Read by QxMD icon Read


Renato C Monteiro
Immunoglobulin A nephropathy or Berger's disease is the most common type of primary glomerulonephritis, which is characterized by IgA1-containing immune-deposits in the glomerular mesangium. Microscopic haematuria and proteinuria are the most common presentations. Mesangial cell proliferation with IgA deposition is found on renal biopsy. Mechanims of the disease implicate at least four key molecules have been implicated in immune complex formation: galactose-deficient IgA1, autoantibodies anti-galactose-deficient-IgA1, soluble CD89 (Fc receptor for IgA) and the CD71 mesangial IgA receptor (transferrin receptor)...
April 2018: Néphrologie & Thérapeutique
Dulama Richani, Robert B Gilchrist
BACKGROUND: The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting embryo and foetal development. However, unlike mural granulosa cells, the oocyte and its surrounding cumulus cells are not directly responsive to LH, indicating that the LH signal is mediated by secondary factors produced by the granulosa cells. The mechanisms by which the oocyte senses the ovulatory LH signal and hence prepares for ovulation has been a subject of considerable controversy for the past four decades...
January 1, 2018: Human Reproduction Update
Ahong Chen, Hongyun Wang, Yuqin Zhang, Xiaoying Wang, Lishuang Yu, Wen Xu, Wei Xu, Yu Lin
Paeoniflorin (PF) is an active ingredient of Radix Paeoniae, which is known to exert neuroprotective effects. However, the mechanims behind the neuroprotective effects of PF are not yet fully understood. The apoptosis of neurons plays an important role in the cerebral ischemia-induced cascade response. This study aimed to investigate neuroprotective effects of PF against glutamate‑induced PC12 cellular cytotoxicity and to determine whether these effects are mediated via the inhibition of apoptosis in vitro and the activity of mitochondrial apoptosis-associated proteins in PC12 cells...
September 2017: International Journal of Molecular Medicine
Norberto Villegas-Negrete, Eduardo A Robleto, Armando Obregón-Herrera, Ronald E Yasbin, Mario Pedraza-Reyes
A forward mutagenesis system based on the acquisition of mutations that inactivate the thymidylate synthase gene (TMS) and confer a trimethoprim resistant (Tmpr) phenotype was developed and utilized to study transcription-mediated mutagenesis (TMM). In addition to thyA, Bacillus subtilis possesses thyB, whose expression occurs under conditions of cell stress; therefore, we generated a thyB- thyA+ mutant strain. Tmpr colonies of this strain were produced with a spontaneous mutation frequency of ~1.4 × 10-9...
2017: PloS One
Ying Dong, Yaling Xu, Pan Li, Chuanqing Wang, Yun Cao, Jialin Yu
Biofilms are difficult to eradicate due to their resistance to antibiotics and host immune cells. Ultrasound microbubbles have emerged as a new treatment modality with the underlying mechanisms largely unknown. In this study, we exposed 24-h-old Staphylococcus epidermidis biofilms established in OptiCell™ chambers to ultrasound in combination with microbubbles, and investigated the activities of vancomycin and neutrophils against S. epidermidis biofilms after treatment. The antibiofilm mechanims of ultrasound microbubbles were explored in terms of bacterial permeability and biofilm-associated gene expression...
September 2017: International Journal of Medical Microbiology: IJMM
Guoqiang Jiang, Jia Liu, Baoyin Ren, Lin Zhang, Lawrence Owusu, Likun Liu, Jing Zhang, Yawei Tang, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bge. (Danshen), is a commonly used traditional Chinese medicine to treat high blood pressure in some countries. It has been shown that Cryptotanshinone induces cancer cells apoptosis and impairs cell migration and invasion. However, the antiproliferation and chemosensitization effects of Cryptotanshinone on ovarian cancer and the underlying mechanism are not fully elucidated...
June 9, 2017: Journal of Ethnopharmacology
Juan L Molina, María Calvó, Eduardo Padilla, Mara Balda, Gabriela González Alemán, Néstor V Florenzano, Gonzalo Guerrero, Danielle Kamis, Beatriz Molina Rangeon, Mercedes Bourdieu, Sergio A Strejilevich, Horacio A Conesa, Javier I Escobar, Igor Zwir, C Robert Cloninger, Gabriel A de Erausquin
Identifying endophenotypes of schizophrenia is of critical importance and has profound implications on clinical practice. Here we propose an innovative approach to clarify the mechanims through which temperament and character deviance relates to risk for schizophrenia and predict long-term treatment outcomes. We recruited 61 antipsychotic naïve subjects with chronic schizophrenia, 99 unaffected relatives, and 68 healthy controls from rural communities in the Central Andes. Diagnosis was ascertained with the Schedules of Clinical Assessment in Neuropsychiatry; parkinsonian motor impairment was measured with the Unified Parkinson's Disease Rating Scale; mesencephalic parenchyma was evaluated with transcranial ultrasound; and personality traits were assessed using the Temperament and Character Inventory...
2017: NPJ Schizophrenia
Christian Kasperk, Carmen Georgescu, Peter Nawroth
Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption...
April 2017: Experimental and Clinical Endocrinology & Diabetes
I S Severina, V I Fedchenko, A V Veselovsky, A E Medvedev
Renalase is a recently discovered secretory protein, which plays a certain (still poorly understood) role in regulation of blood pressure. The review summarizes own and literature data accumulated since the first publication on relanase (2005). Initial reports on FAD-dependent amine oxidase activity of this protein were not confirmed in independent experiments performed in different laboratories. In addition, proposed amine oxidase activity of circulating extracellular renalase requires the presence of FAD, which has not been detected either in blood or urinary renalase...
November 2015: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo, Hernández-Valencia Marcelino, José Gregorio Cruz-Durán, Edgardo Puello-Tamara, Fabián Arechavaleta-Velasco
Preeclampsia is one of the main causes of maternal and perinatal mortality in the world; however, the pathophysiologic pathways haven't been clearly elucidated. It is thought to result from a breakdown of maternal tolerance to paternal antigens in placenta that start an immune response against the trophoblast inducing a defective placentation and a hipoxic/isquemic environment which in turn triggers a systemic inflamatory response. This review gives an overview of the mechanims involved in maternal tolerance, how these are disrupted in preeclampsia, and how they contribute to the inflamatory response...
August 2015: Ginecología y Obstetricia de México
Sunxiao Chen, Hongli Yan, Lei Zhang, Wei Kong, Yi Sun, Weiwei Zhang, Yan Chen, Anmei Deng
BACKGROUND/AIMS: Cryptococcus neoformans infections are becoming increasingly prevalent and remain a life-threatening clinical issue in immune-compromised hosts. The microorganism evades a variety of endogenous anti-fungal mechanims of host immune cells. The signaling pathways in human immune cells that become activated in response to Cryptococcus neoformans infection have yet to be fully characterized. METHODS: Human monocytes were incubated with Cryptococcus neoformans, and the whole transcriptome of monocytes was sequenced before and after exposure to Cryptococcus neoformans using mass parallel sequencing techniques...
2015: Cellular Physiology and Biochemistry
Pasquale Bianco, Zsolt Mártonfalvi, Katalin Naftz, Dorina Kőszegi, Miklós Kellermayer
Titin is a giant filamentous protein of the muscle sarcomere in which stretch induces the unfolding of its globular domains. However, the mechanisms of how domains are progressively selected for unfolding and which domains eventually unfold have for long been elusive. Based on force-clamp optical tweezers experiments we report here that, in a paradoxical violation of mechanically driven activation kinetics, neither the global domain unfolding rate, nor the folded-state lifetime distributions of full-length titin are sensitive to force...
July 21, 2015: Biophysical Journal
Béatrice Gaume, Nathalie Dodet, Jean-Pierre Thomé, Soazig Lemoine
Chlordecone is a persistent organochlorine pesticide widely used between 1972 and 1993 in the French West Indies to control the root borer in banana fields. Chlordecone use resulted in long-term pollution of soils, contamination of waters, of aquatic organisms, and of fields. Chlordecone is known to be neurotoxic, to increase prostate cancer, and to have negative effects on cognitive and motor development during infancy. In Guadeloupe, most of the freshwater species living in contaminated rivers exceed the French legal limit of 20 μg·kg(-1) wet weight...
June 2015: Environmental Science and Pollution Research International
Letizia Scola, Federica M Di Maggio, Loredana Vaccarino, Manuela Bova, Giusy I Forte, Calogera Pisano, Giuseppina Candore, Giuseppina Colonna-Romano, Domenico Lio, Giovanni Ruvolo, Carmela R Balistreri
Thoracic aortic aneurysm (TAA) is a progressive disorder involving gradual dilation of ascending and/or descending thoracic aorta with dissection or rupture as complications. It occurs as sporadic or defined syndromes/familial forms.Genetic, molecular and cellular mechanims of sporadic TAA forms are poorly characterized and known. Thus, our interest has been focused on investigating the role of genetic variants of transforming growth factor-β (TGF-β) pathways in TAA risk. On the other hand, no data on the role of genetic variants of TGF-β pathway in sporadic TAA exist until now...
2014: Mediators of Inflammation
Gabriela Sevignani, Maria Fernanda Soares, Gustavo Lenci Marques, Ana Karyn Ehrenfried de Freitas, Arthur Gentili, Domingos Candiota Chula, Marcelo Mazza do Nascimento
INTRODUCTION: Influenza A (H1N1) virus was first reported on April 2009 and, since then, several studies have reported the characteristics concerning the clinical presentation and pulmonary involvement. However, accurate information about the acute kidney injury (AKI) and kidney histopathological findings in these patients remain scarce. OBJECTIVE: To describe the kidney histopathological findings of 6 patients with H1N1 who developed AKI and underwent kidney biopsy, correlating them with clinical features...
July 2013: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Christophe Jamin, Achouak Achour, Pierre Youinou, Jacques-Olivier Pers
Mechanims of peripheral tolerance include molecular controls and the presence of regulatory lymphocytes. Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytokines, such as IL-10 and with direct cell-to-cell contacts. Tregs targets are antigen presenting cells, such as dendritic cells, effector CD4(+) and CD8(+) lymphocytes but also effector antibody-producing B lymphocytes. Regulatory B lymphocytes (Bregs) have been more recently described and likely represent different sub-populations of B cells that control the development of autoimmune and inflammatory diseases due to the production of IL-10 and using intercellular contacts...
January 2014: La Presse Médicale
Samuele De Minicis, Chris Day, Gianluca Svegliati-Baroni
NAFLD is the most common liver disease worldwide but it is the potential evolution to cirrhosis and hepatocellular carcinoma (HCC) that makes NAFLD of such clinical importance. The current work provides an overview of the main mechanims and potential therapeutical insights involved in NAFLD, NASH, fibrosis and HCC progression.
2013: Current Pharmaceutical Design
Edy Meiyanto, Adam Hermawan, Anindyajati
Targeted therapy has been a very promising strategy of drug development research. Many molecular mechanims of diseases have been known to be regulated by abundance of proteins, such as receptors and hormones. Chemoprevention for treatment and prevention of diseases are continuously developed. Pre-clinical and clinical studies in chemoprevention field yielded many valuable data in preventing the onset of disease and suppressing the progress of their growth, making chemoprevention a challenging and a very rational strategy in future researches...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Maria Emilia P F Silva, Rosilda M Mussury, Maria do Carmo Vieira, Valter V Alves Junior, Zefa V Pereira, Silvana P Q Scalon
Tropaeolum majus L. (nasturtium) is a culture popularly known by its medicinal, ornamental and culinary utility. This work aimed to evaluate the interaction between Astylus variegatus (Germar 1824) (Coleoptera: Melyridae) and the nasturtium flowers associated to the weeks of flourishing, in order to conceive the floral mechanims used by the species to attract A. variegatus. The insects collection was achieved with an entomologic net by the sweeping method, during the weekly flowering, at two hours, from 7am to 5pm...
December 2011: Anais da Academia Brasileira de Ciências
Yue-Ping Guo, Yan Liu, Jing-Bo Li, Yun Huang, Han-Ping Qi, Jing Xie, Xiao-Guang Cui, Zi-Yong Yue, Wen-Zhi Li
BACKGROUND: Previous studies demonstrate that macrophages synthesis and release catecholamines, which regulate the immune responses in an autocrine manner. These responses are mediated in part by β-adrenoceptors expressed on macrophages. Some β-adrenoceptor antagonists are commonly used in clinical conditions. Here we investigated whether the chronic administration of β-adrenoceptor antagonists upregulate adrenergic system of alveolar macrophage and the potential mechanims. METHODS: Propranolol (30 mg/kg·d) or atenolol (5 mg/kg·d) was administered by gavage to rats for 4 weeks...
2011: Cellular Physiology and Biochemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"