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https://www.readbyqxmd.com/read/29141182/optogenetic-activation-of-5-ht-neurons-in-the-dorsal-raphe-suppresses-seizure-induced-respiratory-arrest-and-produces-anticonvulsant-effect-in-the-dba-1-mouse-sudep-model
#1
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold, Norman E Taylor, Ken Solt, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the development of preventive strategies against SUDEP. Serotonin (5-HT) is an important modulator for many vital functions, including respiration and arousal, and a deficiency of 5-HT signaling is strongly implicated in S-IRA in animal models, including the DBA/1 mouse...
November 12, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29140427/sudden-unexpected-cardiac-death-on-monday-in-younger-and-older-men-the-manitoba-follow-up-study
#2
Robert B Tate, Philip D St John
No abstract text is available yet for this article.
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29134467/diterpenoid-natural-compound-c4-crassin-exerts-cytostatic-effects-on-triple-negative-breast-cancer-cells-via-a-pathway-involving-reactive-oxygen-species
#3
Cathy E Richards, Sri H Vellanki, Yvonne E Smith, Ann M Hopkins
PURPOSE: Triple-negative breast cancers (TNBC) lack expression of three common cell surface receptors, i.e., estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). Accordingly, TNBCs are associated with fewer treatment options and a relatively poor prognosis. Having screened a National Cancer Institute natural compound library, the purpose of this study was to investigate the bioactivity of compound C4 (Crassin) in TNBC cells. METHODS: Cell viability assays were performed in two TNBC cell lines, MDA-MB-231 and 4T1, following C4 treatment in the presence or absence of the antioxidant N-acetyl-L-cysteine (NAC)...
November 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29133025/perivalvular-mitral-abscess-fistulised-to-the-pericardial-cavity-revealing-staphylococcal-endocarditis
#4
Paul Desaint, Anthony Chauvat, Thomas Garaud, Olivier Andremont, Gaëtan Plantefève, Hervé Mentec, Damien Contou
BACKGROUND: Fistula to the pericardial cavity is a very rare complication of perivalvular abscess during infective endocarditis, with Staphylococcus aureus being the most commonly associated microorganism. METHODS: We report a fatal septic shock due to a mitral endocarditis revealed by a myocardial abscess fistulised toward the pericardial cavity. RESULTS: A 66-year-old female without previous valvular disease was admitted to intensive care for severe sepsis...
October 31, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29132773/-maternal-deaths-due-to-sudden-death-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#5
E Morau, E Beaumont, E Verspyck
Sudden death is defined as unexpected cardiac arrest occurring less than one hour after the onset of the first symptoms. Between 2010 and 2012, 23 maternal deaths were considered as unexplained sudden deaths and three of them were not evaluated due to a lack of clinical data. In addition, 13 maternal deaths with an identified cause occurred in a clinical context of sudden death (7 cases of pulmonary embolism, 2 cases of epilepsy, and 2 cases of cardiomyopathy). The first maneuvers of resuscitation in the presence of bystanders were attempted in 8 of 22 cases (36%)...
November 10, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29131479/measuring-the-success-of-medical-emergency-teams-potentially-preventable-deaths-versus-total-cardiac-arrest-deaths-a-single-centre-observational-study
#6
Jonathan Barrett, Gabrielle Hawdon, Julie Wade, John Reeves
Measuring the success of Medical Emergency Teams: Potentially preventable deaths versus total cardiac arrest deaths. A single centre observational study. BACKGROUND: Rapid response systems (RRS) have been implemented with the aim of preventing patient deterioration, in-hospital cardiac arrests (IHCA) and related deaths. Not all "unexpected deaths" are preventable, thus compromising the use of unexpected deaths as an outcome measure. AIMS: Our aim was to assess temporal trends in potentially preventable deaths as a subset of total unexpected death rates over a four-year period...
November 13, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29128679/early-onset-epileptic-encephalopathy-with-de-novo-scn8a-mutation
#7
Yangyang Xiao, Jie Xiong, Ding'an Mao, Lingjuan Liu, Jian Li, Xingfang Li, Haiyan Luo, Liqun Liu
Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. In this study, Childhood-Onset Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was diagnosed with EOEE...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29125216/evaluation-of-a-sudden-unexpected-death-in-infancy-intervention-programme-aimed-at-improving-parental-awareness-of-risk-factors-and-protective-infant-care-practices
#8
Christine McIntosh, Adrian Trenholme, Joanna Stewart, Alison Vogel
AIM: Sudden unexpected death in infancy (SUDI) rates for Māori and Pacific infants remain higher than for other ethnic groups in New Zealand and bed-sharing is a major risk factor when there is smoking exposure in pregnancy. Sleep space programmes of education and Pēpi-Pod baby beds require evaluation. METHODS: Two hundred and forty Māori and Pacific women and infants were randomised 1:1, to the Pēpi-Pod sleep space programme, or to a control group with 'usual care'...
November 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29121791/unexpected-survivors-children-with-life-limiting-conditions-of-uncertain-prognosis
#9
Savithri Nageswaran, Anna Hurst, Andrea Radulovic
OBJECTIVE: Prognostication of survival is difficult in children with life-limiting illnesses because of the rarity of these conditions and technological advances improving survival. The objective of this article is to describe the characteristics of children with life-limiting illnesses who survived longer than the expectations of health-care providers. STUDY DESIGN: This is a retrospective cohort study conducted in a tertiary-care children's hospital in North Carolina...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29117446/challenging-rules-creating-values-park-s-sweet-spot-theory-driven-central-optimum-nurse-staffing-zone
#10
EDITORIAL
Claire Su-Yeon Park
The nursing shortage is a serious global issue. Low birth rates and a rapidly aging population are accelerating the demands of nursing professionals. However, the challenging aspects of nurses' work environment-e.g., a poor salary, long shift length, heavy workload, temporary staffing, or bullying-are still ongoing, leading to compromised patient care, more care left undone, adverse events, poor care quality, inequity in access to healthcare, longer waiting times, burnout and illness among nurses, and even unexpected yet preventable patient deaths (Ball et al...
November 8, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29117093/death-of-a-simulated-pediatric-patient-toward-a-more-robust-theoretical-framework
#11
Mary E McBride, Dana Aronson Schinasi, Michael Alice Moga, Shreepada Tripathy, Aaron Calhoun
INTRODUCTION: A theoretical framework was recently proposed that encapsulates learner responses to simulated death due to action or inaction in the pediatric context. This framework, however, was developed at an institution that allows simulated death and thus does not address the experience of those centers at which this technique is not used. To address this, we performed a parallel qualitative study with the intent of augmenting the initial framework. METHODS: We conducted focus groups, using a constructivist grounded theory approach, using physicians and nurses who have experienced a simulated cardiac arrest...
November 8, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29105057/potentially-high-risk-cardiac-arrhythmias-with-focal-to-bilateral-tonic-clonic-seizures-and-generalized-tonic-clonic-seizures-are-associated-with-the-duration-of-periictal-hypoxemia
#12
Katherine J Park, Gaurav Sharma, Jeffrey D Kennedy, Masud Seyal
OBJECTIVE: To investigate potentially high-risk cardiac arrhythmias (PHAs) following focal to bilateral tonic-clonic seizures (FBTCSs) and generalized tonic-clonic seizures (GTCSs) and to study the association of PHAs with seizure characteristics and the severity of associated ictal respiratory dysfunction. METHODS: Electrocardiographic (EKG) and pulse oximetry (SpO2 ) data were recorded concurrently with video-electroencephalographic telemetry in the epilepsy monitoring unit (EMU)...
November 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29104532/specific-physical-exercise-improves-energetic-metabolism-in-the-skeletal-muscle-of-amyotrophic-lateral-sclerosis-mice
#13
Céline Desseille, Séverine Deforges, Olivier Biondi, Léo Houdebine, Domenico D'amico, Antonin Lamazière, Cédric Caradeuc, Gildas Bertho, Gaëlle Bruneteau, Laure Weill, Jean Bastin, Fatima Djouadi, François Salachas, Philippe Lopes, Christophe Chanoine, Charbel Massaad, Frédéric Charbonnier
Amyotrophic Lateral Sclerosis is an adult-onset neurodegenerative disease characterized by the specific loss of motor neurons, leading to muscle paralysis and death. Although the cellular mechanisms underlying amyotrophic lateral sclerosis (ALS)-induced toxicity for motor neurons remain poorly understood, growing evidence suggest a defective energetic metabolism in skeletal muscles participating in ALS-induced motor neuron death ultimately destabilizing neuromuscular junctions. In the present study, we report that a specific exercise paradigm, based on a high intensity and amplitude swimming exercise, significantly improves glucose metabolism in ALS mice...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29103847/5-year-outcomes-after-left%C3%A2-atrial%C3%A2-appendage-closure-from-the-prevail-and-protect-af-trials
#14
Vivek Y Reddy, Shephal K Doshi, Saibal Kar, Douglas N Gibson, Matthew J Price, Kenneth Huber, Rodney P Horton, Maurice Buchbinder, Petr Neuzil, Nicole T Gordon, David R Holmes
BACKGROUND: The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, St. Paul, Minnesota) was equivalent to warfarin for preventing stroke in atrial fibrillation, but had a high rate of complications. In a second randomized trial, PREVAIL (Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy), the complication rate was low...
November 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29103243/postmortem-computer-tomography-appearance-of-the-aortic-arch-in-children-what-is-considered-normal
#15
Natalia Simanovsky, Nurith Hiller, Maxim Timofeev, Eli M Eisenshtein, Zeev Perles, Sigal Tal
BACKGROUND: Virtual autopsies by computer tomography (CT) or magnetic resonance imaging can be valuable in cases of unexplained infant death. The radiologist must be familiar with the normal appearance of all the segments of the thoracic aorta in normal and deceased children. A thorough review of the literature revealed no prior articles describing CT changes in the ascending aorta or the aortic arch in pediatric virtual autopsies. OBJECTIVES: To compare the CT appearance of the thoracic aorta in deceased children and in those younger than 3 years of age...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29095280/primary-hypothyroidism-and-isolated-acth-deficiency-induced-by-nivolumab-therapy-case-report-and-review
#16
REVIEW
Mei Fang Zeng, Li Chen, Hong Ying Ye, Wei Gong, Li Nuo Zhou, Yi Ming Li, Xiao Long Zhao
RATIONALE: Nivolumab is a monoclonal IgG antibody blocking programmed death receptor-1 (PD1), leading to restoration of the natural T-cell-mediated immune response against the cancer cells. However, it also causes plenty of autoimmune-related adverse events, which often involves endocrine system. PATIENT CONCERNS: A 54-year-old male with renal clear cell carcinoma was treated with nivolumab intravenously. Routine monitoring showed elevated thyroid-stimulating hormone and low free thyroxine after the 6th administration of nivolumab...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29090925/quantitative-proteomic-analysis-to-identify-differentially-expressed-proteins-in-the-myocardium-of-epilepsy-using-itraq-coupled-with-nano-lc-ms-ms
#17
Peng Zhang, Li Zhang, Yongguo Li, Shisheng Zhu, Minzhu Zhao, Shijia Ding, Jianbo Li
Epilepsy is a difficult-to-manage neurological disease that can result in organ damage, such as cardiac injury, that contributes to sudden unexpected death in epilepsy (SUDEP). Although recurrent seizure-induced cardiac dysregulation has been reported, the underlying molecular mechanisms are unclear. We established an epileptic model with Sprague-Dawley rats, applying isobaric tags for a relative and absolute quantification (iTRAQ)-based proteomics approach to identify differentially expressed proteins in myocardial tissue...
November 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29089489/thioredoxin-1-protects-against-androgen-receptor-induced-redox-vulnerability-in-castration-resistant-prostate-cancer
#18
Govindi J Samaranayake, Clara I Troccoli, Mai Huynh, Rolando D Z Lyles, Karen Kage, Andrew Win, Vishalakshi Lakshmanan, Deukwoo Kwon, Yuguang Ban, Steven Xi Chen, Enrique Rodriguez Zarco, Merce Jorda, Kerry L Burnstein, Priyamvada Rai
Androgen deprivation (AD) therapy failure leads to terminal and incurable castration-resistant prostate cancer (CRPC). We show that the redox-protective protein thioredoxin-1 (TRX1) increases with prostate cancer progression and in androgen-deprived CRPC cells, suggesting that CRPC possesses an enhanced dependency on TRX1. TRX1 inhibition via shRNA or a phase I-approved inhibitor, PX-12 (untested in prostate cancer), impedes the growth of CRPC cells to a greater extent than their androgen-dependent counterparts...
October 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/29079584/smoke-free-legislation-and-paediatric-hospitalisations-for-acute-respiratory-tract-infections-national-quasi-experimental-study-with-unexpected-findings-and-important-methodological-implications
#19
Jasper V Been, Daniel F Mackay, Christopher Millett, Ireneous Soyiri, Constant P van Schayck, Jill P Pell, Aziz Sheikh
OBJECTIVES: We investigated whether Scottish implementation of smoke-free legislation was associated with a reduction in unplanned hospitalisations or deaths ('events') due to respiratory tract infections (RTIs) among children. DESIGN: Interrupted time series (ITS). SETTING/PARTICIPANTS: Children aged 0-12 years living in Scotland during 1996-2012. INTERVENTION: National comprehensive smoke-free legislation (March 2006)...
October 27, 2017: Tobacco Control
https://www.readbyqxmd.com/read/29075426/trauma-and-ptsd-in-the-who-world-mental-health-surveys
#20
Ronald C Kessler, Sergio Aguilar-Gaxiola, Jordi Alonso, Corina Benjet, Evelyn J Bromet, Graça Cardoso, Louisa Degenhardt, Giovanni de Girolamo, Rumyana V Dinolova, Finola Ferry, Silvia Florescu, Oye Gureje, Josep Maria Haro, Yueqin Huang, Elie G Karam, Norito Kawakami, Sing Lee, Jean-Pierre Lepine, Daphna Levinson, Fernando Navarro-Mateu, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Kate M Scott, Dan J Stein, Margreet Ten Have, Yolanda Torres, Maria Carmen Viana, Maria V Petukhova, Nancy A Sampson, Alan M Zaslavsky, Karestan C Koenen
Background: Although post-traumatic stress disorder (PTSD) onset-persistence is thought to vary significantly by trauma type, most epidemiological surveys are incapable of assessing this because they evaluate lifetime PTSD only for traumas nominated by respondents as their 'worst.' Objective: To review research on associations of trauma type with PTSD in the WHO World Mental Health (WMH) surveys, a series of epidemiological surveys that obtained representative data on trauma-specific PTSD. Method: WMH Surveys in 24 countries (n = 68,894) assessed 29 lifetime traumas and evaluated PTSD twice for each respondent: once for the 'worst' lifetime trauma and separately for a randomly-selected trauma with weighting to adjust for individual differences in trauma exposures...
2017: European Journal of Psychotraumatology
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