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Deepa Japp, Anoop Shah, Sheila Fisken, Martin Denvir, Susan Shenkin, Alan Japp
BACKGROUND: mineralocorticoid receptor antagonists (MRAs) improve outcomes in several populations of patients with heart failure (HF), but there has been no systematic review of MRAs in older patients. OBJECTIVES: systematic review and meta-analysis of the efficacy and safety of MRA treatment in elderly HF patients. DATA SOURCES: trials were identified through a literature search until 24 January 2015. STUDY SELECTION: randomised controlled trials (RCTs) of MRAs in patients with HF and/or left ventricular systolic dysfunction aged ≥65 years, with subgroup analysis of patients ≥65 years or with mean participant age ≥70 years...
August 9, 2016: Age and Ageing
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