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https://www.readbyqxmd.com/read/28575400/enhancing-multiplex-genome-editing-by-natural-transformation-mugent-via-inactivation-of-ssdna-exonucleases
#1
Triana N Dalia, Soo Hun Yoon, Elisa Galli, Francois-Xavier Barre, Christopher M Waters, Ankur B Dalia
Recently, we described a method for multiplex genome editing by natural transformation (MuGENT). Mutant constructs for MuGENT require large arms of homology (>2000 bp) surrounding each genome edit, which necessitates laborious in vitro DNA splicing. In Vibrio cholerae, we uncover that this requirement is due to cytoplasmic ssDNA exonucleases, which inhibit natural transformation. In ssDNA exonuclease mutants, one arm of homology can be reduced to as little as 40 bp while still promoting integration of genome edits at rates of ∼50% without selection in cis...
May 31, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28571262/evaluation-of-microleakage-with-total-etch-self-etch-and-universal-adhesive-systems-in-class-v-restorations-an-in-vitro-study
#2
Anjali Gupta, Pradeep Tavane, Pankaj Kumar Gupta, Bellam Tejolatha, Ashik Ali Lakhani, Ram Tiwari, Shruti Kashyap, Gaurav Garg
INTRODUCTION: Adhesive dentistry is overwhelmingly evolving with respect to the dental surgeon's and patient's perspective. Embracing the concept of minimally invasive dentistry which follows minimum intervention performed to produce good adhesion and tooth coloured restoration, in turn makes the newer generation bonding agents more acceptable and appropriate withstanding the demand for stable restoration. AIM: To study and compare the extent of microleakage between tooth and restoration interface in class V composite resin restorations applying one Total Etch (Adper(TM) single bond), two Self Etch (Adper(TM) SE Plus, Adper(TM) Easy One) and Universal bonding agents using dye penetration method...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569122/rationale-and-design-of-combination-of-an-immune-modulator-fingolimod-with-alteplase-bridging-with-mechanical-thrombectomy-in-acute-ischemic-stroke-famtais-trial
#3
Sheng Zhang, Ying Zhou, Ruiting Zhang, Meixia Zhang, Bruce Campbell, Longting Lin, Fu-Dong Shi, Min Lou
Rationale In acute ischemic stroke patients with large vessel occlusion, although reperfusion within 6 h after stroke onset using combined intravenous alteplase and mechanical thrombectomy (bridging therapy) can improve functional outcome, still approximately 50% patients suffer disability which may result from reperfusion injury. Proof-of-concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in acute ischemic stroke patients as a single therapy beyond 4...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28540347/interdisciplinary-management-of-head-and-neck-vascular-anomalies-clinical-presentation-diagnostic-findings-and-minimalinvasive-therapies
#4
REVIEW
Maliha Sadick, Walter A Wohlgemuth, Roland Huelse, Bettina Lange, Thomas Henzler, Stefan O Schoenberg, Haneen Sadick
OBJECTIVES: Vascular anomalies are included in the 30 000 rare diseases worldwide affecting less than 5/10 000 people. Depending on their morphology and biological properties, they can cause varied disorders with organ involvement. Almost 60% of vascular anomalies have a predilection for the head and neck region in children. Clinical and scientific effort to establish interdisciplinary management concepts for vascular anomalies is increasing worldwide. METHODS: Especially in the head and neck region, clinical impairment and organ dysfunction is associated with cosmetic issues that may represent a physical and psychological issue for the patient...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28526082/proof-of-concept-non-invasive-estimation-of-peripheral-venous-oxygen-saturation
#5
Musabbir Khan, Chris G Pretty, Alexander C Amies, Joel Balmer, Houda E Banna, Geoffrey M Shaw, J Geoffrey Chase
BACKGROUND: Pulse oximeters continuously monitor arterial oxygen saturation. Continuous monitoring of venous oxygen saturation (SvO2) would enable real-time assessment of tissue oxygen extraction (O2E) and perfusion changes leading to improved diagnosis of clinical conditions, such as sepsis. METHODS: This study presents the proof of concept of a novel pulse oximeter method that utilises the compliance difference between arteries and veins to induce artificial respiration-like modulations to the peripheral vasculature...
May 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28512551/consensus-statements-and-clinical-recommendations-on-treatment-indications-surgical-procedures-prosthetic-protocols-and-complications-following-all-on-4-standard-treatment-9th-mozo-grau-ticare-conference-in-quintanilla-spain
#6
REVIEW
Miguel Penarrocha-Diago, María Penarrocha-Diago, Regino Zaragozí-Alonso, David Soto-Penaloza, Meeting On Behalf Of The Ticare Consensus
OBJECTIVES: The present consensus report critically evaluates the scientific evidence based on a comprehensive systematic review of the All-On-4 treatment concept, focusing primarily on the treatment indications, surgical procedures and prosthetic protocols, and secondarily on the mechanical and biological complications involved. MATERIAL AND METHODS: A systematic review was made in advance of the meeting. Consensus statements, treatment guidelines and recommendations for future research were based on within-group as well as plenary debates and discussions of the systematic review...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28512358/delayed-epidural-transplantation-of-human-induced-pluripotent-stem-cell-derived-neural-progenitors-enhances-functional-recovery-after-stroke
#7
I-Hui Lee, Shiang-Suo Huang, Ching-Yu Chuang, Ko-Hsun Liao, Li-Hsin Chang, Chia-Chi Chuang, Yu-Shih Su, Hung-Jui Lin, Jui-Yu Hsieh, Shu-Han Su, Oscar Kuang-Sheng Lee, Hung-Chih Kuo
Induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) are a promising source of tailor-made cell therapy for neurological diseases. However, major obstacles to clinical use still exist. To circumvent complications related to intracerebral administration, we implanted human iPSC-NPCs epidurally over the peri-infarct cortex 7 days after permanent middle cerebral artery occlusion in adult rats. Compared to controls, cell-treated rats showed significant improvements in paretic forelimb usage and grip strength from 10 days post-transplantation (dpt) onwards, as well as reductions in lesion volumes, inflammatory infiltration and astrogliosis at 21 dpt...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511521/cu-sil-denture-a-space-maintainer-for-function-in-paediatric-patients
#8
Shilpa Hiremath, Abhishek Jairaj
The purpose of this report is to introduce Cu-sil like denture as a functional space maintainer. Here, we report two paediatric cases treated with Cu-sil like denture with multiple edentulous spaces and partially erupted/compromised permanent teeth. Cu-sil like denture not only serves as removable partial functional space maintainer, but also restores the vertical dimension of occlusion, mastication and aesthetics in children. Cu-sil like denture is used in elderly patients who are not willing for extraction of remaining few healthy teeth in the oral cavity...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28496929/management-of-patients-with-atrial-fibrillation-focus-on-treatment-options
#9
REVIEW
Pawel Matusik, Jacek Lelakowski, Barbara Malecka, Jacek Bednarek, Remigiusz Noworolski
Atrial fibrillation (AF) is leading cardiac arrhythmia with important clinical implications. Its diagnosis is usually made on the basis on 12-lead ECG or 24-hour Holter monitoring. More and more clinical evidence supports diagnostic use of cardiac event recorders and cardiovascular implantable electronic devices (CIED). Treatment options in patients with atrial fibrillation are extensive and are based on chosen rhythm and/or rate control strategy. The use and selected contraindications to AF related pharmacotherapy, including anticoagulants are shown...
October 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/28467261/stress-reduced-direct-composites-for-the-restoration-of-structurally-compromised-teeth-fiber-design-according-to-the-wallpapering-technique
#10
S Deliperi, D Alleman, D Rudo
PURPOSE: The purpose of this work was to present a restoration technique based on an understanding of the biomechanical properties of the dentinoenamel complex (DEC) and the physical-mechanical properties of the resin-based composite including the stress generated from both polymerization shrinkage and occlusal forces. Technique Summary: The DEC is a functional interphase that provides crack tip shielding; the DEC should be preserved during restorative procedures. Dentists can design the strategic placement of restorative materials into the cavity to both resist the mode of failure and mimic the performance characteristics of the intact natural tooth...
May 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28466671/new-endovascular-technique-to-prevent-distal-embolism-for-iliofemoral-occlusive-disease-reverse-flow-aspiration-with-proximal-sheath-blockage
#11
Yoshimitsu Soga, Yusuke Tomoi, Seiichi Hiramori, Naotaka Murata, Yohei Kobayashi, Kei Ichihashi, Kenji Aodo
PURPOSE: To report the safety and efficacy of a new technique to prevent distal embolism during treatment of iliofemoral occlusions: reverse flow aspiration with proximal sheath blockage (ReFLAP). METHOD: Between October 2013 and December 2014, 90 patients (mean age 74 years; 66 men) were prospectively enrolled in a study to evaluate the ReFLAP technique during treatment of 110 occlusions in the iliac artery (72, 65%) or superficial femoral artery (SFA; 38, 35%)...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28465406/helistroke-neurointerventionalist-helicopter-transport-for-interventional-stroke-treatment-proof-of-concept-and-rationale
#12
Ferdinand K Hui, Amgad El Mekabaty, Jacky Schultz, Kelvin Hong, Karen Horton, Victor Urrutia, Imama Naqvi, Shawn Brast, John K Lynch, Zurab Nadareishvili
BACKGROUND AND PURPOSE: It is increasingly recognized that time is one of the key determinants in acute stroke outcome when interventional stroke therapy is applied. With increasing device efficacy and understanding of imaging triage options, reducing pre-treatment time loss may be a critical component of improving interventional stroke outcomes for the population at large. Time sensitive procedures such as organ harvest have transported physicians to the patient site to improve time to procedure...
May 2, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28422342/the-development-of-lingualized-occlusion
#13
Robert L Engelmeier, Rodney D Phoenix
This article is a historical review of the development of the lingualized occlusion concept over the past century. It focuses on the pioneers of lingualized occlusion and their designs rather than on techniques for achieving a lingualized complete denture occlusion.
April 19, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28402453/medina%C3%A2-embolization-device-for-the-treatment-of-intracranial-aneurysms-safety-and-angiographic-effectiveness-at-6-months
#14
Nader-Antoine Sourour, Saskia Vande Perre, Federico Di Maria, Chrysanthi Papagiannaki, Joseph Gabrieli, Silvia Pistocchi, Bruno Bartolini, Vincent Degos, Alexandre Carpentier, Jacques Chiras, Frédéric Clarençon
BACKGROUND: The Medina Embolization Device (MED) is a new concept device that combines the design of a detachable coil and the one of an intrasaccular flow disruption device. OBJECTIVE: To evaluate the feasibility, safety, and 6- to 9-mo effectiveness of this new device for the treatment of intracranial wide-necked aneurysms. METHODS: Twelve patients (10 females, mean age = 56 yr) with 13 wide-necked intracranial aneurysms (3 ruptured; 10 unruptured) were treated by means of the MED from January 2015 to October 2015...
April 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28402355/digitally-milled-metal-framework-for-fixed-complete-denture-with-metal-occlusal-surfaces-a-design-concept
#15
Bader AlBader, Abdulaziz AlHelal, Periklis Proussaefs, Antonela Garbacea, Mathew T Kattadiyil, Jaime Lozada
Implant-supported fixed complete dentures, often referred to as hybrid prostheses, have been associated with high implant survival rates but also with a high incidence of mechanical prosthetic complications. The most frequent of these complications have been fracture and wear of the veneering material. The proposed design concept incorporates the occlusal surfaces of the posterior teeth as part of a digital milled metal framework by designing the posterior first molars in full contour as part of the framework...
May 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28400917/coronary-stenting-a-matter-of-revascularization
#16
EDITORIAL
Aldo Bonaventura, Fabrizio Montecucco, Luca Liberale
In the last few decades, the recommended treatment for coronary artery disease has been dramatically improved by percutaneous coronary intervention (PCI) and the use of balloon catheters, bare metal stents (BMSs), and drug-eluting stents (DESs). Catheter balloons were burdened by acute vessel occlusion or target-lesion re-stenosis. BMSs greatly reduced those problems holding up the vessel structure, but showed high rates of in-stent re-stenosis, which is characterized by neo-intimal hyperplasia and vessel remodeling leading to a re-narrowing of the vessel diameter...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28398284/manifestations-and-management-of-veno-occlusive-disease-sinusoidal-obstruction-syndrome-in-the-era-of-contemporary-therapies
#17
REVIEW
Priti Tewari, Whitney Wallis, Partow Kebriaei
The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant-associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemotherapy only. Several VOD/SOS management modalities exist that include modes for both prophylaxis and treatment. An extensive review of the literature on monoclonal antibodies, both approved and pending approval by the US Food and Drug Administration, reveals that only a few have been associated with an increased risk for VOD/SOS...
February 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28397407/sanguinate-pegylated-carboxyhemoglobin-bovine-mechanism-of-action-and-clinical-update
#18
Abraham Abuchowski
Historically, blood substitutes were under development that would provide oxygen carrying capacity as well as fluid replacement for both trauma and surgical indications. Their development was halted by the inability of the products to deliver therapeutic amounts of oxygen targeted to hypoxic tissue as well as from the inherent toxicity of the molecules. This led to the concept of an oxygen therapeutic that would be targeted for indications caused by anemia/ischemia/hypoxia but would not exhibit the toxicity that plagued earlier products...
April 2017: Artificial Organs
https://www.readbyqxmd.com/read/28368848/novel-crossing-system-for-the-recanalization-of-complex-chronic-total-occlusions-ex-vivo-proof-of-concept-of-the-soundbite-crossing-system
#19
Simon Bérubé, Andrew Benko, Marc-Antoine Despatis, Louis-Philippe Riel, Marianne Brodmann, Eric Therasse, Martin Brouillette, Jihad A Mustapha, Philippe Généreux
Chronic total occlusion (CTO) lesions are frequent in patients with peripheral and coronary artery disease, and associated with a higher risk of adverse events, including mortality, decreased quality of life, and increased health-care costs. Percutaneous intervention of CTO lesions has been associated with a lower procedural success rate, and current dedicated CTO devices may be of limited use for the non-CTO expert, and associated with increased intraprocedural complication rates. The SoundBite Crossing System (SoundBite Medical Solutions, Inc) is a newly developed device using shockwaves (short-duration, high-amplitude pressure pulses) to facilitate penetration of the proximal cap and crossing of the occlusion...
April 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28368127/is-centric-relation-always-the-position-of-choice-for-tmds-case-report-of-how-tmd-and-airway-dimension-may-be-associated
#20
William E Harrell, Tim Tatum, Mike Koslin
Centric occlusion (CO) and centric relation (CR) have been controversial topics in dentistry for almost 100 years. The concept of CR emerged due to the search for a reproducible mandibular position that would enable the prosthodontic rehabilitation of patients needing denture treatment. The following case study is unique because of 2 questions. Which mandibular treatment splint position (CR or CO) was appropriate for the initial and eventual final treatment of this patient for her temporomandibular disorder/myofascial pain and dysfunction? Also, how might the mandibular position of CR and CO affect the size and shape of the airway? The airway's size and shape is important as it relates to sleep-disordered breathing and potentially leading to obstructive sleep apnea later in life...
April 2017: Compendium of Continuing Education in Dentistry
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