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https://www.readbyqxmd.com/read/28337996/protein-interaction-evolution-from-promiscuity-to-specificity-with-reduced-flexibility-in-an-increasingly-complex-network
#1
T Alhindi, Z Zhang, P Ruelens, H Coenen, H Degroote, N Iraci, K Geuten
A key question regarding protein evolution is how proteins adapt to the dynamic environment in which they function and how in turn their evolution shapes the protein interaction network. We used extant and resurrected ancestral plant MADS-domain transcription factors to understand how SEPALLATA3, a protein with hub and glue properties, evolved and takes part in network organization. Although the density of dimeric interactions was saturated in the network, many new interactions became mediated by SEPALLATA3 after a whole genome triplication event...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330566/the-mads-box-gene-slmbp11-regulates-plant-architecture-and-affects-reproductive-development-in-tomato-plants
#2
Xuhu Guo, Guoping Chen, Muhammad Naeem, Xiaohu Yu, Boyan Tang, Anzhou Li, Zongli Hu
MADS-domain proteins are important transcription factors that are involved in many biological processes of plants. In the present study, SlMBP11, a member of the AGL15 subfamily, was cloned in tomato plants (Solanum lycopersicon M.). SlMBP11 is ubiquitously expressed in all of the tissues we examined, whereas the SlMBP11 transcription levels were significantly higher in reproductive tissues than in vegetative tissues. Plants exhibiting increased SlMBP11 levels displayed reduced plant height, leaf size, and internode length as well as a loss of dominance in young seedlings, highly branched growth from each leaf axil, and increased number of nodes and leaves...
May 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28317937/identification-of-cancer-associated-missense-mutations-in-hace1-that-impair-cell-growth-control-and-rac1-ubiquitylation
#3
Emilie Andrio, Romain Lotte, Daniel Hamaoui, Jacqueline Cherfils, Anne Doye, Mads Daugaard, Poul H Sorensen, Frédéric Bost, Raymond Ruimy, Amel Mettouchi, Emmanuel Lemichez
The E3 ubiquitin ligase HACE1 is a potent tumor suppressor that controls cell proliferation and ubiquitylates the small GTPase Rac1 to target it to proteasomal degradation. Whether and how the activity of HACE1 is regulated by the N-terminal ankyrin (ANK) and the middle (MID) domains is ill defined. Here, we identified in the version 64 of the Catalogue of Somatic Mutations in Cancer (COSMIC) 13 missense mutations of hace1 located outside the HECT domain, and found that all lead to defective control of cell proliferation...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261246/possible-role-of-mads-affecting-flowering-3-and-b-box-domain-protein-19-in-flowering-time-regulation-of-arabidopsis-mutants-with-defects-in-nonsense-mediated-mrna-decay
#4
Zeeshan Nasim, Muhammad Fahim, Ji Hoon Ahn
Eukaryotic cells use nonsense-mediated mRNA decay (NMD) to clear aberrant mRNAs from the cell, thus preventing the accumulation of truncated proteins. In Arabidopsis, two UP-Frameshift (UPF) proteins, UPF1 and UPF3, play a critical role in NMD. Although deficiency of UPF1 and UPF3 leads to various developmental defects, little is known about the mechanism underlying the regulation of flowering time by NMD. Here, we showed that the upf1-5 and upf3-1 mutants had a late-flowering phenotype under long-day conditions and the upf1-5 upf3-1 double mutants had an additive effect in delaying flowering time...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28252035/regulation-of-atypical-map-kinases-erk3-and-erk4-by-the-phosphatase-dusp2
#5
Maria Perander, Rania Al-Mahdi, Thomas C Jensen, Jennifer A L Nunn, Hanne Kildalsen, Bjarne Johansen, Mads Gabrielsen, Stephen M Keyse, Ole-Morten Seternes
The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood. Here we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known regulator of the ERK and p38 MAPKs, is unique amongst the MKP family in being able to bind to both ERK3 and ERK4. This interaction is mediated by a conserved common docking (CD) domain within the carboxyl-terminal domains of ERK3 and ERK4 and the conserved kinase interaction motif (KIM) located within the non-catalytic amino terminus of DUSP2...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251165/novel-chemokine-based-immunotoxins-for-potent-and-selective-targeting-of-cytomegalovirus-infected-cells
#6
Katja Spiess, Mads G Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Thomas N Kledal, Mette M Rosenkilde
Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency. One recent example targeted the virus-encoded G protein-coupled receptor US28 as a strategy for specific and efficient treatment of human cytomegalovirus (HCMV) infections. US28 is expressed on virus-infected cells and scavenge chemokines by rapid internalization. The chemokine-based fusion-toxin protein (FTP) consisted of a variant (F49A) of CX3CL1 specifically targeting US28 linked to the catalytic domain of Pseudomonas exotoxin A (PE)...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28100708/the-origin-of-floral-organ-identity-quartets
#7
Philip Ruelens, Zhicheng Zhang, Hilda van Mourik, Steven Maere, Kerstin Kaufmann, Koen Geuten
The origin of flowers has puzzled plant biologists ever since Darwin referred to their sudden appearance in the fossil record as an abominable mystery. Flowers are considered to be an assembly of protective, attractive, and reproductive male and female leaf-like organs. Their origin cannot be understood by a morphological comparison to gymnosperms, their closest relatives, which develop separate male or female cones. Despite these morphological differences, gymnosperms and angiosperms possess a similar genetic toolbox consisting of phylogenetically related MADS domain proteins...
February 2017: Plant Cell
https://www.readbyqxmd.com/read/28018905/the-mutational-landscape-of-the-oncogenic-mzf1-scan-domain-in-cancer
#8
Mads Nygaard, Thilde Terkelsen, André Vidas Olsen, Valentina Sora, Juan Salamanca Viloria, Fabio Rizza, Sanne Bergstrand-Poulsen, Miriam Di Marco, Mette Vistesen, Matteo Tiberti, Matteo Lambrughi, Marja Jäättelä, Tuula Kallunki, Elena Papaleo
SCAN domains in zinc-finger transcription factors are crucial mediators of protein-protein interactions. Up to 240 SCAN-domain encoding genes have been identified throughout the human genome. These include cancer-related genes, such as the myeloid zinc finger 1 (MZF1), an oncogenic transcription factor involved in the progression of many solid cancers. The mechanisms by which SCAN homo- and heterodimers assemble and how they alter the transcriptional activity of zinc-finger transcription factors in cancer and other diseases remain to be investigated...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28007633/the-go-actiwe-randomized-controlled-trial-an-interdisciplinary-study-designed-to-investigate-the-health-effects-of-active-commuting-and-leisure-time-physical-activity
#9
Mads Rosenkilde, Martin Bæk Petersen, Anne Sofie Gram, Jonas Salling Quist, Jonas Winther, Simon Due Kamronn, Desirée Hornbæk Milling, Jakob Eg Larsen, Astrid Pernille Jespersen, Bente Stallknecht
Regular physical activity is efficacious for improving metabolic health in overweight and obese individuals, yet, many adults lead sedentary lives. Most exercise interventions have targeted leisure time, but physical activity also takes place in other domains of everyday life. Active commuting represents a promising alternative to increase physical activity, but it has yet to be established whether active commuting conveys health benefits on par with leisure time physical activity (LTPA). A 6-month randomized controlled trial was designed to investigate the effects of increased physical activity in transport (bicycling) or leisure time domains (moderate or vigorous intensity endurance exercise)...
December 19, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27968991/wsa206-a-paralog-of-duplicated-mpf2-like-mads-box-family-is-recruited-in-fertility-function-in-withania
#10
Muhammad Ramzan Khan, Humera Ihsan, Ghulam Muhammad Ali
Best known for their implication in calyx inflation, MPF2-like genes pertinent to the STMADS11 clade of the MADS-box family exert their functions in leaf development, flowering time, inflorescence architecture and floral reversion to just name but a few. However, our knowledge about their involvement in fertility function remained obscure. Therefore the major thrust of this study was to probe the recruitment of WSA206 (MPF2-like) protein in fertility function. The WSA206 functions were revealed by knocking down and overexpressing this protein in Withania somnifera...
December 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27965680/molecular-cloning-characterization-and-expression-of-misoc1-a-homolog-of-the-flowering-gene-suppressor-of-overexpression-of-constans1-from-mango-mangifera-indica-l
#11
Junya Wei, Debing Liu, Guoyin Liu, Jie Tang, Yeyuan Chen
MADS-box transcription factor plays a crucial role in plant development, especially controlling the formation and development of floral organs. Mango (Mangifera indica L) is an economically important fruit crop, but its molecular control of flowering is largely unknown. To better understand the molecular basis of flowering regulation in mango, we isolated and characterized the MiSOC1, a putative mango orthologs for the Arabidopsis SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1/AGAMOUS-LIKE 20 (SOC1/AGL20) with homology-based cloning and RACE...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27957330/evidence-of-perturbed-germinal-center-dynamics-but-preserved-antibody-diversity-in-end-stage-renal-disease
#12
Kristian Assing, Christian Nielsen, Marianne Jakobsen, Alexandra Scholze, Mads Nybo, Grete Soerensen, Sussie Mortensen, Knud Vejen, Torben Barington, Claus Bistrup
INTRODUCTION: End-stage renal disease (ESRD) is associated with increased infectious susceptibility and with reduced vaccine responses consistent with compromised humoral immunity. Whether the compromised humoral immunity is due to reduced antibody diversity (reduced somatic hypermutation [SHM]) or altered germinal center (GC) dynamics is not known. The GC-derived chemokine CXCL13 as well as peripheral T follicular helper cells (pTFH) reflect GC dynamics, but have, similar to SHM, never been characterized in relation to ESRD...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27927985/the-arrhythmogenic-calmodulin-p-phe142leu-mutation-impairs-c-domain-ca2-binding-but-not-calmodulin-dependent-inhibition-of-the-cardiac-ryanodine-receptor
#13
Mads Toft Søndergaard, Yingjie Liu, Kamilla Taunsig Larsen, Alma Nani, Xixi Tian, Christian Holt, Ruiwu Wang, Reinhard Wimmer, Filip Van Petegem, Michael Fill, S R Wayne Chen, Michael Toft Overgaard
A number of point mutations in the intracellular Ca(2+)-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlying mechanisms are not clear. These mutations generally decrease Ca(2+) binding to CaM and impair inhibition of CaM-regulated Ca(2+) channels like the cardiac Ca(2+) release channel (ryanodine receptor, RyR2), and it appears that attenuated CaM Ca(2+) binding correlates with impaired CaM-dependent RyR2 inhibition. Here, we investigated the RyR2 inhibitory action of the CaM p.Phe142Leu mutation (F142L; numbered including the start-Met), which markedly reduces CaM Ca(2+) binding...
January 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27895195/a-scottish-poor-law-of-lunacy-poor-law-lunacy-law-and-scotland-s-parochial-asylums
#14
Lauren Farquharson
Scotland's parochial asylums are unfamiliar institutional spaces. Representing the concrete manifestation of the collision between two spheres of legislation, the Poor Law and the Lunacy Law, six such asylums were constructed in the latter half of the nineteenth century. These sites expressed the enduring mandate of the Scottish Poor Law 1845 over the domain of 'madness'. They were institutions whose very existence was fashioned at the directive of the local arm of the Poor Law, the parochial board, and they constituted a continuing 'Scottish Poor Law of Lunacy'...
November 28, 2016: History of Psychiatry
https://www.readbyqxmd.com/read/27817120/identification-of-anthocyanin-biosynthesis-related-micrornas-in-a-distinctive-chinese-radish-raphanus-sativus-l-by-high-throughput-sequencing
#15
Yuyan Sun, Yang Qiu, Mengmeng Duan, Jinglei Wang, Xiaohui Zhang, Haiping Wang, Jiangping Song, Xixiang Li
Anthocyanins are widely distributed water-soluble phytochemical pigments belonging to the flavonoid group. To date, limited knowledge is available about the regulatory roles of miRNAs in anthocyanin biosynthesis in plants. To identify the miRNAs associated with anthocyanin biosynthesis in radish, five small RNA (sRNA) libraries constructed from 'Xinlimei' radish roots at 11, 21, 44, 56 and 73 days (d) were examined using high-throughput sequencing technology. A total of 102.02 million (M) clean reads were generated, from which 483 known and 1415 novel miRNAs were identified...
February 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27696495/quality-of-life-decrements-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#16
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospective studies are lacking. We aimed to assess QoL during ADT using two validated questionnaires and determine contributing factors. DESIGN: Prospective controlled study. PATIENTS: Sixty-three men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age- and radiotherapy-matched prostate cancer controls (n = 29)...
March 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27626377/broad-histone-h3k4me3-domains-in-mouse-oocytes-modulate-maternal-to-zygotic-transition
#17
John Arne Dahl, Inkyung Jung, Håvard Aanes, Gareth D Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjørås, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland
Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is still poorly understood despite recent progress in analysis of gene expression and DNA methylation in early embryogenesis. Dynamic histone modifications may have important roles in MZT, but direct measurements of chromatin states have been hindered by technical difficulties in profiling histone modifications from small quantities of cells. Recent improvements allow for 500 cell-equivalents of chromatin per reaction, but require 10,000 cells for initial steps or require a highly specialized microfluidics device that is not readily available...
September 22, 2016: Nature
https://www.readbyqxmd.com/read/27624831/mads-domain-transcription-factors-and-the-floral-quartet-model-of-flower-development-linking-plant-development-and-evolution
#18
REVIEW
Günter Theißen, Rainer Melzer, Florian Rümpler
The floral quartet model of floral organ specification poses that different tetramers of MIKC-type MADS-domain transcription factors control gene expression and hence the identity of floral organs during development. Here, we provide a brief history of the floral quartet model and review several lines of recent evidence that support the model. We also describe how the model has been used in contemporary developmental and evolutionary biology to shed light on enigmatic topics such as the origin of land and flowering plants...
September 15, 2016: Development
https://www.readbyqxmd.com/read/27591049/spata2-links-cyld-to-lubac-activates-cyld-and-controls-lubac-signaling
#19
Paul R Elliott, Derek Leske, Matous Hrdinka, Katrin Bagola, Berthe K Fiil, Stephen H McLaughlin, Jane Wagstaff, Norbert Volkmar, John C Christianson, Benedikt M Kessler, Stefan M V Freund, David Komander, Mads Gyrd-Hansen
The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD interacts with HOIP via spermatogenesis-associated protein 2 (SPATA2). SPATA2 interacts with CYLD through its non-canonical PUB domain, which binds the catalytic CYLD USP domain in a CYLD B-box-dependent manner. Significantly, SPATA2 binding activates CYLD-mediated hydrolysis of ubiquitin chains...
September 15, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27578171/drosophila-dullard-functions-as-a-mad-phosphatase-to-terminate-bmp-signaling
#20
Hugo Urrutia, Abigail Aleman, Edward Eivers
Bone morphogenetic proteins (BMPs) are growth factors that provide essential signals for normal embryonic development and adult tissue homeostasis. A key step in initiating BMP signaling is ligand induced phosphorylation of receptor Smads (R-Smads) by type I receptor kinases, while linker phosphorylation of R-Smads has been shown to cause BMP signal termination. Here we present data demonstrating that the phosphatase Dullard is involved in dephosphorylating the Drosophila R-Smad, Mad, and is integral in controlling BMP signal duration...
2016: Scientific Reports
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