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https://www.readbyqxmd.com/read/29660407/application-of-water-soluble-polyvinyl-alcohol-based-film-patches-on-laser-microporated-skin-facilitates-intradermal-macromolecule-and-nanoparticle-delivery
#1
Laura Engelke, Gerhard Winter, Julia Engert
The intradermal delivery of biologics has long been recognized as attractive approach for cutaneous immunotherapy, particularly vaccination. Although intradermal (i.d.) or subcutaneous (s.c.) injection provide reproducible dosing and good cost- and delivery efficiency, the major objective to avoid sharps and the need for enhanced storage stability have renewed the interest in alternative needle-free delivery strategies. This study presents a new concept for the delivery of macromolecules and nanoparticles to viable skin layers with a high density of professional antigen-presenting cells (APCs)...
April 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29653080/surgical-treatment-of-native-and-prosthetic-aortic-infection-with-xenopericardial-tube-grafts
#2
Maximilian Kreibich, Matthias Siepe, Julia Morlock, Friedhelm Beyersdorf, Stoyan Kondov, Johannes Scheumann, Fabian A Kari, Tim Berger, Holger Schröfel, Bartosz Rylski, Martin Czerny
BACKGROUND: To report our results of surgical treatment of native and prosthetic aortic infection with xenopericardial tube-grafts from the ascending aorta to beyond the bifurcation. METHODS: Within a 28-month period, 20 patients were treated with a bovine self-made pericardial tube graft to replace infected vascular grafts (after conventional surgical aortic replacement or endovascular stentgraft implantation) or to treat a contaminated surgical site. An integrated standardized therapeutic concept was applied in all patients consisting of complete removal of the infected prosthetic material, extensive debridement, and orthotopic vascular reconstruction with self-made tube grafts constructed from a bovine pericardial patch...
April 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29599590/correlation-between-dentofacial-esthetics-and-mental-temperament-a-clinical-photographic-analysis-using-visagism
#3
Tanikonda Rambabu, Chava Gayatri, Girija S Sajjan, P Venkata Karteek Varma, Visinigiri Srikanth
Background: "Visagism," a proposed novel concept, makes it possible for the patients to express the desirable emotions and personality traits, through their smile. According to this concept, clinicians can design a smile that blends with the patient's physical appearance, personality, and desires. Aim: To establish a relation, if any, between the smile pattern (dentofacial esthetics determined by three parameters, i.e., tooth form, long axes of maxillary anterior teeth, and connection line between embrasure) and the personality traits (four mental temperaments) through the concept of visagism...
January 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29594359/-vascular-surgical-training-concept-for-military-surgeons-in-germany
#4
REVIEW
M Engelhardt, K Elias, B Friemert, K Klemm, C Willy
BACKGROUND: Due to the increasing threat of terrorist attacks and assassinations even in Europe, the interest in management of severe vascular injuries, which, with an increased incidence of 10% are to be expected with such penetrating wounds, is also growing; however, with increasing subspecialization in surgery there is a threat that the know-how in vascular surgery will become lost among non-vascular surgical specialists. Therefore, the Germany military established an educational program, the so-called DUOplus concept, to ensure that future military surgeons acquire and retain the experience and skills to fulfill the demanding role of a deployed surgeon...
March 28, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29593574/the-use-of-biophysical-flow-models-in-the-surgical-management-of-patients-affected-by-chronic-thromboembolic-pulmonary-hypertension
#5
Martina Spazzapan, Priya Sastry, John Dunning, David Nordsletten, Adelaide de Vecchi
Introduction: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) results from progressive thrombotic occlusion of the pulmonary arteries. It is treated by surgical removal of the occlusion, with success rates depending on the degree of microvascular remodeling. Surgical eligibility is influenced by the contributions of both the thrombus occlusion and microvasculature remodeling to the overall vascular resistance. Assessing this is challenging due to the high inter-individual variability in arterial morphology and physiology...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29578825/reduction-of-tribocorrosion-products-when-using-the-platform-switching-concept
#6
G O Alrabeah, J C Knowles, H Petridis
The reduced marginal bone loss observed when using the platform-switching concept may be the result of reduced amounts of tribocorrosion products released to the peri-implant tissues. Therefore, the purpose of this study was to compare the tribocorrosion product release from various platform-matched and platform-switched implant-abutment couplings under cyclic loading. Forty-eight titanium implants were coupled with pure titanium, gold alloy, cobalt-chrome alloy, and zirconia abutments forming either platform-switched or platform-matched groups ( n = 6)...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29567311/conditional-regulation-of-gene-expression-by-ligand-induced-occlusion-of-a-microrna-target-sequence
#7
Huihui Mou, Guocai Zhong, Matthew R Gardner, Haimin Wang, Yi-Wen Wang, Dechun Cheng, Michael Farzan
RNA switches that modulate gene expression with small molecules have a number of scientific and clinical applications. Here, we describe a novel class of small regulatory on switches based on the ability of a ligand-bound aptamer to promote stem formation between a microRNA target sequence (miR-T) and a complementary competing strand. Two on switch architectures employing this basic concept were evaluated, differing in the location of a tetracycline aptamer and the region of a miR-21 target sequence (miR-21-T) masked by its competing strand...
February 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29564221/orthodontic-and-orthopedic-treatment-for-a-growing-patient-with-tessier-number-0-cleft
#8
Seung-Hak Baek, Yoon-Hee Park, Jee Hyeok Chung, Sukwha Kim, Jin-Young Choi
The purpose of this case report was to introduce the concept of orthodontic and orthopedic treatment for a growing patient with Tessier number 0 cleft. A 5-year-old boy patient with Tessier number 0 cleft presented congenitally missing maxillary central incisors (MXCI), a bony defect at the premaxilla, a constricted maxillary arch, an anterior openbite, and maxillary hypoplasia. His treatment was divided into three stages: management of the bony defect at the premaxilla and the congenitally missing MXCIs using a fan-type expansion plate, iliac bone grafting, and eruption guidance of the maxillary lateral incisors into the graft area for substitution of MXCIs; management of the maxillary hypoplasia using sequential facemask therapy with conventional and skeletal anchorage; and management of the remaining occlusal problems using fixed orthodontic treatment...
March 2018: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29554712/-use-of-bronchial-blockers-for-lung-isolation
#9
Tom Kreft, Thomas Hachenberg
Traditionally the double-lumen-tube (DLT) is considered the gold standard for lung separation. Despite being equally feasible for standard situations, there are special populations and circumstances requiring the use of a bronchial blocker (BB) to establish one-lung ventilation. Children under 8 years of age and patients without a patent orotracheal airway necessitate the use of a bronchial blocker in most cases, as well as those requiring selective lobar blockade or a rapid sequence induction. Surgery with predicted postoperative mechanical ventilation or in tracheotomized patients at least favors their use by avoiding the complications of a tube exchange...
March 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29540335/-definition-description-clinicopathological-features-pathogenesis-and-natural-history-of-endometriosis-cngof-has-endometriosis-guidelines
#10
B Borghese, P Santulli, L Marcellin, C Chapron
Endometriosis and adenomyosis are histologically defined. The frequency of endometriosis cannot be precisely estimated in the general population. Endometriosis is considered a disease when it causes pain and/or infertility. Endometriosis is a heterogeneous disease with three well-recognized subtypes that are often associated with each other: superficial endometriosis (SUP), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). DIE is frequently multifocal and mainly affects the following structures: the uterosacral ligaments, the posterior vaginal cul-de-sac, the bladder, the ureters, and the digestive tract (rectum, recto-sigmoid junction, appendix)...
March 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29534984/fibromuscular-dysplasia-contemporary-concepts-and-future-directions
#11
REVIEW
Nupoor Narula, Daniella Kadian-Dodov, Jeffrey W Olin
Fibromuscular dyplasia (FMD) is an under-recognized non-atherosclerotic, non-inflammatory arteriopathy that occurs most commonly in middle-aged women, but may affect individuals of all age groups. FMD may result in stenosis, aneurysm, dissection, occlusion, or arterial tortuosity. Recently published data demonstrated a genetic association of FMD with a variant in the phosphatase and actin regulator 1 gene (PHACTR1), substantiating that the pathogenesis of this condition has genetic contribution. The renal and extracranial carotid and vertebral arteries are most often involved, although any arterial bed may be affected...
March 10, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29533711/clinical-results-of-a-new-concept-of-neurothrombectomy-coverage-at-a-remote-hospital-drive-the-doctor
#12
Fatih Seker, Markus A Möhlenbruch, Simon Nagel, Christian Ulfert, Silvia Schönenberger, Johannes Pfaff, Peter A Ringleb, Thorsten Steiner, Martin Bendszus, Christian Herweh
Background Many tertiary care hospitals cannot provide a continuous thrombectomy service due to the lack of a neurointerventionalist. Aims In this study, we present procedural and clinical results of a new concept in which neuroradiologists of a university hospital provide neurointerventional stroke service to a remote hospital ("drive the doctor"). Methods All consecutive patients with acute ischemic stroke due to large vessel occlusion of the anterior circulation treated with mechanical thrombectomy after hours at a remote hospital (distance of about 100 km) between 2012 and 2016 were analyzed retrospectively...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29501598/decellularized-and-secured-porcine-arteries-with-naoh-based-process-proof-of-concept
#13
Mathieu van Steenberghe, Thomas Schubert, Caroline Bouzin, Carlo Caravaggio, Yves Guiot, Daela Xhema, Pierre Gianello
BACKGROUND: There is a need for small caliber vascular prosthesis. Synthetic grafts are hindered by thrombogenicity and rapid occlusion. Decellularized matrices could be an alternative. We assessed in vitro and in vivo the biocompatibility of porcine artery treated with a chemical/physical process for decellularization and graft securization with non/conventional pathogens inactivation. METHODS: Porcine carotid arteries (PCA) were treated. First, biopsies (n=4/tissue) were performed before/after treatment to assess decellularization (HE / DAPI / DNA / Miller)...
February 28, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29497380/triple-gene-therapy-for-stroke-a-proof-of-concept-in-vivo-study-in-rats
#14
Mikhail E Sokolov, Farid V Bashirov, Vage A Markosyan, Tatyana V Povysheva, Filip O Fadeev, Andrey A Izmailov, Maxim S Kuztetsov, Zufar Z Safiullov, Maxim M Shmarov, Boris S Naroditskyi, András Palotás, Rustem R Islamov
Natural brain repair after stroke is extremely limited, and current therapeutic options are even more scarce with no clinical break-through in sight. Despite restricted regeneration in the central nervous system, we have previously proved that human umbilical cord blood mono-nuclear cells (UCB-MC) transduced with adenoviral vectors carrying genes encoding vascular endothelial growth factor (VEGF), glial cell-derived neurotrophic factor (GDNF), and neural cell adhesion molecule (NCAM) successfully rescued neurons in amyotrophic lateral sclerosis and spinal cord injury...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29495023/a-guide-to-managing-tooth-wear-the-radboud-philosophy
#15
B Loomans, N Opdam
This paper explains a conservative, pragmatic and minimally invasive intervention concept for the treatment of severe tooth wear patients based on the Radboud Tooth Wear Project in the Netherlands. Guidelines and flowcharts for management of severe tooth wear patients and rehabilitation in increased vertical dimension of occlusion are presented. We concluded that: (a) Restorative treatment is not always indicated, even for patients with severe tooth wear. (b) If the patient has no complaints, counselling and monitoring is probably the best option...
March 9, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29467621/immunosignals-of-oligodendrocyte-markers-and-myelin-associated-proteins-are-critically-affected-after-experimental-stroke-in-wild-type-and-alzheimer-modeling-mice-of-different-ages
#16
Dominik Michalski, Anna L Keck, Jens Grosche, Henrik Martens, Wolfgang Härtig
Because stroke therapies are still limited and patients are often concerned by long-term sequelae with significant impairment of daily living, elaborated neuroprotective strategies are needed. During the last decades, research substantially improved the knowledge on cellular pathologies responsible for stroke-related tissue damage. In this context, the neurovascular unit (NVU) concept has been established, summarizing the affections of neurons, associated astrocytes and the vasculature. Although oligodendrocytes were already identified to play a major role in other brain pathologies, their role during stroke evolution and long-lasting tissue damage is poorly understood...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29467545/vulnerable-atherosclerotic-plaque-review-of-current-concepts-and-advanced-imaging
#17
Miloslav Spacek, David Zemanek, Martin Hutyra, Martin Sluka, Milos Taborsky
Atherosclerosis is the most common cause of both carotid and coronary steno-occlusive disease. Rupture of an atherosclerotic plaque may lead to the formation of an overlying thrombosis resulting in complete arterial occlusion or downstream embolism. Clinically, this may manifest as a stroke or acute myocardial infarction, the overall leading causes of mortality and disability in developed countries. In this article, we summarize current concepts of the development of vulnerable plaque and provide an overview of commonly used imaging methods that may suggest/indicate atherosclerotic plaque vulnerability...
February 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29456102/the-prognostic-capacity-of-transvaginal-hydrolaparoscopy-to-predict-non-ivf-conception
#18
Mianne van Kessel, Rachel Tros, Jur Oosterhuis, Walter H Kuchenbecker, Elly M Vernooij, Marlies Y Bongers, Ben Willem J Mol, Carolien A Koks
Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates. Between 2000 and 2011, 1033 subfertile women participated in the study. The primary outcome measure was intrauterine pregnancy, either after natural conception or after treatment with intrauterine insemination or ovulation induction. Cumulative intrauterine pregnancy rates were calculated using Kaplan-Meier analysis and fecundity rate ratios (FRR) were established...
February 5, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#19
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29447311/a-simplified-approach-for-restoration-of-worn-dentition-using-the-full-mock-up-concept-clinical-case-reports
#20
Stefen Koubi, Galip Gurel, Patrice Margossian, Richard Massihi, Herve Tassery
Treatment of tooth wear has increased over the last two decades. However, the treatments involved have not been satisfactory to most patients, nor have they achieved the expected goal on some worn teeth. New approaches have emerged to reconstruct full arches in a minimally invasive way that take advantage of developments in the field of adhesive dentistry. These new concepts constitute a revolution in dentistry and their application requires adapted techniques and training. The purpose of this article is to suggest a precise and reproducible method that simplifies the treatment of worn dentition...
March 2018: International Journal of Periodontics & Restorative Dentistry
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