keyword
https://read.qxmd.com/read/37139806/nlrc3-participates-in-inhibiting-the-pulmonary-inflammatory-response-of-sepsis-induced-acute-lung-injury
#21
JOURNAL ARTICLE
Ruiting Li, Yue Zhao, Xue Zhang, Le Yang, Xiaojing Zou
Acute lung injury (ALI) progresses rapidly, is difficult to treat, and has a high fatality rate. The excessive inflammatory response is an important pathological mechanism of ALI. NLRC3 (NLR family CARD domain-containing 3), a non-inflammasome member of the NLR family, has been found that it could negatively regulates various biological pathways associated with inflammatory response, such as NF-κB (nuclear factor kappa B), PI3K (Phosphatidylinositol 3'-kinase)-Akt (protein kinase B)-mTOR (mammalian target of the rapamycin), and STING (stimulator of interferon genes) pathways, which are responsible for the progression of pulmonary inflammation and participate in regulating the pathological progression of ALI...
May 4, 2023: Immunological Investigations
https://read.qxmd.com/read/37108455/alveolar-capillary-barrier-protection-in-vitro-lung-cell-type-specific-effects-and-molecular-mechanisms-induced-by-1%C3%AE-25-dihydroxyvitamin-d3
#22
JOURNAL ARTICLE
Junyu Xiong, Patrick Kaleja, Larissa Ückert, Niloufar Nezaratizadeh, Stefanie Krantz, Martin Friedrich Krause, Stefanie Fitschen-Oestern, Andreas Seekamp, Liam Cassidy, Andreas Tholey, Sabine Fuchs
Low serum levels of 1α, 25-dihydroxyvitamin D3 (VD3) are associated with a higher mortality in trauma patients with sepsis or ARDS. However, the molecular mechanisms behind this observation are not yet understood. VD3 is known to stimulate lung maturity, alveolar type II cell differentiation, or pulmonary surfactant synthesis and guides epithelial defense during infection. In this study, we investigated the impact of VD3 on the alveolar-capillary barrier in a co-culture model of alveolar epithelial cells and microvascular endothelial cells respectively in the individual cell types...
April 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36907882/re-analysis-of-ventilator-free-days-vfd-in-acute-respiratory-distress-syndrome-ards-studies
#23
JOURNAL ARTICLE
Rejina Mariam Verghis, Cliona McDowell, Bronagh Blackwood, Bohee Lee, Daniel F McAuley, Mike Clarke
BACKGROUND: Over recent decades, improvements in healthcare have reduced mortality and morbidity rates in many conditions. This has resulted, in part, from the identification of effective interventions in randomised trials, and in conducting such trials, a composite outcome measure (COM) with multiple components will increase event rates, which allows study completion with a smaller sample size. In critical care research, the COM "ventilator-free days" (VFD) combines mortality and duration of mechanical ventilation (MV) into a single continuous measure, which can be analysed in a variety of ways...
March 13, 2023: Trials
https://read.qxmd.com/read/36803290/same-but-different-ecmo-in-covid-19-and-ards-of-other-etiologies-comparison-of-survival-outcomes-and-management-in-different-ards-groups
#24
JOURNAL ARTICLE
Alenka Golicnik, Ina Zivanovic, Vojka Gorjup, Jernej Berden
Background: COVID-19 has led to increased numbers of patients in need of venovenous extracorporeal membrane oxygenation (ECMO) support, but knowledge on management in comparison to acute respiratory distress syndrome (ARDS) of other etiologies is still lacking. We analyzed venovenous ECMO management and survival outcomes in patients with COVID-19 in comparison to influenza ARDS and pulmonary ARDS of other origin. Results: Retrospective analysis of prospective venovenous ECMO registry-based data collection was performed...
February 19, 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/36717098/hemoglobin-increases-leukocyte-adhesion-and-initiates-lung-microvascular-endothelial-activation-via-toll-like-receptor-4-signaling
#25
JOURNAL ARTICLE
Adrienne K Conger, Toria Tomasek, Kyle J Riedmann, Joel S Douglas, Lucia E Berkey, Lorraine B Ware, Julie A Bastarache, Jamie E Meegan
Cell-free hemoglobin is a pathophysiological driver of endothelial injury during sepsis and acute respiratory distress syndrome (ARDS), but the precise mechanisms are not fully understood. We hypothesized that hemoglobin (Hb) increases leukocyte adhesion and endothelial activation in human lung microvascular endothelial cells (HLMVEC). We stimulated primary HLMVEC, or leukocytes isolated from healthy human donors, with Hb (0.5 mg/mL) and found that leukocyte adhesion to lung endothelium in response to Hb is an endothelial-dependent process...
January 30, 2023: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/36700766/pld2-deletion-alleviates-disruption-of-tight-junctions-in-sepsis-induced-ali-by-regulating-pa-stat3-phosphorylation-pathway
#26
JOURNAL ARTICLE
Tiantian Qian, Boyang Qi, Yuxin Fei, Jun Li, Liqing Luo, Bingjie Lv, Yutong Song, Shurui Sheng, Wenhan Xiao, Xiao Huang, Xiaozhi Wang
BACKGROUND: Increased inflammatory exudation caused by endothelium and endothelial junction damage is a typical pathological feature of acute respiratory distress syndrome/acute lung injury (ARDS/ALI). Previous studies have shown that phospholipase D2 (PLD2) can increase the inflammatory response and has a close relationship with the severity of sepsis-induced ALI and the mortality of sepsis, but its mechanism is unknown. This study explored the effect and mechanism of PLD2 deletion on the structure and function of endothelial tight junction (TJ) in lipopolysaccharide (LPS)-induced ALI...
January 2023: International Immunopharmacology
https://read.qxmd.com/read/36527981/effect-of-tracheostomy-timing-in-pediatric-patients-with-traumatic-brain-injury
#27
JOURNAL ARTICLE
Irim Salik, Ankita Das, Alexandria F Naftchi, Sima Vazquez, Eris Spirollari, Jose F Dominguez, Vishad Sukul, Dylan Stewart, Augustine Moscatello
BACKGROUND: Traumatic brain injury (TBI) is a prevalent cause of disability and death in the pediatric population, often requiring prolonged mechanical ventilation. Patients with significant TBI or intracranial hemorrhage require advanced airway management to protect against aspiration, hypoxia, and hypercarbia, eventually necessitating tracheostomy. While tracheostomy is much less common in children compared to adults, its prevalence among pediatric populations has been steadily increasing...
January 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/36505005/inflammatory-biomarkers-and-cardiac-injury-in-covid-19-patients
#28
JOURNAL ARTICLE
Ayesha Mumtaz, Erum Rehman, Mohammad Anisur Rahaman, Shazia Rehman
INTRODUCTION: Cardiac injury has received considerable attention due to the higher risk of morbidity and mortality associated with coronavirus disease. However, in a developing country, there is a scarcity of data on cardiac injury in COVID-19 patients related to inflammatory biomarkers. METHODS: Therefore, the present research retrospectively analyzes data from three territorial hospitals in Pakistan's Punjab province to investigate the potential impact of the cardiac injury on the mortality and severity of COVID-19-infected patients...
2022: Frontiers in Public Health
https://read.qxmd.com/read/36478088/knockdown-of-lncrna-aslnc12002-alleviates-epithelial-mesenchymal-transition-of-type-ii-alveolar-epithelial-cells-in-sepsis-induced-acute-respiratory-distress-syndrome
#29
JOURNAL ARTICLE
Kaixuan Feng, Weifeng Huang, Jiawei Shang, Feng Ping, Qin Tan, Wei Wang, Yingchuan Li, Yongmei Cao
Patients with sepsis-induced acute respiratory distress syndrome (ARDS) have higher mortality and poor prognosis than pneumonia-induced ARDS. Pulmonary fibrosis is an irreversible accumulation of connective tissue in the interstitium of the lung and closely associated with the epithelial-mesenchymal transition (EMT) of type II alveolar epithelial cells (AECIIs). Therefore, it is undoubtedly worth studying whether the EMT of AECIIs in sepsis-induced ARDS patients is different from that in patients with pneumonia-induced ARDS in the regulatory mechanism...
December 7, 2022: Human Cell
https://read.qxmd.com/read/36452899/advanced-development-and-mechanism-of-sepsis-related-acute-respiratory-distress-syndrome
#30
REVIEW
Huankai Gong, Yao Chen, Meiling Chen, Jiankang Li, Hong Zhang, Shijiao Yan, Chuanzhu Lv
The introduction of the Sepsis 3.0 guidelines in 2016 improved our understanding of sepsis diagnosis and therapy. Personalized treatment strategies and nursing methods for sepsis patients are recommended in the "Save Sepsis Campaign" in 2021. However, mortality in sepsis patients remains high. Patients with sepsis-related acute respiratory distress syndrome account for around 30% of them, with fatality rates ranging from 30 to 40%. Pathological specimens from individuals with sepsis-related ARDS frequently demonstrate widespread alveolar damage, and investigations have revealed that pulmonary epithelial and pulmonary endothelial injury is the underlying cause...
2022: Frontiers in Medicine
https://read.qxmd.com/read/36386029/clinical-characteristics-and-outcomes-in-neonates-with-perinatal-acute-respiratory-distress-syndrome-in-china-a%C3%A2-national-multicentre-cross-sectional-study
#31
JOURNAL ARTICLE
Long Chen, Jie Li, Yuan Shi
BACKGROUND: Neonatal acute respiratory distress syndrome (NARDS) was defined in 2017 and the epidemiological data remain unknown. Our objective was to explore aetiological factors, clinical characteristics and outcomes in patients with perinatal NARDS. METHODS: A multicentre, prospective, cross-sectional study was performed in 58 tertiary neonatal intensive care units in China from Jan 1, 2018 to June 30, 2019. Neonates diagnosed with NARDS were included. Primary outcomes were aetiological factors, clinical characteristics and outcomes...
January 2023: EClinicalMedicine
https://read.qxmd.com/read/36377383/apelin-13-ameliorates-lps-induced-endothelial-to-mesenchymal-transition-and-post-acute-lung-injury-pulmonary-fibrosis-by-suppressing-transforming-growth-factor-%C3%AE-1-signaling
#32
JOURNAL ARTICLE
Huang Liu, Qingqiang Shi, Ling Tang, Hanghang Wang, Daoxin Wang
The pathophysiology of acute respiratory distress syndrome (ARDS) involves cytokine storms, alveolar-capillary barrier destruction, and fibrotic progression. Pulmonary interstitial fibrosis is an important factor affecting the prognosis of ARDS patients. Endothelial-to-mesenchymal transition (EndMT) plays an important role in the development of fibrotic diseases, and the occurrence of EndMT has been observed in experimental models of LPS-induced acute lung injury (ALI). Apelin is an endogenous active polypeptide that plays an important role in maintaining endothelial cell homeostasis and inhibiting fibrotic progression in various diseases...
January 1, 2023: Shock
https://read.qxmd.com/read/36309049/quercetin-protects-against-lps-induced-lung-injury-in-mice-via-sirt1-mediated-suppression-of-pkm2-nuclear-accumulation
#33
JOURNAL ARTICLE
Ling-Li Chen, Chao Song, Yan Zhang, Yi Li, Yu-Hao Zhao, Feng-Yu Lin, Duo-Duo Han, Min-Hui Dai, Wen Li, Pin-Hua Pan
The role of NOD-like receptor protein 3 (NLRP3)-mediated macrophages pyroptosis in acute lung injury (ALI) is well-established. Quercetin (Que) is a natural bioflavonoid compound with anti-inflammatory and antioxidative properties that reportedly inhibits the NLRP3 inflammasome in sepsis-induced organ dysfunctions such as ALI. However, the mechanism underlying the inhibitory effect of quercetin on NLRP3 activation remains unclear. In this study, we established an endotoxin-induced ALI mouse model with an in vitro LPS challenge...
October 26, 2022: European Journal of Pharmacology
https://read.qxmd.com/read/36291185/therapeutic-targeting-of-nf-%C3%AE%C2%BAb-in-acute-lung-injury-a-double-edged-sword
#34
REVIEW
Michelle Warren Millar, Fabeha Fazal, Arshad Rahman
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most recently, COVID-19. Although our understanding of the mechanisms of ALI/ARDS pathogenesis and resolution has considerably increased in recent years, the mortality rate remains unacceptably high (~40%), primarily due to the lack of effective therapies for ALI/ARDS. Dysregulated inflammation, as characterized by massive infiltration of polymorphonuclear leukocytes (PMNs) into the airspace and the associated damage of the capillary-alveolar barrier leading to pulmonary edema and hypoxemia, is a major hallmark of ALI/ARDS...
October 21, 2022: Cells
https://read.qxmd.com/read/36217353/tomographic-findings-and-mortality-in-patients-with-severe-and-critical-pneumonia-with-covid-19-diagnosis
#35
O Jiménez-Zarazúa, L N Vélez-Ramírez, A Hernández-Ramírez, B I Arévalo-Rivas, M A Galván-Casas, G U García-Zavala, J D Mondragón
Introduction: A high percentage of patients with non-severe (17.9%) and severe (2.9%) atypical pneumonia do not display pulmonary tomographic findings upon hospital admission; furthermore, lesion associated with COVI-19 are peripherally distributed in a multifocal ground-glass pattern, as well as displaying an irregular consolidation pattern, with a posterior or lower lobe predilection. The main objective of this study was to identify the pulmonary radiological patterns in patients diagnosed with SARS-CoV-2 pneumonia, the factors associated with the need for mechanical ventilation, as well as their survival rates at 30 days...
2022: Respiratory Medicine Case Reports
https://read.qxmd.com/read/36187926/rare-variant-collapsing-analyses-identified-risk-genes-for-neonatal-acute-respiratory-distress-syndrome
#36
JOURNAL ARTICLE
Huiyao Chen, Xiang Chen, Liyuan Hu, Chang Ye, Jiantao Zhang, Guoqiang Cheng, Lin Yang, Yulan Lu, Xinran Dong, Wenhao Zhou
BACKGROUND: Acute respiratory distress syndrome (ARDS) could account for a considerable proportion of neonatal death, while the genetic etiology and pathophysiology of neonatal ARDS remain elusive. In this case-control study, 515 neonates were enrolled in the China Neonatal Genomes Project (CNGP, NCT03931707) from August 2016 to June 2021, including 196 ARDS and 319 non-ARDS matched by sex, gestational age, birth weight, perinatal asphyxia, pneumonia, sepsis, and necrotizing enterocolitis...
2022: Computational and Structural Biotechnology Journal
https://read.qxmd.com/read/35991210/efficacy-and-safety-of-ly3127804-an-anti-angiopoietin-2-antibody-in-a-randomized-double-blind-placebo-controlled-clinical-trial-in-patients-hospitalized-with-pneumonia-and-presumed-or-confirmed-covid-19
#37
JOURNAL ARTICLE
Rosie S Jones, Patricia S Smith, Paul H Berg, Amparo de la Peña, Paul P Cook, Imad Shawa, Kathleen M Kioussopoulos, Yu Hu, Robert J Schott
BACKGROUND: Severe cases of coronavirus disease 2019 (COVID-19) are characterized by progressive respiratory failure and the development of acute respiratory distress syndrome (ARDS), with high mortality rates for patients requiring mechanical ventilation. Levels of the vascular growth factor Angiopoietin 2 (Ang2) in plasma have been strongly correlated with increased ARDS risk in patients with pneumonia or sepsis. The intent of this study was to determine whether LY3127804, an anti-Ang2 monoclonal antibody, could reduce the need for mechanical ventilation among patients admitted to the hospital with pneumonia and presumed or confirmed COVID-19...
2022: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://read.qxmd.com/read/35852995/circulating-extracellular-histones-exacerbate-acute-lung-injury-by-augmenting-pulmonary-endothelial-dysfunction-via-tlr4-dependent-mechanism
#38
JOURNAL ARTICLE
Junghyun Kim, Baalachandran Ramasubramanian, Yue Li, Chen-Ou Zhang, Yunbo Ke, Pratap Karki, Konstantin G Birukov, Anna A Birukova
Extracellular histones released into the circulation following trauma, sepsis, and ARDS may act as potent damage-associated molecular pattern signals leading to multiple organ failure. Endothelial cell (EC) dysfunction caused by extracellular histones has been demonstrated in vitro and in vivo, however precise mechanistic details of histone-induced EC dysfunction and exacerbation of ongoing inflammation remain poorly understood. This study investigated the role of extracellular histones in exacerbating pre-existing endothelial dysfunction and acute lung injury...
July 19, 2022: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/35770004/plasma-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-in-the-acute-respiratory-distress-syndrome
#39
JOURNAL ARTICLE
Thomas S Metkus, Bo Soo Kim, Steven R Jones, Seth S Martin, Steven P Schulman, Thorsten M Leucker
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is a mediator of the immune response to sepsis. PCSK9 is also highly expressed in pneumocytes and pulmonary endothelial cells. We hypothesized that serum PCSK9 levels would be associated with death and ICU outcomes in patients with ARDS. METHODS: Using data and plasma samples from the NIH BioLINCC data repository, we assembled a cohort of 1,577 patients with the acute respiratory distress syndrome (ARDS) enrolled in two previously completed clinical trials, EDEN and SAILS...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35693774/mettl3-mediated-n6-methyladenosine-modification-of-trim59-mrna-protects-against-sepsis-induced-acute-respiratory-distress-syndrome
#40
JOURNAL ARTICLE
Yi Chen, Yuling Wu, Linjie Zhu, Caiyang Chen, Saihong Xu, Dan Tang, Yingfu Jiao, Weifeng Yu
N6-methyladenosine (m6 A) RNA modification is a fundamental determinant of mRNA metabolism in eukaryotic cells and is involved in numerous physiological and pathological processes. However, the specific role of m6 A modification in sepsis-induced acute respiratory distress syndrome(ARDS) remains unknown. Here, we show that the levels of m6 A RNA were significantly decreased in septic lungs and that METTL3 was the main regulator involved in the absence of m6 A RNA modification. Pulmonary endothelial barrier damage is a critical process in the pathogenesis of acute lung injury during sepsis...
2022: Frontiers in Immunology
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