Alicia de Coo, Raquel Cruz, Inés Quintela, David Herrera, Mariano Sanz, Pedro Diz, Segundo Rodríguez Grandío, Nuria Vallcorba, Isabel Ramos, Alfonso Oteo, Cristina Serrano, Alejandro Esmatges, Francisco Enrile, Leopoldo Mateos, Roberto García, Pablo Álvarez-Novoa, Blas Noguerol, Ion Zabalegui, José Blanco-Moreno, Ángel Alonso, Ramón Lorenzo, Angel Carracedo, Juan Blanco
AIM: To identify loci associated with stages III/IV, grade C periodontitis (PIII/IV-C) through a genome-wide association study (GWAS). MATERIALS AND METHODS: 441 Caucasian Spanish PIII/IV-C cases from the SEPA Network of Research Clinics and 1141 controls from the Banco Nacional de ADN were genotyped with "Axiom Spain Biobank Array," which contains 757836 markers, including rare and low-frequency Spanish variants. The analysis of the individual association and subsequently the gene-level analysis with Sequence Kernel Association Test (SKAT) were carried out adjusting for age, sex and PC1 covariates...
July 2021: Journal of Clinical Periodontology