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https://www.readbyqxmd.com/read/28892874/mortality-from-multiple-sclerosis-in-british-military-personnel
#1
E Clare Harris, Keith T Palmer, Vanessa Cox, Andrew Darnton, John Osman, David Coggon
BACKGROUND: While analysing trends in occupational mortality in England and Wales, we noticed an unexpectedly elevated proportion of deaths from multiple sclerosis (MS) among men in the armed forces. AIMS: To document and explore possible explanations for the observed excess. METHODS: We analysed data on underlying cause of death and last full-time occupation for 3,688,916 deaths among men aged 20-74 years in England and Wales during 1979-2010, calculating proportional mortality ratios (PMRs) standardised for age...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28859337/amygdala-tdp-43-pathology-in-frontotemporal-lobar-degeneration-and-motor-neuron-disease
#2
Takahiro Takeda, Danielle Seilhean, Isabelle Le Ber, Stéphanie Millecamps, Véronique Sazdovitch, Kazuo Kitagawa, Toshiki Uchihara, Charles Duyckaerts
TDP-43-positive inclusions are present in the amygdala in frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND) including amyotrophic lateral sclerosis. Behavioral abnormalities, one of the chief symptoms of FTLD, could be, at least partly, related to amygdala pathology. We examined TDP-43 inclusions in the amygdala of patients with sporadic FTLD/MND (sFTLD/MND), FTLD/MND with mutation of the C9ORF72 (FTLD/MND-C9) and FTLD with mutation of the progranulin (FTLD-GRN). TDP-43 inclusions were common in each one of these subtypes, which can otherwise be distinguished on topographical and genetic grounds...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28833988/beyond-weakness-characterization-of-pain-sensory-profile-and-conditioned-pain-modulation-in-patients-with-motor-neuron-disease-a-controlled-study
#3
L C G Lopes, R Galhardoni, V Silva, F M H Jorge, L T Yeng, D Callegaro, G Chadi, M J Teixeira, D Ciampi de Andrade
BACKGROUND: Motor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non-motor symptoms in these patients have been rarely reported. METHODS: This cross-sectional study aimed to describe non-motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55...
August 22, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28829002/supporting-wellbeing-in-motor-neurone-disease-for-patients-carers-social-networks-and-health-professionals-a-scoping-review-and-synthesis
#4
Melanie Harris, Geoff Thomas, Mary Thomas, Paul Cafarella, Allegra Stocks, Julia Greig, R Doug McEvoy
OBJECTIVE: Disease management in motor neurone disease (MND) is focused on preserving quality of life. However, the emphasis has so far been on physical symptoms and functioning and not psychosocial wellbeing. MND affects the wellbeing of carers, of family and social network members, and of healthcare providers, as well as of the patients. We therefore aimed to assess and synthesize the knowledge about maximizing MND-related psychosocial wellbeing across all these groups. METHOD: We used a systematic search and selection process to assess the scope of the literature along with a narrative synthesis of recent high-quality reviews...
August 22, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28817497/self-care-in-people-with-motor-neuron-disease-an-integrative-review
#5
Barbara Bassola, Maura Lusignani
INTRODUCTION: Self-care is a crucial aspect in the management of chronic diseases. People with motor neuron disease (MND) live with a chronic degenerative condition in rapid evolution, which leads them to high dependencies. During their illness, they must apply several behaviors including adherence to ventilation and nutritional therapy. OBJECTIVE: The purpose of this review is to systematically explore the concept of self-care for people with MND. METHOD: An integrative review of the literature has been conducted...
August 16, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28807138/prevalence-and-predictors-of-post-stroke-mood-disorders-a-meta-analysis-and-meta-regression-of-depression-anxiety-and-adjustment-disorder
#6
Alex J Mitchell, Bhavisha Sheth, John Gill, Motahare Yadegarfar, Brendon Stubbs, Mohammad Yadegarfar, Nick Meader
OBJECTIVE: To ascertain the prevalence and predictors of mood disorders, determined by structured clinical interviews (ICD or DSM criteria) in people after stroke. METHODS: Major electronic databases were searched from inception to June 2016 for studies involving major depression (MDD), minor depression (MnD), dysthymia, adjustment disorder, any depressive disorder (any depressive disorder) and anxiety disorders. Studies were combined using both random and fixed effects meta-analysis and results were stratified as appropriate...
July 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28794983/multimodal-structural-mri-in-the-diagnosis-of-motor-neuron-diseases
#7
Pilar M Ferraro, Federica Agosta, Nilo Riva, Massimiliano Copetti, Edoardo Gioele Spinelli, Yuri Falzone, Gianni Sorarù, Giancarlo Comi, Adriano Chiò, Massimo Filippi
This prospective study developed an MRI-based method for identification of individual motor neuron disease (MND) patients and test its accuracy at the individual patient level in an independent sample compared with mimic disorders. 123 patients with amyotrophic lateral sclerosis (ALS), 44 patients with predominantly upper motor neuron disease (PUMN), 20 patients with ALS-mimic disorders, and 78 healthy controls were studied. The diagnostic accuracy of precentral cortical thickness and diffusion tensor (DT) MRI metrics of corticospinal and motor callosal tracts were assessed in a training cohort and externally proved in a validation cohort using a random forest analysis...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28776108/erratum-to-trends-in-research-literature-describing-dysphagia-in-motor-neuron-diseases-mnd-a-scoping-review
#8
Ashley A Waito, Teresa J Valenzano, Melanie Peladeau-Pigeon, Catriona M Steele
No abstract text is available yet for this article.
August 3, 2017: Dysphagia
https://www.readbyqxmd.com/read/28752495/changing-clinical-phenotypes-of-hiv-associated-neurocognitive-disorders
#9
Ned Sacktor
HIV-associated neurocognitive disorder (HAND) remains a common cause of cognitive impairment and persists in 15-55% of HIV+ individuals in the combination antiretroviral therapy (CART) era. CART is now the primary treatment for HAND, but it is effective in only a subset of patients. In the pre-CART era, HIV-associated dementia was the most common form of HAND. However, in CART-treated patients, the prevalence of HIV-associated dementia has declined substantially, and milder stages of HAND, i.e., ANI and MND predominate...
July 27, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28745179/nurse-backs-challenge-to-law-on-assisted-dying
#10
Petra Kendall-Raynor
When Alison Pickard was diagnosed with motor neurone disease (MND), she had established a nursing career that spanned five decades. Now, more than five years on from her diagnosis, she has given written evidence backing a High Court bid to challenge current legislation and make assisted dying legal.
July 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28745177/assisted-dying-debate-highlights-need-to-prioritise-palliative-care
#11
(no author information available yet)
Nurse Alison Pickard's experience makes for difficult reading. She has been diagnosed with motor neurone disease (MND) and gave evidence in support of a change to the law on assisted dying in a High Court case in London.
July 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28745069/a-case-series-of-pls-patients-with-frontotemporal-dementia-and-overview-of-the-literature
#12
Bálint S de Vries, Laura M M Rustemeijer, Anneke J van der Kooi, Joost Raaphorst, Carin D Schröder, Tanja C W Nijboer, Jeroen Hendrikse, Jan H Veldink, Leonard H van den Berg, Michael A van Es
OBJECTIVE: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a separate disease or a subtype of ALS has been debated. In ALS comorbid frontotemporal dementia (FTD) is frequently seen (±15%). However, cognitive and behavioural changes are generally not considered to be a part of PLS. METHODS: To report the clinical findings and frequency of PLS patients that developed FTD in a referral-based cohort and provide an overview of the literature...
July 26, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28731850/the-diagnostic-accuracy-of-biomarkers-for-diagnosis-of-primary-biliary-cholangitis-pbc-in-anti-mitochondrial-antibody-ama-negative-pbc-patients-a-review-of-literature
#13
Federica de Liso, Caterina Matinato, Mariangela Ronchi, Rita Maiavacca
Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, is an autoimmune disease of the liver characterized by anti-mitochondrial antibodies (AMA) in 90%-95% of patients. The aim of this study was to evaluate the diagnostic value of several serum biomarkers in patients with PBC but negative for AMA. Some antinuclear antibodies (ANA) pattern, detected by indirect immunofluorescence (IIF), such as multiple nuclear dot (MND) and rim-like patterns are well-known to be specific for PBC. The corresponding nuclear antigens are the components of the nuclear pore complex (Gp210 for rim-like pattern) and Sp100, PML proteins (for MND pattern) detectable by immunoblotting and ELISA methods...
July 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28727213/farming-and-incidence-of-motor-neuron-disease-french-nationwide-study
#14
S Kab, F Moisan, A Elbaz
BACKGROUND AND PURPOSE: The association of farming with motor neuron disease (MND) is unclear, with conflicting studies. We performed a French nationwide study of the association of farming with MND incidence, and compared findings with those for Parkinson's disease (PD), which has been shown to be more frequent in farmers. METHODS: We used the French national health insurance and hospital discharge databases to identify MND/PD incident cases. The Mutualité Sociale Agricole (MSA) guarantees health insurance for farmers and agricultural workers...
September 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28687523/tdp-43-in-the-spectrum-of-mnd-ftld-pathologies
#15
REVIEW
Lanier Heyburn, Charbel E-H Moussa
The relationship between RNA-binding proteins, particularly TAR DNA binding protein 43 (TDP-43), and neurodegeneration is an important area of research. TDP-43 is involved in so many cellular processes that perturbation of protein homeostasis can lead to countless downstream effects. Understanding what leads to this disease-related protein imbalance and the resulting cellular and molecular effects will help to develop targets for disease intervention, whether it be prevention of protein accumulation, or addressing a secondary effect of protein accumulation...
September 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28686046/the-challenges-of-dysphagia-in-treating-motor-neurone-disease
#16
Siobhan Vesey
Motor neurone disease (MND) is a relatively rare degenerative disorder. Its impacts are manifested in progressive loss of motor function and often accompanied by wider non-motor changes. Swallowing and speech abilities are frequently severely impaired. Effective management of dysphagia (swallowing difficulty) symptoms and nutritional care requires a holistic multidisciplinary approach. Care must be patient focused, facilitate patient decision making, and support planning towards end of life care. This article discusses the challenges of providing effective nutritional care to people living with motor neurone disease who have dysphagia...
July 1, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28681543/supportive-care-needs-of-patients-with-amyotrophic-lateral-sclerosis-motor-neuron-disease-and-their-caregivers-a-scoping-review
#17
REVIEW
Juyeon Oh, Jung A Kim
AIM AND OBJECTIVE: The aim of this study is to identify the supportive care needs of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) patients and their caregivers, categorize and summarize them into a Supportive Care Needs Framework, and identify gaps in literature. BACKGROUND: Little is known about the supportive care needs of ALS/MND patients and their caregivers, and this subject has not previously been systemically reviewed. DESIGN: Scoping review...
July 5, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28676497/farrell-valve-relieves-bloating-in-gastrostomy-patient
#18
Alison Phippen, Elaine Brennan, John Ealing, Samantha Kay, David Waterman
Dysphagia and weight loss are experienced by up to 80% of patients with motor neuron disease (MND). Enteral tube feeding can benefit these patients but side effects including fullness, bloating, diarrhoea and constipation are frequent and can lead to non-compliance. Changes in feed formulation, regimens and the use of prokinetic medication can help symptoms. We describe a case where the use of gastric pressure relief bags during enteral feeding improved symptoms of bloating in a hospice inpatient with MND. Symptoms recurred when these were not used, which were only partially relieved by manual venting of the gastrostomy tube...
July 3, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28666709/structural-and-functional-brain-signatures-of-c9orf72-in-motor-neuron-disease
#19
Federica Agosta, Pilar M Ferraro, Nilo Riva, Edoardo Gioele Spinelli, Teuta Domi, Paola Carrera, Massimiliano Copetti, Yuri Falzone, Maurizio Ferrari, Christian Lunetta, Giancarlo Comi, Andrea Falini, Angelo Quattrini, Massimo Filippi
This study investigated structural and functional magnetic resonance imaging abnormalities in hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) motor neuron disease (MND) relative to disease severity-matched sporadic MND cases. We enrolled 19 C9orf72 and 67 disease severity-matched sporadic MND patients, and 22 controls. Sporadic cases were grouped in patients with: no cognitive/behavioral deficits (sporadic-motor); same patterns of cognitive/behavioral impairment as C9orf72 cases (sporadic-cognitive); shorter disease duration versus other sporadic groups (sporadic-early)...
September 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28664472/trends-in-research-literature-describing-dysphagia-in-motor-neuron-diseases-mnd-a-scoping-review
#20
REVIEW
Ashley A Waito, Teresa J Valenzano, Melanie Peladeau-Pigeon, Catriona M Steele
Dysphagia in motor neuron diseases (MNDs) is highly complex, affecting all stages of swallowing and leading to impaired swallowing safety and efficiency. In order to explore the degree to which research is capturing the symptom of dysphagia in MND, we conducted a scoping review of the existing literature. The primary aims of this review were to identify common themes within the literature on dysphagia in MND, explore patterns and trends in research focus, and identify if any imbalances exist between the research themes related to dysphagia description and management...
June 29, 2017: Dysphagia
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