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Vitamin D3 AND renin

Lise Sofie Bislev, Lene Langagergaard Rødbro, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark
OBJECTIVE: Emerging evidence support a positive, bidirectional and clinical relevant interaction between parathyroid hormone (PTH) and the renin-angiotensin-aldosterone-system (RAAS). A beneficial effect of the widely used RAAS inhibitors might include a PTH lowering effect, as high PTH levels may be harmful to cardiovascular health. We aimed to investigate whether PTH levels are lowered by short-term treatment with an angiotensin 2 receptor blocker (valsartan) independently of co-administration of vitamin D3...
May 7, 2018: Clinical Endocrinology
Georg Goliasch, Günther Silbernagel, Marcus E Kleber, Tanja B Grammer, Stefan Pilz, Andreas Tomaschitz, Philipp E Bartko, Gerald Maurer, Wolfgang Koenig, Alexander Niessner, Winfried März
Cardiovascular risk assessment in patients with diabetes relies on traditional risk factors. However, numerous novel biomarkers have been found to be independent predictors of cardiovascular disease, which might significantly improve risk prediction in diabetic patients. We aimed to improve prediction of cardiovascular risk in diabetic patients by investigating 135 evolving biomarkers. Based on selected biomarkers a clinically applicable prediction algorithm for long-term cardiovascular mortality was designed...
July 5, 2017: Scientific Reports
Lin Shen, Chen Ma, Bo Shuai, Yanping Yang
Active vitamin D is closely related to the circulating renin-angiotensin system (RAS) in experimental animal models and humans; however, corresponding local bone data remain limited. The present study examined whether 1,25-dihydroxyvitamin D3 supplementation altered local bone RAS elements in a murine model of glucocorticoid-induced osteoporosis (GIOP). A total of 36 8-week-old mice were randomized into three equal-sized groups: The sham, GIOP and 1,25-dihydroxyvitamin D3 treatment groups. After 12 weeks, the cancellous bone microstructure of the third lumbar vertebra and left femur from the mice from each group were examined using micro-computed tomography...
June 2017: Experimental and Therapeutic Medicine
Martin R Grübler, Martin Gaksch, Katharina Kienreich, Nicolas Verheyen, Johannes Schmid, Bríain W J Ó Hartaigh, Georg Richtig, Hubert Scharnagl, Andreas Meinitzer, Burkert Pieske, Astrid Fahrleitner-Pammer, Winfried März, Andreas Tomaschitz, Stefan Pilz
Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency. The Styrian Vitamin D Hypertension Trial was a single-center, double-blind, placebo-controlled randomized clinical trial conducted from 2011 to 2014. Two hundred patients with arterial hypertension and 25(OH)D levels <30 ng/mL were enrolled...
July 2016: Journal of Clinical Hypertension
Domenico Santoro, Vincenzo Pellicanò, Valeria Cernaro, Viviana Lacava, Antonio Lacquaniti, Marco Atteritano, Michele Buemi
Vitamin D has been known for a long time as a major factor involved in the calcium- phosphate balance and homeostasis, along with parathyroid hormone (PTH). While vitamin D effects on calcium and phosphate are fully known, recent studies attempted to link vitamin D status and cardiovascular diseases. The involvement of vitamin D on vascular remodeling is mediated by several mechanisms such as activation of renin-angiotensin-aldosterone system (RAAS), cell proliferation and anti-apoptotic cell pathways. This correlation is highlighted by the fact that the activated form of vitamin D (1,25 (OH)2 D3) can be synthesized by the same endothelial cells, due to the constitutive presence of endothelial 1α-hydroxylase...
2016: Current Medicinal Chemistry
Michael Gekle
The kidney undergoes age-related changes, reaching full functionality after the age of 5years and suffering a slow but progressive decline in its regulatory range of function (e.g. matching sodium and potassium excretion to dietary intake), starting at the age of ~20years, as well as in function (e.g. glomerular filtration) starting at a higher age. Age-related decline in renal function is also a matter of gender, race and genetic background. Pathogenetically, mediators of chronic inflammation, oxidative stress and the renin-angiotensin-aldosterone (RAAS) system are relevant factors determining renal aging, due to an enhanced incidence of cellular damage combined with reduced repair capacities...
January 2017: Experimental Gerontology
Carlos Cuervo, Carolyn L Abitbol, Gaston E Zilleruelo, Michael Freundlich
BACKGROUND: As 1,25(OH)2D3 vitamin D3 induces fibroblast growth factor-23 (FGF-23) production and suppresses the renin-angiotensin-aldosterone system (RAAS), its absence in vitamin-D-dependent rickets type I (VDDR-I) may have adverse health consequences. CASE DESCRIPTION: An infant presented at age 8 months with hypocalcemia and rickets and very low 1,25(OH)2D3 levels. Genetic analysis confirmed VDRR-I, and calcitriol therapy was initiated. During periods of nonadherence to therapy, chemical measurements revealed detectable FGF-23 levels, with undetectable 1,25(OH)2D3, hypophosphatemia, low tubular reabsorption of phosphate, hypocalcemia, and very elevated parathyroid hormone (PTH) levels...
July 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Eric Seibert, Ulrike Lehmann, Annett Riedel, Christof Ulrich, Frank Hirche, Corinna Brandsch, Jutta Dierkes, Matthias Girndt, Gabriele I Stangl
PURPOSE: The Nutrition Societies in Germany, Austria, and Switzerland recommend a daily intake of 20 µg vitamin D3 for adults when endogenous synthesis is absent. The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months. METHODS: The study was conducted in Halle (Saale), Germany (51(o) northern latitude) as a placebo-controlled, double-blinded, randomised trial (from January to April)...
March 2017: European Journal of Nutrition
Zhaoke Wu, Ting Wang, Shenshen Zhu, Ling Li
OBJECTIVES: Low vitamin D status has been shown to be associated with coronary artery disease. We planned to research the effects of vitamin D3 supplementation on the severity of coronary artery disease. DESIGN: We investigated the effect of 0.5 μg vitamin D3 per day in a randomized, placebo-controlled, double-blind study in 90 stable coronary artery disease patients residing in Beijing. Coronary angiography was performed before and after 6 months of treatment that took place between January and June...
2016: Scandinavian Cardiovascular Journal: SCJ
Sandro Mazzaferro, Marzia Pasquali
Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton. The more active metabolites, a receptor and a D binding protein, appear later, along with the increasing complexity of animal species living in the sea. In the sea, however, the biological function of vitamin D is unlikely to be linked with mineral metabolism, and we can hypothesize a relationship with an immune response. It is in terrestrial animals exhibiting cellular bone that the complexity of vitamin D increases...
January 2016: Nephrology, Dialysis, Transplantation
Claudia Yuste, Borja Quiroga, Soledad García de Vinuesa, Maria Angeles Goicoechea, Daniel Barraca, Ursula Verdalles, Jose Luño
BACKGROUND: Vitamin D deficiency and polypharmacy is a common problem over chronic kidney disease (CKD) population. OBJECTIVES: To assess the clinical and analytical characteristics of CKD patients with 25-OH-D3 deficiency (<15 ng/mL), including the possible role of associated drugs. METHODS: A single center observational review of 137 incident patients referred to our outpatient clinic with different stages of CKD and 25-OH-D3<15ng/mL (male gender 53...
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Stefan Pilz, Martin Gaksch, Katharina Kienreich, Martin Grübler, Nicolas Verheyen, Astrid Fahrleitner-Pammer, Gerlies Treiber, Christiane Drechsler, Bríain Ó Hartaigh, Barbara Obermayer-Pietsch, Verena Schwetz, Felix Aberer, Julia Mader, Hubert Scharnagl, Andreas Meinitzer, Elisabeth Lerchbaum, Jacqueline M Dekker, Armin Zittermann, Winfried März, Andreas Tomaschitz
UNLABELLED: Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values and cardiovascular risk factors. The Styrian Vitamin D Hypertension Trial is a single-center, double-blind, placebo-controlled study conducted from June 2011 to August 2014 at the endocrine outpatient clinic of the Medical University of Graz, Austria...
June 2015: Hypertension
Wei Zhang, Lulu Chen, Luqing Zhang, Ming Xiao, Jiong Ding, David Goltzman, Dengshun Miao
Previously, we reported that active vitamin D deficiency in mice causes secondary hypertension and cardiac dysfunction, but the underlying mechanism remains largely unknown. To clarify whether exogenous active vitamin D rescues hypertension by normalizing the altered central renin-angiotensin system (RAS) via an antioxidative stress mechanism, 1-alpha-hydroxylase [1α(OH)ase] knockout mice [1α(OH)ase(-/-)] and their wild-type littermates were fed a normal diet alone or with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], or a high-calcium, high-phosphorus "rescue" diet with or without antioxidant N-acetyl-l-cysteine (NAC) supplementation for 4 weeks...
February 19, 2015: Neuroscience Letters
Julia Wranicz, Dorota Szostak-Węgierek
UNLABELLED: Apart from the classic role of vitamin D, its hormonal active form, calcitriol is also characterized by pleiotropic effects on various organs and tissues. For the last several years, many researchers have shown an association between deficiency of vitamin D and the risk of type 2 diabetes mellitus (T2DM). Recent investigations suggested the need of vitamin D supplementation in T2DM prevention. It was shown that vitamin D deficiency decreases insulin secretion. It was also observed that proper vitamin D supplementation may improve the ability of the cells of the islets of Langerhans to synthesize many proteins de novo and to convert proinsulin to insulin...
2014: Roczniki Państwowego Zakładu Higieny
Adeera Levin, Taylor Perry, Prathibha De Zoysa, Mhairi K Sigrist, Karin Humphries, Mila Tang, Ognjenka Djurdjev
BACKGROUND: Vitamin D deficiency is associated with cardiovascular (CV) risk in multiple populations, including those with chronic kidney disease (CKD). The active form of the hormone (1,25 OH2D3) binds to receptors in multiple organs. CKD patients are deficient in both 25 Vitamin D and 1,25 OH2D3. Clinical trial data demonstrating the benefits of vitamin D formulations are limited, and fail to show significant benefits on CV outcomes, and have compared different compounds, in various populations, and focused on a variety of outcomes...
November 7, 2014: BMC Cardiovascular Disorders
Urszula Dougherty, Reba Mustafi, Farhana Sadiq, Anas Almoghrabi, Devkumar Mustafi, Maggi Kreisheh, Sumana Sundaramurthy, Weicheng Liu, Vani J Konda, Joel Pekow, Sharad Khare, John Hart, Loren Joseph, Alice Wyrwicz, Gregory S Karczmar, Yan Chun Li, Marc Bissonnette
PURPOSE: We previously showed that EGF receptor (EGFR) promotes tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS) model, whereas vitamin D suppresses tumorigenesis. EGFR-vitamin D receptor (VDR) interactions, however, are incompletely understood. Vitamin D inhibits the renin-angiotensin system (RAS), whereas RAS can activate EGFR. We aimed to elucidate EGFR-VDR cross-talk in colorectal carcinogenesis. EXPERIMENTAL DESIGN: To examine VDR-RAS interactions, we treated Vdr(+/+) and Vdr(-/-) mice with AOM/DSS...
November 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
M E Kleber, G Goliasch, T B Grammer, S Pilz, A Tomaschitz, G Silbernagel, G Maurer, W März, A Niessner
OBJECTIVE: Algorithms to predict the future long-term risk of patients with stable coronary artery disease (CAD) are rare. The VIenna and Ludwigshafen CAD (VILCAD) risk score was one of the first scores specifically tailored for this clinically important patient population. The aim of this study was to refine risk prediction in stable CAD creating a new prediction model encompassing various pathophysiological pathways. Therefore, we assessed the predictive power of 135 novel biomarkers for long-term mortality in patients with stable CAD...
August 2014: Journal of Internal Medicine
Ruslinda Mustafar, Rozita Mohd, Norazinizah Ahmad Miswan, Rizna Cader, Halim A Gafor, Marlyn Mohamad, Shamsul Azhar Shah, Nor Azmi Kamaruddin, Norella Kong Chiew Tong
BACKGROUND: Hypovitaminosis D (serum 25-OHD < 30 ng/mL) is common in patients with chronic kidney disease (CKD). Vitamin D is believed to involve in the regulation of renin-angiotensin system and may be renoprotective. OBJECTIVES: To compare the effects of calcium with or without calcitriol on renal function in patients with CKD. PATIENTS AND METHODS: A prospective randomized trial was performed involving patients with stages 2-4 CKD and hypovitaminosis D...
January 2014: Nephro-urology Monthly
Sigrid Jehle, Alessia Lardi, Barbara Felix, Henry N Hulter, Christoph Stettler, Reto Krapf
OBJECTIVE: Vitamin D (D₃) status is reported to correlate negatively with insulin production and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). However, few placebo-controlled intervention data are available. We aimed to assess the effect of large doses of parenteral D3 on glycosylated haemoglobin (HbA(₁c)) and estimates of insulin action (homeostasis model assessment insulin resistance: HOMA-IR) in patients with stable T2DM. MATERIALS AND METHODS: We performed a prospective, randomised, double-blind, placebo-controlled pilot study at a single university care setting in Switzerland...
March 20, 2014: Swiss Medical Weekly
Rebecca S Boxer, Brian D Hoit, Brian J Schmotzer, Gregory T Stefano, Amanda Gomes, Lavinia Negrea
BACKGROUND: Vitamin D deficiency is associated with heart failure (HF) events, and in animal models vitamin D down-regulates renin-angiotensin-aldosterone system hormones. METHODS: Patients with New York Heart Association (NYHA) functional class II-IV HF and a 25OH-D level ≤37.5 ng/mL received 50,000 IU vitamin D3 weekly (n = 31) or placebo (n = 33) for 6 months. Serum aldosterone, renin, echocardiography, and health status were determined at baseline and 6 months...
May 2014: Journal of Cardiac Failure
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