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https://www.readbyqxmd.com/read/28714500/exploring-the-immunomodulatory-and-anticancer-properties-of-zerumbone
#1
REVIEW
Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Syed Nasir Abbas Bukhari
Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety and their significant contribution towards understanding targeted drug action and drug delivery mechanisms. Zerumbone, the main constituent of Zingiber zerumbet rhizomes, has been investigated for its wide-spectrum role in treating multitargeted diseases. The rhizomes have been used as food flavoring agents in various cuisines and in herbal medicine. Many in vivo and in vitro studies have provided evidence of zerumbone as a potent immunomodulator as well as a potential anti-cancer agent...
July 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28709132/protective-effects-of-6-gingerol-on-vascular-endothelial-cell-injury-induced-by-high-glucose-via-activation-of-pi3k-akt-enos-pathway-in-human-umbilical-vein-endothelial-cells
#2
Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
6-Gingerol (6-Gin), an active constituent of Zingiber officinale, has been reported to have anti-inflammatory, anti-oxidative, anti-cancerous etc. bioactivities. However, little is known about its endothelial protective effects and the underlying mechanisms. In this study, our purpose was to investigate the protective effects of 6-Gin and its underlying mechanisms. HUVECs were exposed to high glucose (HG, 33mM glucose) for 48h, followed by 50μM 6-Gin with or without LY294002 (10μM), AKT inhibitor IV (0.5μM) or L-NAME (5mM) for another 24h...
July 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28691127/selenium-nanoparticles-with-low-level-ionizing-radiation-exposure-ameliorate-nicotine-induced-inflammatory-impairment-in-rat-kidney
#3
Walid E Zahran, Sawsan M Elsonbaty, Fatma S M Moawed
Occupational exposure to low-level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. Nicotine, a major toxic component of cigarette smoke, is responsible for smoking-mediated renal dysfunction. The present study was therefore aimed to investigate the protective impact of ginger Zingiber officinale selenium nanoparticles (SeNPs) with whole-body low-dose gamma radiation (γ-R) against nicotine-induced nephrotoxicity in male albino rats. Nicotine intoxication was induced with 0...
July 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28654013/in-vitro-anti-leishmanial-activity-of-essential-oils-extracted-from-vietnamese-plants
#4
Thanh Binh Le, Claire Beaufay, Duc Trong Nghiem, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq
Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana(Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated...
June 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28653916/biological-activities-of-allium-sativum-and-zingiber-officinale-extracts-on-clinically-important-bacterial-pathogens-their-phytochemical-and-ft-ir-spectroscopic-analysis
#5
Uzma Azeem Awan, Shaukat Ali, Amna Mir Shahnawaz, Irsa Shafique, Atiya Zafar, Muhammad Abdul Rauf Khan, Tahseen Ghous, Azhar Saleem, Saiqa Andleeb
The spread of bacterial infectious diseases is a major public threat. Herbs and spices have offered an excellent, important and useful source of antimicrobial agents against many pathological infections. In the current study, the antimicrobial potency of fresh, naturally and commercial dried Allium sativum and Zingiber officinale extracts had been investigated against seven local clinical bacterial isolates such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus epidermidis, and Serratia marcesnces by the agar disc diffusion method...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28646880/6-shogaol-a-neuroactive-compound-of-ginger-jahe-gajah-induced-neuritogenic-activity-via-ngf-responsive-pathways-in-pc-12-cells
#6
Syntyche Ling Sing Seow, Sok Lai Hong, Guan Serm Lee, Sri Nurestri Abd Malek, Vikineswary Sabaratnam
BACKGROUND: Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this study was to investigate the potential of 6-shogaol to mimic the neuritogenic activity of nerve growth factor (NGF) in rat pheochromocytoma (PC-12) cells...
June 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28597159/metabolite-analysis-of-endophytic-fungi-from-cultivars-of-zingiber-officinale-rosc-identifies-myriad-of-bioactive-compounds-including-tyrosol
#7
C Anisha, E K Radhakrishnan
Endophytic fungi associated with rhizomes of four cultivars of Zingiber officinale were identified by molecular and morphological methods and evaluated for their activity against soft rot pathogen Pythium myriotylum and clinical pathogens. The volatile bioactive metabolites produced by these isolates were identified by GC-MS analysis of the fungal crude extracts. Understanding of the metabolites produced by endophytes is also important in the context of raw consumption of ginger as medicine and spice. A total of fifteen isolates were identified from the four varieties studied...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28593517/ginger-extract-as-green-biocide-to-control-microbial-corrosion-of-mild-steel
#8
Jayaraman Narenkumar, Punniyakotti Parthipan, Ayyakkannu Usha Raja Nanthini, Giovanni Benelli, Kadarkarai Murugan, Aruliah Rajasekar
In latest years, various techniques and chemicals have been used for the control of microbial influenced corrosion (MIC) of metals. The application of botanical-based biocides is one of the effective and practical techniques in the fight against MIC. In the present study, the role of aqueous extract of ginger (Zingiber officinale) (GIE) as green biocide to control MIC of mild steel 1010 (MS) in a cooling water system was investigated. Biocorrosion behavior of Bacillus thuringiensis EN2 on MS and its control by GIE was analyzed by electrochemical measurements...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28585369/chemical-composition-and-antibacterial-antifungal-allelopathic-and-acetylcholinesterase-inhibitory-activities-of-cassumunar-ginger
#9
Ram S Verma, Neeta Joshi, Rajendra C Padalia, Ved R Singh, Prakash Goswami, Sajendra K Verma, Hina Iqbal, Debabrata Chanda, Rajesh K Verma, Mahendra P Darokar, Amit Chauhan, Manish K Kandwal
BACKGROUND: Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae), commonly known as cassumunar-ginger, is a folk remedy for the treatments of inflammations, sprains, rheumatism and asthma. The aim of this study was to assess the chemical composition, and antibacterial, antifungal, allelopathic and acetylcholinesterase inhibitory activities of the essential oil of Z. montanum originated from India. RESULTS: The hydrodistilled essential oil of Z. montanum rhizome was analyzed using GC-FID and GC-MS...
June 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28572957/effect-of-spices-formulations-on-the-physicochemical-and-sensory-properties-of-nnam-gon-a-cameroonian-dish-prepared-with-cucurbitaceae-seeds
#10
Josiane E Manejo Djiogue, Richard M Nguimbou, Leopold N Tatsadjieu, Yannick D Mang, Nicolas Y Njintang
Nnam gon, a cake made by steam cooking a mixture of Cucurbitaceae seeds paste and others ingredients specially spices, is a highly prized dish in Central African region. A preliminary investigation conducted as part of this study highlighted that formulations used in the processing of Nnam gon vary according to the spices used. This study was carried out to determine the best formulation for the preparation of this dish. For this purpose, Nnam gon samples were produced from four formulations which differ according to the number of spices used: F0 (no spices); F1 (0...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28567627/endophytic-nocardiopsis-sp-from-zingiber-officinale-with-both-antiphytopathogenic-mechanisms-and-antibiofilm-activity-against-clinical-isolates
#11
Rohini Sabu, K R Soumya, E K Radhakrishnan
Novel and potential antimicrobial compounds are essential to tackle the frequently emerging multidrug-resistant pathogens and also to develop environment friendly agricultural practices. In the current study, endophytic actinomycetes from rhizome of Zingiber officinale were explored in terms of its diversity and bioactive properties. Fourteen different organisms were isolated, identified and screened for activity against Pythium myriotylum and human clinical pathogens. Among these, Nocardiopsis sp. ZoA1 was found to have highest inhibition with excellent antibacterial effects compared to standard antibiotics...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28559707/formulation-and-evaluation-of-a-water-in-oil-cream-containing-herbal-active-ingredients-and-ferulic-acid
#12
Mirela Moldovan, Abir Lahmar, Cătălina Bogdan, Simona Părăuan, Ioan Tomuţă, Maria Crişan
BACKGROUND AND AIMS: The main aims of the present study were to formulate an anti-age cream based on vegetal ingredients and ferulic acid and to evaluate the physical characteristics and the efficacy of the cream. METHODS: The active ingredients were Centella asiatica oil, Spilanthes acmella oil, Zingiber officinale extract and ferulic acid. Formulation 1 (F1) was prepared using glyceryl stearate and Ceteareth-25® as emulsifiers and Formulation 2 (F2) using glyceryl stearate and potassium cetyl phosphate, all other ingredients remaining the same...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28554232/two-new-monoterpenoid-glycosides-from-the-fresh-rhizome-of-tongling-white-ginger-zingiber-officinale
#13
Tao Guo, Su-Bei Tan, Ya Wang, Jun Chang
Two new monoterpenoid glycosides, trans-1,8-cineole-3,6-dihydroxy-3-O-β-D-glucopyranoside (1), and 5,9-dihydroxy borneol 2-O-β-D-glucopyranoside (2), together with four known monoterpenoid glycosides (3-6), were isolated from the water-soluble constituents of the fresh rhizome of Tongling White Ginger (Zingiber officinale). Their structures were decisively elucidated by spectroscopic analysis. In vitro tests for antimicrobial activity showed that compounds 1 and 3 possess significant activity against two Gram-positive organisms, Staphylococcus aureus and Staphylococcus epidermidis...
May 29, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28546949/properties-of-macerated-herbal-oil
#14
Fahsai Kantawong, Supawatchara Singhatong, Aomjai Srilamay, Kantarose Boonyuen, Niroot Mooti, Phenphichar Wanachantararak, Thasaneeya Kuboki
Introduction: The addition of herbs into hot sesame oil could increase the oil-pulling efficiency of sesame oil. The aim of present study was to modify the proportion of herbs and sesame oil with the addition of other ingredients including menthol, camphor, and borneol and improve the medicinal properties and the scent of the oil. Methods: Macerated herbal oil was prepared by heat extraction of five species of herbs (Zingiber cassumunar, Zingiber zerumbet, Plantago major Linn, Citrus hystrix, and Amomum biflorum) with hot sesame oil...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546803/effect-of-tribulus-terrestris-ginger-saffron-and-cinnamomum-on-menopausal-symptoms-a-randomised-placebo-controlled-clinical-trial
#15
Simin Taavoni, Neda Nazem Ekbatani, Hamid Haghani
Menopausal symptoms experienced by women vary widely, and while many women transition through menopause with manageable symptoms, others experience severe symptoms, which may impair their quality of life. The purpose of this study was to determine the effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms. A randomised, triple-blind, controlled trial design was used for this study. The participants were 80 postmenopausal women aged 50-60 years. A demographic data form and the Menopause Rating Scale were used to collect data...
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28512603/bactericidal-activity-of-herbal-volatile-oil-extracts-against-multidrug-resistant-acinetobacter-baumannii
#16
Amornrat Intorasoot, Piyaorn Chornchoem, Siriwoot Sookkhee, Sorasak Intorasoot
AIM: The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (Alpinia galanga Linn.), ginger (Zingiber officinale), plai (Zingiber cassumunar Roxb.), lime (Citrus aurantifolia), kaffir lime (Citrus hystrix DC.), sweet basil (Ocimum basilicum Linn.), tree basil (Ocimum gratissimum), lemongrass (Cymbopogon citratus DC.), clove (Syzygium aromaticum), and cinnamon (Cinnamomum verum) against four standard strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii, and 30 clinical isolates of multidrug-resistant A...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28505392/beneficial-effects-of-ginger-zingiber-officinale-roscoe-on-obesity-and-metabolic-syndrome-a-review
#17
REVIEW
Jing Wang, Weixin Ke, Rui Bao, Xiaosong Hu, Fang Chen
In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects are mediated by transcription factors, such as peroxisome proliferator-activated receptors, adenosine monophosphate-activated protein kinase, and nuclear factor κB...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28499256/from-common-to-rare-zingiberaceae-plants-a-metabolomics-study-using-gc-ms
#18
Gina B Barbosa, Nirupama S Jayasinghe, Siria H A Natera, Ellen D Inutan, Nonita P Peteros, Ute Roessner
Zingiberaceae plants, commonly known as gingers, have been popular for their medicinal and culinary uses since time immemorial. In spite of their numerous health-promoting applications, many Zingiberaceae plants still receive no scientific attention. Moreover, existing reports mostly focused only on the Zingiberaceae rhizomes. Here, untargeted metabolite profiling using Gas Chromatography - Mass Spectrometry (GC-MS) was used to compare the metabolic composition of leaves and rhizomes of the more common gingers, Zingiber officinale Rosc...
August 2017: Phytochemistry
https://www.readbyqxmd.com/read/28497331/zingiber-cernuum-zingiberaceae-essential-oil-as-effective-larvicide-and-oviposition-deterrent-on-six-mosquito-vectors-with-little-non-target-toxicity-on-four-aquatic-mosquito-predators
#19
Mohan Rajeswary, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
Mosquitoes are responsible for the transmission of many pathogens and parasites, which cause serious diseases in humans and animals. Currently, botanical products have been suggested as alternative tools in the fight against arthropod vectors. In this study, the essential oil (EO) extracted from Zingiber cernuum was tested as larvicide and oviposition deterrent on six mosquito species of public health relevance, including malaria and Zika virus vectors. The EO showed high toxicity on third instar larvae of Anopheles stephensi (LC50 = 41...
May 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28494418/zingiber-officinale-and-6-gingerol-alleviate-liver-and-kidney-dysfunctions-and-oxidative-stress-induced-by-mercuric-chloride-in-male-rats-a-protective-approach
#20
Deepmala Joshi, Sunil Kumar Srivastav, Sateesh Belemkar, Vaibhav A Dixit
Mercury toxicity is an emerging problem in the world as its concentration is rising continuously due to increased industrial, medicinal and domestic uses. Exposure to mercury represents a serious challenge to humans and other living biomes. The aim of the present study was to assess the protective effect of natural products as Zingiber officinale extract and its active compound (6-gingerol) against mercuric chloride-induced hepatorenal toxicity and oxidative stress in male rats. Male Sprague-Dawley rats (150±10g, n=6 per group) were administered HgCl2 (12μmol/kg, ip; once only) the treatment of Zingiber officinale Rosc...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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