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https://www.readbyqxmd.com/read/29761290/isolation-and-functional-characterization-of-a-floral-repressor-bcflc2-from-pak-choi-brassica-rapa-ssp-chinensis
#1
Feiyi Huang, Tongkun Liu, Jin Wang, Xilin Hou
BcFLC2 functioned as a repressor of flowering by directly regulating BcTEM1, BcMAF2, BcSOC1 and BcSPL15 in Pak-choi. FLOWERING LOCUS C (FLC) plays an important role in regulating flowering time. Here, we functionally described an FLC homologous gene, BcFLC2, that negatively regulated flowering in Pak-choi (Brassica rapa ssp. chinensis). The sequence comparison to Arabidopsis FLC showed that BcFLC2 also had a MADS-box domain at the N terminus. BcFLC2 was highly expressed in the leaves, roots, stems and stamens, and its expression was repressed by vernalization in Pak-choi...
May 14, 2018: Planta
https://www.readbyqxmd.com/read/29744943/the-floral-homeotic-protein-sepallata3-recognizes-target-dna-sequences-by-shape-readout-involving-a-conserved-arginine-residue-in-the-mads-domain
#2
Sandra Käppel, Rainer Melzer, Florian Rümpler, Christian Gafert, Günter Theißen
SEPALLATA3 of Arabidopsis thaliana is a MADS-domain transcription factor and a key regulator of flower development. MADS-domain proteins bind to sequences termed 'CArG-boxes' (consensus 5'-CC(A/T)6 GG-3'). Since only a fraction of the CArG-boxes in the Arabidopsis genome are bound by SEPALLATA3, more elaborate principles have to be discovered to better understand which features turn CArG-boxes into genuine recognition sites. Here, we investigate to which extent the shape of the DNA is involved in a 'shape readout' that contributes to the binding of SEPALLATA3...
May 9, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29736250/mikc-c-type-mads-box-genes-in-rosa-chinensis-the-remarkable-expansion-of-abcde-model-genes-and-their-roles-in-floral-organogenesis
#3
Jinyi Liu, Xiaodong Fu, Yuwei Dong, Jun Lu, Min Ren, Ningning Zhou, Changquan Wang
MIKCC -type MADS-box (MIKCC ) genes encode transcription factors that have crucial roles in controlling floral organogenesis and flowering time in plants. Although this gene family has been well characterized in many plant species, its evolutionary and comprehensive functional analysis in rose is lacking. In this study, 58 non-redundant MIKCC uni-transcripts were extensively identified from rose transcriptomes. Phylogenetic analysis placed these genes into 12 clades with their Arabidopsis and strawberry counterparts, and revealed that ABCDE model (including AP1/FUL, AP3/PI, AG, and SEP clades), and SOC1 and AGL6 clade genes have remarkably expanded in Rosa chinensis , whereas genes from the FLC and AGL17 clades were undetectable...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29720991/a-survey-of-mikc-type-mads-box-genes-in-non-seed-plants-algae-bryophytes-lycophytes-and-ferns
#4
REVIEW
Gokilavani Thangavel, Saraswati Nayar
MADS box transcription factors have been studied extensively in flowering plants but remain less studied in non-seed plants. MADS box is one such example of a gene which is prevalent across many classes of plants ranging from chlorophyta to embryophyta as well as fungi and animals. MADS box transcription factors are of two types, Type I and Type II. Type II transcription factors (TF) that consist of a MADS domain, I region, K domain, and C terminal domain are discussed in this review. The Type II/ MIKC class is widespread across charophytes and all major lineages of land plants but unknown in green and red algae...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29686472/development-and-predictive-validity-of-the-cirrhosis-associated-ascites-symptom-scale-a-cohort-study-of-103-patients
#5
Agnete Nordheim Riedel, Nina Kimer, Anne-Sofie Houlberg Jensen, Emilie Kristine Dahl, Mads Israelsen, Luise Aamann, Lise Lotte Gluud
AIM: To develop a scale of domains associated with the health-related quality-of-life (HRQOL) in patients with cirrhosis-related ascites. METHODS: We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom (CAS) scale describing symptoms with a potential detrimental impact on health related quality of life (HRQL) (the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with (1) tense/severe; (2) moderate/mild; or (3) no ascites (controls)...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29663368/a-peptide-that-blocks-the-interaction-of-nf-%C3%AE%C2%BAb-p65-subunit-with-smad4-enhances-bmp2-induced-osteogenesis
#6
Mariko Urata, Shoichiro Kokabu, Takuma Matsubara, Goro Sugiyama, Chihiro Nakatomi, Hiroshi Takeuchi, Shizu Hirata-Tsuchiya, Kazuhiro Aoki, Yukihiko Tamura, Yasuko Moriyama, Yasunori Ayukawa, Miho Matsuda, Min Zhang, Kiyoshi Koyano, Chiaki Kitamura, Eijiro Jimi
Bone morphogenetic protein (BMP) potentiates bone formation through the Smad signaling pathway in vitro and in vivo. The transcription factor nuclear factor κB (NF-κB) suppresses BMP-induced osteoblast differentiation. Recently, we identified that the transactivation (TA) 2 domain of p65, a main subunit of NF-κB, interacts with the mad homology (MH) 1 domain of Smad4 to inhibit BMP signaling. Therefore, we further attempted to identify the interacting regions of these two molecules at the amino acid level...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29660180/a-chromatin-loop-represses-wuschel-expression-in-arabidopsis
#7
Lin Guo, Xiuwei Cao, Yuhao Liu, Jun Li, Yongpeng Li, Dongming Li, Ke Zhang, Caixia Gao, Aiwu Dong, Xigang Liu
WUSCHEL (WUS) is critical for plant meristem maintenance and determinacy in Arabidopsis, and the regulation of its spatiotemporal expression patterns is complex. We previously found that AGAMOUS (AG), a key MADS-domain transcription factor in floral organ identity and floral meristem determinacy, can directly suppress WUS expression through the recruitment of the Polycomb group (PcG) protein TERMINAL FLOWER 2 (TFL2, also known as LIKE HETEROCHROMATIN PROTEIN 1, LHP1) at the WUS locus; however, the mechanism by which WUS is repressed remains unclear...
April 16, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29617274/identification-and-characterization-of-the-mads-box-genes-and-their-contribution-to-flower-organ-in-carnation-dianthus-caryophyllus-l
#8
Xiaoni Zhang, Qijian Wang, Shaozong Yang, Shengnan Lin, Manzhu Bao, Mohammed Bendahmane, Quanshu Wu, Caiyun Wang, Xiaopeng Fu
Dianthus is a large genus containing many species with high ornamental economic value. Extensive breeding strategies permitted an exploration of an improvement in the quality of cultivated carnation, particularly in flowers. However, little is known on the molecular mechanisms of flower development in carnation. Here, we report the identification and description of MADS-box genes in carnation ( DcaMADS ) with a focus on those involved in flower development and organ identity determination. In this study, 39 MADS-box genes were identified from the carnation genome and transcriptome by the phylogenetic analysis...
April 4, 2018: Genes
https://www.readbyqxmd.com/read/29616182/molecular-cloning-characterization-and-expression-analysis-of-mads-box-genes-associated-with-reproductive-development-in-momordica-dioica-roxb
#9
Jatindra Nath Mohanty, Raj Kumar Joshi
The repertoire and functions of MADS-box family transcription factors (TFs) largely remains unexplored with respect to floral organogenesis of Momordica dioica Roxb. Degenerative PCR followed by rapid amplification of cDNA ends was employed in the present study to clone and characterize 17 MADS-box genes (designated as MdMADS01 to MdMADS17 ) from the floral buds of M. dioica. The cloned genes were clustered into three subgroups (11 MIKCC , 4 MIKC* and 2 Mα) based on phylogenetic relationships with the MADS-box genes from Cucumis sativus, Cucumis melo and Arabidopsis thaliana ...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29604523/genome-wide-analysis-of-the-mads-box-gene-family-in-polyploid-cotton-gossypium-hirsutum-and-in-its-diploid-parental-species-gossypium-arboreum-and-gossypium-raimondii
#10
Sarah Muniz Nardeli, Sinara Artico, Gustavo Mitsunori Aoyagi, Stéfanie Menezes de Moura, Tatiane da Franca Silva, Maria Fatima Grossi-de-Sa, Elisson Romanel, Marcio Alves-Ferreira
The MADS-box gene family encodes transcription factors that share a highly conserved domain known to bind to DNA. Members of this family control various processes of development in plants, from root formation to fruit ripening. In this work, a survey of diploid (Gossypium raimondii and Gossypium arboreum) and tetraploid (Gossypium hirsutum) cotton genomes found a total of 147, 133 and 207 MADS-box genes, respectively, distributed in the MIKC, Mα, Mβ, Mγ, and Mδ subclades. A comparative phylogenetic analysis among cotton species, Arabidopsis, poplar and grapevine MADS-box homologous genes allowed us to evaluate the evolution of each MADS-box lineage in cotton plants and identify sequences within well-established subfamilies...
March 20, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29588413/hydrophobic-patches-on-smad2-and-smad3-determine-selective-binding-to-cofactors
#11
Ken-Ichi Miyazono, Saho Moriwaki, Tomoko Ito, Akira Kurisaki, Makoto Asashima, Masaru Tanokura
The transforming growth factor-β (TGF-β) superfamily of cytokines regulates various biological processes, including cell proliferation, immune responses, autophagy, and senescence. Dysregulation of TGF-β signaling causes various diseases, such as cancer and fibrosis. SMAD2 and SMAD3 are core transcription factors involved in TGF-β signaling, and they form heterotrimeric complexes with SMAD4 (SMAD2-SMAD2-SMAD4, SMAD3-SMAD3-SMAD4, and SMAD2-SMAD3-SMAD4) in response to TGF-β signaling. These heterotrimeric complexes interact with cofactors to control the expression of TGF-β-dependent genes...
March 27, 2018: Science Signaling
https://www.readbyqxmd.com/read/29562355/tetramerization-of-mads-family-transcription-factors-sepallata3-and-agamous-is-required-for-floral-meristem-determinacy-in-arabidopsis
#12
Véronique Hugouvieux, Catarina S Silva, Agnès Jourdain, Arnaud Stigliani, Quentin Charras, Vanessa Conn, Simon J Conn, Cristel C Carles, François Parcy, Chloe Zubieta
The MADS transcription factors (TF) constitute an ancient family of TF found in all eukaryotes that bind DNA as obligate dimers. Plants have dramatically expanded the functional diversity of the MADS family during evolution by adding protein-protein interaction domains to the core DNA-binding domain, allowing the formation of heterotetrameric complexes. Tetramerization of plant MADS TFs is believed to play a central role in the evolution of higher plants by acting as one of the main determinants of flower formation and floral organ specification...
March 19, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29559991/isolation-and-functional-characterization-of-a-floral-repressor-bcmaf1-from-pak-choi-brassica-rapa-ssp-chinensis
#13
Feiyi Huang, Tongkun Liu, Xilin Hou
MADS-box genes form a large gene family in plants and are involved in multiple biological processes, such as flowering. However, the regulation mechanism of MADS-box genes in flowering remains unresolved, especially under short-term cold conditions. In the present study, we isolated BcMAF1 , a Pak-choi ( Brassica rapa ssp. Chinensis ) MADS AFFECTING FLOWERING ( MAF ), as a floral repressor and functionally characterized BcMAF1 in Arabidopsis and Pak-choi. Subcellular localization and sequence analysis indicated that BcMAF1 was a nuclear protein and contained a conserved MADS-box domain...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29540194/mads-box-family-genes-in-sheepgrass-and-their-involvement-in-abiotic-stress-responses
#14
Junting Jia, Pincang Zhao, Liqin Cheng, Guangxiao Yuan, Weiguang Yang, Shu Liu, Shuangyan Chen, Dongmei Qi, Gongshe Liu, Xiaoxia Li
BACKGROUND: MADS-box genes are categorized into A, B, C, D and E classes and are involved in floral organ identity and flowering. Sheepgrass (Leymus chinensis (Trin.) Tzvel) is an important perennial forage grass and adapts well to many adverse environments. However, there are few studies on the molecular mechanisms of flower development in sheepgrass, especially studies on MADS-domain proteins. RESULTS: In this study, we cloned 11 MADS-box genes from sheepgrass (Leymus chinensis (Trin...
March 14, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29523711/fertilization-independent-seed-polycomb-repressive-complex-2-plays-a-dual-role-in-regulating-type-i-mads-box-genes-in-early-endosperm-development
#15
Shanshan Zhang, Dongfang Wang, Huajian Zhang, Megan I Skaggs, Alan Lloyd, Di Ran, Lingling An, Karen S Schumaker, Gary N Drews, Ramin Yadegari
Early endosperm development presents a unique system in which to uncover epigenetic regulatory mechanisms because the contributing maternal and paternal genomes possess differential epigenetic modifications. In Arabidopsis ( Arabidopsis thaliana ), the initiation of endosperm coenocytic growth upon fertilization and the transition to endosperm cellularization are regulated by the FERTILIZATION-INDEPENDENT SEED (FIS)-Polycomb Repressive Complex 2 (PRC2), a putative H3K27 methyltransferase. Here, we address the possible role of the FIS-PRC2 complex in regulating the type I MADS-box gene family, which has been shown previously to regulate early endosperm development...
May 2018: Plant Physiology
https://www.readbyqxmd.com/read/29497767/genome-wide-association-study-identified-genetic-variations-and-candidate-genes-for-plant-architecture-component-traits-in-chinese-upland-cotton
#16
Junji Su, Libei Li, Chi Zhang, Caixiang Wang, Lijiao Gu, Hantao Wang, Hengling Wei, Qibao Liu, Long Huang, Shuxun Yu
Thirty significant associations between 22 SNPs and five plant architecture component traits in Chinese upland cotton were identified via GWAS. Four peak SNP loci located on chromosome D03 were simultaneously associated with more plant architecture component traits. A candidate gene, Gh_D03G0922, might be responsible for plant height in upland cotton. A compact plant architecture is increasingly required for mechanized harvesting processes in China. Therefore, cotton plant architecture is an important trait, and its components, such as plant height, fruit branch length and fruit branch angle, affect the suitability of a cultivar for mechanized harvesting...
June 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29487282/g-protein-%C3%AE-%C3%AE-subunits-determine-grain-size-through-interaction-with-mads-domain-transcription-factors-in-rice
#17
Qian Liu, Ruixi Han, Kun Wu, Jianqing Zhang, Yafeng Ye, Shuansuo Wang, Jianfeng Chen, Yajun Pan, Qi Li, Xiaopeng Xu, Jiawu Zhou, Dayun Tao, Yuejin Wu, Xiangdong Fu
The simultaneous improvement of grain quality and yield of cereal crops is a major challenge for modern agriculture. Here we show that a rice grain yield quantitative trait locus qLGY3 encodes a MADS-domain transcription factor OsMADS1, which acts as a key downstream effector of G-protein βγ dimers. The presence of an alternatively spliced protein OsMADS1lgy3 is shown to be associated with formation of long and slender grains, resulting in increases in both grain quality and yield potential of rice. The Gγ subunits GS3 and DEP1 interact directly with the conserved keratin-like domain of MADS transcription factors, function as cofactors to enhance OsMADS1 transcriptional activity and promote the co-operative transactivation of common target genes, thereby regulating grain size and shape...
February 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29477338/the-cancer-mutation-d83v-induces-an-%C3%AE-helix-to-%C3%AE-strand-conformation-switch-in-mef2b
#18
Xiao Lei, Yi Kou, Yang Fu, Niroop Rajashekar, Haoran Shi, Fang Wu, Jiang Xu, Yibing Luo, Lin Chen
MEF2B is a major target of somatic mutations in non-Hodgkin lymphoma. Most of these mutations are non-synonymous substitutions of surface residues in the MADS-box/MEF2 domain. Among them, D83V is the most frequent mutation found in tumor cells. The link between this hotspot mutation and cancer is not well understood. Here we show that the D83V mutation induces a dramatic α-helix to β-strand switch in the MEF2 domain. Located in an α-helix region rich in β-branched residues, the D83V mutation not only removes the extensive helix stabilization interactions but also introduces an additional β-branched residue that further shifts the conformation equilibrium from α-helix to β-strand...
April 13, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29474735/mads-box-genes-and-crop-domestication-the-jack-of-all-traits
#19
Susanne Schilling, Sirui Pan, Alice Kennedy, Rainer Melzer
MADS-box genes are key regulators of virtually every aspect of plant reproductive development. They play especially prominent roles in flowering time control, inflorescence architecture, floral organ identity determination, and seed development. The developmental and evolutionary importance of MADS-box genes is widely acknowledged. However, their role during flowering plant domestication is less well recognized. Here, we provide an overview illustrating that MADS-box genes have been important targets of selection during crop domestication and improvement...
March 24, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29474620/a-conserved-leucine-zipper-like-motif-accounts-for-strong-tetramerization-capabilities-of-sepallata-like-mads-domain-transcription-factors
#20
Florian Rümpler, Günter Theißen, Rainer Melzer
The development of angiosperm flowers is regulated by homeotic MIKC-type MADS-domain transcription factors that activate or repress target genes via the formation of DNA-bound, organ-specific tetrameric complexes. The protein-protein interaction (PPI) capabilities differ considerably between different MIKC-type proteins. In Arabidopsis thaliana the floral homeotic protein SEPALLATA3 (SEP3) acts as a hub that incorporates numerous other MADS-domain proteins into tetrameric complexes that would otherwise not form...
April 9, 2018: Journal of Experimental Botany
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