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https://www.readbyqxmd.com/read/28327145/diagnostic-challenges-and-case-management-of-the-first-imported-case-of-plasmodium-knowlesi-in-sri-lanka
#1
A Dewanee Ranaweera, Manjula N Danansuriya, Kusumawathie Pahalagedera, W M Kumudunayana T de A W Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C Hapuarachchi, Hema D B Herath, Deepika Fernando
BACKGROUND: Sri Lanka has achieved 'malaria-free' status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges encountered and the rapid response initiated to manage a Plasmodium infection, which was later confirmed as Plasmodium knowlesi, the first reported case from Sri Lanka, is discussed. CASE PRESENTATION: An army officer who returned from Malaysia in October 2016 was found to be positive for Plasmodium both by microscopy and rapid diagnostic test (RDT) by the Anti Malaria Campaign Sri Lanka (AMC) during his third visit to a health care provider...
March 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28322705/three-divergent-subpopulations-of-the-malaria-parasite-plasmodium-knowlesi
#2
Paul C S Divis, Lee C Lin, Jeffrine J Rovie-Ryan, Khamisah A Kadir, Fread Anderios, Shamilah Hisam, Reuben S K Sharma, Balbir Singh, David J Conway
Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28302017/targeting-pyrimidine-pathway-of-plasmodium-knowlesi-new-strategies-towards-identification-of-novel-antimalarial-chemotherapeutic-agents
#3
Mayank Rashmi, Manoj Kumar Yadav, D Swati
Plasmodium knowlesi has been recently recognized as a human malarial parasite, particularly in the region of south-east Asia. The effective prevention and treatment of this disease is increasingly bound to fail due to the emergence of drug resistance. Hence, design of new drugs against known targets is gaining importance. Pyrimidine pathway is a crucial metabolic pathway in P. knowlesi, and the enzymes involved are also unique in terms of their structure and function as compared to its human counterpart. Thus targeting Dihydroorotase, an enzyme involved in the pyrimidine pathway, provides a promising route for novel drug development...
March 15, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28230261/plasmodium-knowlesi
#4
Peter Chiodini, Barbara J Bain
No abstract text is available yet for this article.
February 23, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28219910/severe-plasmodium-knowlesi-with-dengue-coinfection
#5
Mohd Jazman Che Rahim, Nurashikin Mohammad, Alwi Muhd Besari, Wan Syamimee Wan Ghazali
We report a case of severe Plasmodium knowlesi and dengue coinfection in a previously healthy 59-year-old Malay man who presented with worsening shortness of breath, high-grade fever with chills and rigors, dry cough, myalgia, arthralgia, chest discomfort and poor appetite of 1 week duration. There was a history mosquito fogging around his neighbourhood in his hometown. Further history revealed that he went to a forest in Jeli (northern part of Kelantan) 3 weeks prior to the event. Initially he was treated as severe dengue with plasma leakage complicated with type 1 respiratory failure as evidenced by positive serum NS1-antigen and thrombocytopenia...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28201638/contribution-of-plasmodium-knowlesi-to-multi-species-human-malaria-infections-in-north-sumatera-indonesia
#6
Inke Nd Lubis, Hendri Wijaya, Munar Lubis, Chairuddin P Lubis, Paul Cs Divis, Khalid B Beshir, Colin J Sutherland
No abstract text is available yet for this article.
February 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28182750/chemoprophylaxis-with-sporozoite-immunization-in-p-knowlesi-rhesus-monkeys-confers-protection-and-elicits-sporozoite-specific-memory-t-cells-in-the-liver
#7
Sathit Pichyangkul, Michele D Spring, Kosol Yongvanitchit, Utaiwan Kum-Arb, Amporn Limsalakpetch, Rawiwan Im-Erbsin, Ratawan Ubalee, Pattaraporn Vanachayangkul, Edmond J Remarque, Evelina Angov, Philip L Smith, David L Saunders
Whole malaria sporozoite vaccine regimens are promising new strategies, and some candidates have demonstrated high rates of durable clinical protection associated with memory T cell responses. Little is known about the anatomical distribution of memory T cells following whole sporozoite vaccines, and immunization of nonhuman primates can be used as a relevant model for humans. We conducted a chemoprophylaxis with sporozoite (CPS) immunization in P. knowlesi rhesus monkeys and challenged via mosquito bites. Half of CPS immunized animals developed complete protection, with a marked delay in parasitemia demonstrated in the other half...
2017: PloS One
https://www.readbyqxmd.com/read/28165471/antibody-independent-mechanisms-regulate-the-establishment-of-chronic-plasmodium-infection
#8
Thibaut Brugat, Adam James Reid, Jing-Wen Lin, Deirdre Cunningham, Irene Tumwine, Garikai Kushinga, Sarah McLaughlin, Philip Spence, Ulrike Böhme, Mandy Sanders, Solomon Conteh, Ellen Bushell, Tom Metcalf, Oliver Billker, Patrick E Duffy, Chris Newbold, Matthew Berriman, Jean Langhorne
Malaria is caused by parasites of the genus Plasmodium. All human-infecting Plasmodium species can establish long-lasting chronic infections(1-5), creating an infectious reservoir to sustain transmission(1,6). It is widely accepted that the maintenance of chronic infection involves evasion of adaptive immunity by antigenic variation(7). However, genes involved in this process have been identified in only two of five human-infecting species: Plasmodium falciparum and Plasmodium knowlesi. Furthermore, little is understood about the early events in the establishment of chronic infection in these species...
February 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28129569/investigating-the-antiplasmodial-activity-of-primary-sulfonamide-compounds-identified-in-open-source-malaria-data
#9
Gillian M Fisher, Silvia Bua, Sonia Del Prete, Megan S J Arnold, Clemente Capasso, Claudiu T Supuran, Katherine T Andrews, Sally-Ann Poulsen
In the past decade there has been a significant reduction in deaths due to malaria, in part due to the success of the gold standard antimalarial treatment - artemisinin combination therapies (ACTs). However the potential threat of ACT failure and the lack of a broadly effective malaria vaccine are driving efforts to discover new chemical entities (NCEs) to target this disease. The primary sulfonamide (PS) moiety is a component of several clinical drugs, including those for treatment of kidney disease, glaucoma and epilepsy, however this chemotype has not yet been exploited for malaria...
January 13, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28122651/clinical-features-and-management-of-plasmodium-knowlesi-infections-in-humans
#10
Cyrus Daneshvar, Timothy William, Timothy M E Davis
Plasmodium knowlesi is a simian malaria of primarily the macaque species of South East Asia. While it was known that human infections could be induced during the years of malariotherapy, naturally occurring P. knowlesi human infections were thought to be rare. However, in 2004, knowlesi infections became recognized as an important infection amongst human populations in Sarawak, Malaysian Borneo. Since then, it has become recognized as a disease affecting people living and visiting endemic areas across South East Asia...
January 26, 2017: Parasitology
https://www.readbyqxmd.com/read/28107750/effect-of-clinically-approved-hdac-inhibitors-on-plasmodium-leishmania-and-schistosoma-parasite-growth
#11
Ming Jang Chua, Megan S J Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F Späth, Eric Prina, Raymond J Pierce, David P Fairlie, Tina S Skinner-Adams, Katherine T Andrews
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression, is a key strategy for discovering new drug leads. In this study, four clinically approved anti-cancer drugs (Vorinostat, Belinostat, Panobinostat and Romidepsin) that target histone/lysine deacetylase enzymes were examined for in vitro activity against Plasmodium knowlesi, Schistosoma mansoni, Leishmania amazonensis and L...
December 23, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28086789/detection-of-plasmodium-knowlesi-plasmodium-falciparum-and-plasmodium-vivax-using-loop-mediated-isothermal-amplification-lamp-in-a-co-endemic-area-in-malaysia
#12
Kim A Piera, Ammar Aziz, Timothy William, David Bell, Iveth J González, Bridget E Barber, Nicholas M Anstey, Matthew J Grigg
BACKGROUND: Plasmodium knowlesi is the most common cause of malaria in Malaysia. However, microscopic diagnosis is inaccurate and rapid diagnostic tests (RDTs) are insufficiently sensitive. PCR is sensitive and specific but not feasible at a district level. Loop-mediated isothermal amplification (LAMP) shows potential with only basic requirements. A commercially available LAMP assay, the Eiken Loopamp™ MALARIA Pan Detection kit, is sensitive for Plasmodium falciparum and Plasmodium vivax, but has not previously been evaluated for P...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28056979/malaria-epidemiology-in-central-myanmar-identification-of-a-multi-species-asymptomatic-reservoir-of-infection
#13
Isaac Ghinai, Jackie Cook, Teddy Tun Win Hla, Hein Myat Thu Htet, Tom Hall, Inke Nd Lubis, Rosanna Ghinai, Therese Hesketh, Ye Naung, Mya Mya Lwin, Tint Swe Latt, David L Heymann, Colin J Sutherland, Chris Drakeley, Nigel Field
BACKGROUND: The spread of artemisinin-resistant Plasmodium falciparum is a global health concern. Myanmar stands at the frontier of artemisinin-resistant P. falciparum. Myanmar also has the highest reported malaria burden in Southeast Asia; it is integral in the World Health Organization's plan to eliminate malaria in Southeast Asia, yet few epidemiological data exist for the general population in Myanmar. METHODS: This cross-sectional, probability household survey was conducted in Phyu township, Bago Region (central Myanmar), during the wet season of 2013...
January 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28049516/genetic-clustering-and-polymorphism-of-the-merozoite-surface-protein-3-of-plasmodium-knowlesi-clinical-isolates-from-peninsular-malaysia
#14
Jeremy Ryan De Silva, Yee Ling Lau, Mun Yik Fong
BACKGROUND: The simian malaria parasite Plasmodium knowlesi has been reported to cause significant numbers of human infection in South East Asia. Its merozoite surface protein-3 (MSP3) is a protein that belongs to a multi-gene family of proteins first found in Plasmodium falciparum. Several studies have evaluated the potential of P. falciparum MSP3 as a potential vaccine candidate. However, to date no detailed studies have been carried out on P. knowlesi MSP3 gene (pkmsp3). The present study investigates the genetic diversity, and haplotypes groups of pkmsp3 in P...
January 3, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28049485/the-dangers-of-accepting-a-single-diagnosis-case-report-of-concurrent-plasmodium-knowlesi-malaria-and-dengue-infection
#15
Soon Eu Chong, Rhendra Hardy Mohamad Zaini, Siti Suraiya, Kok Tong Lee, Jo Anne Lim
BACKGROUND: Dengue and malaria are two common, mosquito-borne infections, which may lead to mortality if not managed properly. Concurrent infections of dengue and malaria are rare due to the different habitats of its vectors and activities of different carrier mosquitoes. The first case reported was in 2005. Since then, several concurrent infections have been reported between the dengue virus (DENV) and the malaria protozoans, Plasmodium falciparum and Plasmodium vivax. Symptoms of each infection may be masked by a simultaneous second infection, resulting in late treatment and severe complications...
January 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28019000/avian-and-simian-malaria-do-they-have-a-cancer-connection
#16
REVIEW
Martin Ward, Giovanni Benelli
It has been claimed that infectious agents transmitted by mosquitoes (Diptera: Culicidae) may have a greater connection to cancer then hitherto supposed and that the immune system struggles to recognize and fight some of these infectious agents. One of the claims made is that there is a connection between human malaria and brain cancers in the USA. However, the USA declared itself free of human malaria in the last century, yet cancer incidences remain high, suggesting any overall cancer connection is slight...
December 26, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27938428/plasmodium-knowlesi-a-relevant-versatile-experimental-malaria-model
#17
Erica M Pasini, Anne-Marie Zeeman, Annemarie Voorberg-VAN DER Wel, Clemens H M Kocken
The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite-host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model...
December 12, 2016: Parasitology
https://www.readbyqxmd.com/read/27894375/plasmodium-knowlesi-and-human-malaria-parasites-in-khan-phu-vietnam-gametocyte-production-in-humans-and-frequent-co-infection-of-mosquitoes
#18
Y Maeno, R Culleton, N T Quang, S Kawai, R P Marchand, S Nakazawa
Four species of malaria parasite, Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium knowlesi infect humans living in the Khanh Phu commune, Khanh Hoa Province, Vietnam. The latter species also infects wild macaque monkeys in this region. In order to understand the transmission dynamics of the three species, we attempted to detect gametocytes of the three species in the blood of infected individuals, and sporozoites in the salivary glands of mosquitoes from the same region. For the detection of gametocyte-specific mRNA, we targeted region 3 of pfg377, pvs25, pmg and pks25 as indicators of the presence of P...
November 29, 2016: Parasitology
https://www.readbyqxmd.com/read/27829470/the-role-of-plasmodium-knowlesi-in-the-history-of-malaria-research
#19
G A Butcher, G H Mitchell
In recent years, a malaria infection of humans in South East Asia, originally diagnosed as a known human-infecting species, Plasmodium malariae, has been identified as a simian parasite, Plasmodium knowlesi. This species had been subject to considerable investigation in monkeys since the 1930s. With the development of continuous culture of the erythrocytic stages of the human malarial parasite, Plasmodium falciparum in 1976, the emphasis in research shifted away from knowlesi. However, its importance as a human pathogen has provoked a renewed interest in P...
November 10, 2016: Parasitology
https://www.readbyqxmd.com/read/27777305/expansion-of-lysine-rich-repeats-in-plasmodium-proteins-generates-novel-localization-sequences-that-target-the-periphery-of-the-host-erythrocyte
#20
Heledd M Davies, Konstantinos Thalassinos, Andrew R Osborne
Repetitive low complexity sequences, mostly assumed to have no function, are common in proteins that are exported by the malaria parasite into its host erythrocyte. We identify a group of exported proteins containing short lysine-rich tandemly repeated sequences that are sufficient to localize to the erythrocyte periphery, where key virulence-related modifications to the plasma membrane and the underlying cytoskeleton are known to occur. Efficiency of targeting is dependent on repeat number, indicating that novel targeting modules could evolve by expansion of short lysine-rich sequences...
December 9, 2016: Journal of Biological Chemistry
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