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https://www.readbyqxmd.com/read/29773783/cholesteryl-ester-storage-disease-fatal-outcome-without-causal-therapy-in-a-female-patient-with-the-preventable-sequelae-of-progressive-liver-disease-after-many-years-of-mild-symptoms
#1
Ali Canbay, Meike N Müller, Stathis Philippou, Guido Gerken, Andreas Tromm
BACKGROUND Cholesteryl ester storage disease (CESD), also known as lysosomal acid lipase deficiency (LAL-D), is a rare autosomal-recessive inheritable lysosomal storage disease. Since 2015, a causal treatment with sebelipase alfa, which replaces the missing LAL enzyme, has been approved. We report a fatal course of LAL-D in a female patient. CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly. At that time, no specific treatment for CESD was available and the spontaneous course of the disease had to be awaited...
May 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29743940/delayed-anxiety-and-depressive-morbidity-among-dengue-patients-in-a-multi-ethnic-urban-setting-first-report-from-sri-lanka
#2
Nayana Gunathilaka, Miyuru Chandradasa, Layani Champika, Shirom Siriwardana, Lakmini Wijesooriya
Background: Although the physical consequences of dengue are well documented, delayed psychological co-morbidities are not well studied to date. Therefore, the objective of the present study was to determine the prevalence of depressive, anxiety and stress symptoms among past dengue patients. Methods: A community-based, case-control study in a multi-ethnic urban setting was conducted in Sri Lanka involving adults who were diagnosed to have dengue fever by a positive dengue IgM antibody response between 6 and 24 months ago...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29719498/anxiety-and-10-year-risk-of-incident-dementia-an-association-shaped-by-depressive-symptoms-results-of-the-prospective-three-city-study
#3
Marion Mortamais, Meriem Abdennour, Valérie Bergua, Christophe Tzourio, Claudine Berr, Audrey Gabelle, Tasnime N Akbaraly
Background: Anxiety is common in patients with cognitive impairment and dementia. However, whether anxiety is a risk factor for dementia is still not known. We aimed to examine the association between trait anxiety at baseline and the 10-year risk of incident dementia to determine to which extent depressive symptoms influence this relationship in the general population. Methods: Data came from 5,234 community-dwelling participants from the Three-City prospective cohort study, aged 65 years at baseline and followed over 10 years...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29704471/transplantation-of-autologous-esophageal-mucosa-to-prevent-stricture-after-circumferential-endoscopic-submucosal-dissection-of-early-esophageal-cancer-with-video
#4
ZhongLi Liao, GuoBin Liao, Xin Yang, Xue Peng, Xia Zhang, Xia Xie, XiaoYan Zhao, ShiMing Yang, ChaoQiang Fan, JianYing Bai
BACKGROUD AND STUDY AIMS: Esophageal stricture is a common adverse event after endoscopic submucosal dissection (ESD) when it involves entire circumference of esophagus. We aimed to assess the effectiveness and safety of endoscopic transplantation of autologous esophageal mucosa in preventing stricture formation after circumferential ESD. PATIENTS AND METHODS: Nine patients who underwent circumferential ESD for early esophageal cancer were enrolled. After undergoing ESD, autologous esophageal mucosal patches were attached to the "ulcer surface" using hemoclips and then fixed with a covered metal mesh stent...
April 25, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29679138/sexual-quality-of-life-body-image-distress-and-psychosocial-outcomes-in-colorectal-cancer-a-longitudinal-study
#5
Jennifer Barsky Reese, Elizabeth Handorf, Jennifer A Haythornthwaite
PURPOSE: The objectives were to assess changes in sexual QOL and body image distress over time and to examine longitudinal associations between sexual QOL and body image variables with psychosocial outcomes in a sample of colorectal cancer patients. METHODS: Participants (N = 141) completed a mail-based survey assessing sexual QOL [sexual distress (ISS), treatment impact on sexual function (SFQ), sexual function (FSFI; IIEF)], body image distress (BIS), and psychosocial outcomes [relationship quality (DAS-4), depressive symptoms (CESD-SF), and health-related QOL (HRQOL; FACT-C)]; 88 patients completed 6-month follow-up surveys (62%)...
April 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29622276/prospective-assessment-of-patient-reported-outcomes-in-gynecologic-cancer-patients-before-and-after-pelvic-exenteration
#6
Shannon D Armbruster, Charlotte C Sun, Shannon N Westin, Diane C Bodurka, Lois Ramondetta, Larissa A Meyer, Pamela T Soliman
OBJECTIVE: Pelvic exenteration (PE) is a surgical procedure associated with significant morbidity offered to select women with locally advanced or recurrent gynecologic cancers. This ongoing study examines an array of patient-reported outcomes and satisfaction with PE. METHODS: Since February 2009, prospectively enrolled participants completed questionnaires evaluating body image (BIS), depression (CESD), social support (DUFSS), symptoms (MDASI), sexual function (SAQ), functional status (SF-12), quality of life (The Stoma-QOL), satisfaction with decision (SWD) and an investigator-designed survey at baseline, 6, and 12months after PE...
April 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29614768/the-effect-of-leisure-activity-diversity-and-exercise-time-on-the-prevention-of-depression-in-the-middle-aged-and-elderly-residents-of-taiwan
#7
Hsiao-Yun Lee, Chia-Pin Yu, Chih-Da Wu, Wen-Chi Pan
Previous studies have confirmed that activity participation is beneficial to mental health, but few studies focus on older adults' depression. Based on the theory of social integration, this study examined the effects of leisure activity diversity and exercise time on depression in late adulthood. Subjects in the 2011 Survey of Health and Living Status of the Middle-Aged and Elderly in Taiwan were extracted. A series of logistic regressions were conducted to discern factors related to the odds of having depression...
April 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29559030/effect-of-ssri-and-calcium-channel-blockers-on-depression-symptoms-and-cognitive-function-in-elderly-persons-treated-for-hypertension-three-city-cohort-study
#8
Phillip J Tully, Ruth Peters, Karine Pérès, Kaarin J Anstey, Christophe Tzourio
BACKGROUND: Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. METHODS: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243)...
March 21, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29533326/depressive-symptoms-exercise-capacity-and-clinical-outcomes-after-lung-transplantation
#9
Patrick J Smith, Rebecca Byrd, Megan Lusby, Emily Clausen, Laurie D Snyder
OBJECTIVE: Depressive symptoms are common among lung transplant recipients and have been associated with worse clinical outcomes. However, few studies have examined the association between depressive symptoms assessed at multiple time points or behavioral mechanisms by which posttransplant depressive symptoms may confer greater clinical risk. We therefore examined the associations between depressive symptoms, exercise capacity, chronic lung allograft dysfunction (CLAD), and mortality prospectively in a large sample of lung transplant recipients...
May 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29417491/meditation-and-yoga-practice-are-associated-with-smaller-right-amygdala-volume-the-rotterdam-study
#10
Rinske A Gotink, Meike W Vernooij, M Arfan Ikram, Wiro J Niessen, Gabriel P Krestin, Albert Hofman, Henning Tiemeier, M G Myriam Hunink
To determine the association between meditation and yoga practice, experienced stress, and amygdala and hippocampal volume in a large population-based study. This study was embedded within the population-based Rotterdam Study and included 3742 participants for cross-sectional association. Participants filled out a questionnaire assessing meditation practice, yoga practice, and experienced stress, and underwent a magnetic resonance scan of the brain. 2397 participants underwent multiple brain scans, and were assessed for structural change over time...
February 7, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29415030/religiosity-prevalence-and-its-association-with-depression-and-anxiety-symptoms-among-hispanic-latino-adults
#11
Shir Lerman, Molly Jung, Elva M Arredondo, Janice M Barnhart, Jianwen Cai, Sheila F Castañeda, Martha L Daviglus, Rebeca A Espinoza, Aida L Giachello, Kristine M Molina, Krista Perreira, Hugo Salgado, Sylvia Wassertheil-Smoller, Robert C Kaplan
OBJECTIVES: Religion plays an important role in the lives of people in the United States. We examined the prevalence of religiosity among Hispanic/Latinos in four regions of the United States and looked at its correlation to depression and anxiety symptoms. DESIGN: The population-based Hispanic Community Health Study/ Study of Latinos enrolled a cohort of Hispanic/Latino adults (N = 16,415) ages 18-74 in four US cities from June 2008 to June 2011. Participants with complete data on religiosity (i...
2018: PloS One
https://www.readbyqxmd.com/read/29360051/assessing-advanced-theory-of-mind-and-alexithymia-in-patients-suffering-from-enduring-borderline-personality-disorder
#12
Agnieszka Pluta, Maria Kulesza, Piotr Grzegorzewski, Katarzyna Kucharska
Findings on the theory of mind (ToM) abilities in borderline personality disorder (BPD) have been inconsistent. Surprisingly, no studies have focused on the complex aspects of ToM while simultaneously measuring alexithymia as well as comorbid depressive and anxiety symptoms, therefore, our study aimed to fill this gap. 30 female patients with BPD and 38 healthy controls (HCs) completed the Faux Pas Test (FPT) and the Toronto Alexithymia Scale-20 (TAS-20). The clinical and intellectual assessment comprised of the Structured Clinical Interview for DSM-IV-TR Axis II Disorders (SCID-II), the Borderline Personality Inventory (BPI), the State-Trait Anxiety Inventory (STAI), the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R), and the Raven's Progressive Matrices (RPM)...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29334644/predictors-of-remission-from-probable-depression-among-hong-kong-adolescents-a-large-scale-longitudinal-study
#13
Xue Yang, Joseph T F Lau, Mason C M Lau
BACKGROUND: This study investigated the incidence of remission from probable depression among adolescents in Hong Kong. Remissions were defined as having Center for Epidemiological Studies Depression Scale (CESD) scores changed from ≥16 at baseline to <16 over the 12-month follow-up period. The study tested the predictors of remissions, including perceived changes in family support, self-efficacy, self-esteem, positive affect, negative events, social anxiety, and loneliness. METHODS: The study surveyed 9666 secondary school students and identified 5487 (57%) students with probable depression in Hong Kong...
March 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29321125/efficacy-of-a-web-based-safety-decision-aid-for-women-experiencing-intimate-partner-violence-randomized-controlled-trial
#14
Jane Koziol-McLain, Alain C Vandal, Denise Wilson, Shyamala Nada-Raja, Terry Dobbs, Christine McLean, Rose Sisk, Karen B Eden, Nancy E Glass
BACKGROUND: Intimate partner violence (IPV) is a human rights violation and leading health burden for women. Safety planning is a hallmark of specialist family violence intervention, yet only a small proportion of women access formal services. A Web-based safety decision aid may reach a wide audience of women experiencing IPV and offer the opportunity to prioritize and plan for safety for themselves and their families. OBJECTIVE: The aim of this study was to test the efficacy of a Web-based safety decision aid (isafe) for women experiencing IPV...
January 10, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29289025/impact-of-misclassification-error-in-the-estimation-of-maternal-major-depression-disorder-prevalence-in-home-visitation-programs
#15
Arthur H Owora, Hélène Carabin
The objective of this study was to measure the bias introduced by misclassification error when estimating the prevalence of MDD among mothers in two community-based studies. Baseline data were collected from mothers participating in two home visitation study sites in South Central United States between 2010 and 2014. The operational definition of MDD was a Center of Epidemiological Studies-Depression - Short Form (CESD-SF) score of 10 or higher. Misclassification error was adjusted for using CESD-SF sensitivity and specificity priors that were either antepartum or postpartum specific or non-specific...
March 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29246491/impact-of-loss-of-soat2-function-on-disease-progression-in-the-lysosomal-acid-lipase-deficient-mouse
#16
Adam M Lopez, Jen-Chieh Chuang, Stephen D Turley
Although only a small proportion of cholesterol in the body is esterified, in several diseases marked expansion of the esterified cholesterol (EC) pool occurs. These include Wolman disease (WD) and Cholesteryl Ester Storage Disease (CESD) which both result from mutations in LIPA, the gene that encodes lysosomal acid lipase (LAL). The respective contributions that our three cholesterol esterifying enzymes make to EC production, especially in disorders like CESD, are not well defined. The current studies represent a detailed exploration of our earlier findings in young male LAL-deficient mice also missing sterol O-acyltransferase 2 (SOAT2, also called ACAT2)...
February 2018: Steroids
https://www.readbyqxmd.com/read/29170689/perception-of-community-tolerance-and-prevalence-of-depression-among-transgender-persons
#17
Ashli A Owen-Smith, Craig Sineath, Travis Sanchez, Robin Dea, Shawn Giammattei, Theresa Gillespie, Monica F Helms, Enid M Hunkeler, Virginia P Quinn, Douglas Roblin, Jennifer Slovis, Robert Stephenson, Patrick S Sullivan, Vin Tangpricha, Cory Woodyatt, Michael Goodman
Purpose: The goal of the study was to examine the association between depression and perceived community tolerance after controlling for various demographic and personal characteristics, treatment receipt, and past experiences with abuse or discrimination. Methods: An on-line survey assessed depressive symptoms among transgender and gender non-conforming individuals. Depression was assessed using the 7-item Beck Depression Inventory for Primary Care (BDI-PC) and the 10-item Center for Epidemiologic Studies Depression (CESD-10) scale...
2017: Journal of Gay & Lesbian Mental Health
https://www.readbyqxmd.com/read/29167898/factors-associated-with-failure-of-adult-strabismus-20-questionnaire-scores-to-improve-following-strabismus-surgery
#18
Sarah R Hatt, David A Leske, Kemuel L Philbrick, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) typically improves following strabismus surgery. Nevertheless, for some patients, HRQOL does not improve, and reasons for this are unknown. Objective: To identify factors associated with failure of adult strabismus-20 (AS-20) HRQOL scores to improve following strabismus surgery. Design, Setting, and Participants: Prospective observational case series at the Mayo Clinic, Rochester, Minnesota, comprising 276 adults, between July 2012 and August 2016...
January 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29166890/continuous-passive-motion-and-physical-therapy-cpm-versus-physical-therapy-pt-versus-delayed-physical-therapy-dpt-after-surgical-release-for-elbow-contractures-a-study-protocol-for-a-prospective-randomized-controlled-trial
#19
Jetske Viveen, Job N Doornberg, Izaak F Kodde, Pjotr Goossens, Koen L M Koenraadt, Bertram The, Denise Eygendaal
BACKGROUND: The elbow is prone to stiffness after trauma. To regain functional elbow motion several conservative- and surgical treatment options are available. Conservative treatment includes physical therapy, intra-articular injections with corticosteroids and a static progressive or dynamic splinting program. If conservative treatment fails, an operative release of the posttraumatic stiff elbow is often performed. The best Evidence-Based rehabilitation protocol for patients after an operative release is unknown to date and differs per surgeon, hospital and country...
November 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29108600/why-does-college-education-matter-unveiling-the-contributions-of-selection-factors
#20
Hui Zheng
This study investigates the contributions of pre-college selection factors that may partially lead to the college degree - health link by using longitudinal data from the National Longitudinal Survey of Youth (1979) cohort. Propensity score matching method finds that the effects of college degree on various health outcomes (self-rated health, physical component summary index, health limitations, CESD scale) are reduced by 51% on average (range: 37%-70%) in the matched sample. Among these observed factors, cognitive skill is the biggest confounder, followed by pre-college health and socioeconomic characteristics (marital aspiration, years of schooling, marriage, fertility, poverty status) and non-cognitive skills (e...
November 2017: Social Science Research
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