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https://www.readbyqxmd.com/read/28877520/protective-effect-of-ginger-zingiber-officinale-roscoe-extract-against-oxidative-stress-and-mitochondrial-apoptosis-induced-by-interleukin-1%C3%AE-in-cultured-chondrocytes
#1
Azam Hosseinzadeh, Kobra Bahrampour Juybari, Mohammad Javad Fatemi, Tunku Kamarul, Aboulfazl Bagheri, Neda Tekiyehmaroof, Ali Mohammad Sharifi
AIMS: The protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated oxidative stress and mitochondrial apoptosis were investigated in C28I2 human chondrocytes. METHODS: The effects of various concentrations of ginger extract on C28I2 human chondrocyte viability were evaluated in order to obtain noncytotoxic concentrations of the drug by methylthiotetrazole assay. The cells were pretreated with 5 and 25 μg/mL ginger extract for 24 h, followed by incubation with IL-1β (10 ng/mL) for 24 h...
September 7, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28872719/oral-herbal-medicines-marketed-in-brazil-for-the-treatment-of-osteoarthritis-a-systematic-review-and-meta-analysis
#2
REVIEW
Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Sean Alexander Kennedy, Maria Carolina de Oliveira E Silva, Marcus Tolentino Silva, Cristiane de Cássia Bergamaschi
Herbal medications are commonly used to manage symptoms associated with osteoarthritis (OA). This systematic review evaluated the effectiveness and safety of oral medications used in Brazil for the treatment of OA. Randomized clinical trials involving adults with OA treated by a herbal medicine or a control group were eligible. The primary outcomes measured were pain, physical function, swelling, stiffness and quality of life; and the secondary outcomes were adverse events, activity limitations and treatment satisfaction...
September 5, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28846029/ayurvedic-preparation-of-zingiber-officinale-roscoe-effects-on-cardiac-and-on-smooth-muscle-parameters
#3
Alberto Leoni, Roberta Budriesi, Ferruccio Poli, Mariacaterina Lianza, Alessandra Graziadio, Alice Venturini, Massimiliano Broccoli, Matteo Micucci
The rhizome of the Zingiber officinale Roscoe, a biennial herb growing in South Asia, is commonly known as ginger. Ginger is used in clinical disorders, such as constipation, dyspepsia, diarrhoea, nausea and vomiting and its use is also recommended by the traditional medicine for cardiopathy, high blood pressure, palpitations and as a vasodilator to improve the circulation. The decoction of ginger rhizome is widely used in Ayurvedic medicine. In this papery by high-performance liquid chromatography, we have seen that its main phytomarkers were 6-gingerol, 8-gingerol and 6-shogaol and we report the effects of the decoction of ginger rhizome on cardiovascular parameters and on vascular and intestinal smooth muscle...
August 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28844217/helicobacter-pylori-outer-membrane-protein-q-genotypes-and-their-susceptibility-to-anti-adhesive-phytotherapeutic-agents
#4
Javed Yakoob, Zaigham Abbas, Malik Hassan Mehmood, Kanwal Tariq, Saima Azhar Saleem, Safia Awan, Abdul Malik, Saeed Hamid, Rustam Khan, Wasim Jafri
OBJECTIVE: Helicobacter pylori is a Gram-negative organism. Its outer membrane protein Q (HopQ) mediates host-pathogen interactions; HopQ genotypes 1 and 2 are found associating with gastroduodenal pathologies. The authors measured the anti-adhesion effects of the extracts of Abelmoschus esculentus, Zingiber officinale, Trachyspermum ammi, Glycyrrhiza glabra, Curcuma longa and Capsicum annum against HopQ genotypes and H. pylori cytotoxin-associated gene A (CagA). METHODS: DNA was extracted by polymerase chain reaction of the HopQ genotypes (i...
September 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28842272/pharmacotherapeutic-potential-of-ginger-and-its-compounds-in-age-related-neurological-disorders
#5
REVIEW
Jin Gyu Choi, Sun Yeou Kim, Minsun Jeong, Myung Sook Oh
Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms...
August 24, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28835766/effects-of-the-hydroalcoholic-extract-of-zingiber-officinale-on-arginase-i-activity-and-expression-in-the-retina-of-streptozotocin-induced-diabetic-rats
#6
Nasrin Lamuchi-Deli, Mohammad Aberomand, Hossein Babaahmadi-Rezaei, Ghorban Mohammadzadeh
BACKGROUND: Emerging evidence suggests that an increased arginase activity is involved in vascular dysfunction in experimental animals. Zingiber officinale Roscoe, commonly known as ginger, has been widely used in the traditional medicine for treatment of diabetes. OBJECTIVES: This study aimed at investigating the effects of the hydroalcoholic extract of Z. officinale on arginase I activity and expression in the retina of streptozotocin (STZ)-induced diabetic rats...
April 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28830774/purification-biochemical-characterization-and-antioxidant-property-of-zcpg-a-cysteine-protease-from-zingiber-montanum-rhizome
#7
Kizukala Jamir, Kottapalli Seshagirirao
Zingiber montanum cysteine protease glycoprotein (ZCPG) was purified to homogeneity by DEAE- cellulose and Sephadex G50 resulting in sixteen fold purification and total activity of 39.4U/mg. ZCPG presented a prominent single peak in HPLC chromatogram with an estimated molecular weight of 48kDa on native PAGE. SDS-PAGE gave two subunits of ∼24.3 and ∼24.6kDa showing its heterodimeric form. Protein sequencing was studied by MALDI-TOF MS/MS. Isoelectrofocusing exhibited two isoforms with pI values of 4.8 and 5...
August 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28827002/identification-of-pgc-1%C3%AE-activating-constituents-in-zingiberaceous-crude-drugs
#8
Yuto Nishidono, Takashi Fujita, Akira Kawanami, Mikio Nishizawa, Ken Tanaka
The activity of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) as an index of thermogenesis induced by four Indonesian Zingiberaceous crude drugs, Boesenbergia rotunda, Curcuma longa, Kaempferia galanga, Zingiber montanum, was examined, and GC-MS analyses of extracts of these drugs were performed. The results showed that activation of PGC-1α by K. galanga was high, whereas no activation was shown for the other drugs. Ethyl p-methoxycinnamate and ethyl cinnamate were identified as the PGC-1α activating compounds of K...
August 18, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28820276/attenuation%C3%A2-of-sulfite-induced-testicular-injury-in-rats-by-zingiber-officinale-roscoe
#9
Akbar Afkhami Fathabad, Shahnaz Shekarforoush, Maryam Hoseini, Zahra Ebrahimi
Sulfite salts, including sodium metabisulfte, are widely used as preservatives in foods and pharmaceutical agents. Previous studies suggest that oxidative stress may be an important mediator of testicular injury. The present study was designed to elucidate the effect of exposure to sodium metabisulfite by gavage without or with Zingiber officinale (ginger) extract on the rat testes. Thirty-two male Wistar rats were randomly divided into control, ginger-treated (500 mg/kg/day), sodium metabisulfite- (SMB-) treated (260 mg/kg/day), and SMB + ginger- (SZ-) treated groups...
August 18, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28808381/characterization-antibacterial-and-antioxidant-properties-of-silver-nanoparticles-synthesized-from-aqueous-extracts-of-allium-sativum-zingiber-officinale-and-capsicum-frutescens
#10
Gloria Aderonke Otunola, Anthony Jide Afolayan, Emmanuel Olusegun Ajayi, Samuel Wale Odeyemi
BACKGROUND: Herbal drug delivery is limited by poor solubility and bioavailability which can be overcome with suitable nanomaterials that will enhance their pharmacokinetics and performance. OBJECTIVE: This study aimed to analyze the synthesis, characterization, and biological activities of silver nanoparticles (AgNPs) from three spices. MATERIALS AND METHODS: AgNPs were prepared using 0.1 M silver nitrate and aqueous extracts of Allium sativum L...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28802845/fluorescence-quenching-structural-and-unfolding-studies-of-a-purified-cysteine-protease-zcpg-from-zingiber-montanum-rhizome
#11
Kizukala Jamir, Kottapalli Seshagirirao
A first attempt was made to study the fluorescence quenching, structure and unfolding nature of the purified Zingiber montanum (J.Koenig) Link ex A.Dietr. cysteine protease glycoprotein (ZCPG). ATR-IR spectra showed the presences of amide groups along with carbohydrate stretch indicating the glycoprotein nature. UV-vis spectra determined the presences of peptide groups and aromatic sidechains of tyrosine, tryptophan and phenylalanine. Far UV-Circular Dichroism spectrum revealed that the secondary structure consists of 47...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28793909/-6-gingerol-from-zingiber-officinale-potentiates-glp-1-mediated-glucose-stimulated-insulin-secretion-pathway-in-pancreatic-%C3%AE-cells-and-increases-rab8-rab10-regulated-membrane-presentation-of-glut4-transporters-in-skeletal-muscle-to-improve-hyperglycemia-in
#12
Mehdi Bin Samad, Md Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J M A Hannan
BACKGROUND: [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Lepr(db/db) diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28762585/therapeutic-effects-of-6-gingerol-8-gingerol-and-10-gingerol-on-dextran-sulfate-sodium-induced-acute-ulcerative-colitis-in-rats
#13
Feng Zhang, Na Ma, Yong-Feng Gao, Li-Li Sun, Ji-Guo Zhang
Ulcerative colitis is one of the most common types of inflammatory bowel disease and is multifactorial and relapsing. 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale), has been reported to improve ulcerative colitis. The present study aims to investigate the therapeutic efficacy of two analogous forms of 6-gingerol, 8-gingerol, and 10-gingerol, on ulcerative colitis. Colitis was induced in rats through consumption of 5% (w/v) dextran sulfate sodium drinking water for 7 consecutive days...
August 1, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28745291/biogenic-fabrication-of-cunps-cu-bioconjugates-and-in-vitro-assessment-of-antimicrobial-and-antioxidant-activity
#14
Raksha Pandit, Swapnil Gaikwad, Mahendra Rai
In the present study, the authors synthesised copper nanoparticles (CuNPs) by using extract of Zingiber officinale (ginger) and later the NPs were bioconjugated with nisin, which shows antimicrobial activity against food spoilage microorganisms. CuNPs and its bioconjugate were characterised by ultraviolet-vis spectroscopy, NP tracking analysis, Zetasizer, transmission electron microscopy analysis, X-ray diffraction and Fourier transform infra-red (FTIR) spectroscopy. Zeta potential of CuNPs and its bioconjugate were found to be very stable...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28714500/exploring-the-immunomodulatory-and-anticancer-properties-of-zerumbone
#15
REVIEW
Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Syed Nasir Abbas Bukhari
Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety and their significant contribution towards understanding targeted drug action and drug delivery mechanisms. Zerumbone, the main constituent of Zingiber zerumbet rhizomes, has been investigated for its wide-spectrum role in treating multitargeted diseases. The rhizomes have been used as food flavoring agents in various cuisines and in herbal medicine. Many in vivo and in vitro studies have provided evidence of zerumbone as a potent immunomodulator as well as a potential anti-cancer agent...
July 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28709132/protective-effects-of-6-gingerol-on-vascular-endothelial-cell-injury-induced-by-high-glucose-via-activation-of-pi3k-akt-enos-pathway-in-human-umbilical-vein-endothelial-cells
#16
Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
6-Gingerol (6-Gin), an active constituent of Zingiber officinale, has been reported to have anti-inflammatory, anti-oxidative, anti-cancerous etc. bioactivities. However, little is known about its endothelial protective effects and the underlying mechanisms. In this study, our purpose was to investigate the protective effects of 6-Gin and its underlying mechanisms. HUVECs were exposed to high glucose (HG, 33mM glucose) for 48h, followed by 50μM 6-Gin with or without LY294002 (10μM), AKT inhibitor IV (0.5μM) or L-NAME (5mM) for another 24h...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28691127/selenium-nanoparticles-with-low-level-ionizing-radiation-exposure-ameliorate-nicotine-induced-inflammatory-impairment-in-rat-kidney
#17
Walid E Zahran, Sawsan M Elsonbaty, Fatma S M Moawed
Occupational exposure to low-level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. Nicotine, a major toxic component of cigarette smoke, is responsible for smoking-mediated renal dysfunction. The present study was therefore aimed to investigate the protective impact of ginger Zingiber officinale selenium nanoparticles (SeNPs) with whole-body low-dose gamma radiation (γ-R) against nicotine-induced nephrotoxicity in male albino rats. Nicotine intoxication was induced with 0...
July 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28654013/in-vitro-anti-leishmanial-activity-of-essential-oils-extracted-from-vietnamese-plants
#18
Thanh Binh Le, Claire Beaufay, Duc Trong Nghiem, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq
Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana(Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated...
June 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28653916/biological-activities-of-allium-sativum-and-zingiber-officinale-extracts-on-clinically-important-bacterial-pathogens-their-phytochemical-and-ft-ir-spectroscopic-analysis
#19
Uzma Azeem Awan, Shaukat Ali, Amna Mir Shahnawaz, Irsa Shafique, Atiya Zafar, Muhammad Abdul Rauf Khan, Tahseen Ghous, Azhar Saleem, Saiqa Andleeb
The spread of bacterial infectious diseases is a major public threat. Herbs and spices have offered an excellent, important and useful source of antimicrobial agents against many pathological infections. In the current study, the antimicrobial potency of fresh, naturally and commercial dried Allium sativum and Zingiber officinale extracts had been investigated against seven local clinical bacterial isolates such as Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus epidermidis, and Serratia marcesnces by the agar disc diffusion method...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28646880/6-shogaol-a-neuroactive-compound-of-ginger-jahe-gajah-induced-neuritogenic-activity-via-ngf-responsive-pathways-in-pc-12-cells
#20
Syntyche Ling Sing Seow, Sok Lai Hong, Guan Serm Lee, Sri Nurestri Abd Malek, Vikineswary Sabaratnam
BACKGROUND: Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this study was to investigate the potential of 6-shogaol to mimic the neuritogenic activity of nerve growth factor (NGF) in rat pheochromocytoma (PC-12) cells...
June 24, 2017: BMC Complementary and Alternative Medicine
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