keyword
https://read.qxmd.com/read/38497616/promising-aryl-selenoate-derivatives-as-antileishmanial-agents-and-their-effects-on-gene-expression
#21
JOURNAL ARTICLE
Celia Fernández-Rubio, Mercedes Rubio-Hernández, Verónica Alcolea, Aroia Burguete-Mikeo, Paul A Nguewa, Silvia Pérez-Silanes
Leishmaniasis remains one of the main public health problems worldwide, with special incidence in the poorest populations. Selenium and its derivatives can be potent therapeutic options against protozoan parasites. In this work, 17 aryl selenoates were synthesized and screened against three species of Leishmania ( Leishmania major , Leishmania amazonensis , and Leishmania infantum ). Initial screening in promastigotes showed L. infantum species was more sensitive to selenoderivatives than the others. The lead Se-(2-selenocyanatoethyl) thiophene-2-carboselenoate ( 16 ) showed a half-maximal effective concentration of 3...
March 18, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38497599/beyond-the-neoliberal-label-a-historical-perspective-on-sexual-actors-and-responsibility-in-hiv-prevention-in-england-1986-2023
#22
JOURNAL ARTICLE
Alvaro Martinez-Lacabe
Framed across three distinct periods of the history of neoliberalism and the HIV epidemic in England, this article conducts a detailed examination of the concept of personal responsibility and its contested uses within HIV prevention. The article questions the theoretical potential of neoliberal subjectivities to comprehend behaviours related to the pharmaceuticalised governance (or lack thereof) of gay men's sexual health, exploring the gap between theories emphasising individual responsibility and the practical experiences of gay men...
March 18, 2024: Health (London)
https://read.qxmd.com/read/38497583/real-life-experience-on-covid-19-and-seasonal-influenza-vaccines-co-administration-in-the-vaccination-hub-of-the-university-hospital-of-palermo-italy
#23
JOURNAL ARTICLE
Claudio Costantino, Walter Mazzucco, Arianna Conforto, Livia Cimino, Alessia Pieri, Sara Rusignolo, Nicole Bonaccorso, Floriana Bravatà, Laura Pipitone, Martina Sciortino, Marcello Tocco, Elena Zarcone, Giorgio Graziano, Fabio Tramuto, Carmelo Massimo Maida, Alessandra Casuccio, Francesco Vitale
With the pandemic, there has been a global reduction in influenza virus circulation, with WHO reporting, during 2021/22 season, laboratory testing positivity rate for influenza of less than 3%. Influenza surveillance systems anticipated a peak of influenza cases in the Northern Hemisphere during 2022/2023 season and the Italian Ministry of Health recommended the routinary co-administration of influenza with bivalent COVID-19 vaccines for the 2022/2023 season. At the Vaccination Hub of the University Hospital (UH) of Palermo, more than 700 subjects received influenza and COVID-19 booster doses in co-administration, during the 2021/2022 season...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497482/impact-of-secondary-amenorrhea-on-cardiovascular-disease-risk-in-physically-active-women-a-systematic-review-and-meta-analysis
#24
JOURNAL ARTICLE
Nicole L Tegg, Caitlynd Myburgh, Emma O'Donnell, Megan Kennedy, Colleen M Norris
BACKGROUND: Exercise-associated secondary amenorrhea results in estrogen deficiency, which may lead to dysfunction in estrogen's normal cardioprotective pathways. Estrogen may be essential in a woman's endothelial adaptations to exercise. The objective of this review was to assess the association between secondary amenorrhea in physically active women and cardiovascular disease (CVD) risk. METHODS AND RESULTS: A literature search was performed in January 2023 and updated in August 2023 of the Cumulative Index to Nursing and Allied Health Literature (EBSCOhost), Cochrane Library, Embase (Ovid), MEDLINE (Ovid), SPORTDiscus (EBSCOhost), and Scopus from inception to present with no date or language limitations...
March 18, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38497439/algorithmic-surveillance-in-the-era-of-the-mental-health-appsphere
#25
JOURNAL ARTICLE
Idil Abdillahi
Digital mental health applications, also known as mHealth apps, are designed to help users manage their mental health using technology such as mobile devices and smartphones. However, there has been little critical engagement surrounding their impact on marginalized communities, and Black people in Canada. This article aims to explore how state and private actors conceptualize the digitalization of mental health access, leading to the creation and implementation of these apps. It is important to consider the links and interconnections between the platform and the app, and to be cautious and curious before adopting yet another app that claims to manage and mitigate moods and address mental health needs...
March 2024: American Journal of Community Psychology
https://read.qxmd.com/read/38497422/views-and-experiences-of-young-women-from-a-migrant-or-refugee-background-regarding-the-contraceptive-implant-in-australia
#26
JOURNAL ARTICLE
Gianna M L Robbers, Natalie Cousins, Yen Li Lim, Jane Estoesta, Jessica R Botfield
Young people comprise a significant proportion of migrants and refugees in Australia. Many encounter challenges in accessing contraception information and services. This study explored the views and experiences of young women from migrant and/or refugee backgrounds regarding the contraceptive implant and related decision-making. Interviews were conducted with 33 women, aged 15-24, living in New South Wales, Australia, who spoke a language other than English and had some experience of the implant. Three themes were developed from the data as follows: 'Finding your own path': contraception decision-making (in which participants described sex and contraception as being taboo in their community, yet still made independent contraceptive choices); Accessing 'trustworthy' contraception information and navigating services (in which participants consulted online resources and social media for contraception information, and preferred discussions with healthcare providers from outside their community); and Views and experiences of the contraceptive implant (while the implant was described as a 'Western' method, most participants regarded it as an acceptable, convenient, cost-effective, and confidential means of contraception)...
March 18, 2024: Culture, Health & Sexuality
https://read.qxmd.com/read/38497416/patient-engagement-with-an-automated-postdischarge-text-messaging-program-for-improving-care-transitions
#27
JOURNAL ARTICLE
Hassan Fakhoury, Ricardo Trochez, Sunil Kripalani, Neesha Choma, Emily Blessinger, Lyndsay A Nelson
Automated text messaging is a promising approach to monitor patients after hospital discharge and avert readmissions; however, it is not known to what extent patients would engage with this type of program and whether engagement may vary based on patients' characteristics. Using data from a 30-day postdischarge texting program at a large university hospital, we examined engagement over time (operationalized as response rate to text messages) and patient characteristics associated with engagement. Of the 1324 patients in the study sample, 838 (63%) stayed in the program for the full duration...
March 18, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://read.qxmd.com/read/38497392/the-prevalence-of-obesity-and-relationship-between-obesity-indicators-and-chronic-diseases-in-northern-shaanxi-china
#28
JOURNAL ARTICLE
Xiong Yang, Xiaoxia Hao, Mingxia Liu, Yaoda Hu, Xing Wang, Yonglin Liu
INTRODUCTION: Obesity not only affects human health but also is an important risk factor for a variety of chronic diseases. Therefore, it is particularly important to analyse the epidemic trend of obesity and actively carry out the prevention and control of obesity in the population. MATERIAL AND METHODS: A total of 4565 adults were selected by multi-stage stratified random sampling in Shenmu, Shaanxi Province, China. Univariate analysis was used to explore the epidemic characteristics of obesity in this region...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38497364/psychometric-properties-of-the-japanese-version-of-the-health-enhancement-lifestyle-profile-help-j-using-rasch-analysis-a-preliminary-study
#29
JOURNAL ARTICLE
Megumi Nakamura, Katsushi Yokoi, Hiroko Tanimura, Eric J Hwang
The Health Enhancement Lifestyle Profile (HELP) was an assessment instrument for health-related behaviors and was translated into Japanese (HELP-J) using subjective rating scales. This study investigated the internal validity of the HELP-J using a Rasch analysis. Snowball and purposive sampling were used for data collection. The data obtained from the 109 respondents were subjected to Rasch analysis to assess their internal validity. The rating scale analysis supported a 3-category scale; five of the seven subscales showed unidimensionality...
March 18, 2024: Occupational Therapy in Health Care
https://read.qxmd.com/read/38497357/reliability-testing-of-the-health-of-the-nation-outcome-scales-2018
#30
JOURNAL ARTICLE
Jon Painter, Mick James
WHAT IS KNOWN ON THE SUBJECT: The Health of the Nation Outcome Scales (HoNOS) is a widely used clinical measure designed to rate and monitor the outcomes of service users accessing specialist mental healthcare. Since its development (in 1996), numerous research studies have confirmed the HoNOS captures the aspects of care that it purports to (validity), and that clinicians' ratings are consistent both over time, and between different raters (reliability). WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE: In 2018, the HoNOS was reviewed with updates made to some terminology and other revisions intended to remove ambiguity in the guidance for raters...
March 18, 2024: Journal of Psychiatric and Mental Health Nursing
https://read.qxmd.com/read/38497338/therapeutic-strategies-to-modulate-gut-microbial-health-approaches-for-sarcopenia-management
#31
REVIEW
Shreya Das, B Preethi, Sapana Kushwaha, Richa Shrivastava
Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatment. Alterations in gut microbial composition have emerged as a significant contributor to the pathophysiology of multiple diseases. Recently, its association with muscle health has pointed to its potential role in mediating sarcopenia. The current review focuses on the association of gut microbiota and mediators of muscle health, connecting the dots between the influence of gut microbiota and their metabolites on biomarkers of sarcopenia...
March 6, 2024: Histology and Histopathology
https://read.qxmd.com/read/38497332/individual-patient-data-meta-analysis-of-the-effects-of-fluoxetine-on-functional-outcomes-after-acute-stroke
#32
JOURNAL ARTICLE
Gillian Elizabeth Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BACKGROUND: Three large randomised controlled trials of fluoxetine for stroke recovery have been performed. We perfomed an individual patient data meta-analysis (IPDM) on the combined data. METHODS: Fixed effects meta-analyses was performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38497271/cross-talk-and-mutual-shaping-between-the-immune-system-and-the-microbiota-during-an-oyster-s-life
#33
REVIEW
Delphine Destoumieux-Garzón, Caroline Montagnani, Luc Dantan, Noémie de San Nicolas, Marie-Agnès Travers, Léo Duperret, Guillaume M Charrière, Eve Toulza, Guillaume Mitta, Céline Cosseau, Jean-Michel Escoubas
The Pacific oyster Crassostrea gigas lives in microbe-rich marine coastal systems subjected to rapid environmental changes. It harbours a diversified and fluctuating microbiota that cohabits with immune cells expressing a diversified immune gene repertoire. In the early stages of oyster development, just after fertilization, the microbiota plays a key role in educating the immune system. Exposure to a rich microbial environment at the larval stage leads to an increase in immune competence throughout the life of the oyster, conferring a better protection against pathogenic infections at later juvenile/adult stages...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497258/a-new-lexicon-in-the-age-of-microbiome-research
#34
REVIEW
Thomas C G Bosch, Martin J Blaser, Edward Ruby, Margaret McFall-Ngai
At a rapid pace, biologists are learning the many ways in which resident microbes influence, and sometimes even control, their hosts to shape both health and disease. Understanding the biochemistry behind these interactions promises to reveal completely novel and targeted ways of counteracting disease processes. However, in our protocols and publications, we continue to describe these new results using a language that originated in a completely different context. This language developed when microbial interactions with hosts were perceived to be primarily pathogenic, as threats that had to be vanquished...
May 6, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38497224/poor-accuracy-and-sustainability-of-the-first-step-fib4-easl-pathway-for-stratifying-steatotic-liver-disease-risk-in-the-general-population
#35
JOURNAL ARTICLE
Antonio De Vincentis, Federica Tavaglione, Shinichi Namba, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Samantha Maurotti, Claudio Pedone, Raffaele Antonelli Incalzi, Luca Valenti, Stefano Romeo, Umberto Vespasiani-Gentilucci
BACKGROUND AND AIMS: The European Association for the Study of the Liver introduced a clinical pathway (EASL CP) for screening significant/advanced fibrosis in people at risk of steatotic liver disease (SLD). We assessed the performance of the first-step FIB4 EASL CP in the general population across different SLD risk groups (MASLD, Met-ALD and ALD) and various age classes. METHODS: We analysed a total of 3372 individuals at risk of SLD from the 2017-2018 National Health and Nutrition Examination Survey (NHANES17-18), projected to 152...
March 18, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38497208/evaluation-of-the-antifungal-effect-of-plant-extracts-on-oral-candida-spp-a-critical-methodological-analysis-of-the-last-decade
#36
REVIEW
M Maziere, J C Andrade, P Rompante, C F Rodrigues
INTRODUCTION: In 2022, the World Health Organization published a report encouraging researchers to focus on Candida spp. to strengthen the global response to fungal oral infections and antifungal resistance. In the context of innovative research, it seems pertinent to investigate the antifungal potential of natural extracts of plants and the methodology involved in the recent reports. The aim of this systematic review is to identify the current state of in vitro research on the evaluation of the ability of plant extracts to inhibit Candida spp...
March 18, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38497205/women%C3%A2-s-experiences-of-menopause-a-qualitative-study-among-women-in-soweto-south-africa
#37
JOURNAL ARTICLE
Sostina Spiwe Matina, Emily Mendenhall, Emmanuel Cohen
Women today are experiencing menopause for decades more than in previous generations. This 'change of life' is defined by an entire stage of physical, hormonal, and emotional changes that accompany menstrual irregularity and the cessation of fertility, although limited medical research has focused on it. Yet, the inevitability of menopause is universal for all human females around 50 years old. In this article, we conducted twenty-five 20-60 min semi-structured qualitative interviews. Most women marked menopause by fertility cessation and social transition to old age, pushing back against a medical framework of menopause that emphasises hormonal deficiency and becoming disordered...
January 2024: Global Public Health
https://read.qxmd.com/read/38497200/-switching-hats-insights-from-experienced-clinical-interviewers-turned-novice-research-interviewers
#38
JOURNAL ARTICLE
Brightlin N Dhas, Jackie Fox, Benshamir Bright, Dina B El Haj, Abraham P James, Hussain A H J Bu Hazaa, Sultan S H Al Abdulla
Health professionals/clinicians interview people regularly as part of their role. However, a qualitative research interview differs considerably to a clinical interview. If clinicians approach qualitative research interviewing based on their expertise in clinical interviewing, it could cause insufficiencies in qualitative data generation. In this reflection article, we, a team of four experienced clinical occupational therapists with no previous experience in qualitative research interviewing, share our experiences while learning to become qualitative research interviewers before undertaking our first qualitative research project...
March 18, 2024: Qualitative Health Research
https://read.qxmd.com/read/38497108/hormone-replacement-therapy-in-gynecological-cancer-survivors-and-brca-mutation-carriers-a-mito-group-survey
#39
JOURNAL ARTICLE
Innocenza Palaia, Giuseppe Caruso, Violante Di Donato, Camilla Turetta, Antonella Savarese, Giorgia Perniola, Roberta Gallo, Andrea Giannini, Vanda Salutari, Giorgio Bogani, Federica Tomao, Diana Giannarelli, Gabriella Gentile, Angela Musella, Ludovico Muzii, Sandro Pignata
OBJECTIVE: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT...
March 4, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38497098/clinical-utility-of-point-of-care-glucose-testing-in-the-assessment-of-gestational-diabetes-prospective-cohort-study
#40
JOURNAL ARTICLE
Wiaam Al-Hasani, Ruvini Ranasinghe, Helen Rogers, William Spanier, Katie Spears, Carol Gayle, Lisa Long, Georgios K Dimitriadis, Katharine F Hunt, Royce P Vincent
OBJECTIVE: To assess the clinical utility of point-of-care (POC) capillary blood glucose (CBG) testing in the assessment of gestational diabetes mellitus (GDM) during oral glucose tolerance test (OGTT). DESIGN: Prospective cohort study. SETTING: Antenatal clinics at King's College Hospital. POPULATION: Women screened for GDM between March and June 2020. METHODS: The CBG was measured using the POC StatStrip® test and the venous plasma glucose (VPG) was measured by Roche analyser (Cobas 8000 c702)...
March 18, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
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