keyword
https://read.qxmd.com/read/38033482/are-there-any-pleiotropic-benefits-of-vitamin-d-in-patients-with-diabetic-kidney-disease-a-systematic-review-of-randomized-controlled-trials
#1
JOURNAL ARTICLE
Jaya K Sharma, Sono Khan, Tristin Wilson, Nathan Pilkey, Sanjana Kapuria, Angélique Roy, Michael A Adams, Rachel M Holden
BACKGROUND: Type 2 diabetes (T2D) and kidney disease are risk factors for vitamin D deficiency. Native forms of vitamin D have a lower risk of hypercalcemia than calcitriol, the active hormone. The enzyme responsible for activating native vitamin D is now known to be expressed throughout the body; therefore, native vitamin D may have clinically relevant effects in many body systems. OBJECTIVE: The objective of this systematic review was to examine the effect of native vitamin D supplementation on clinical outcomes and surrogate laboratory measures in patients with T2D and diabetic kidney disease (DKD)...
2023: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/36835159/vitamin-d-and-diabetic-kidney-disease
#2
REVIEW
Ho-Yin Huang, Ting-Wei Lin, Zi-Xuan Hong, Lee-Moay Lim
Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH)2 D3 , modulates serum calcium-phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is associated with podocyte preservation, regulates the renin-angiotensin-aldosterone system, and has anti-inflammatory effects. Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide...
February 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36558489/the-impact-of-serum-levels-of-vitamin-d3-and-its-metabolites-on-the-prognosis-and-disease-severity-of-covid-19
#3
JOURNAL ARTICLE
Hani M J Khojah, Sameh A Ahmed, Sultan S Al-Thagfan, Yaser M Alahmadi, Yasser A Abdou
Vitamin D is among the increasingly consumed dietary supplements during the COVID-19 pandemic. It plays a regulatory role in the immune system and moderates the renin-angiotensin system, which is implicated in infection pathogenesis. However, the investigation of serum levels of vitamin D3 forms and their relative ratios in COVID-19 patients is worth investigation to understand the impacts of disease severity. Hence, we investigated the serum levels of vitamin D3 (cholecalciferol) and its metabolites (calcifediol and calcitriol), in addition to their relative ratios and correlations with angiotensin-converting enzyme 2 (ACE2), interleukin-6 (Il-6), and neutrophil-lymphocyte ratio (NLR) in COVID-19 patients compared with healthy controls...
December 15, 2022: Nutrients
https://read.qxmd.com/read/36033312/exposure-to-airborne-particulate-matter-induces-renal-tubular-cell-injury-in-vitro-the-role-of-vitamin-d-signaling-and-renin-angiotensin-system
#4
JOURNAL ARTICLE
Eungu Kang, Hyung Eun Yim, Yoon Jeong Nam, Sang Hoon Jeong, Joo-Ae Kim, Ju-Han Lee, Min Hwa Son, Kee Hwan Yoo
Background: Exposure to air pollution can interfere with the vitamin D endocrine system. This study investigated the effects of airborne particulate matter (PM) on renal tubular cell injury in vitro and explored the underlying mechanisms. Methods: HK-2 human renal proximal tubule cells were treated with PM with or without 1,25(OH)2 D3 analog, 19-Nor-1,25(OH)2 D2 (paricalcitol, 10 nM) for 48 h. The dose- and time-dependent cytotoxicity of PM with or without paricalcitol was determined via cell counting kit-8 assay...
August 2022: Heliyon
https://read.qxmd.com/read/35930297/modulation-of-cardiometabolic-risk-and-cardiorenal-syndrome-by-oral-vitamin-d-3-supplementation-in-black-and-white-southern-sahara-residents-with-chronic-kidney-disease-stage-3-focus-on-racial-and-ethnic-disparities
#5
JOURNAL ARTICLE
Asma Bouazza, Amina Tahar, Samir AitAbderrhmane, Messaoud Saidani, Elhadj-Ahmed Koceir
OBJECTIVES: Several studies have shown that cholecalciferol supplementation (25OHD-S) in chronic kidney disease (CKD) improves kidney injury by reducing fibrosis-related vascular calcification and declining apoptosis-linked nephron damage. METHODS: The oral 25OHD-S was evaluated in 60,000 IU/month/36 weeks versus in 2000 IU/d/24 weeks in CKD Stage 3 with serum 25OHD level < 20 ng/mL. The study was undertaken on 156 black subjects and 150 white subjects Southern Sahara (SS)...
December 2022: Renal Failure
https://read.qxmd.com/read/35319388/changes-in-metabolic-parameters-in-patients-with-diabetic-kidney-disease-depending-on-the-status-of-d3
#6
JOURNAL ARTICLE
Yulia Pastukhova, Francesco Luzza, Sviatoslav Shevel, Oleksii Savchuk, Liudmyla Ostapchenko, Tetyana Falalyeyeva, Nataliia Molochek, Olena Kuryk, Oleksandr Korotkyi, Nazarii Kobyliak
BACKGROUND: Type 2 diabetes is a metabolic disease characterized by hyperglycemia on the background of insulin resistance and decreased insulin secretion. A relatively large number of patients with this type of diabetes have abdominal obesity, which also affects insulin resistance development. Chronic hyperglycemia can lead to damage and dysfunction of various organs, and a striking example is diabetic nephropathy. Diabetic nephropathy is a specific kidney damage that occurs due to complications of diabetes and is accompanied by the formation of diffuse or nodular glomerulosclerosis, which can lead to terminal renal failure and requires the immediate substitution of renal therapy or renal transplantation...
March 21, 2022: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/34684596/covid-19-mortality-risk-correlates-inversely-with-vitamin-d3-status-and-a-mortality-rate-close-to-zero-could-theoretically-be-achieved-at-50-ng-ml-25-oh-d3-results-of-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Lorenz Borsche, Bernd Glauner, Julian von Mendel
BACKGROUND: Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic. METHODS: Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels...
October 14, 2021: Nutrients
https://read.qxmd.com/read/34064039/the-molecular-basis-of-covid-19-pathogenesis-conventional-and-nanomedicine-therapy
#8
REVIEW
Shirin Kouhpayeh, Laleh Shariati, Maryam Boshtam, Ilnaz Rahimmanesh, Mina Mirian, Yasaman Esmaeili, Malihe Najaflu, Negar Khanahmad, Mehrdad Zeinalian, Maria Trovato, Franklin R Tay, Hossein Khanahmad, Pooyan Makvandi
In late 2019, a new member of the Coronaviridae family, officially designated as "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), emerged and spread rapidly. The Coronavirus Disease-19 (COVID-19) outbreak was accompanied by a high rate of morbidity and mortality worldwide and was declared a pandemic by the World Health Organization in March 2020. Within the Coronaviridae family, SARS-CoV-2 is considered to be the third most highly pathogenic virus that infects humans, following the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV)...
May 21, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33960201/effects-of-vitamin-d-supplementation-on-cardiovascular-and-glycemic-biomarkers
#9
RANDOMIZED CONTROLLED TRIAL
Jennifer Miao, Katherine N Bachmann, Shi Huang, Yan Ru Su, Jeffery Dusek, Christopher Newton-Cheh, Pankaj Arora, Thomas J Wang
Background Experimental and observational studies have suggested a link between vitamin D and cardiovascular and metabolic disease, but this has not been confirmed in randomized controlled trials. We sought to determine whether vitamin D supplementation reduces biomarkers of insulin resistance, inflammation, neurohormonal activation, and lipids. Methods and Results This was a prespecified, secondary analysis of the DAYLIGHT (Vitamin D Therapy in Individuals at High Risk of Hypertension) randomized controlled trial...
May 18, 2021: Journal of the American Heart Association
https://read.qxmd.com/read/33798678/vitamin-d-decreases-silencer-methylation-to-downregulate-renin-gene-expression
#10
JOURNAL ARTICLE
Daniesha Govender, Lidija Damjanovic, Chajinsi A Gaza, Vanessa Meyer
Renin, encoded by REN, is an essential enzyme in the renin-angiotensin aldosterone system (RAAS) which is responsible for the maintenance of blood pressure homeostasis. Transcriptional regulation of REN has been linked to enhancer-promoter crosstalk, cAMP response element-binding protein (CREB), the active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), and a less well-characterized intronic silencer element. We hypothesized that in addition to these, differential DNA methylation is linked to REN expression and influenced by 1,25(OH)2 D3 ...
June 20, 2021: Gene
https://read.qxmd.com/read/33433800/vitamin-d-deficiency-exacerbates-colonic-inflammation-due-to-activation-of-the-local-renin-angiotensin-system-in-the-colon
#11
JOURNAL ARTICLE
Xinzhi Wei, Xue Li, Jie Du, Xin Ge, Yue Sun, Xin Li, Zhe Xun, Weicheng Liu, Zhan-You Wang, Yan Chun Li
BACKGROUND: The renin-angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitamin D is unclear with regard to the pathogenesis of IBD. AIMS: To investigate whether vitamin D suppresses the local colonic RAS to prevent colonic mucosal inflammation in a mouse model of experimental colitis. METHODS: C57BL/6 mice fed vitamin D-deficient (VDD) diet for 8 weeks were induced to colitis by 2,4,6-trinitrobenzenesulfonic acid (TNBS), with mice fed vitamin D-sufficient (VDS) diet as controls...
November 2021: Digestive Diseases and Sciences
https://read.qxmd.com/read/33185582/covid-19-in-age-related-neurodegenerative-diseases-is-there-a-role-for-vitamin-d3-as-a-possible-therapeutic-strategy
#12
REVIEW
Milena de Barros Viana, Bárbara Dos Anjos Rosário, Maria de Fátima Santana de Nazaré, Débora Estadella, Daniel Araki Ribeiro, Glauce Socorro de Barros Viana
The coronavirus disease (COVID-19), identified in Wuhan, China, on December 2019, was declared a pandemic by the World Health Organization, on March, 2020. Since then, efforts have been gathered to describe its clinical course and to determine preventive measures and treatment strategies. Adults older than 65 years of age are more susceptible to serious clinical symptoms and present higher mortality rates. Angiotensin-converting enzyme 2 (ACE2) is a major receptor for some coronavirus infection, including SARS-COV-2, but is also a crucial determinant in anti-inflammation processes during the renin-angiotensin system (RAS) functioning - converting angiotensin II to angiotensin 1-7...
February 23, 2021: Reviews in the Neurosciences
https://read.qxmd.com/read/32603019/phenol-glycosides-extract-of-fructus-ligustri-lucidi-attenuated-depressive-like-behaviors-by-suppressing-neuroinflammation-in-hypothalamus-of-mice
#13
JOURNAL ARTICLE
Rui Feng, Ming-Chao He, Qiang Li, Xiao-Qiang Liang, De-Zhi Tang, Jia-Li Zhang, Shu-Fen Liu, Fu-Hui Lin, Yan Zhang
Depression is partially caused by inflammation in central nervous system. This study investigated the ameliorative effects of phenol glycosides (PG) from Ligustrum lucidum Ait. (Oleaceae) on neuroinflammation and depressive-like behavior in mice hypothalamus as well as the molecular mechanism. Mice were administered with PG extract for 2 weeks prior to treatment with LPS. The mice treated with PG extract showed resistance to LPS-induced reduction in body weight and LPS-induced depressive-like behaviors shown by sucrose preference, tail suspension test, forced swimming test and open field test...
December 2020: Phytotherapy Research: PTR
https://read.qxmd.com/read/32073675/the-effect-of-vitamin-d-treatment-on-clinical-and-biochemical-outcomes-of-primary-aldosteronism
#14
JOURNAL ARTICLE
Noor Ashikin Ismail, Nor Azmi Kamaruddin, Shamsul Azhar Shah, Norlela Sukor
INTRODUCTION: Primary aldosteronism (PA) contributed to the cardiovascular disease and metabolic alterations independent of the blood pressure level. Evidence exists that aldosterone excess also affects calcium and mineral homeostasis. PA subjects have been shown to have greater prevalence of vitamin D deficiency. However, the impact of vitamin D treatment in this population has never been assessed. OBJECTIVE: This study aimed to evaluate the effect of vitamin D treatment on clinical and biochemical outcomes of PA patients...
June 2020: Clinical Endocrinology
https://read.qxmd.com/read/31866564/vitamin-d3-potentiates-the-renoprotective-effects-of-vildagliptin-in-a-rat-model-of-fructose-salt-induced-insulin-resistance
#15
JOURNAL ARTICLE
Nehal S Wahba, Rasha H Abdel-Ghany, Salah A Ghareib, Mohamed Abdel-Aal, Amira E Alsemeh
Insulin resistance (IR) seemingly plays a role in chronic kidney disease (CKD). The present study has elucidated the crucial interplay of oxidative stress, inflammatory, apoptotic and profibrotic signaling pathways, linking IR to CKD. The study aimed at investigating the pleiotropic nephroprotective effects of either vildagliptin or vitamin D3 in a fructose/salt-induced IR rat model, highlighting the potential molecular mechanisms underlying their action. Another interesting target was to evaluate the potential capacity of vitamin D3 to potentiate the nephroprotective effects of vildagliptin...
March 1, 2020: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/31216906/potential-role-of-estradiol-in-ovariectomy-induced-derangement-of-renal-endocrine-functions
#16
JOURNAL ARTICLE
Ahmed A El-Gendy, Wael M Elsaed, Hesham I Abdallah
Menopause is an important physiological event associated with structural and functional changes in the kidneys. An animal model of bilateral ovariectomy was used to study the effects of estrogen depletion, replacement and antiestrogen on renal structure and endocrine function. Sixty female rats were divided into six groups; group I was the control group, the remaining five groups underwent ovariectomy: group II received no treatment. The other groups received estradiol in group III, tamoxifen in group IV, estradiol followed by tamoxifen in group V and tamoxifen followed by estradiol in group VI...
November 2019: Renal Failure
https://read.qxmd.com/read/30221529/comparing-serum-level-of-vitamin-d3-in-patients-with-isolated-coronary-artery-ectasia-and-normal-coronary-artery-individuals
#17
JOURNAL ARTICLE
Ali Hosseinsabet, Mohsen Faal, Akbar Shafiee, Hassan Aghajani, Maryam Sotoudeh Anvari, Arash Jalali, Younes Nozari, Hamidreza Pourhosseini, Mojtaba Salarifar, Alireza Amirzadegan, Seyed Ebrahim Kassaian, Mohammad Alidoosti, Alimohammad Hajizeinali, Ebrahim Nematipour
BACKGROUND: Coronary artery ectasia (CAE) is identified as dilation of one or more segments of coronary arteries that reaches 1.5 times or more, compared with near segments that are normal. Several etiologies like atherosclerosis, autoimmune diseases and congenital anomalies have been proposed for this condition. Vitamin D deficiency activates the renin-angiotensin-aldosterone system, which affects the cardiovascular system. For these reasons, we investigated the serum level of vitamin D in patients with CAE compared with individuals with normal coronary arteries...
September 1, 2018: Archives of Iranian Medicine
https://read.qxmd.com/read/30043092/the-effect-of-vitamin-d3-supplementation-on-markers-of-cardiovascular-health-in-hyperparathyroid-vitamin-d-insufficient-women-a-randomized-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Lise Sofie Bislev, Lene Langagergaard Rødbro, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen, Alisa D Kjaergaard, Søren Andreas Ladefoged, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
PURPOSE: Emerging data supports an association between parathyroid hormone (PTH) and aldosterone. It has been speculated, that potential adverse cardiovascular effects of vitamin D insufficiency may partly be caused by the development of secondary hyperparathyroidism with increased activity of the renin-angiotensin-aldosterone system (RAAS). We aimed to investigate the effect of normalizing vitamin D status and/or reducing PTH levels on RAAS activity and other markers of cardiovascular health...
October 2018: Endocrine
https://read.qxmd.com/read/29733445/effects-of-treatment-with-an-angiotensin-2-receptor-blocker-and-or-vitamin-d3-on-parathyroid-hormone-and-aldosterone-a-randomized-placebo-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Lise Sofie Bislev, Lene Langagergaard Rødbro, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
OBJECTIVE: Emerging evidence supports a positive, bidirectional and clinical relevant interaction between parathyroid hormone (PTH) and the renin-angiotensin-aldosterone-system (RAAS). A beneficial effect of the widely used RAAS inhibitors might include a PTH-lowering effect, as high PTH levels may be harmful to cardiovascular health. We aimed to investigate whether PTH levels are lowered by short-term treatment with an angiotensin 2 receptor blocker (valsartan) independently of coadministration of vitamin D3...
November 2018: Clinical Endocrinology
https://read.qxmd.com/read/28680124/refining-long-term-prediction-of-cardiovascular-risk-in-diabetes-the-vildia-score
#20
JOURNAL ARTICLE
Georg Goliasch, Günther Silbernagel, Marcus E Kleber, Tanja B Grammer, Stefan Pilz, Andreas Tomaschitz, Philipp E Bartko, Gerald Maurer, Wolfgang Koenig, Alexander Niessner, Winfried März
Cardiovascular risk assessment in patients with diabetes relies on traditional risk factors. However, numerous novel biomarkers have been found to be independent predictors of cardiovascular disease, which might significantly improve risk prediction in diabetic patients. We aimed to improve prediction of cardiovascular risk in diabetic patients by investigating 135 evolving biomarkers. Based on selected biomarkers a clinically applicable prediction algorithm for long-term cardiovascular mortality was designed...
July 5, 2017: Scientific Reports
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