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https://www.readbyqxmd.com/read/29785319/a-multi-faceted-pandemic-a-review-of-the-state-of-knowledge-on-the-zika-virus
#1
REVIEW
Anneliese Depoux, Aline Philibert, Serge Rabier, Henri-Jean Philippe, Arnaud Fontanet, Antoine Flahault
While until recently the small and isolated Zika outbreaks in Eastern Asia and Pacific islands had been overlooked, the large-scale outbreak that started in Brazil in 2015 and the increase of microcephaly cases in the same place and time made media headlines. Considered as harmless until recently, Zika has given rise to an important global crisis that poses not only health challenges but also environmental, economical, social, and ethical challenges for states and people around the world. The main objective of this paper is to review the recent Zika outbreak by covering a broad range of disciplines and their interactions...
2018: Public Health Reviews
https://www.readbyqxmd.com/read/29780762/framing-and-visual-type-effect-on-future-zika-vaccine-uptake-intent
#2
Jeanine P D Guidry, Kellie E Carlyle, Jessica G LaRose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams
Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study's purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Design and methods: In order to study the effects of Zika message framing (gain vs . loss) and visual type (photo vs . infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U...
February 5, 2018: Journal of Public Health Research
https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#3
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29773562/neuroimaging-findings-of-zika-virus-associated-neurologic-complications-in-adults
#4
REVIEW
L C Hygino da Cruz, O J M Nascimento, F P P L Lopes, I R F da Silva
When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges...
May 17, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29772278/zika-virus-incidence-preventive-and-reproductive-behaviors-correlates-from-new-survey-data
#5
Climent Quintana-Domeque, José Raimundo Carvalho, Victor Hugo de Oliveira
During the outbreak of the Zika virus, Brazilian health authorities recommended that pregnant women take meticulous precaution to avoid mosquito bites and that women in general use contraceptive methods to postpone/delay pregnancies. In this article, we present new estimates on the Zika virus incidence, its correlates and preventive behaviors in the Northeast of Brazil, where the outbreak initiated, using survey data collected between March 30th and June 3rd of 2016. The target population were women aged 15-49 in the capital cities of the nine states of the Northeast region of Brazil...
May 1, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29761581/congenital-zika-syndrome-pitfalls-in-the-placental-barrier
#6
REVIEW
Nia Robinson, Evangelina E Mayorquin Galvan, Isidro G Zavala Trujillo, Maria G Zavala-Cerna
Much progress with respect to congenital Zika virus (ZIKV) pathogenesis has been achieved after the 2015 outbreak in Brazil. It is now accepted that ZIKV is vertically transmitted, infects cells of the developing central nervous system and the placenta, yet it is unclear to what extent placental affection contributes to the development of congenital ZIKV. The association between fulminant villitis and severe fetal involvement emerges as a possibility. ZIKV is unique among the Flaviviruses in its ability to be sexually transmitted, possibly responsible for its teratogenicity...
May 15, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29758005/a-review-of-the-ongoing-research-on-zika-virus-treatment
#7
REVIEW
Suely da Silva, Daniel Oliveira Silva Martins, Ana Carolina Gomes Jardim
The Zika fever is an arboviral disease resulting from the infection with Zika virus (ZIKV). The virus is transmitted to humans by the bite of Aedes mosquitos, mainly Aedes aegypti and Aedes albopictus . ZIKV has been detected for decades in African and Asian regions and, since 2007, has spread to other continents; among them, infections are most reported in the Americas. This can be explained by the presence of vectors in highly populated and tropical regions where people are susceptible to contamination. ZIKV has been considered by the World Health Organization a serious public health problem because of the increasing number of cases of congenital malformation and neurological disorders related to its infection, such as microcephaly, Guillain⁻Barré syndrome, meningoencephalitis, and myelitis...
May 14, 2018: Viruses
https://www.readbyqxmd.com/read/29757270/establishing-mouse-models-for-zika-virus-induced-neurological-disorders-using-intracerebral-injection-strategies-embryonic-neonatal-and-adult
#8
Stephanie A Herrlinger, Qiang Shao, Li Ma, Melinda Brindley, Jian-Fu Chen
The Zika virus (ZIKV) is a flavivirus currently endemic in North, Central, and South America. It is now established that the ZIKV can cause microcephaly and additional brain abnormalities. However, the mechanism underlying the pathogenesis of ZIKV in the developing brain remains unclear. Intracerebral surgical methods are frequently used in neuroscience research to address questions about both normal and abnormal brain development and brain function. This protocol utilizes classical surgical techniques and describes methods that allow one to model ZIKV-associated human neurological disease in the mouse nervous system...
April 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29753607/maternal-immunization-with-a-dna-vaccine-candidate-elicits-specific-passive-protection-against-post-natal-zika-virus-infection-in-immunocompetent-balb-c-mice
#9
Ran Wang, Xianzheng Liao, Dongying Fan, Lei Wang, Ji Song, Kaihao Feng, Mingyuan Li, Peigang Wang, Hui Chen, Jing An
Zika virus (ZIKV) infection is closely associated in the fetus with microcephaly and in the adults with Guillain-Barré syndrome and even male infertility. It is an urgent international priority to develop a safe and effective vaccine that offers protection to both women of childbearing age and their children. In this study, female immunocompetent BALB/c mice were immunized with a DNA-based vaccine candidate, pVAX1-ZME, expressing the prM/E protein of ZIKV, and the immunogenicity for maternal mice and the post-natal protection for suckling mice were evaluated...
May 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29747890/detection-and-prevention-of-perinatal-infection-cytomegalovirus-and-zika-virus
#10
REVIEW
Amber M Wood, Brenna L Hughes
Congenital cytomegalovirus is the most common viral congenital infection, and affects up to 2% of neonates. Significant sequelae may develop after congenital cytomegalovirus, including hearing loss, cognitive defects, seizures, and death. Zika virus is an emerging virus with perinatal implications; a congenital Zika virus syndrome has been identified, and includes findings such as microcephaly, fetal nervous system abnormalities, and neurologic sequelae after birth. Screening, diagnosis, prevention, and treatment of these perinatal infections are reviewed in this article...
June 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29743741/computed-tomography-and-magnetic-resonance-imaging-findings-in-infants-with-microcephaly-potentially-related-to-congenital-zika-virus-infection
#11
Aníbal Araujo Alves Peixoto Filho, Simone Baltar de Freitas, Márcio Morikoshi Ciosaki, Lourenço Nogueira E Oliveira, Onildo Tavares Dos Santos Júnior
The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a maternal history of rash during pregnancy...
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29740383/nervous-system-injury-and-neuroimaging-of-zika-virus-infection
#12
REVIEW
Shanshan Wu, Yu Zeng, Alexander Lerner, Bo Gao, Meng Law
In 2016, World Health Organization announced Zika virus infection and its neurological sequalae are a public health emergency of global scope. Preliminary studies have confirmed a relationship between Zika virus infection and certain neurological disorders, including microcephaly and Guillain-Barre syndrome (GBS). The neuroimaging features of microcephaly secondary to Zika virus infection include calcifications at the junction of gray-white matter and subcortical white matter with associated cortical abnormalities, diminution of white matter, large ventricles with or without hydrocephalus, cortical malformations, hypoplasia of cerebellum and brainstem, and enlargement of cerebellomedullary cistern...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29738748/femur-sparing-pattern-of-abnormal-fetal-growth-in-pregnant-women-from-new-york-city-after-maternal-zika-virus-infection
#13
Christie L Walker, Audrey A Merriam, Eric O Ohuma, Manjiri K Dighe, Michael Gale, Lakshmi Rajagopal, Aris T Papageorghiou, Cynthia Gyamfi-Bannerman, Kristina M Adams Waldorf
BACKGROUND: Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which can induce fetal brain injury and growth restriction following maternal infection during pregnancy. Prenatal diagnosis of ZIKV-associated fetal injury in the absence of microcephaly is challenging due to an incomplete understanding of how maternal ZIKV infection affects fetal growth and the use of different sonographic reference standards around the world. We hypothesized that skeletal growth is unaffected by ZIKV infection and that the femur length can represent an internal standard to detect growth deceleration of the fetal head and/or abdomen by ultrasound...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29726827/zika-virus-infection-and-microcephaly-in-infants-is-the-association-casual-or-causal-public-health-viewpoint
#14
Satinder Aneja
No abstract text is available yet for this article.
April 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29726826/zika-virus-infection-and-microcephaly-in-infants-is-the-association-casual-or-causal-pediatric-neurologist-s-viewpoint
#15
Suvasini Sharma
No abstract text is available yet for this article.
April 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29726825/zika-virus-infection-and-microcephaly-in-infants-is-the-association-casual-or-causal-evidence-based-medicine-viewpoint
#16
Joseph L Mathew
No abstract text is available yet for this article.
April 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29724036/probing-molecular-insights-into-zika-virus%C3%A2-host-interactions
#17
REVIEW
Ina Lee, Sandra Bos, Ge Li, Shusheng Wang, Gilles Gadea, Philippe Desprès, Richard Y Zhao
The recent Zika virus (ZIKV) outbreak in the Americas surprised all of us because of its rapid spread and association with neurologic disorders including fetal microcephaly, brain and ocular anomalies, and Guillain⁻Barré syndrome. In response to this global health crisis, unprecedented and world-wide efforts are taking place to study the ZIKV-related human diseases. Much has been learned about this virus in the areas of epidemiology, genetic diversity, protein structures, and clinical manifestations, such as consequences of ZIKV infection on fetal brain development...
May 2, 2018: Viruses
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#18
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29719255/a-single-injection-of-human-neutralizing-antibody-protects-against-zika-virus-infection-and-microcephaly-in-developing-mouse-embryos
#19
Cui Li, Fei Gao, Lei Yu, Ruoke Wang, Yisheng Jiang, Xuanling Shi, Chibiao Yin, Xiaoping Tang, Fuchun Zhang, Zhiheng Xu, Linqi Zhang
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is generally benign in humans. However, an emergent strain of ZIKV has become widespread, causing severe pre- and post-natal neurological defects. There is now an urgent need for prophylactic and therapeutic agents. To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these antibodies conveyed distinct levels of adult and in utero protection from ZIKV infection, which closely mirrored their respective in vitro neutralizing activities...
May 1, 2018: Cell Reports
https://www.readbyqxmd.com/read/29712653/direct-activation-of-adenosine-monophosphate-activated-protein-kinase-ampk-by-pf-06409577-inhibits-flavivirus-infection-through-modification-of-host-cell-lipid-metabolism
#20
Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A Martín Acebes
Mosquito-borne flaviviruses are a group of RNA viruses that constitute global threats for human and animal health. Replication of these pathogens is strictly dependent on cellular lipid metabolism. We have evaluated the effect of the pharmacological activation of Adenosine Monophosphate-activated Protein Kinase (AMPK), a master regulator of lipid metabolism, on the infection of three medically relevant flaviviruses: West Nile virus (WNV), Zika virus (ZIKV) and dengue virus (DENV). WNV is responsible for recurrent outbreaks of meningitis and encephalitis affecting humans and horses worldwide...
April 30, 2018: Antimicrobial Agents and Chemotherapy
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