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zika microcephalie

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https://www.readbyqxmd.com/read/29150641/repurposing-of-the-anti-malaria-drug-chloroquine-for-zika-virus-treatment-and-prophylaxis
#1
Sergey A Shiryaev, Pinar Mesci, Antonella Pinto, Isabella Fernandes, Nicholas Sheets, Sujan Shresta, Chen Farhy, Chun-Teng Huang, Alex Y Strongin, Alysson R Muotri, Alexey V Terskikh
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution. We demonstrate that the common anti-malaria drug chloroquine (CQ) extends the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice. However, the severity of ZIKV infection in these mice precludes the study of foetal (vertical) viral transmission...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145400/zika-virus-an-updated-review-of-competent-or-naturally-infected-mosquitoes
#2
REVIEW
Yanouk Epelboin, Stanislas Talaga, Loïc Epelboin, Isabelle Dusfour
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-scale urban ZIKV outbreaks were associated with neurological complications such as microcephaly and several other neurological malformations in fetuses and newborns. This paper is a systematic review intended to list all mosquito species studied for ZIKV infection or for their vector competence...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29141913/multiplexed-biomarker-panels-discriminate-zika-and-dengue-virus-infection-in-humans
#3
Guang Song, Hee-Sool Rho, Jianbo Pan, Pedro Ramos, Ki-Jun Yoon, Freddy A Medina, Emily M Lee, Daniel J Eichinger, Guo-Li Ming, Jorge L Muñoz-Jordan, Hengli Tang, Ignacio Pino, Hongjun Song, Jiang Qian, Heng Zhu
Zika virus (ZIKV) and dengue virus (DENV) are closely related flaviviruses that cause widespread, acute febrile illnesses, notably microcephaly for fetuses of infected pregnant women. Detecting the viral cause of these illnesses is paramount to determine risks to patients, counsel pregnant women, and help fight outbreaks. A combined diagnostic algorithm for ZIKV and DENV requires Reverse transcription polymerase chain reaction (RT-PCR) and IgM antibody detection. RT-PCR differentiates between DENV and ZIKV infections during the acute phases of infection, but differentiation based on IgM antibodies is currently nearly impossible in endemic areas...
November 15, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#4
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#5
Mauricio Lacerda Nogueira, Nivison Ruy Rocha Nery Júnior, Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Georgia de Freitas Guimarães, Nathalia Zini, Rafael Alves da Silva, Gislaine Celestino Dutra Silva, Ligia Cosentino Junqueira Franco, Paula Rahal, Cintia Bittar, Bruno Carneiro, Pedro Fernando Vasconcelos da Costa, Daniele Freitas Henriques, Deusenia Machado Ulisses Barbosa, Patrícia Lopes Rombola, Luciana de Grande, Andréia Francesli Negri Reis, Sacha Ariane Palomares, Marcia Wakai Catelan, Lilian Elisa Arão Antonio Cruz, Silvia Helena Necchi, Rita de Cassia Vilella Mendonça, Izalco Nuremberg Penha Dos Santos, Suzimeiri Brigatti Alavarse Caron, Federico Costa, Fernando A Bozza, Antonio Soares de Souza, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Nikos Vasilakis, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Albert Icksang Ko
OBJECTIVE: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns' outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. METHODS: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV-positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29132236/neuroimaging-findings-using-transfontanellar-ultrasound-in-newborns-with-microcephaly-and-zika-virus-infection-a-comment
#6
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
November 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29131923/zika-virus-a-review-for-pediatricians
#7
Taylor Heald-Sargent, William Muller
For the past several years, the Zika virus has been a topic of conversation among pediatric health care providers in many settings. This article provides current answers to many questions that may be posed to pediatricians, including inquiries about clinical presentation, testing, and prevention. Although infants born with congenital Zika syndrome often have microcephaly, there are other characteristic features, such as eye abnormalities, that one should recognize. Additionally, testing for the syndrome must be considered in all infants at risk for infection, including those who are asymptomatic at birth...
November 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29127595/neurological-manifestations-of-congenital-zika-virus-infection
#8
Tania Saad, Alessandra Augusta PennaeCosta, Fernanda Veiga de Góes, Marcela de Freitas, Julia Valeriano de Almeida, Lúcio José de Santa Ignêz, Ana Paula Amancio, Renata Joviano Alvim, Ludmilla Athayde Antunes Kramberger
INTRODUCTION: In 2015, it was observed a rise in the number of microcephalic newborns associated with a history of non-specific febrile sickness and rash during pregnancy in Brazil. Since then, microcephaly has emerged as a public health concern. A few months after, the causal relation between congenital microcephaly and the Zika virus was discovered. Zika virus, an arbovirus, is a new TORCH member that leads to congenital infection through vertical transmission and harms the developing brain, disrupting synaptogenesis, and causing other central nervous system lesions...
November 10, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29126899/merimepodib-an-impdh-inhibitor-suppresses-replication-of-zika-virus-and-other-emerging-viral-pathogens
#9
Xiao Tong, Jeanon Smith, Natalya Bukreyeva, Takaaki Koma, John T Manning, Raj Kalkeri, Ann D Kwong, Slobodan Paessler
Zika virus (ZIKV), a member of the Flaviviridae family, has recently been linked to abnormal pregnancies, fetal death, microcephaly, and Guillain-Barré syndrome in humans. Merimepodib (MMPD, VX-497), a potent inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), has shown antiviral activity against HCV and a variety of DNA and RNA viruses in vitro. In this report, we expand the antiviral spectrum of MMPD, and demonstrate that MMPD inhibits ZIKV RNA replication with an EC50 of 0.6 μM. Furthermore, MMPD reduces the virus production of ZIKV as well as several other important emerging viral pathogens such as Ebola, Lassa, Chikungunya, and Junin viruses...
November 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29121000/meeting-summary-state-and-local-implementation-strategies-for-increasing-access-to-contraception-during-zika-preparedness-and-response-united-states-september-2016
#10
Charlan D Kroelinger, Lisa Romero, Eva Lathrop, Shanna Cox, Isabel Morgan, Meghan T Frey, Lee Warner, Kathryn M Curtis, Karen Pazol, Wanda D Barfield, Dana Meaney-Delman, Denise J Jamieson
Zika virus infection during pregnancy is a cause of microcephaly and other serious brain abnormalities (1). To support state and territory response to the threat of Zika, CDC's Interim Zika Response Plan outlined activities for vector control; clinical management of exposed pregnant women and infants; targeted communication about Zika virus transmission among women and men of reproductive age; and primary prevention of Zika-related adverse pregnancy and birth outcomes by prevention of unintended pregnancies through increased access to contraception...
November 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29118981/zika-virus-disease-microcephaly-and-guillain-barr%C3%A3-syndrome-in-colombia-epidemiological-situation-during-21%C3%A2-months-of-the-zika-virus-outbreak-2015-2017
#11
Nelson Méndez, Misael Oviedo-Pastrana, Salim Mattar, Isaac Caicedo-Castro, German Arrieta
Background: The Zika virus disease (ZVD) has had a huge impact on public health in Colombia for the numbers of people affected and the presentation of Guillain-Barre syndrome (GBS) and microcephaly cases associated to ZVD. Methods: A retrospective descriptive study was carried out, we analyze the epidemiological situation of ZVD and its association with microcephaly and GBS during a 21-month period, from October 2015 to June 2017. The variables studied were: (i) ZVD cases, (ii) ZVD cases in pregnant women, (iii) laboratory-confirmed ZVD in pregnant women, (iv) ZVD cases associated with microcephaly, (v) laboratory-confirmed ZVD associated with microcephaly, and (vi) ZVD associated to GBS cases...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29117563/outcomes-of-congenital-zika-disease-depend-on-timing-of-infection-and-maternal-fetal-interferon-action
#12
Jinling Chen, Yuejin Liang, Panpan Yi, Lanman Xu, Hal K Hawkins, Shannan L Rossi, Lynn Soong, Jiyang Cai, Ramkumar Menon, Jiaren Sun
Zika virus (ZIKV) infection during pregnancy in humans results in intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses and provide clinical benefits to the fetus. Because IFN-λ shares signaling cascades and antiviral functions with IFN-I, we investigated the in vivo effects of IFN-λ in ZIKV-infected pregnant mice. IFN-λ administration during mid-pregnancy reduced ZIKV burden in maternal and fetal organs and alleviated placental injuries and fetal demise...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29116029/zikv-infection-effects-changes-in-gene-splicing-isoform-composition-and-lncrna-expression-in-human-neural-progenitor-cells
#13
Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, Minhua Luo, Jinlong Yang, Jumin Zhou
BACKGROUND: The Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcriptome of ZIKV infected human neural progenitor cells (hNPCs) for changes in alternative splicing (AS), gene isoform (ISO) composition and long noncoding RNAs (lncRNAs) expression. METHODS: We analyzed differentially expressed lncRNAs, AS, ISO from RNA-seq data in ZIKV infected hNPCs...
November 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/29110197/zika-virus-infection-in-children-epidemiology-and-clinical-manifestations
#14
Marcos Vinicius da Silva Pone, Sheila Moura Pone, Andrea Araujo Zin, Pedro Henrique Barros Mendes, Mitsue Senra Aibe, Elisa Barroso de Aguiar, Tallita de Oliveira Gomes da Silva
PURPOSE: The purpose of this review is to comprehensively review Congenital Zika Syndrome in regard to their epidemiology and clinical manifestations. METHODS: This subject review of congenital Zika syndrome was composed after conducting a thorough review of the available literature on this topic using PubMed and other primary sources. RESULTS: The first epidemic of Zika virus infection in Brazil was followed by an unexpected sharp increase in the incidence of infants born with microcephaly and the description of a new disease, the congenital Zika syndrome...
November 6, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29110196/challenges-for-molecular-and-serological-zikv-infection-confirmation
#15
Zilton Farias Meira de Vasconcelos, Renata Campos Azevedo, Nathália Thompson, Leonardo Gomes, Letícia Guida, Maria Elisabeth Lopes Moreira
BACKGROUND: Zika Virus (ZIKV), member of Flaviviridae family and Flavivirus genus, has recently emerged as international public health emergency after its association with neonatal microcephaly cases. Clinical diagnosis hindrance involves symptom similarities produced by other arbovirus infections, therefore laboratory confirmation is of paramount importance. DISCUSSION: The most reliable test available is based on ZIKV RNA detection from body fluid samples. However, short viremia window periods and asymptomatic infections diminish the success rate for RT-PCR positivity...
November 6, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29107512/american-strain-of-zika-virus-causes-more-severe-microcephaly-than-an-old-asian-strain-in-neonatal-mice
#16
Feng Zhang, Hong-Jiang Wang, Qin Wang, Zhong-Yu Liu, Ling Yuan, Xing-Yao Huang, Guanghui Li, Qing Ye, Haozhen Yang, Lei Shi, Yong-Qiang Deng, Cheng-Feng Qin, Zhiheng Xu
Zika virus (ZIKV) has evolved from an overlooked mosquito-borne flavivirus into a global health threat due to its astonishing causal link to microcephaly and other disorders. ZIKV has been shown to infect neuronal progenitor cells of the fetal mouse brain, which is comparable to the first-trimester human fetal brain, and result in microcephaly. However, whether there are different effects between the contemporary ZIKV strain and its ancestral strain in the neonatal mouse brain, which is comparable with the second-trimester human fetal brain, is unclear...
November 2017: EBioMedicine
https://www.readbyqxmd.com/read/29101612/the-congenital-zika-virus-infection-still-a-puzzle
#17
José Francisco M Salomão
BACKGROUND: As a new disease, some features of the congenital Zika virus infection are not yet fully understood. The current Brazilian outbreak brought up an unexpected increase in the number of microcephaly cases as this strain is essentially neurotropic and associated with devastating effects on the developing central nervous system. OBJECT: This focus session aims to discuss the several issues related to the epidemiology, diagnosis, clinical features, and treatment of the congenital Zika virus infection...
November 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29099873/assessing-zika-virus-replication-and-the-development-of-zika-specific-antibodies-after-a-mid-gestation-viral-challenge-in-guinea-pigs
#18
Craig J Bierle, Claudia Fernández-Alarcón, Nelmary Hernandez-Alvarado, Jason C Zabeli, Bradley C Janus, Dira S Putri, Mark R Schleiss
Primary Zika virus (ZIKV) infections that occur during pregnancy can cause spontaneous abortion and profoundly disrupt fetal development. While the full range of developmental abnormalities associated with congenital Zika syndrome is not yet known, severe cases of the syndrome can present with microcephaly, extensive neurologic and ocular damage, and pronounced joint malformations. Animal models that accurately recapitulate congenital Zika syndrome are urgently needed for vaccine development and for the study of ZIKV pathogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29096380/discovery-of-potential-zika-virus-rna-polymerase-inhibitors-by-docking-based-virtual-screening
#19
Anjali Singh, Nandan Kumar Jana
Zika virus (ZIKV) infection has been associated with Guillain-Barre syndrome in adults and microcephaly in infants. The existence of insufficient structural data in most of the protein databases hinders the synthesis of anti-ZIKV pharmaceutics. In this work, we attempted to model the catalytic domain of the ZIKV RNA polymerase (RdRpC) along with a detailed assessment of conserved aspartates in ZIKV RdRpC palm domain as potential drug targets. The conserved and catalytically active aspartate residues present in the predicted RdRpC protein were virtually screened against a ZINC database for inhibitors, and the selected potential drug candidates were further filtered based on their ADMET profiles...
October 24, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29096005/management-of-zika-virus-in-pregnancy-a-review
#20
Helen Perry, Asma Khalil, Emma Aarons, Katherine Russell, Patrick O'Brien
Introduction/background: Since 2015, an epidemic of Zika virus spread across the Americas. This coincided with an increased incidence of microcephaly reported at birth in Brazil, with subsequent evidence of a causal association. Sources of data: Systemic reviews, observational studies, public health organizations. Areas of agreement: Zika virus causes microcephaly and brain abnormalities in infants born to mothers infected during or shortly before pregnancy...
October 31, 2017: British Medical Bulletin
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