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https://www.readbyqxmd.com/read/29792307/putative-vaccine-candidates-and-drug-targets-identified-by-reverse-vaccinology-and-subtractive-genomics-approaches-to-control-haemophilus-ducreyi-the-causative-agent-of-chancroid
#1
Alissa de Sarom, Arun Kumar Jaiswal, Sandeep Tiwari, Letícia de Castro Oliveira, Debmalya Barh, Vasco Azevedo, Carlo Jose Oliveira, Siomar de Castro Soares
Chancroid is a sexually transmitted infection (STI) caused by the Gram-negative bacterium Haemophilus ducreyi The control of chancroid is difficult and the only current available treatment is antibiotic therapy; however, antibiotic resistance has been reported in endemic areas. Owing to recent outbreaks of STIs worldwide, it is important to keep searching for new treatment strategies and preventive measures. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 28 strains of H...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29792255/effectiveness-of-adolescent-peer-education-programs-on-reducing-hiv-sti-risk-an-integrated-review
#2
Ganga Mahat, Mary Ann Scoloveno
There is empirical evidence suggesting that peer education is efficacious in changing adolescent sexual risk behaviors; however, it is unclear if there are similarities in outcomes across studies. Thus, the purpose of this review was to synthesize published research on peer-led HIV/STI intervention programs for adolescents in an effort to determine the efficacy of peer education on knowledge, attitudes, normative beliefs, and sexual behavior. Data collection included online searches of published research from Index Medicus (Medline), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Educational Resources Information Center (ERIC), Educational Index, and PsycINFO (including PsycARTICLES) from 2000 to 2016...
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29790254/chemsex-and-new-hiv-diagnosis-in-gay-bisexual-and-other-men-who-have-sex-with-men-attending-sexual-health-clinics
#3
M Pakianathan, W Whittaker, M J Lee, J Avery, S Green, B Nathan, A Hegazi
OBJECTIVES: The aim of the study was to analyse associations between chemsex and new HIV and sexually transmitted infection (STI) diagnoses among gay, bisexual and other men who have sex with men (GBMSM) accessing sexual health clinics. METHODS: A retrospective case note review was carried out for all GBMSM attending two London sexual health clinics between 1 June 2014 and 31 July 2015. RESULTS: Chemsex status was documented for 1734 of 1840 patients...
May 22, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29790075/pathways-from-resilient-coping-to-safer-sex-communication-among-african-caribbean-and-black-women-in-toronto-canada-results-from-a-cross-sectional-survey
#4
Carmen H Logie, Moses Okumu, Shannon Ryan, Mary Yehdego
PURPOSE: African, Caribbean, and Black (ACB) women in Canada are disproportionately impacted by HIV and other sexually transmitted infections. Although there is reported suboptimal consistent condom use with ACB women, limited research has explored safer sex communication among this population. Coping frameworks highlight the role that resilient coping and condom use self-efficacy may play in facilitating safer sex communication. Structural perspectives stress the need to explore associations between HIV vulnerabilities and food insecurity...
May 22, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29788827/video-based-education-versus-nurse-led-education-for-partner-notification-in-thai-women-with-sexually-transmitted-infections-a-randomized-controlled-trial
#5
Chenchit Chayachinda, Chanakarn Kerdklinhom, Suphaphon Tachawatcharapunya, Nattha Saisaveoy
Health education on sexually transmitted infections (STIs), condom use, and partner notification (PN) is required to increase partner evaluation/treatment (PET) rate. To examine this issue, a randomized controlled trial comparing video-based and nurse-led education in women diagnosed with their first STI at the Siriraj Female STI clinic was conducted from March 2015 to March 2017. PN was assessed at two weeks and PET was done at four weeks. Of 330 patients, 225 were included in the analysis (N = 113 and N = 112 for video-based and nurse-led groups, respectively)...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29784080/how-can-university-sexual-health-promotion-events-reach-those-most-at-risk-a-cross-sectional-study
#6
Matthew E Dunn, Merryn McKinnon
Background: The rate of notifications of sexually transmissible infections (STIs) in Australians has increased dramatically, especially in those aged 16-30 years. This age bracket, typical of university students, is the most likely to report multiple sexual partners in the previous year. Individuals who have sex with multiple partners in a year have a significantly increased chance of contracting an STI, making them an important audience for sexual health promotion. This study aimed to determine how university sexual health promotion events can better reach this higher-risk subset of the population...
May 22, 2018: Sexual Health
https://www.readbyqxmd.com/read/29782292/evaluation-of-symptomatic-patients-with-resistant-discharge
#7
Cemile Sonmez, Selma Usluca, Ismail Hakki Usluca, Irem Kalipci, Figen Sezen, Cemal Resat Atalay, Selcuk Kilic
The aim of this study was to detect the presence of Chlamydia trachomatis, Neisseria (N.) gonorrhoeae, Mycoplasma (M.) hominis, M. genitalium, Ureaplasma (U.) urealyticum, and Trichomonas (T.) vaginalis in patients with resistant discharge. The study also evaluated the concordance of the diagnostic tests. Samples from 156 patients were tested by direct microscopy and culture for T. vaginalis and Mycoplasma IES for M. hominis and U. urealyticum. Multiplex Polymerase Chain Reaction (PCR) was used to determine the presence of six agents...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781922/screening-for-sexually-transmitted-infections-after-cervical-cancer-screening-guideline-and-medicaid-policy-changes-a-population-based-analysis
#8
Natasha Parekh, Julie M Donohue, Jennifer Corbelli, Aiju Men, David Kelley, Marian Jarlenski
BACKGROUND: Sexually transmitted infection (STI) screening prevents complications and is cost-effective. Annual screening is recommended in sexually active women <25 years and older women at increased risk. Cervical cancer (CC) screening guideline changes in 2009 and 2012 recommended less frequent screening, causing concern that STI screening would decrease. Pennsylvania Medicaid implemented a family planning program in 2007 which covered women's health services (including STI testing) for uninsured women...
May 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29779513/common-sexually-transmitted-infections-in-women
#9
REVIEW
Ashley L Hodges, Aimee Chism Holland
The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. In this article, specific recommendations for women are included regarding screening, diagnosing, and treating common vaginal and cervical infections. Screening women for infections of the vagina and cervix is essential because untreated infections may result in complications that have current and long-term health consequences and impact quality of life...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29779005/hbv-and-hcv-test-uptake-and-correlates-among-men-who-have-sex-with-men-in-china-a-nationwide-cross-sectional-online-survey
#10
Thomas Fitzpatrick, Stephen W Pan, Weiming Tang, Wilson Guo, Joseph D Tucker
OBJECTIVES: Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause substantial morbidity and mortality in low-income and middle-income countries, including China. WHO guidelines recommend men who have sex with men (MSM) receive HBV and HCV screening. The purpose of this study was to determine the proportion of MSM in China who have HBV and HCV tested and identify correlates of test uptake. METHODS: We conducted an online cross-sectional survey of young MSM in China...
May 19, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29778101/prevalence-of-self-reported-symptoms-of-sexually-transmitted-infections-knowledge-and-sexual-behaviour-among-youth-in-semi-rural-tanzania-in-the-period-of-adolescent-friendly-health-services-strategy-implementation
#11
Ramadhani Abdul, Annette A M Gerritsen, Mary Mwangome, Eveline Geubbels
BACKGROUND: Global evidence shows that sexually transmitted infections (STIs) prevalence and sexual risk behaviours are high among youth, and knowledge about STIs is low. In Tanzania, there is limited recent evidence regarding these issues. The aim of this study was to describe the health seeking behaviour of youth reporting STI symptoms in semi-rural Tanzania and to evaluate the association of socio-demographic characteristics, STI knowledge and sexual risk behaviour with STI symptom reporting...
May 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29776395/linking-young-men-who-have-sex-with-men-ymsm-to-sti-physicians-a-nationwide-cross-sectional-survey-in-china
#12
Bolin Cao, Peipei Zhao, Cedric Bien, Stephen Pan, Weiming Tang, Julia Watson, Guodong Mi, Yi Ding, Zhenzhou Luo, Joseph D Tucker
BACKGROUND: Many young men who have sex with men (YMSM) are reluctant to seek health services and trust local physicians. Online information seeking may encourage YMSM to identify and see trustworthy physicians, obtain sexual health services, and obtain testing for sexually transmitted infections (STIs). This study examined online STI information seeking behaviors among Chinese YMSM and its association with offline physician visits. METHODS: We conducted a nationwide online survey among YMSM through WeChat, the largest social media platform in China...
May 18, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29775498/the-jarisch-herxheimer-reaction-in-syphilis-could-molecular-typing-help-to-understand-it-better
#13
M Arando, C Fernandez, M Mota-Foix, A Alvarez, P Armegol, M J Barberá, J Esperalba, M Vall-Mayans
OBJECTIVES: The Jarisch-Herxheimer reaction (JHR) is a febrile inflammatory reaction that may occur in patients after treatment of syphilis. The overall rate is estimated to be 10-25% with broad variations over time. It appears to be related to factors like stage of the disease or reagin titres. In this study we aimed to describe the incidence of and risk factors including strain typing for JHR among patients with syphilis. METHODS: From January through October 2015, 224 consecutive patients (82 of them with HIV) who were diagnosed with early syphilis were enrolled in this prospective observational study in a referral STI clinic in Barcelona...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29771866/bipolar-disorder-is-associated-with-an-increased-risk-of-sexually-transmitted-infections-a-nationwide-population-based-cohort-study
#14
Shih-Fen Chen, Ling-Yi Wang, Jen-Huai Chiang, Yu-Chih Shen
BACKGROUND: Previous studies have suggested that sexually transmitted infections (STI) tend to increase in patients with bipolar disorder during a manic or hypomanic episode. However, in the long-term course of this disease, it is unclear whether patients with bipolar disorder have a higher risk of incident STI. METHODS: Using the National Health Insurance Research Database (NHIRD) of Taiwan, 3,721 patients with bipolar disorder and 14,884 controls without bipolar disorder matched by gender and age were enrolled between 2000 and 2010 and followed until the end of 2013...
May 1, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29770100/lymphogranuloma-venereum-in-quebec-re-emergence-among-men-who-have-sex-with-men
#15
C A Boutin, S Venne, M Fiset, C Fortin, D Murphy, A Severini, C Martineau, J Longtin, A C Labbé
Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis genotypes L1 , L2 and L3 . This LGV is associated with significant morbidity and increased risk of HIV transmission. While fewer than two cases per year were reported in Quebec before 2005, LGV emerged in 2005-2006 with 69 cases, followed by a period of low incidence (2007-2012), and subsequent re-emergence since 2013. Objectives: To describe the incidence of LGV in Quebec and the characteristics of the affected population, including demographics and risk factors, clinical manifestations, laboratory tests, treatments and reinfection rates...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770099/chlamydia-in-canada-2010-2015
#16
Y Choudhri, J Miller, J Sandhu, A Leon, J Aho
Background: Chlamydia is the most commonly reported notifiable sexually transmitted infection in Canada. Rates have been steadily increasing since 1997. Objective: To summarize trends in chlamydia rates for the period 2010-2015 in Canada. Methods: Laboratory-confirmed cases of chlamydia were reported to the Public Health Agency of Canada by all the Canadian provinces and territories. The overall national rate was computed, as were rates per sex, age group and province/territory...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770098/infectious-and-congenital-syphilis-in-canada-2010-2015
#17
Y Choudhri, J Miller, J Sandhu, A Leon, J Aho
Background: Syphilis is the third most commonly reported notifiable sexually transmitted infection (STI) in Canada, following chlamydia and gonorrhea, respectively. Rates of this STI have been rising rapidly in Canada since 2001. Objective: To summarize trends observed in syphilis rates for 2010 to 2015 in Canada. Methods: Laboratory-confirmed cases of infectious syphilis and early congenital syphilis were reported to the Public Health Agency of Canada by all of the Canadian provinces and territories...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770097/gonorrhea-in-canada-2010-2015
#18
Y Choudhri, J Miller, J Sandhu, A Leon, J Aho
Background: Gonorrhea is the second most commonly reported sexually transmitted infection (STI) in Canada after chlamydia, and rates for this STI have been increasing since 1997. Objective: To summarize trends observed in gonorrhea rates for 2010-2015 in Canada. Methods: Laboratory-confirmed cases of gonorrhea are reported to the Public Health Agency of Canada (PHAC) by all of the Canadian provinces and territories. The overall national rate was computed, as were rates per sex, age group and province/territory...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769718/ankrd16-prevents-neuron-loss-caused-by-an-editing-defective-trna-synthetase
#19
My-Nuong Vo, Markus Terrey, Jeong Woong Lee, Bappaditya Roy, James J Moresco, Litao Sun, Hongjun Fu, Qi Liu, Thomas G Weber, John R Yates, Kurt Fredrick, Paul Schimmel, Susan L Ackerman
Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. Here, using positional cloning, we identified Ankrd16, a gene that acts epistatically with the Aars sti mutation to attenuate neurodegeneration. ANKRD16, a vertebrate-specific protein that contains ankyrin repeats, binds directly to the catalytic domain of AlaRS...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29768621/sexual-violence-against-women-and-care-in-the-health-sector-in-santa-catarina-brazil
#20
Carmem Regina Delziovo, Elza Berger Salema Coelho, Eleonora d'Orsi, Sheila Rubia Lindner
This is a study on sexual violence against women in the Brazilian State of Santa Catarina notified to the Notifiable Diseases Information System (SINAN) in the period 20082013. It aimed to estimate pregnancy and sexually transmitted infections (STIs) resulting from sexual violence and to test the association between pregnancy, STIs and care provided in health services. In total, 1,230 pregnancy notifications and 1.316 STI notifications were analyzed. Variables were age, schooling, time to receive care, STI prophylaxis, emergency contraception, number of perpetrators and recurrent violence, which were analyzed using proportions and 95% confidence intervals...
May 2018: Ciência & Saúde Coletiva
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