keyword
MENU ▼
Read by QxMD icon Read
search

Knowlesi

keyword
https://www.readbyqxmd.com/read/29723510/infection-of-mosquitoes-from-in-vitro-cultivated-plasmodium-knowlesi-h-strain
#1
Jennifer S Armistead, Roberto R Moraes Barros, Tyler J Gibson, Whitney A Kite, J Patrick Mershon, Lynn E Lambert, Sachy E Orr-Gonzalez, Juliana M Sá, John H Adams, Thomas E Wellems
In vitro studies of sexual blood stages of the most fatal malaria species, Plasmodium falciparum, have revealed key processes by which gametocytes develop and transmit infection from humans to anopheline mosquitoes. However, most malaria cases outside sub-Saharan Africa are caused by other Plasmodium spp., frequently Plasmodium vivax and Plasmodium knowlesi, a zoonotic parasite of macaque monkeys. Gametocytes of P. vivax and P. knowlesi exhibit distinct morphology, faster development, and a shorter life span compared with gametocytes of P...
April 30, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29720188/two-clusters-of-plasmodium-knowlesi-cases-in-a-malaria-elimination-area-sabang-municipality-aceh-indonesia
#2
Herdiana Herdiana, Irnawati Irnawati, Farah Novita Coutrier, Alfian Munthe, Mardiati Mardiati, Titik Yuniarti, Elvieda Sariwati, Maria Endang Sumiwi, Rintis Noviyanti, Paul Pronyk, William A Hawley
In malaria elimination areas, malaria cases are sporadic and consist predominantly of imported cases. Plasmodium knowlesi cases have been reported throughout Southeast Asia where long-tailed and pig-tailed macaques and Anopheles leucosphyrus group mosquitoes are sympatric. The limitation of microscopic examination to diagnose P. knowlesi is well known. In consequence, no P. knowlesi case has previously been reported from routine health facility-based case finding activities in Indonesia. This report describes two clusters of unexpected locally acquired P...
May 2, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29716542/in-depth-comparative-analysis-of-malaria-parasite-genomes-reveals-protein-coding-genes-linked-to-human-disease-in-plasmodium-falciparum-genome
#3
Xuewu Liu, Yuanyuan Wang, Jiao Liang, Luojun Wang, Na Qin, Ya Zhao, Gang Zhao
BACKGROUND: Plasmodium falciparum is the most virulent malaria parasite capable of parasitizing human erythrocytes. The identification of genes related to this capability can enhance our understanding of the molecular mechanisms underlying human malaria and lead to the development of new therapeutic strategies for malaria control. With the availability of several malaria parasite genome sequences, performing computational analysis is now a practical strategy to identify genes contributing to this disease...
May 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29690924/the-effect-of-regularly-dosed-paracetamol-versus-no-paracetamol-on-renal-function-in-plasmodium-knowlesi-malaria-packnow-study-protocol-for-a-randomised-controlled-trial
#4
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29673877/the-plasmodium-knowlesi-mahrp2-ortholog-localizes-to-structures-connecting-sinton-mulligan-s-clefts-in-the-infected-erythrocyte
#5
Kwame Kumi Asare, Miako Sakaguchi, Amuza Byaruhanga Lucky, Masahito Asada, Shinya Miyazaki, Yuko Katakai, Satoru Kawai, Chihong Song, Kazuyoshi Murata, Kazuhide Yahata, Osamu Kaneko
During development within the host erythrocyte malaria parasites generate nascent membranous structures which serve as a pathway for parasite protein transport to modify the host cell. The molecular basis of such membranous structures is not well understood, particularly for malaria parasites other than Plasmodium falciparum. To characterize the structural basis of protein trafficking in the Plasmodium knowlesi-infected erythrocyte, we identified a P. knowlesi ortholog of MAHRP2, a marker of the tether structure that connects membranous structures in the P...
April 16, 2018: Parasitology International
https://www.readbyqxmd.com/read/29606107/plasmodium-knowlesi-infection-in-a-returning-german-traveller-from-thailand-a-case-report-on-an-emerging-malaria-pathogen-in-a-popular-low-risk-travel-destination
#6
Guenter Froeschl, Marcus Beissner, Kristina Huber, Gisela Bretzel, Michael Hoelscher, Camilla Rothe
BACKGROUND: Thailand is a major destination for German travellers with more than 760,000 arrivals in 2015. At the same time, malaria is a concern in travel recommendations with regard to this destination. The World Malaria Report of 2016 mentions only P. falciparum and P. vivax as prevalent species for Thailand, however, P. knowlesi infections have been occasionally reported in Thailand. In German travellers, only five cases of P. knowlesi infections have been reported to date. CASE PRESENTATION: A 45-year-old German male tourist travelled to Thailand from 25 December 2016 to 13 January 2017...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29565973/first-case-of-human-infection-with-plasmodium-knowlesi-in-laos
#7
Moritoshi Iwagami, Masami Nakatsu, Phonepadith Khattignavong, Pheovaly Soundala, Lavy Lorphachan, Sengdeuane Keomalaphet, Phonepadith Xangsayalath, Satoru Kawai, Bouasy Hongvanthong, Paul T Brey, Shigeyuki Kano
No abstract text is available yet for this article.
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29554284/a-systematic-review-performance-of-rdts-for-the-detection-of-plasmodium-knowlesi-plasmodium-malariae-and-plasmodium-ovale-mono-infections-in-human-blood
#8
Seda Yerlikaya, Ana Campillo, Iveth J Gonzalez
Despite the increased use and worldwide distribution of malaria rapid diagnostic tests (RDTs) which distinguish between Plasmodium falciparum and non-falciparum species, little is known about their performance for detecting Plasmodium knowlesi (Pk), Plasmodium malariae (Pm), and Plasmodium ovale (Po). The objective of this review is to analyze results of published studies evaluating the diagnostic accuracy of malaria RDTs in detecting Pk, Pm and Po mono-infections.MEDLINE, EMBASE, Web of Science and CENTRAL databases were systematically searched to identify studies which reported on the performance of RDTs in detecting Pk, Pm,Po mono-infections...
March 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29540177/genetic-diversity-and-natural-selection-of-plasmodium-knowlesi-merozoite-surface-protein-1-paralog-gene-in-malaysia
#9
Md Atique Ahmed, Muh Fauzi, Eun-Taek Han
BACKGROUND: Human infections due to the monkey malaria parasite Plasmodium knowlesi is on the rise in most Southeast Asian countries specifically Malaysia. The C-terminal 19 kDa domain of PvMSP1P is a potential vaccine candidate, however, no study has been conducted in the orthologous gene of P. knowlesi. This study investigates level of polymorphisms, haplotypes and natural selection of full-length pkmsp1p in clinical samples from Malaysia. METHODS: A total of 36 full-length pkmsp1p sequences along with the reference H-strain and 40 C-terminal pkmsp1p sequences from clinical isolates of Malaysia were downloaded from published genomes...
March 14, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29505599/phosphoethanolamine-n-methyltransferase-is-a-potential-biomarker-for-the-diagnosis-of-p-knowlesi-and-p-falciparum-malaria
#10
Robert G E Krause, J P Dean Goldring
BACKGROUND: Plasmodium knowlesi is recognised as the main cause of human malaria in Southeast Asia. The disease is often misdiagnosed as P. falciparum or P. malariae infections by microscopy, and the disease is difficult to eliminate due to its presence in both humans and monkeys. P. knowlesi infections can rapidly cause severe disease and require prompt diagnosis and treatment. No protein biomarker exists for the rapid diagnostic test (RDT) detection of P. knowlesi infections. Plasmodium knowlesi infections can be diagnosed by PCR...
2018: PloS One
https://www.readbyqxmd.com/read/29487058/reduced-red-blood-cell-deformability-in-plasmodium-knowlesi-malaria
#11
Bridget E Barber, Bruce Russell, Matthew J Grigg, Rou Zhang, Timothy William, Amirah Amir, Yee Ling Lau, Mark D Chatfield, Arjen M Dondorp, Nicholas M Anstey, Tsin W Yeo
The simian parasite Plasmodium knowlesi can cause severe and fatal human malaria. However, little is known about the pathogenesis of this disease. In falciparum malaria, reduced red blood cell deformability (RBC-D) contributes to microvascular obstruction and impaired organ perfusion. In P knowlesi infection, impaired microcirculatory flow has been observed in Macaca mulatta (rhesus macaques), unnatural hosts who develop severe and fatal disease. However, RBC-D has not been measured in human infection or in the natural host M fascicularis (long-tailed macaques)...
February 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29465117/gold-i-phosphine-compounds-as-parasite-attenuating-agents-for-malaria-vaccine-and-drug-development
#12
Aloysious Ssemaganda, Leanne M Low, Krista R Verhoeft, Mathias Wambuzi, Barbarah Kawoozo, Sharon B Nabasumba, Juliet Mpendo, Bernard S Bagaya, Noah Kiwanuka, Danielle I Stanisic, Susan J Berners-Price, Michael F Good
Here, the anti-malarial activity of two gold(i) phosphine compounds auranofin and [Au(d2pype)2 ]Cl (where d2pype is 1,2-bis(di-2-pyridylphosphino)ethane), were examined to inform their use as potential drugs and malaria parasite-attenuating agents. In vitro, the gold compounds were active against Plasmodium falciparum and P. knowlesi as well as the rodent parasite P. chabaudi AS. Attenuation of the parasite was observed when mice were inoculated with P. chabaudi AS infected red blood cells treated in vitro with [Au(d2pype)2 ]Cl (1 or 2 μM) or auranofin (2 μM) for 2 or 3 h...
March 1, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29409854/genetic-and-haplotype-analyses-targeting-cytochrome-b-gene-of-plasmodium-knowlesi-isolates-of-malaysian-borneo-and-peninsular-malaysia
#13
Eric Tzyy Jiann Chong, Joveen Wan Fen Neoh, Tiek Ying Lau, Yvonne Ai-Lian Lim, Kek Heng Chua, Ping-Chin Lee
Malaria is a notorious disease which causes major global morbidity and mortality. This study aims to investigate the genetic and haplotype differences of Plasmodium knowlesi (P. knowlesi) isolates in Malaysian Borneo and Peninsular Malaysia based on the molecular analysis of the cytochrome b (cyt b) gene. The cyt b gene of 49 P. knowlesi isolates collected from Sabah, Malaysian Borneo and Peninsular Malaysia was amplified using PCR, cloned into a commercialized vector and sequenced. In addition, 45 cyt b sequences were retrieved from humans and macaques bringing to a total of 94 cyt b gene nucleotide sequences for phylogenetic analysis...
May 2018: Acta Tropica
https://www.readbyqxmd.com/read/29402283/high-prevalence-of-malaria-in-a-non-endemic-setting-comparison-of-diagnostic-tools-and-patient-outcome-during-a-four-year-survey-2013-2017
#14
Adriana Calderaro, Giovanna Piccolo, Sara Montecchini, Mirko Buttrini, Sabina Rossi, Maria Loretana Dell'Anna, Valeria De Remigis, Maria Cristina Arcangeletti, Carlo Chezzi, Flora De Conto
BACKGROUND: Malaria is no longer endemic in Italy since 1970 when the World Health Organization declared Italy malaria-free, but it is now the most commonly imported disease. The aim of the study was to analyse the trend of imported malaria cases in Parma, Italy, during January 2013-June 2017, reporting also the treatment and the outcome of cases, exploring the comparison of the three diagnostic tests used for malaria diagnosis: microscopy, immunochromatographic assay (ICT) (BinaxNOW® ) and Real-time PCR assays detecting Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale curtisi, Plasmodium ovale wallikeri, and Plasmodium knowlesi...
February 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29378588/plasmodium-species-differentiation-by-non-expert-on-line-volunteers-for-remote-malaria-field-diagnosis
#15
Alejandra Ortiz-Ruiz, María Postigo, Sara Gil-Casanova, Daniel Cuadrado, José M Bautista, José Miguel Rubio, Miguel Luengo-Oroz, María Linares
BACKGROUND: Routine field diagnosis of malaria is a considerable challenge in rural and low resources endemic areas mainly due to lack of personnel, training and sample processing capacity. In addition, differential diagnosis of Plasmodium species has a high level of misdiagnosis. Real time remote microscopical diagnosis through on-line crowdsourcing platforms could be converted into an agile network to support diagnosis-based treatment and malaria control in low resources areas. This study explores whether accurate Plasmodium species identification-a critical step during the diagnosis protocol in order to choose the appropriate medication-is possible through the information provided by non-trained on-line volunteers...
January 30, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29370297/a-novel-pcr-based-system-for-the-detection-of-four-species-of-human-malaria-parasites-and-plasmodium-knowlesi
#16
Kanako Komaki-Yasuda, Jeanne Perpétue Vincent, Masami Nakatsu, Yasuyuki Kato, Norio Ohmagari, Shigeyuki Kano
A microscopy-based diagnosis is the gold standard for the detection and identification of malaria parasites in a patient's blood. However, the detection of cases involving a low number of parasites and the differentiation of species sometimes requires a skilled microscopist. Although PCR-based diagnostic methods are already known to be very powerful tools, the time required to apply such methods is still much longer in comparison to traditional microscopic observation. Thus, improvements to PCR systems are sought to facilitate the more rapid and accurate detection of human malaria parasites Plasmodium falciparum, P...
2018: PloS One
https://www.readbyqxmd.com/read/29338786/a-systematic-review-of-transfusion-transmitted-malaria-in-non-endemic-areas
#17
Federica Verra, Andrea Angheben, Elisa Martello, Giovanni Giorli, Francesca Perandin, Zeno Bisoffi
BACKGROUND: Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient's bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29334944/changes-in-malaria-epidemiology-in-germany-2001-2016-a-time-series-analysis
#18
Sabine Vygen-Bonnet, Klaus Stark
BACKGROUND: German surveillance data showed a sharp rise of malaria cases in 2014 and 2015 due to the increased arrival of refugees from malaria endemic countries. A time series analysis of data from 2001 to 2016 was performed in order to describe the epidemiology of imported malaria in Germany in general and of the recent increase in particular. RESULTS: In total, 11,678 malaria cases were notified between 2001 and 2016 (range 526-1063 cases/year). Newly arriving refugees averaged 10 cases/year (1...
January 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29260656/recombinase-polymerase-amplification-combined-with-a-lateral-flow-strip-for-the-detection-of-plasmodium-knowlesi
#19
Meng-Yee Lai, Choo-Huck Ooi, Yee-Ling Lau
The aim of this study was to develop a recombinase polymerase amplification (RPA) combined with a lateral flow (LF) strip method for specific diagnosis of Plasmodium knowlesi . With incubation at 37°C, the 18S rRNA gene of P. knowlesi was successfully amplified within 12 minutes. By adding a specifically designed probe to the reaction solution, the amplified RPA product can be visualized on a LF strip. The RPA assay exhibited high sensitivity with limits of detection down to 10 parasites/μL of P. knowlesi ...
March 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29258833/a-reference-genome-and-methylome-for-the-plasmodium-knowlesi-a1-h-1-line
#20
Ernest Diez Benavente, Paola Florez de Sessions, Robert W Moon, Munira Grainger, Anthony A Holder, Michael J Blackman, Cally Roper, Christopher J Drakeley, Arnab Pain, Colin J Sutherland, Martin L Hibberd, Susana Campino, Taane G Clark
Plasmodium knowlesi, a common parasite of macaques, is recognised as a significant cause of human malaria in Malaysia. The P. knowlesi A1H1 line has been adapted to continuous culture in human erythrocytes, successfully providing an in vitro model to study the parasite. We have assembled a reference genome for the PkA1-H.1 line using PacBio long read combined with Illumina short read sequence data. Compared with the H-strain reference, the new reference has improved genome coverage and a novel description of methylation sites...
March 2018: International Journal for Parasitology
keyword
keyword
92410
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"