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https://www.readbyqxmd.com/read/29350193/layer-structured-bismuth-selenides-bi2se3-and-bi3se4-for-high-energy-and-flexible-all-solid-state-micro-supercapacitors
#1
Chunxue Hao, Lidan Wang, Fusheng Wen, Jianyong Xiang, Lei Li, Wentao Hu, Zhongyuan Liu
In this work, bismuth selenides (Bi2Se3 and Bi3Se4), both of which have a layered rhombohedral crystal structure, have been found to be useful as electrode materials for supercapacitor applications. In a liquid electrolyte system (6M KOH), Bi2Se3 nanoplates exhibit much better performance as an electrode material than Bi3Se4 nanoparticles do, delivering a higher specific capacitance (272.9 F g-1) than that of Bi3Se4 (193.6 F g-1) at 5 mV s-1. This result may be attributed to the fact that Bi2Se3 nanoplates possess more active electrochemical surfaces for the reversible surface redox reactions owing to their planar quintuple stacked layers (septuple layers for Bi3Se4)...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29347946/effects-of-long-term-balance-training-with-vibrotactile-sensory-augmentation-among-community-dwelling-healthy-older-adults-a-randomized-preliminary-study
#2
Tian Bao, Wendy J Carender, Catherine Kinnaird, Vincent J Barone, Geeta Peethambaran, Susan L Whitney, Mohammed Kabeto, Rachael D Seidler, Kathleen H Sienko
BACKGROUND: Sensory augmentation has been shown to improve postural stability during real-time balance applications. Limited long-term controlled studies have examined retention of balance improvements in healthy older adults after training with sensory augmentation has ceased. This pilot study aimed to assess the efficacy of long-term balance training with and without sensory augmentation among community-dwelling healthy older adults. METHODS: Twelve participants (four males, eight females; 75...
January 18, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29341617/enhancing-docetaxel-delivery-to-multidrug-resistant-cancer-cells-with-albumin-coated-nanocrystals
#3
Sheryhan F Gad, Joonyoung Park, Ji Eun Park, Gihan N Fetih, Sozan S Tous, Wooin Lee, Yoon Yeo
Intravenous delivery of poorly water-soluble anticancer drugs such as docetaxel (DTX) is challenging due to the low bioavailability and the toxicity related to solubilizing excipients. Colloidal nanoparticles are used as alternative carriers, but low drug loading capacity and circulation instability limit their clinical translation. To address these challenges, DTX nanocrystals (NCs) were prepared using Pluronic F127 as an intermediate stabilizer and albumin as a functional surface modifier, which were previously found to be effective in producing small and stable NCs...
January 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29329558/quality-of-life-and-problems-associated-with-obturators-of-patients-with-maxillectomies
#4
Marwa Mohammed Ali, Nadia Khalifa, Mohammed Nasser Alhajj
BACKGROUND: Maxillary defects predispose patients to different undesirable effects. The aim of this study was to assess the quality of life (QoL) of patients with maxillary defects (acquired/congenital) wearing obturators. METHODS: The study comprised 30 patients aged between 16 and 78 years. Interviews were conducted to collect information pertaining to patients; sociodemographic, self-reported function of obturator using Obturator Functioning Scale (OFS), self-evaluation of general health using Visual Analogue Scale (VAS), radiotherapy treatment, salivary gland removal, reconstructive surgery, neck dissection and length of time obturators were worn...
January 5, 2018: Head & Face Medicine
https://www.readbyqxmd.com/read/29327400/a-vitamin-b12-conjugate-of-exendin-4-improves-glucose-tolerance-without-associated-nausea-or-hypophagia-in-rodents
#5
Elizabeth G Mietlicki-Baase, Claudia G Liberini, Jayme L Workinger, Ron L Bonaccorso, Tito Borner, David J Reiner, Kieran Koch-Laskowski, Lauren E McGrath, Rinzin Lhamo, Lauren M Stein, Bart C De Jonghe, George G Holz, Christian L Roth, Robert P Doyle, Matthew R Hayes
AIMS: While pharmacological glucagon-like peptide-1 receptor (GLP-1R) agonists are FDA-approved for treating type 2 diabetes mellitus (T2DM) and obesity, a major side effect is nausea/malaise. We recently developed a conjugate of vitamin B12 bound to the GLP-1R agonist exendin-4 (Ex4), which displays enhanced proteolytic stability and retention of GLP-1R agonism. Here, we evaluate whether the conjugate (B12-Ex4) can improve glucose tolerance without producing anorexia and malaise. MATERIALS AND METHODS: We evaluated the effects of systemic B12-Ex4 and unconjugated Ex4 on food intake and body weight change, oral glucose tolerance, and nausea/malaise in male rats, and on intraperitoneal glucose tolerance in mice...
January 12, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29316403/microsolvated-model-for-the-kinetics-and-thermodynamics-of-glycosidic-bond-dissociative-cleavage-of-nucleoside-d4g
#6
Yang Jiang, Ying Xue, Yi Zeng
Using the microsolvated model that involves explicit water molecules and implicit solvent in the optimization, two proposed dissociative hydrolysis mechanisms of 2',3'-didehydro-2',3'-dideoxyguanosine (d4G) have been firstly investigated by means of M062X(CPCM, water)/6-31++G(d,p) method. The glycosidic bond dissociation for the generation of oxacarbenium ion intermediate is the rate-determining step (RDS). The subsequent nucleophilic water attack from different side of the oxacarbenium ion intermediate gives either the α-product [(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-ol] or β-product [(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-ol], and is thus referred to as α-path (inversion) and β-path (retention)...
January 9, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29280251/carbon-supported-nickel-selenide-hollow-nanowires-as-advanced-anode-materials-for-sodium-ion-batteries
#7
Xuming Yang, Jiaolong Zhang, Zhenguang Wang, Hongkang Wang, Chunyi Zhi, Denis Y W Yu, Andrey L Rogach
Carbon-supported nickel selenide (Ni0.85 Se/C) hollow nanowires are prepared from carbon-coated selenium nanowires via a self-templating hydrothermal method, by first dissolving selenium in the Se/C nanowires in hydrazine, allowing it to diffuse out of the carbon layer, and then reacting with nickel ions into Ni0.85 Se nanoplates on the outer surface of the carbon. Ni0.85 Se/C hollow nanowires are employed as anode materials for sodium-ion batteries, and their electrochemical performance is evaluated via the cyclic voltammetry and electrochemical impedance spectroscopy combined with ex situ X-ray photoelectron spectroscopy and X-ray diffraction measurements...
December 27, 2017: Small
https://www.readbyqxmd.com/read/29262256/macrocyclization-of-interferon-poly-%C3%AE-amino-acid-conjugates-significantly-improves-the-tumor-retention-penetration-and-antitumor-efficacy
#8
Yingqin Hou, Yu Zhou, Hao Wang, Ruijue Wang, Jingsong Yuan, Yali Hu, Kai Sheng, Juan Feng, Shengtao Yang, Hua Lu
Cyclization and polymer conjugation are two commonly used approaches for enhancing the pharmacological properties of protein drugs. However, cyclization of parental proteins often only affords a modest improvement in biochemical or cell-based in vitro assays. Moreover, very few studies have included a systematic pharmacological evaluation of cyclized protein-based therapeutics in live animals. On the other hand, polymer-conjugated proteins have longer circulation half-lives but usually show poor tumor penetration and suboptimal pharmacodynamics due to increased steric hindrance...
December 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29258521/long-term-trends-in-supply-and-sustainability-of-the-health-workforce-in-remote-aboriginal-communities-in-the-northern-territory-of-australia
#9
Yuejen Zhao, Deborah J Russell, Steven Guthridge, Mark Ramjan, Michael P Jones, John S Humphreys, Timothy A Carey, John Wakerman
BACKGROUND: International evidence suggests that a key to improving health and attaining more equitable health outcomes for disadvantaged populations is a health system with a strong primary care sector. Longstanding problems with health workforce supply and turnover in remote Aboriginal communities in the Northern Territory (NT), Australia, jeopardise primary care delivery and the effort to overcome the substantial gaps in health outcomes for this population. This research describes temporal changes in workforce supply in government-operated clinics in remote NT communities through a period in which there has been a substantial increase in health funding...
December 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29231217/ultrathin-nickel-hydroxide-on-carbon-coated-3d-porous-copper-structures-for-high-performance-supercapacitors
#10
Kyeong-Nam Kang, Ik-Hee Kim, Ananthakumar Ramadoss, Sun-I Kim, Jong-Chul Yoon, Ji-Hyun Jang
An ultrathin nickel hydroxide layer electrodeposited on a carbon-coated three-dimensional porous copper structure (3D-C/Cu) is suggested as an additive and binder-free conductive electrode with short electron path distances, large electrochemical active sites, and improved structural stability, for high performance supercapacitors. The 3D-porous copper structure (3D-Cu) provides high electrical conductivity and facilitates electron transport between the Ni(OH)2 active materials and the current collector of the Ni-plate...
December 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29203656/enigmatic-origin-of-the-poxvirus-membrane-from-the-endoplasmic-reticulum-shown-by-3d-imaging-of-vaccinia-virus-assembly-mutants
#11
Andrea S Weisberg, Liliana Maruri-Avidal, Himani Bisht, Bryan T Hansen, Cindi L Schwartz, Elizabeth R Fischer, Xiangzhi Meng, Yan Xiang, Bernard Moss
The long-standing inability to visualize connections between poxvirus membranes and cellular organelles has led to uncertainty regarding the origin of the viral membrane. Indeed, there has been speculation that viral membranes form de novo in cytoplasmic factories. Another possibility, that the connections are too short-lived to be captured by microscopy during a normal infection, motivated us to identify and characterize virus mutants that are arrested in assembly. Five conserved vaccinia virus proteins, referred to as Viral Membrane Assembly Proteins (VMAPs), that are necessary for formation of immature virions were found...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29188695/an-implant-retained-obturator-%C3%A2-a-case-study
#12
James Puryer, Claire Forbes-Haley
This case describes the oral rehabilitation of a patient following maxillary hemi-section due to squamous cell carcinoma of the palate. Planned treatment was construction of a maxillary implant-supported obturator. Two dental implants were placed in his maxilla to aid the support and retention of an obturator. However, owing to bone availability, their angulation was suboptimal and compromised the retention of the obturator. This case describes alternative implant attachments to aid the retention and stability of implant-retained dentures constructed in cases with suboptimal implant placement...
May 2017: Dental Update
https://www.readbyqxmd.com/read/29183740/facile-immobilization-of-bacillus-licheniformis-%C3%AE-glutamyltranspeptidase-onto-graphene-oxide-nanosheets-and-its-application-to-the-biocatalytic-synthesis-of-%C3%AE-l-glutamyl-peptides
#13
Long-Liu Lin, Meng-Chun Chi, Eng-Gin Lan, Min-Guan Lin, Tzong-Yuan Juang, Tzu-Fan Wang
For the practical application of Bacillus licheniformis γ-glutamyltranspeptidase (BlGGT), we illustrated a simple and efficient approach to fabricate a biocatalytic system by immobilizing the enzyme onto graphene oxide (GO) nanosheets via both non-covalent (GO-BlGGT) and covalent (GO/GA-BlGGT) bonds. The enzyme-loading capacity for the prepared GO/GA nanomaterial was 3.47mg/mg support, corresponding to 68.7% recovery of the initial activity. Native and enzyme-bound layered GOs were characterized by X-ray diffraction, followed by Raman and Fouier transform infrared spectroscopy, elemental analysis and thermogram analysis...
November 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29155537/case-study-management-of-a-loose-upper-denture-opposed-by-a-shortened-dental-arch
#14
Laurie Powell
For many years, it has been considered necessary to restore posterior support with a bilateral free-end saddle when a full upper denture is opposed by a shortened dental arch. It was thought that this would provide occlusal stability and prevent anterior bite collapse and temporomandibular dysfunction. As free-end saddle partial dentures are often poorly tolerated by patients, this case study tests whether a retentive full-upper denture occluding with a shortened dental arch offers enough to fulfil a patient’s needs...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29091720/loss-of-the-caenorhabditis-elegans-pocket-protein-lin-35-reveals-muvb-s-innate-function-as-the-repressor-of-dream-target-genes
#15
Paul D Goetsch, Jacob M Garrigues, Susan Strome
The DREAM (Dp/Retinoblastoma(Rb)-like/E2F/MuvB) transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket protein, and the MuvB subcomplex, form and function at target gene promoters remains unknown. The current model invokes that the pocket protein links E2F-DP and MuvB and is essential for gene repression. We tested this model by assessing how the conserved yet less redundant DREAM system in Caenorhabditis elegans is affected by absence of the sole C...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29090984/a-qualitative-study-on-patient-s-perceptions-of-two-types-of-attachments-for-implant-overdentures
#16
Rubens Ferreira de Albuquerque Junior, Marina Pisani, Christophe Bedos, Cláudia Helena Lovato da Silva, Olivier Fromentin
The aim of this qualitative study was to gain a deeper understanding of patient's perceptions of wearing implant retained overdentures with ball-shaped or cylindrical attachment systems. Twenty-two wearers of implant-supported overdentures participated in this qualitative study based on a randomized crossover clinical trial that aimed to compare a cylindrical attachment (Locator, Zest Anchors Inc, Escondido, CA, USA) and a ball attachment (Retentive Anchor, Straumann AG, Basel, Switzerland). In the phase I of the study, group A experienced ball attachments (n=11) and group B Locator attachment (n=11) for one year...
November 1, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29084295/two-implant-supported-mandibular-overdentures-do-clinical-denture-quality-and-inter-implant-distance-affect-patient-satisfaction
#17
Sara A Alfadda, Mohammad D Al Amri, Amal Al-Ohali, Arwa Al-Hakami, Noura Al-Madhi
PURPOSE: To investigate the following three null hypotheses in patients rehabilitated with a mandibular overdenture supported by two unsplinted implants: (1) patient satisfaction is not related to the clinical quality of the dentures; (2) inter-implant distance (IID) has no effect on the clinical quality of the dentures; and (3) IID does not influence patient satisfaction. MATERIALS AND METHODS: Forty edentulous patients who were rehabilitated with a two-implant-supported mandibular overdenture participated in the study...
November 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29037033/carboxymethylcellulose-mediates-the-transport-of-carbon-nanotube-magnetite-nanohybrid-aggregates-in-water-saturated-porous-media
#18
Dengjun Wang, Chang Min Park, Arvid Masud, Nirupam Aich, Chunming Su
Carbon-metal oxide nanohybrids (NHs) are increasingly recognized as the next-generation, promising group of nanomaterials for solving emerging environmental issues and challenges. This research, for the first time, systematically explored the transport and retention of carbon nanotube-magnetite (CNT-Fe3O4) NH aggregates in water-saturated porous media under environmentally relevant conditions. A macromolecule modifier, carboxymethylcellulose (CMC), was employed to stabilize the NHs. Our results show that transport of the magnetic CNT-Fe3O4 NHs was lower than that of nonmagnetic CNT due to larger hydrodynamic sizes of NHs (induced by magnetic attraction) and size-dependent retention in porous media...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29027707/a-trichosporonales-genome-tree-based-on-27-haploid-and-three-evolutionarily-conserved-natural-hybrid-genomes
#19
Masako Takashima, Sira Sriswasdi, Ri-Ichiroh Manabe, Moriya Ohkuma, Takashi Sugita, Wataru Iwasaki
To construct a backbone tree consisting of basidiomycetous yeasts, draft genome sequences from 25 species of Trichosporonales (Tremellomycetes, Basidiomycota) were generated. In addition to the hybrid genomes of Trichosporon coremiiforme and T. ovoides that we described previously, we identified an interspecies hybrid genome in Cutaneotrichosporon mucoides (formerly T. mucoides). This hybrid genome had a gene retention rate of approximately 55%, and its closest haploid relative was C. dermatis. After constructing the C...
October 13, 2017: Yeast
https://www.readbyqxmd.com/read/28990973/the-issue-of-gadolinium-retained-in-tissues-insights-on-the-role-of-metal-complex-stability-by-comparing-metal-uptake-in-murine-tissues-upon-the-concomitant-administration-of-lanthanum-and-gadolinium-diethylentriamminopentaacetate
#20
Enza Di Gregorio, Giuseppe Ferrauto, Chiara Furlan, Stefania Lanzardo, Raffaele Nuzzi, Eliana Gianolio, Silvio Aime
OBJECTIVES: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude. MATERIALS AND METHODS: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0...
October 3, 2017: Investigative Radiology
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