja Young Lim, Yordan Kostov, Leah Tolosa, Richard Pierson, Daniel Herr, Govind Rao
Blood gas measurements provide vital clinical information in critical care. The current "gold standard" for blood gas measurements involves obtaining blood samples, which can be painful and can lead to bleeding, thrombus formation, or infection. Mass transfer equilibrium-based transcutaneous blood gas monitors have been used since the 1970s, but they require heating the skin to ≥42 °C to speed up the transcutaneous gas diffusion. Thus, these devices have a potential risk for skin burns. Here we report a new generation of noninvasive device for respiratory status assessment...
April 5, 2018: Medical Engineering & Physics
Wendy Aartsen, Paul Peeters, Scott Wagers, Bryn Williams-Jones
Projects in public-private partnerships, such as the Innovative Medicines Initiative (IMI), produce data services and platforms (digital assets) to help support the use of medical research data and IT tools. Maintaining these assets beyond the funding period of a project can be a challenge. The reason for that is the need to develop a business model that integrates the perspectives of all different stakeholders involved in the project, and these digital assets might not necessarily be addressing a problem for which there is an addressable market of paying customers...
2018: Frontiers in Medicine
Thomas Kriechbaumer, Hans-Arno Jacobsen
Energy metering has gained popularity as conventional meters are replaced by electronic smart meters that promise energy savings and higher comfort levels for occupants. Achieving these goals requires a deeper understanding of consumption patterns to reduce the energy footprint: load profile forecasting, power disaggregation, appliance identification, startup event detection, etc. Publicly available datasets are used to test, verify, and benchmark possible solutions to these problems. For this purpose, we present the BLOND dataset: continuous energy measurements of a typical office environment at high sampling rates with common appliances and load profiles...
March 27, 2018: Scientific Data
Sam Cartwright-Hatton, Donna Ewing, Suzanne Dash, Zoe Hughes, Ellen J Thompson, Cassie M Hazell, Andy P Field, Helen Startup
OBJECTIVES: Children of anxious parents are at high risk of anxiety disorders themselves. The evidence suggests that this is due to environmental rather than genetic factors. However, we currently do little to reduce this risk of transmission. There is evidence that supporting parenting in those with mental health difficulties can ameliorate this risk. Therefore, the objective of this study was to test the feasibility of a new one-session, group-based, preventive parenting intervention for parents with anxiety disorders...
March 25, 2018: British Journal of Clinical Psychology
Wenlin Jia, Jian Zhang, Yumiao Lu, Guangchao Li, Weihua Yang, Qian Wang
Static magnetic field (SMF) with the intensity of 15 mT was applied during partial nitrification (PN) process to evaluate the impacts on nitrogen transformation and microbial characteristics. Results showed that the startup period of PN process at ambient temperature was markedly shortened by SMF, and the nitrite accumulation increased by 18% due to SMF exposure. The ammonia oxidizing bacteria (AOB) amoA gene copy numbers in the reactor with SMF exposure were 40% higher than that without SMF exposure, indicating the AOB abundance was enriched by SMF exposure...
March 14, 2018: Bioresource Technology
Rupesh K Chikara, Erik C Chang, Yi-Chen Lu, Dar-Shong Lin, Chin-Teng Lin, Li-Wei Ko
A reward or punishment can modulate motivation and emotions, which in turn affect cognitive processing. The present simultaneous functional magnetic resonance imaging-electroencephalography study examines neural mechanisms of response inhibition under the influence of a monetary reward or punishment by implementing a modified stop-signal task in a virtual battlefield scenario. The participants were instructed to play as snipers who open fire at a terrorist target but withhold shooting in the presence of a hostage...
2018: Frontiers in Human Neuroscience
Ilaria Pigliautile, Anna Laura Pisello
Urban population is predicted to increase rapidly and massively in the next decades, by producing also the exacerbation of urban scale climate change imputable to anthropogenic actions, such as urban heat island. In this view, urban pedestrians assume a key role in determining city livability in dense built environments, typically much more polluted than suburban or rural areas. Despite that, urban heat island experimental studies are pretty focused on data collected by means of permanent microclimate stations for environmental monitoring, also coupled with satellite measurements or mobile stations equipped over transportation media...
February 26, 2018: Science of the Total Environment
Norbert Serfozo, Jakub Ondráček, Thodoros Glytsos, Mihalis Lazaridis
The aim of this study was to evaluate the nanoparticle emissions from a laser printer in a chamber in conjunction with emissions from printers in a print room (PR) and to characterize the processes that lead to increased nanoparticle concentrations, as well as to estimate the human particle dose of the printers' users. Measurements were conducted in a small stainless steel environmental chamber under controlled conditions, where the evolution of particle size distributions (PSDs) with time and printed pages was studied in detail...
February 27, 2018: Environmental Science and Pollution Research International
(no author information available yet)
New startups are developing pattern-recognition algorithms that could one day help pathologists more accurately spot tumors on digitized tissue images, thereby aiding in diagnosis, treatment, drug discovery, and more.
February 23, 2018: Cancer Discovery
Alexander J Cowell, Gary A Zarkin, Brendan J Wedehase, Jennifer Lerch, Scott T Walters, Faye S Taxman
INTRODUCTION: Although substance use is common among probationers in the United States, treatment initiation remains an ongoing problem. Among the explanations for low treatment initiation are that probationers are insufficiently motivated to seek treatment, and that probation staff have insufficient training and resources to use evidence-based strategies such as motivational interviewing. A web-based intervention based on motivational enhancement principles may address some of the challenges of initiating treatment but has not been tested to date in probation settings...
April 2018: Journal of Substance Abuse Treatment
Nicole E Curci, Patrick Gartland, Prasad R Shankar, Jeffrey S Montgomery, David C Miller, Arvin K George, Matthew S Davenport
PURPOSE: To evaluate a 12-month long-distance prostate MRI quality assurance (QA) program. METHODS: The need for IRB approval was waived for this prospective longitudinal QA effort. One academic institution experienced with prostate MRI [~ 1000 examinations/year (Site 2)] partnered with a private institution 240 miles away that was starting a new prostate MRI program (Site 1). Site 1 performed all examinations (N = 249). Four radiologists at Site 1 created finalized reports, then sent images and reports to Site 2 for review on a rolling basis...
February 22, 2018: Abdominal Radiology
Louise McCusker, Marie-Louise Turner, Georgina Pike, Helen Startup
BACKGROUND: The effective treatment of Borderline Personality Disorder (BPD) presents healthcare providers with a significant challenge. The evidence base remains limited partially due to a lack of professional consensus and service user involvement regarding ways of measuring change. As a result, the limited evidence that is available draws on such a wide range of outcome measures, that comparison across treatment types is hindered, maintaining a lack of clarity regarding the clinical needs of this group...
February 19, 2018: Behavioural and Cognitive Psychotherapy
(no author information available yet)
Biotechnology startup Arvinas is developing proteolysis-targeting chimeras (PROTAC) that combat cancer by degrading disease-causing proteins. The company's first PROTACs will target prostate and breast cancers, and a recent deal with Pfizer will allow Arvinas to develop PROTACs for other cancer types.
February 16, 2018: Cancer Discovery
Julia Hagen, Wolfgang Lauer
As is the case in other sectors, innovative digital products have started to enter the health market, too. If digital products like apps are considered medical devices, startups are often confronted with regulatory procedures that they deem to be slow and with which they are not familiar. This applies to both the certification procedures and the requirements and procedures for reimbursement, where problems could occur. The aim of this article is to better understand the startups' experience in navigating through these procedures, the hurdles they encounter, and their need for support...
February 5, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Chantal Herberz, Ralph Steidl, Pascal Werner, Julia Hagen
Digital health products and services have started to fundamentally change healthcare and prevention. Products intended for a medical use require CE-marking and potentially certification (ISO 13485) of the company. Startups play an important role in the development of new digital products and services. Two startups share their experience with these processes. Becoming a part of standard care and hence being reimbursed is a challenge for startups. For this reason, startups pursue alternative sources of income, too...
January 30, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
R M Holzem, C M Gardner, C K Gunsch
Triclosan (TCS) is a broad range antimicrobial agent used in many personal care products, which is commonly discharged to wastewater treatment facilities (WWTFs). This study examined the impact of TCS on wastewater treatment performance using laboratory bench-scale sequencing batch reactors (SBRs) coupled with anaerobic digesters. The SBRs were continuously fed synthetic wastewater amended with or without 0.68 μM TCS, with the aim of determining the effect of chronic TCS exposure as opposed to a pulse TCS addition as previously studied...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Nikolaos Zirogiannis, Alex J Hollingsworth, David M Konisky
We analyze excess emissions from industrial facilities in Texas using data from the Texas Commission on Environmental Quality. Emissions are characterized as excess if they are beyond a facility's permitted levels and if they occur during startups, shutdowns, or malfunctions. We provide summary data on both the pollutants most often emitted as excess emissions and the industrial sectors and facilities responsible for those emissions. Excess emissions often represent a substantial share of a facility's routine (or permitted) emissions...
January 27, 2018: Environmental Science & Technology
Belén Cruz Zapata, José Luis Fernández-Alemán, Ambrosio Toval, Ali Idri
One of the key factors for the adoption of mobile technologies, and in particular of mobile health applications, is usability. A usable application will be easier to use and understand by users, and will improve user's interaction with it. This paper proposes a software requirements catalog for usable mobile health applications, which can be used for the development of new applications, or the evaluation of existing ones. The catalog is based on the main identified sources in literature on usability and mobile health applications...
January 25, 2018: Journal of Medical Systems
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