keyword
https://read.qxmd.com/read/38500106/lung-tissue-expression-of-epithelial-injury-markers-is-associated-with-acute-lung-injury-severity-but-does-not-discriminate-sepsis-from-ards
#1
JOURNAL ARTICLE
Natália de Souza Xavier Costa, Giovana da Costa Sigrist, Alexandre Santos Schalch, Luciano Belotti, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage (DAD) is considered its histological hallmark. Sepsis is one of the most common aetiology of ARDS with the highest case-fatality rate. Identifying ARDS patients and differentiate them from other causes of acute respiratory failure remains a challenge. To address this, many studies have focused on identifying biomarkers that can help assess lung epithelial injury...
March 18, 2024: Respiratory Research
https://read.qxmd.com/read/38489236/semaphorin-7a-coordinates-neutrophil-response-during-pulmonary-inflammation-and-sepsis
#2
JOURNAL ARTICLE
Tiago Folgosa Granja, David Köhler, Linyan Tang, Philipp Burkard, Claudia Eggstein, Katherina Hemmen, Katrin G Heinze, Ka-Lin Heck-Swain, Michael Koeppen, Sven Günther, Maximilian Klaus Blaha, Harry Magunia, Maximilian Bamberg, Franziska Magdalena Konrad, Kristian-Christos Ngamsri, Anika Fuhr, Marius Keller, Alice Bernard, Helene Haeberle, Tamam Bakchoul, Alexander Zarbock, Bernhard Nieswandt, Peter Rosenberger
RATIONALE: Pulmonary defense mechanisms are critical for host integrity during pneumonia and sepsis. This defense is fundamentally dependent on the activation of neutrophils during the innate immune response. Recent work has shown that Semaphorin 7A (Sema7A) holds significant impact on platelet function, yet its role on neutrophil function within the lung is not well understood. OBJECTIVE: To identify the role of Sema7A during pulmonary inflammation and sepsis. MEASUREMENTS AND MAIN RESULTS: In ARDS patients we were able to show a correlation between Sema7A and oxygenation levels...
March 15, 2024: Blood Advances
https://read.qxmd.com/read/38472357/neutrophil-aldh2-is-a-new-therapeutic-target-for-the-effective-treatment-of-sepsis-induced-ards
#3
JOURNAL ARTICLE
Changchang Xu, Lin Zhang, Shaoyu Xu, Zichen Wang, Qi Han, Ying Lv, Xingfang Wang, Xiangxin Zhang, Qingju Zhang, Ying Zhang, Simeng He, Qiuhuan Yuan, Yuan Bian, Chuanbao Li, Jiali Wang, Feng Xu, Yihai Cao, Jiaojiao Pang, Yuguo Chen
Acetaldehyde dehydrogenase 2 (ALDH2) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute respiratory distress syndrome (ARDS) remains unknown. Here, we showed that human subjects carrying the ALDH2rs671 mutation were highly susceptible to developing septic ARDS. Intriguingly, ALDH2rs671 -ARDS patients showed higher levels of blood cell-free DNA (cfDNA) and myeloperoxidase (MPO)-DNA than ALDH2WT -ARDS patients. To investigate the mechanisms underlying ALDH2 deficiency in the development of septic ARDS, we utilized Aldh2 gene knockout mice and Aldh2rs671 gene knock-in mice...
March 12, 2024: Cellular & Molecular Immunology
https://read.qxmd.com/read/38436177/analysis-of-332-fiberoptic-bronchoscopies-performed-in-a-respiratory-intensive-care-unit-a-retrospective-study
#4
JOURNAL ARTICLE
K Uluç, E Akkütük Öngel, N Köylü İlkaya, Ö Devran, Ş M Çolakoğlu, H Kutbay Özçelik
OBJECTIVE: Fiberoptic bronchoscopy (FOB) is widely used in the intensive care unit for diagnostic and therapeutic purposes. Our study aimed to evaluate FOB's indications, complications, and clinical outcomes in our intensive care unit's mechanically ventilated patients and identify the microorganisms grown in bronchoalveolar lavage (BAL) specimens. PATIENTS AND METHODS: Between January 1, 2022, and June 30, 2023, a total of 332 FOBs were performed on 178 patients in the respiratory intensive care unit...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38338744/a-narrative-review-the-role-of-nets-in-acute-respiratory-distress-syndrome-acute-lung-injury
#5
REVIEW
Xinyu Zhou, Jiajia Jin, Tangfeng Lv, Yong Song
Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and the alleviation and treatment of ARDS remains a major research focus. There are various causes of ARDS, among which pneumonia and non-pulmonary sepsis are the most common. Trauma and blood transfusion can also cause ARDS. In ARDS, the aggregation and infiltration of neutrophils in the lungs have a great influence on the development of the disease. Neutrophils regulate inflammatory responses through various pathways, and the release of neutrophils through neutrophil extracellular traps (NETs) is considered to be one of the most important mechanisms...
January 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38291476/role-and-intervention-of-pad4-in-nets-in-acute-respiratory-distress-syndrome
#6
REVIEW
Xiaojie Liu, Tianjun Li, Huailong Chen, Li Yuan, Hushan Ao
BACKGROUND: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Acute respiratory distress syndrome (ARDS) is a common sepsis-associated injury that can increase postoperative mortality but the mechanism is still unclear. MAIN TEXT: The role of neutrophils in the pathophysiology of sepsis was deeply challenged after the discovery of NETosis, a process resulting in neutrophil extracellular traps (NETs) release. NETs can support thrombin generation and the concept of immunothrombosis has emerged as a new innate response to infection...
January 30, 2024: Respiratory Research
https://read.qxmd.com/read/38237770/rvd1-improves-resident-alveolar-macrophage-self-renewal-via-the-alx-mapk14-s100a8-a9-pathway-in-acute-respiratory-distress-syndrome
#7
JOURNAL ARTICLE
Yang Ye, Qian Yang, Jinling Wei, Chenxi Shen, Haixing Wang, Rong Zhuang, Yuan Cao, Yajun Ding, Haoran Xu, Shuyang Xiang, Hongxia Mei, Zhongwang Li, Xiya Ren, Chen Zhang, Ji Xiao, Shengxing Zheng, Ting Li, Ruifeng Zeng, Huacheng Liu, Han Lin, Wangning Shang-Guan, Ming Li, Shengwei Jin, Qian Wang
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is a pulmonary inflammatory process primarily caused by sepsis. The resolution of inflammation is an active process involving the endogenous biosynthesis of specialized pro-resolving mediators, including resolvin D1 (RvD1). Resident alveolar macrophages (RAMs) maintain pulmonary homeostasis and play a key role in the resolution phase. However, the role of RAMs in promoting the resolution of inflammation by RvD1 is unclear. OBJECTIVES: Here, we investigated the mechanisms of RvD1 on regulating RAMs to promote the resolution of ARDS...
January 16, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38035100/acute-respiratory-distress-syndrome-heterogeneity-and-the-septic-ards-subgroup
#8
REVIEW
Huikang Xu, Shiying Sheng, Weiwei Luo, Xiaofang Xu, Zhaocai Zhang
Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury characterized by the damage of alveolar epithelial cells and pulmonary capillary endothelial cells. It is mainly manifested by non-cardiogenic pulmonary edema, resulting from intrapulmonary and extrapulmonary risk factors. ARDS is often accompanied by immune system disturbance, both locally in the lungs and systemically. As a common heterogeneous disease in critical care medicine, researchers are often faced with the failure of clinical trials...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37909847/role-of-brain-derived-neurotrophic-factor-in-endotoxaemia-induced-acute-lung-injury
#9
JOURNAL ARTICLE
Jinye Shi, Shuang Song, Kaixuan Wu, Gui Liang, Aizhong Wang, Xiaotao Xu
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), which is a pulmonary manifestation of a systemic reactive inflammatory syndrome, is a serious disease with high mortality, and sepsis is an important risk factor in the development of ALI. Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family. It plays an essential role in the regulation of the modification of synaptic efficacy and brain metabolic activity and enhances neuronal survival. However, the role and underlying mechanism of BDNF in sepsis-induced ALI remain unclear...
November 1, 2023: Experimental Physiology
https://read.qxmd.com/read/37873450/modeling-sepsis-associated-ards-using-a-lung-endothelial-microphysiological-system
#10
Nai-Wen Liang, Carole Wilson, Brooke Davis, Ian Wolf, Tonela Qyli, Joy Moy, David J Beebe, Lynn M Schnapp, Sheena C Kerr, Hilary E Faust
Acute respiratory distress syndrome due to non-pulmonary causes exhibits prominent endothelial activation which is challenging to assess in critically ill patients. Preclinical in vivo models of sepsis and ARDS have failed to yield useful therapies in humans, perhaps due to interspecies differences in inflammatory responses. Use of microphysiological systems (MPS) offer improved fidelity to human biological responses and better predict pharmacological responses than traditional culture. We adapted a lung endothelial MPS based on the LumeNEXT platform to evaluate the effect of plasma from critically ill sepsis patients on endothelial permeability, adhesion molecule expression and inflammatory cytokine production...
October 10, 2023: bioRxiv
https://read.qxmd.com/read/37822934/a-hub-gene-signature-as-a-therapeutic-target-and-biomarker-for-sepsis-and-geriatric-sepsis-induced-ards-concomitant-with-covid-19-infection
#11
JOURNAL ARTICLE
Guojun Qian, Hongwei Fang, Anning Chen, Zhun Sun, Meiying Huang, Mengyuan Luo, Erdeng Cheng, Shengyi Zhang, Xiaokai Wang, Hao Fang
BACKGROUND: COVID-19 and sepsis represent formidable public health challenges, characterized by incompletely elucidated molecular mechanisms. Elucidating the interplay between COVID-19 and sepsis, particularly in geriatric patients suffering from sepsis-induced acute respiratory distress syndrome (ARDS), is of paramount importance for identifying potential therapeutic interventions to mitigate hospitalization and mortality risks. METHODS: We employed bioinformatics and systems biology approaches to identify hub genes, shared pathways, molecular biomarkers, and candidate therapeutics for managing sepsis and sepsis-induced ARDS in the context of COVID-19 infection, as well as co-existing or sequentially occurring infections...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37670670/endothelial-glycocalyx-degradation-patterns-in-sepsis-associated-pediatric-acute-respiratory-distress-syndrome-a-single-center-retrospective-observational-study
#12
JOURNAL ARTICLE
Colin J Sallee, Joseph A Hippensteel, Kristen R Miller, Kaori Oshima, Andrew T Pham, Robert P Richter, John Belperio, Yamila L Sierra, Andreas Schwingshackl, Peter M Mourani, Eric P Schmidt, Anil Sapru, Aline B Maddux
BACKGROUND: Sepsis-associated destruction of the pulmonary microvascular endothelial glycocalyx (EGCX) creates a vulnerable endothelial surface, contributing to the development of acute respiratory distress syndrome (ARDS). Constituents of the EGCX shed into circulation, glycosaminoglycans and proteoglycans, may serve as biomarkers of endothelial dysfunction. We sought to define the patterns of plasma EGCX degradation products in children with sepsis-associated pediatric ARDS (PARDS), and test their association with clinical outcomes...
March 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/37647034/promoting-mitochondrial-dynamic-equilibrium-attenuates-sepsis-induced-acute-lung-injury-by-inhibiting-pro-inflammatory-polarization-of-alveolar-macrophages
#13
JOURNAL ARTICLE
Maomao Sun, Zhenhua Zeng, Gege Xu, Sheng An, Zhiya Deng, Ran Cheng, Yi Yao, Junjie Wu, Hongbin Hu, Qiaobing Huang, Jie Wu
Sepsis-induced acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterized by widespread pulmonary inflammation and immune response, in which pro-inflammatory polarization of alveolar macrophages (AMs) plays an important role. Mitochondria are the key intracellular signaling platforms regulating immune cell responses. Moreover, accumulating evidence suggests that the mitochondrial dynamics of macrophages are imbalanced in sepsis and severe ALI/ARDS. However, the functional significance of mitochondrial dynamics of AMs in septic ALI/ARDS remains largely unknown, and whether it regulates the polarized phenotype of AMs is also unclear...
August 22, 2023: Shock
https://read.qxmd.com/read/37547902/acute-respiratory-distress-syndrome-in-patients-with-cardiovascular-disease
#14
REVIEW
Asma Zainab, Megan Gooch, Divina M Tuazon
Heart and lung interaction within the thoracic cavity is well known during inhalation and exhalation, both spontaneously and during mechanical ventilation. Disease and dysfunction of one organ affect the function of the other. A review of the cause-and-effect relationship between cardiovascular disease and acute respiratory distress syndrome (ARDS) is of significance, as the disease burden of both conditions has both a national and global impact on health care. This literature review examines the relationship between cardiovascular disease and ARDS over the past 25 years...
2023: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/37547124/single-cell-rna-sequencing-and-transcriptome-analysis-revealed-the-immune-microenvironment-and-gene-markers-of-acute-respiratory-distress-syndrome
#15
JOURNAL ARTICLE
Dan He, Qiao Yu, Xiaona Zeng, Jihua Feng, Ruiqi Yang, Huan Wan, Ying Zhong, Yanli Yang, Ruzhi Zhao, Junyu Lu, Jianfeng Zhang
BACKGROUND: Acute respiratory distress syndrome (ARDS) is caused by severe pulmonary inflammation and the leading cause of death in the intensive care unit. METHODS: We used single-cell RNA sequencing to compare peripheral blood mononuclear cells from sepsis-induced ARDS (SEP-ARDS) and pneumonic ARDS (PNE-ARDS) patient. Then, we used the GSE152978 and GSE152979 datasets to identify molecular dysregulation mechanisms at the transcriptional level in ARDS. RESULTS: Markedly increased CD14 cells were the predominant immune cell type observed in SEP-ARDS and PNE-ARDS patients...
2023: Journal of Inflammation Research
https://read.qxmd.com/read/37484575/pediatric-acute-respiratory-distress-syndrome-in-a-moroccan-intensive-care-unit-a-retrospective-observational-study-of-23-cases
#16
Said Benlamkaddem, Fatima Bouyerman, Mohamed Adnane Berdai, Mustapha Harandou
Acute respiratory distress syndrome (ARDS) is a life-threatening condition despite medical development. Unlike adult, ARDS, in pediatric population, has been recently defined in the Pediatric Acute Lung Injury Consensus Conference (PALICC), 2015. We conduct a retrospective descriptive study, in pediatric intensive care unit (PICU) of Hassan II University Hospital during a period of 2 years (2019 to 2021) in which we included 23 pediatric cases of ARDS defined using 2012 Berlin criteria. They represent 2.7% of all patients admitted in our unit (23 patients of 850 admissions), with a male predominance 17 males/6 females, the median of age was 4...
2023: Pan African Medical Journal
https://read.qxmd.com/read/37371733/serine-threonine-protein-phosphatases-1-and-2a-in-lung-endothelial-barrier-regulation
#17
REVIEW
Rahul S Patil, Anita Kovacs-Kasa, Boris A Gorshkov, David J R Fulton, Yunchao Su, Robert K Batori, Alexander D Verin
Vascular barrier dysfunction is characterized by increased permeability and inflammation of endothelial cells (ECs), which are prominent features of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and sepsis, and a major complication of the SARS-CoV-2 infection and COVID-19. Functional impairment of the EC barrier and accompanying inflammation arises due to microbial toxins and from white blood cells of the lung as part of a defensive action against pathogens, ischemia-reperfusion or blood product transfusions, and aspiration syndromes-based injury...
June 5, 2023: Biomedicines
https://read.qxmd.com/read/37328874/a-long-lasting-porcine-model-of-ards-caused-by-pneumonia-and-ventilator-induced-lung-injury
#18
REVIEW
Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vázquez, Laia Fernández-Barat, Montserrat Rigol, Ricard Mellado-Artigas, Gerard Frigola, Marta Camprubí-Rimblas, Pau Ferrer, Daniel Martinez, Antonio Artigas, Carlos Ferrando, Miquel Ferrer, Antoni Torres
BACKGROUND: Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia-the most common risk factor in humans-and analyze the additional effect of ventilator-induced lung injury (VILI). METHODS: Bronchoscopy-guided instillation of a multidrug-resistant Pseudomonas aeruginosa strain was performed in ten healthy pigs. In six animals (pneumonia-with-VILI group), pulmonary damage was further increased by VILI applied 3 h before instillation and until ARDS was diagnosed by PaO2 /FiO2  < 150 mmHg...
June 16, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37235919/factors-associated-with-acute-respiratory-distress-syndrome-in-brain-injured-patients-a-systematic-review-and-meta-analysis
#19
REVIEW
Shaurya Taran, Doulia M Hamad, Stephan von Düring, Armaan K Malhotra, Areti Angeliki Veroniki, Victoria A McCredie, Jeffrey M Singh, Bettina Hansen, Marina Englesakis, Neill K J Adhikari
PURPOSE: Acute respiratory distress syndrome (ARDS) is common in patients with acute brain injury admitted to the ICU. We aimed to identify factors associated with ARDS in this population. METHODS: We searched MEDLINE, Embase, Cochrane Central, Scopus, and Web of Science from inception to January 14, 2022. Three reviewers independently screened articles and selected English-language studies reporting risk factors for ARDS in brain-injured adult patients. Data were extracted on ARDS incidence, adjusted and unadjusted risk factors, and clinical outcomes...
October 2023: Journal of Critical Care
https://read.qxmd.com/read/37180159/mesenchymal-stem-cell-derived-exosomes-for-treatment-of-sepsis
#20
JOURNAL ARTICLE
Kento Homma, Nikolay Bazhanov, Kazuki Hashimoto, Masaru Shimizu, Thomas Heathman, Qi Hao, Ranjana Nawgiri, Vidarshi Muthukumarana, Jae Woo Lee, Donald S Prough, Perenlei Enkhbaatar
INTRODUCTION: The pathogenesis of sepsis is an imbalance between pro-inflammatory and anti-inflammatory responses. At the onset of sepsis, the lungs are severely affected, and the injury progresses to acute respiratory distress syndrome (ARDS), with a mortality rate of up to 40%. Currently, there is no effective treatment for sepsis. Cellular therapies using mesenchymal stem cells (MSCs) have been initiated in clinical trials for both ARDS and sepsis based on a wealth of pre-clinical data...
2023: Frontiers in Immunology
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