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zika microcephalie

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https://www.readbyqxmd.com/read/27909576/zika-antiviral-chemotherapy-identification-of-drugs-and-promising-starting-points-for-drug-discovery-from-an-fda-approved-library
#1
Bruno S Pascoalino, Gilles Courtemanche, Marli T Cordeiro, Laura H V G Gil, Lucio Freitas-Junior
Background The recent epidemics of Zika virus (ZIKV) implicated it as the cause of serious and potentially lethal congenital conditions such microcephaly and other central nervous system defects, as well as the development of the Guillain-Barré syndrome in otherwise healthy patients. Recent findings showed that anti-Dengue antibodies are capable of amplifying ZIKV infection by a mechanism similar to antibody-dependent enhancement, increasing the severity of the disease. This scenario becomes potentially catastrophic when the global burden of Dengue and the advent of the newly approved anti-Dengue vaccines in the near future are taken into account...
2016: F1000Research
https://www.readbyqxmd.com/read/27906905/description-of-13-infants-born-during-october-2015-january-2016-with-congenital-zika-virus-infection-without-microcephaly-at-birth-brazil
#2
Vanessa van der Linden, André Pessoa, William Dobyns, A James Barkovich, Hélio van der Linden Júnior, Epitacio Leite Rolim Filho, Erlane Marques Ribeiro, Mariana de Carvalho Leal, Pablo Picasso de Araújo Coimbra, Maria de Fátima Viana Vasco Aragão, Islane Verçosa, Camila Ventura, Regina Coeli Ramos, Danielle Di Cavalcanti Sousa Cruz, Marli Tenório Cordeiro, Vivian Maria Ribeiro Mota, Mary Dott, Christina Hillard, Cynthia A Moore
Congenital Zika virus infection can cause microcephaly and severe brain abnormalities (1). Congenital Zika syndrome comprises a spectrum of clinical features (2); however, as is the case with most newly recognized teratogens, the earliest documented clinical presentation is expected to be the most severe. Initial descriptions of the effects of in utero Zika virus infection centered prominently on the finding of congenital microcephaly (3). To assess the possibility of clinical presentations that do not include congenital microcephaly, a retrospective assessment of 13 infants from the Brazilian states of Pernambuco and Ceará with normal head size at birth and laboratory evidence of congenital Zika virus infection was conducted...
December 2, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27902933/the-fda-approved-drug-sofosbuvir-inhibits-zika-virus-infection
#3
Kristen M Bullard-Feibelman, Jennifer Govero, Zhe Zhu, Vanessa Salazar, Milena Veselinovic, Michael S Diamond, Brian J Geiss
The rapidly expanding Zika virus (ZIKV) epidemic has affected thousands of individuals with severe cases causing Guillain-Barré syndrome, congenital malformations, and microcephaly. Currently, there is no available vaccine or therapy to prevent or treat ZIKV infection. We evaluated whether sofosbuvir, an FDA-approved nucleotide polymerase inhibitor for the distantly related hepatitis C virus, could have antiviral activity against ZIKV infection. Cell culture studies established that sofosbuvir efficiently inhibits replication and infection of several ZIKV strains in multiple human tumor cell lines and isolated human fetal-derived neuronal stem cells...
November 27, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27902502/zika-virus-and-patient-blood-management
#4
Lawrence T Goodnough, Marisa B Marques
Sporadic Zika virus infections had only occurred in Africa and Asia until an outbreak in Micronesia (Oceania) in 2007. In 2013 to 2014, several outer Pacific Islands reported local outbreaks. Soon thereafter, the virus was likely introduced in Brazil from competing athletes from French Polynesia and other countries that participated in a competition there. Transmission is thought to have occurred through mosquito bites and spread to the immunologically naive population. Being also a flavivirus, the Zika virus is transmitted by the Aedes mosquito that is endemic in South and Central America that is also the vector of West Nile virus, dengue, and chikungunya...
November 29, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27901259/neurological-manifestations-of-chikungunya-and-zika-infections
#5
Talys J Pinheiro, Luis F Guimarães, Marcus Tulius T Silva, Cristiane N Soares
The epidemics of Chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have been considered the most important epidemiological occurrences in the Americas. The clinical picture of CHIKV infection is characterized by high fever, exanthema, myalgia, headaches, and arthralgia. Besides the typical clinical picture of CHIKV, atypical manifestations of neurological complications have been reported: meningo-encephalitis, meningoencephalo-myeloradiculitis, myeloradiculitis, myelitis, myeloneuropathy, Guillain-Barré syndrome and others...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27899230/experimental-zika-virus-infection-induces-spinal-cord-injury-and-encephalitis-in-newborn-swiss-mice
#6
Natália C C A Fernandes, Juliana S Nogueira, Rodrigo A Réssio, Cinthya S Cirqueira, Lidia M Kimura, Karolina R Fernandes, Mariana S Cunha, Renato P Souza, Juliana M Guerra
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America, with neurological symptons including meningoencephalitis and Guillain-Barré syndrome in adults, besides an apparent increased incidence of microcephaly in infants born to infected mothers. It is becoming a necessity to have a trustworthy animal model to better understand ZIKV infection. In this study we used newborn white Swiss mice as a model to investigate the ZIKV strain recently isolated in Brazil. ZIKV was inoculated via intracerebral and subcutaneous routes and analysed through gross histopathology and immunohistochemistry...
November 26, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#7
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27892990/zika-virus-what-the-otolaryngologist-should-know-a-review
#8
Demetri Arnaoutakis, Tapan Padhya
Importance: Initially discovered in 1947, Zika virus infection received little notoriety as a tropical disease until 2015 when an outbreak of microcephaly cases was reported in Brazil. Zika is a single-stranded RNA arbovirus of the Flaviviridae family. The primary source of infection in humans stems from Aedes aegypti mosquito bites but can also occur through sexual, blood, and perinatal transmission. With expectations that 3 to 4 million people across the Americas will be infected over the next year, the World Health Organization has declared this event a Public Health Emergency of International Concern...
November 17, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27891786/a-quality-assessment-of-reporting-sources-for-microcephaly-in-utah-2003-to-2013
#9
Amy Steele, Jane Johnson, Amy Nance, Robert Satterfield, C J Alverson, Cara Mai
BACKGROUND: Obtaining accurate microcephaly prevalence is important given the recent association between microcephaly and Zika virus. Assessing the quality of data sources can guide surveillance programs as they focus their data collection efforts. The Utah Birth Defect Network (UBDN) has monitored microcephaly by data sources since 2003. The objective of this study was to examine the impact of reporting sources for microcephaly surveillance. METHODS: All reported cases of microcephaly among Utah mothers from 2003 to 2013 were clinically reviewed and confirmed...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891785/editorial-brain-malformation-surveillance-in-the-zika-era
#10
EDITORIAL
Edwin Trevathan
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891783/population-based-microcephaly-surveillance-in-the-united-states-2009-to-2013-an-analysis-of-potential-sources-of-variation
#11
Janet D Cragan, Jennifer L Isenburg, Samantha E Parker, C J Alverson, Robert E Meyer, Erin B Stallings, Russell S Kirby, Philip J Lupo, Jennifer S Liu, Amanda Seagroves, Mary K Ethen, Sook Ja Cho, MaryAnn Evans, Rebecca F Liberman, Jane Fornoff, Marilyn L Browne, Rachel E Rutkowski, Amy E Nance, Marlene Anderka, Deborah J Fox, Amy Steele, Glenn Copeland, Paul A Romitti, Cara T Mai
BACKGROUND: Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging. METHODS: Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27885789/zika-virus-associated-microcephaly-micrencephaly-fetal-brain-imaging-in-comparison-with-neuropathology
#12
T Vipotnik Vesnaver, N Tul, S Mehrabi, F Parissone, P Štrafela, J Mlakar, J Pižem, M Korva, T Avšič Zupanc, M Popović
No abstract text is available yet for this article.
November 24, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27885741/zika-and-pregnancy-a-comprehensive-review
#13
Adrija Hajra, Dhrubajyoti Bandyopadhyay, Lyndsey R Heise, Rajarshi Bhadra, Somedeb Ball, Shyamal Kumar Hajra
Zika virus (ZIKV) infection is a well-nurtured topic for healthcare personnel nowadays. Central nervous system involvement including microcephaly and ocular involvements has already been reported in neonates of affected pregnant ladies. In this article, we have discussed these effects on the newborns of ZIKV-infected mothers. The proposed pathogenesis, modes of transmission of this infection from mothers to the fetuses, diagnosis of the cases and precaution for the pregnant ladies have also been discussed. We have gathered the recently available data on the risk of ZIKV for expectant mothers from PubMed, https://www...
November 25, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27882950/neutralization-mechanism-of-a-highly-potent-antibody-against-zika-virus
#14
Shuijun Zhang, Victor A Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S G Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G Widman, Jian Shi, Ralph S Baric, Shee-Mei Lok
The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the antibody to block fusion, we determined the cryoEM structures of the C10-ZIKV complex at pH levels mimicking the extracellular (pH8.0), early (pH6.5) and late endosomal (pH5.0) environments. The 4...
November 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27881434/zika-related-microcephaly-may-appear-after-birth-study-finds
#15
Michael McCarthy
No abstract text is available yet for this article.
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27878897/minimal-immune-determinants-connect-zika-virus-human-cytomegalovirus-and-toxoplasma-gondii-to-microcephaly-related-human-proteins
#16
Guglielmo Lucchese, Darja Kanduc
Aiming at the molecular definition of the relationship(s) between prenatal infections and fetal microcephaly and using pentapeptides as minimal immune determinants, we analyzed the peptide matching between proteins from infectious agents involved in microcephalic syndromes (namely Zika virus, human Cytomegalovirus, and Toxoplasma gondii) and human proteins that, when altered, have been specifically associated with microcephaly. We report that an unexpected high number of epitopic pentapeptides (ie, 34) are common to the three fetopathogenic agents and repeatedly occur throughout an important number of microcephaly-related human proteins...
November 23, 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27878100/neurological-manifestations-of-zika-virus-infection
#17
REVIEW
Ana-Belén Blázquez, Juan-Carlos Saiz
Zika virus (ZIKV) is a flavivirus (Flaviviridae family) transmitted mainly by Aedes mosquitoes. The virus was restricted to the African continent until its spread to south-east Asia in the 1980's, the Micronesia in 2007, the French Polynesia in 2013 and, more recently in the Americas in 2015, where, up to date, the World Health Organization (WHO) has estimated about 3-4 million total cases of ZIKV infection. During outbreaks in the French Polynesia and Brazil in 2013 and 2015, respectively, national health authorities reported potential neurological complications of ZIKV disease, chiefly an upsurge in Guillain-Barré syndrome, which coincided with ZIKV outbreaks...
November 12, 2016: World Journal of Virology
https://www.readbyqxmd.com/read/27876396/anatomical-animal-and-cellular-evidence-for-zika-induced-pathogenesis-of-fetal-microcephaly
#18
REVIEW
Jing-Zhang Wang, Xin-Hua Guo, Dian-Guo Xu
Several recent articles published by Brain and Development in 2016 demonstrated some rare, but innovative, genetic mechanisms for microcephaly. This concise mini-review presented another novel pathogenic mechanism for microcephaly, which has actually been a worldwide medical challenge since the World Health Organization (WHO) defined the outbreak of the Zika virus (ZIKV) as an International Public Health Emergency on 1 Feb, 2016. As a recent noteworthy clinical phenomenon, the ZIKV outbreak was accompanied by a dramatically increased number of microcephalus fetuses...
November 19, 2016: Brain & Development
https://www.readbyqxmd.com/read/27872736/zika-virus-a-review-from-the-virus-basics-to-proposed-management-strategies
#19
REVIEW
Lorenzo Zammarchi, Michele Spinicci, Alessandro Bartoloni
This review aims to summarize the body of knowledge available on Zika virus to date. A comprehensive review of the scientific literature on Zika virus was performed with the aim to stress relevant aspects for healthcare professionals in the non-endemic areas. For several years, the Zika virus infection was considered an extremely rare exotic disease with poor clinical relevance. However, Zika virus has recently gained the attention of the scientific community and public opinion since the virus spread to the Pacific islands and the South America in an unprecedented epidemic, and additionally due to the definitive evidence that the infection could be complicated by Guillain-Barré syndrome, passed through vertical transmission, and result in central nervous system abnormalities (including microcephaly) of the fetus...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27869982/characteristics-of-the-first-cases-of-microcephaly-possibly-related-to-zika-virus-reported-in-the-metropolitan-region-of-recife-pernambuco-state-brazil
#20
Alexander Vargas, Eduardo Saad, George Santiago Dimech, Roselene Hans Santos, Maria Auxiliadora Vieira Caldas Sivini, Luciana Carolina Albuquerque, Patricia Michelly Santos Lima, Idalacy de Carvalho Barreto, Michelly Evangelista de Andrade, Nathalie Mendes Estima, Patrícia Ismael de Carvalho, Rayane Souza de Andrade Azevedo, Rita de Cássia de Oliveira Vasconcelos, Romildo Siqueira Assunção, Lívia Carla Vinhal Frutuoso, Greice Madeleine Ikeda do Carmo, Priscila Bochi de Souza, Marcelo Yoshito Wada, Wanderson Kleber de Oliveira, Cláudio Maierovitch Pessanha Henriques, Jadher Percio
OBJECTIVE: to describe the first cases of microcephaly possibly related to Zika virus in live born babies reported in the Metropolitan Region of Recife, Pernambuco State, Brazil. METHODS: this was a descriptive case series study (cases reported between August 1st and October 31st 2015), using medical record data and data from a questionnaire answered by the mothers of the babies. RESULTS: 40 microcephaly cases were confirmed, distributed in eight municipalities within the Metropolitan Region, with Recife itself having the highest concentration of cases (n=12); median head circumference was 29 cm, median chest girth was 31 cm and median weight was 2,628 grams; 21/25 cases had brain calcification, ventriculomegaly or lissencephaly; 27 of the 40 mothers reported rash during pregnancy, 20 in the first trimester and 7 in the second trimester, as well as itching, headache, myalgia and absence of fever...
October 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
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