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https://www.readbyqxmd.com/read/27906708/acute-respiratory-distress-syndrome-mimics-the-role-of-lung-biopsy
#1
Mylène Aublanc, Sophie Perinel, Claude Guérin
PURPOSE OF REVIEW: Acute respiratory distress syndrome (ARDS) mimics is a condition looking like ARDS but that does not fulfill every criterion according to the recent Berlin definition. The purpose of this review is to better delineate ARDS mimics, to discuss why the complete diagnosis of ARDS is important, and to make a brief overview on the role of open lung biopsy in this setting. RECENT FINDINGS: Recent autopsy and lung biopsy data from ARDS patients compared lung histologic findings with the new Berlin definition of ARDS...
November 30, 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27836209/-extracorporeal-co2-removal-as-life-support-system-for-a-severe-organizing-pneumonia
#2
G Rival, O Millet, G Capellier
INTRODUCTION: Acute lung injuries are usually found in intensive care unit. The diffuse alveolar damage (DAD) is the associated histological pattern and the most severe end-stage of the disease. Organizing pneumonia (OP), for which corticosteroids are the reference therapy, can mimic DAD. While postponing the response to treatment, to limit mechanical ventilation side effects, extracorporeal membrane oxygene can be proposed. We present a case of a severe OP for which extracorporeal CO2 removal (ECCO2R) is used as a bridge to recovery under corticosteroid therapy...
November 8, 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27835672/the-expression-of-water-and-ion-channels-in-diffuse-alveolar-damage-is-not-dependent-on-dad-etiology
#3
Ruy Camargo Pires-Neto, Fabiola Del Carlo Bernardi, Priscila Alves de Araujo, Thais Mauad, Marisa Dolhnikoff
INTRODUCTION: Aquaporins and ion channels are membrane proteins that facilitate the rapid movement of water and solutes across biological membranes. Experimental and in vitro studies reported that the function of these channels and pulmonary edema resolution are impaired in acute lung injury (ALI). Although current evidence indicates that alveolar fluid clearance is impaired in patients with ALI/diffuse alveolar damage (DAD), few human studies have addressed the alterations in pulmonary channels in this clinical condition...
2016: PloS One
https://www.readbyqxmd.com/read/27809827/acute-exacerbation-of-ipf-has-systemic-consequences-with-multiple-organ-injury-with-sra-and-tnf-%C3%AE-cells-in-the-systemic-circulation-playing-central-roles-in-multiple-organ-injury
#4
Iwao Emura, Hiroyuki Usuda
BACKGROUND: The pathophysiologic mechanisms underlying acute exacerbation of idiopathic pulmonary fibrosis (IPF) are not fully understood. Few studies have examined autopsy findings in patients who have died from an acute exacerbation of IPF. The pathologic findings in systemic organs have not been described. METHODS: We retrospectively reviewed the autopsy findings in 12 patients who had died from an acute exacerbation of IPF and two of connective tissue disease- associated interstitial lung disease between 2005 and 2015...
November 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27805533/lung-biopsy-findings-of-patients-who-have-undergone-a-liver-and-kidney-transplant
#5
Gonca Özgün, Merih Tepeoğlu, Binnaz Handan Özdemir, Eda Yılmaz Akçay, Ebru Şebnem Ayva, Emine Ebru Deniz, Mehmet Haberal
OBJECTIVES: Our objective was to analyze the incidence of pulmonary disorders in solid-organ transplant recipients and report on outcomes in these patients. MATERIALS AND METHODS: Seventy liver and kidney transplant patients, who underwent lung biopsy because of pulmonary symptoms between January 2000 and December 2015, were enrolled in the study. We examined and evaluated histopathologic findings of these patients based on clinical data recorded in patients' files...
November 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27746429/influence-of-smoking-in-interstitial-pneumonia-presenting-with-a-non-specific-interstitial-pneumonia-pattern
#6
Tetsuro Sawata, Masashi Bando, Masayuki Nakayama, Naoko Mato, Hideaki Yamasawa, Yukihiko Sugiyama
Objective The influence of smoking on the pathogenesis and clinical course of interstitial pneumonia has recently attracted attention. To clarify the influence of smoking on the clinical patient characteristics and therapeutic effects in patients with interstitial pneumonia presenting with a non-specific interstitial pneumonia (NSIP) pattern, we compared the clinical patient characteristics and therapeutic effects in smokers and nonsmokers in this study. Methods We divided 31 NSIP (16 idiopathic nonspecific interstitial pneumonia and 15 collagen vascular disease-associated nonspecific interstitial pneumonia) patients into smoker and non-smoker groups for each case...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27719979/imaging-of-acute-lung-injury
#7
Brett M Elicker, Kirk T Jones, David M Naeger, James A Frank
Acute lung injury (ALI) is the clinical syndrome associated with histopathologic diffuse alveolar damage. It is a common cause of acute respiratory symptoms and admission to the intensive care unit. Diagnosis of ALI is typically based on clinical and radiographic criteria; however, because these criteria can be nonspecific, diagnostic uncertainty is common. A multidisciplinary approach that synthesizes clinical, imaging, and pathologic data can ensure an accurate diagnosis. Radiologists must be aware of the radiographic and computed tomographic findings of ALI and its mimics...
November 2016: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27719825/correction-to-data-in-the-presence-of-diffuse-alveolar-damage-on-open-lung-biopsy-is-associated-with-mortality-in-patients-with-acute-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#8
https://www.readbyqxmd.com/read/27713201/-fatal-respiratory-failure-developed-during-chemotherapy-for-diffuse-large-b-cell-lymphoma-that-occurred-late-after-lung-transplantation
#9
Akihiko Kitahara, Seijiro Sato, Terumoto Koike, Masanori Tsuchida
We report here a case of fatal respiratory failure developed during chemotherapy for diffuse large B cell lymphoma that occurred late after lung transplantation. 25-year- old man underwent lung transplantation from brain death donor for respiratory failure due to interstitial pneumonia at the age of 16 years old. Two years after transplantation, his respiratory function decreased gradually. Chronic lung allograft dysfunction including bronchiolitis obliterans( BOS) and restrictive allograft syndrome was suspected and immunosuppression was enhanced...
October 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27676455/impact-of-allograft-injury-time-of-onset-on-the-development-of-chronic-lung-allograft-dysfunction-after-lung-transplantation
#10
M Y Shino, S S Weigt, N Li, A Derhovanessian, D M Sayah, R H Huynh, R Saggar, A L Gregson, A Ardehali, D J Ross, J P Lynch, R M Elashoff, J A Belperio
The impact of allograft injury time of onset on the risk of chronic lung allograft dysfunction (CLAD) remains unknown. We hypothesized that episodes of late-onset (≥6 months) allograft injury would produce an augmented CXCR3/ligand immune response, leading to increased CLAD. In a retrospective single-center study, 1894 transbronchial biopsy samples from 441 lung transplant recipients were reviewed for the presence of acute rejection (AR), lymphocytic bronchiolitis (LB), diffuse alveolar damage (DAD), and organizing pneumonia (OP)...
September 27, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27660154/transbronchial-cryobiopsy-in-diffuse-parenchymal-lung-disease-retrospective-analysis-of-74-cases
#11
Kamonpun Ussavarungsi, Ryan M Kern, Anja C Roden, Jay H Ryu, Eric S Edell
BACKGROUND: Diagnostic evaluation of patients with diffuse parenchymal lung disease (DPLD) is best achieved by a multidisciplinary team correlating clinical, radiologic, and pathologic features. Surgical lung biopsies remain the gold standard for histopathologic diagnosis of idiopathic interstitial pneumonias. Emerging data suggest an increasing role for transbronchial cryobiopsy (TBC) in DPLD evaluation. We describe our experience with TBC in patients with DPLD. METHODS: We retrospectively reviewed medical records of patients with radiographic features of DPLD who underwent TBC at Mayo Clinic, Rochester, Minnesota in June 2013-September 2015...
September 19, 2016: Chest
https://www.readbyqxmd.com/read/27647196/mass-spectrometry-based-proteomics-in-acute-respiratory-distress-syndrome-a-powerful-modality-for-pulmonary-precision-medicine
#12
REVIEW
Xue-Feng Xu, Hua-Ping Dai, Yan-Ming Li, Fei Xiao, Chen Wang
OBJECTIVE: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by hypoxemic respiratory failure and diffuse alveolar inflammatory damage. This review aimed to search and discuss the mass spectrometry (MS)-based proteomic studies on different subsets of ARDS patients. DATA SOURCES: Original research articles were collected from the PubMed database published in English up to December 2015. STUDY SELECTION: The literature search was done using the term "(acute lung injury OR acute respiratory distress syndrome) AND (proteomics OR proteome OR mass spectrum OR differential in-gel electrophoresis OR two-dimensional polyacrylamide gel electrophoresis)"...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27631255/antineutrophilic-cytoplasmic-antibody-associated-vasculitis-with-hypocomplementemia-has-a-higher-incidence-of-serious-organ-damage-and-a-poor-prognosis
#13
Shoichi Fukui, Naoki Iwamoto, Masataka Umeda, Ayako Nishino, Yoshikazu Nakashima, Tomohiro Koga, Shin-Ya Kawashiri, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Shuntaro Sato, Atsushi Kawakami
A relationship between antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and complement has been shown, and complement has an important role in the pathogenesis of AAV. The clinical characteristics of AAV with hypocomplementemia still remain unclear.We conducted an observational study of 81 patients with AAV (median onset age 71 years; 58% female). Using medical records, we analyzed the patients' baseline variables, laboratory data, clinical symptoms, and therapeutic outcomes after treatments including episodes of relapses, initiation of dialysis, and death...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27611185/lung-metabolic-activation-as-an-early-biomarker-of-acute-respiratory-distress-syndrome-and-local-gene-expression-heterogeneity
#14
Tyler J Wellman, Nicolas de Prost, Mauro Tucci, Tilo Winkler, Rebecca M Baron, Piotr Filipczak, Benjamin Raby, Jen-Hwa Chu, R Scott Harris, Guido Musch, Luiz F Dos Reis Falcao, Vera Capelozzi, Jose G Venegas, Marcos F Vidal Melo
BACKGROUND: Acute respiratory distress syndrome (ARDS) is an inflammatory condition comprising diffuse lung edema and alveolar damage. ARDS frequently results from regional injury mechanisms. However, it is unknown whether detectable inflammation precedes lung edema and opacification and whether topographically differential gene expression consistent with heterogeneous injury occurs in early ARDS. The authors aimed to determine the temporal relationship between pulmonary metabolic activation and density in a large animal model of early ARDS and to assess gene expression in differentially activated regions...
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27608777/predicting-survival-in-ards
#15
EDITORIAL
Niteen D Karnik, Anish V Gupta
Acute respiratory distress syndrome (ARDS) is a fulminant clinical disorder of varied etiology, characterized by diffuse lung injury and severe hypoxemia. It is a leading cause of ICU admission and the associated high mortality has sparked a lot of research on etiology, outcome, scoring systems, mortality predictors, biomarkers including inflammatory cytokines and even genomics in ARDS. The previously used AECC (American European Consensus Conference) definition (1994) of ARDS was replaced by the recent Berlin definition (2012) so as to improve its validity and reliability...
November 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27583344/data-on-cux1-isoforms-in-idiopathic-pulmonary-fibrosis-lung-and-systemic-sclerosis-skin-tissue-sections
#16
Tetsurou Ikeda, Maria Fragiadaki, Xu Shi-Wen, Markella Ponticos, Korsa Khan, Christopher Denton, Patricia Garcia, George Bou-Gharios, Akio Yamakawa, Chikao Morimoto, David Abraham
This data article contains complementary figures related to the research article entitled, "Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts" (Ikeda et al. (2016) [2], http://dx.doi.org/10.1016/j.bbrep.2016.06.022), which presents that TGF-β increased CUX1 binding in the proximal promoter and enhancer of the COL1A2 and regulated COL1. Further, in the scleroderma (SSc) lung and diffuse alveolar damage lung sections, CUX1 localized within the α- smooth muscle actin (α-SMA) positive cells (Fragiadaki et al...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27547739/gonococcal-endocarditis-an-ever-present-threat
#17
Fernando Peixoto Ferraz de Campos, Vitor Sérgio Kawabata, Márcio Sommer Bittencourt, Silvana Maria Lovisolo, Aloísio Felipe-Silva, Ana Paula Silva de Lemos
The incidence of severe complications of the Neisseria gonorrhoeae infection has presented variations over recent decades since the advent of penicillin. Gonococcal endocarditis (GE) still remains an ever-present threat afflicting the society's poor and sexually active young population. This entity frequently requires surgical intervention and usually exhibits a poor outcome. The interval between the onset of symptoms and the diagnosis does not usually exceed 4 weeks. One of the characteristics of GE is a proclivity for aortic valve involvement with large vegetation and valve ring abscess formation...
April 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/27530476/the-utility-of-surgical-lung-biopsy-in-critically-ill-patients-with-diffuse-pulmonary-infiltrates-a-retrospective-review
#18
L Donaldson, A J Gill, M Hibbert
BACKGROUND: There are conflicting reports regarding the role of surgical lung biopsy in patients who present to the Intensive Care Unit with unexplained respiratory failure and diffuse pulmonary infiltrates on imaging. AIM: To describe the utility of surgical lung biopsy in patients presenting to the Intensive Care Unit with unexplained respiratory failure and diffuse pulmonary infiltrates. METHODS: A retrospective cohort study was performed...
August 17, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27523002/radiological-and-pathological-correlation-in-anti-mda5-antibody-positive-interstitial-lung-disease-rapidly-progressive-perilobular-opacities-and-diffuse-alveolar-damage
#19
Haruka Chino, Akimasa Sekine, Tomohisa Baba, Tae Iwasawa, Koji Okudela, Tamiko Takemura, Harumi Itoh, Shinji Sato, Yasuo Suzuki, Takashi Ogura
We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27413002/pulmonary-changes-in-norwegian-fatal-cases-of-pandemic-influenza-h1n1-2009-infection-a-morphologic-and-molecular-genetic-study
#20
Pål Voltersvik, Lara A Aqrawi, Susanne Dudman, Olav Hungnes, Leif Bostad, Karl A Brokstad, Rebecca J Cox
BACKGROUND: During the pandemic outbreak of the 2009 swine influenza (A(H1N1)pdm09), 32 fatal cases occurred in Norway and 19 of these were included in this study. OBJECTIVES: We characterised pulmonary changes in these fatal Norwegian cases. PATIENTS AND METHODS: Upon hospitalisation, detailed clinical information and specimens from the upper and lower respiratory pathways were collected. At post-mortem, lung tissue was collected, formalin-fixed and paraffin-embedded...
November 2016: Influenza and Other Respiratory Viruses
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