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https://www.readbyqxmd.com/read/28421826/6-gingerol-improves-testicular-function-in-mice-model-of-chronic-ulcerative-colitis
#1
E O Farombi, I A Adedara, B O Ajayi, T E Idowu, O O Eriomala, F O Akinbote
The persistent inflammation and oxidative stress at the local site in ulcerative colitis reportedly extend to the testes via systemic circulation resulting in testicular dysfunction. The influence of 6-gingerol (6G), a phenolic compound isolated from Zingiber officinale, on colitis-mediated testicular dysfunction in mice was investigated in this study. Chronic ulcerative colitis was induced in mice using 2.5% dextran sulfate sodium (DSS) in drinking water for three cycles. Each cycle consisted of 7 consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28414123/anti-factor-xa-activities-of-zingerone-with-anti-platelet-aggregation-activity
#2
Wonhwa Lee, Sae-Kwang Ku, Mi-Ae Kim, Jong-Sup Bae
Zingerone (ZGR), a phenolic alkanone found in Zingiber officinale, has been reported to have various pharmacological activities such as anti-inflammatory, anti-apoptotic, and protecting myocardial infarction and irritable bowel disorder. The aim was to identify the unreported bioactive anti-factor Xa (FXa) and anti-platelet activities of ZGR. ZGR was evaluated for their anti-FXa and anti-platelet aggregation properties by monitoring clotting time, platelet aggregation, FXa activity and production, and thrombus formation...
April 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28410218/6-shogaol-attenuates-lps-induced-inflammation-in-bv2-microglia-cells-by-activating-ppar-%C3%AE
#3
Qinghe Han, Qinghai Yuan, Xiaolin Meng, Junyuan Huo, Yuxin Bao, Guanghong Xie
6-Shogaol, a pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects. However, the anti-inflammatory effects and biological mechanism of 6-Shogaol in LPS-activated BV2 microglia remains largely unknown. In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated 1 h before LPS treatment. The production of inflammatory mediators were detected by ELISA. The expression of NF-κB and PPAR-γ were detected by western blot analysis...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408818/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingiber-cassumunar-roxb-by-therapeutic-ultrasound-in-a-rat-model
#4
Jirakrit Leelarungrayub, Jiradej Manorsoi, Aranya Manorsoi
OBJECTIVE: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28405575/factorial-analysis-of-the-binding-properties-of-acetylated-ginger-starch-in-metronidazole-tablet-formulations
#5
Oluyemisi Adebowale Bamiro, Abioye Josephina Duro-Emanuel
INTRODUCTION: The delivery of drug is often affected by formulation processes and the excipients used in the formulation. MATERIALS AND METHODS: A 2(3) factorial analysis was used in this study to evaluate the effect of acetylated ginger starch (AGS) (Zingiber officinale) as a binder in metronidazole tablets, in comparison to corn starch (CS) BP. The individual and interacting effects of variables (binder type X1, binder concentration X2, and compression pressure X3) used on tablet properties such as friability, crushing strength, crushing strength friability ratio (CSFR), disintegration and crushing strength friability/disintegration time ratio (CSFR/DT) were determined...
January 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28398734/construction-of-prediction-models-for-the-transient-receptor-potential-vanilloid-subtype-1-trpv1-stimulating-activity-of-ginger-and-processed-ginger-based-on-lc-hrms-data-and-pls-regression-analyses
#6
Taichi Yoshitomi, Naohiro Oshima, Yuto Goto, Shunsuke Nakamori, Daigo Wakana, Naoko Anjiki, Koji Sugimura, Noriaki Kawano, Hiroyuki Fuchino, Osamu Iida, Toshiko Kagawa, Hideto Jinno, Nobuo Kawahara, Yoshinori Kobayashi, Takuro Maruyama
To construct a model formula to evaluate the thermogenetic effect of ginger (Zingiber officinale Roscoe) from the ingredient information, we established transient receptor potential vanilloid subtype 1 (TRPV1)-stimulating activity prediction models by using a partial least-squares projections to latent structures (PLS) regression analysis in which the ingredient data from liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and the stimulating activity values for TRPV1 receptor were used as explanatory and objective variables, respectively...
April 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28393526/identification-of-ginger-zingiber-officinale-roscoe-volatiles-and-localization-of-aroma-active-constituents-by-gc-olfactometry
#7
Xueli Pang, Jianmin Cao, Dabin Wang, Jun Qiu, Fanyu Kong
For the characterization of chemical components contributing to the aroma of ginger, which could benefit the development of deep-processed ginger products, volatile extracts were isolated by a combination of direct solvent extraction-solvent-assisted flavor evaporation and static headspace analysis. Aroma-impact components were identified by gas chromatography-olfactometry-mass spectrometry, and the most potent odorants were further screened by aroma extract dilution analysis (AEDA) and static headspace dilution analysis (SHDA)...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28390419/which-potential-harms-and-benefits-of-using-ginger-in-the-management-of-nausea-and-vomiting-of-pregnancy-should-be-addressed-a-consensual-study-among-pregnant-women-and-gynecologists
#8
Ramzi Shawahna, Assim Taha
BACKGROUND: Nausea and vomiting of pregnancy (NVP) affect approximately 80-90% of the pregnant women. Ginger (Zingiber officinale Roscoe) is the most widely used herbal therapy in the management of NVP. Like conventional therapies, herbal therapies have potential harms and benefits that patients need to be informed about in order to develop their therapy preferences. The aim of this study was to achieve consensus among women who suffered NVP and physicians often consulted by pregnant women on a core list of potential harms and benefits of using ginger to manage NVP to be addressed during clinical consultations...
April 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28390258/diosmin-essential-oil-combination-for-dermal-photo-protection-using-a-lipoid-colloidal-carrier
#9
Rabab Kamel, Haidy Abbas, Ahmed Fayez
Solar irradiation induces skin inflammatory processes causing deleterious effects like premature ageing. In this study, the designed lipoid colloidal carrier (LCC) was loaded with Diosmin in combination with different essential oils, to be used as a topical photo-protective preparation. To investigate the ability of the essential oils to potentiate Diosmin effects, the Diosmin/essential oil-loaded LCCs (LCC2, LCC3 and LCC4) were compared to the Diosmin-loaded LCC (LCC1). The incorporated essential oils were those of Rosmarinus officinalis, Zingiber officinale or Vitis vinifera in LCC2, LCC3 and LCC4, respectively...
March 30, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28389345/zingiber-officinale-its-antibacterial-activity-on-pseudomonas-aeruginosa-and-mode-of-action-evaluated-by-flow-cytometry
#10
Ankita Singh Chakotiya, Ankit Tanwar, Alka Narula, Rakesh Kumar Sharma
Biofilm formation, low membrane permeability and efflux activity developed by Pseudomonas aeruginosa, play an important role in the mechanism of infection and antimicrobial resistance. In the present study we evaluate the antibacterial effect of Zingiber officinale against multi-drug resistant strain of P. aeruginosa. The study explores antibacterial efficacy and time-kill study concomitantly the effect of herbal extract on bacterial cell physiology with the use of flow cytometry and inhibition of biofilm formation...
April 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28373059/protective-properties-of-6-gingerol-rich-fraction-from-zingiber-officinale-ginger-on-chlorpyrifos-induced-oxidative-damage-and-inflammation-in-the-brain-ovary-and-uterus-of-rats
#11
Amos O Abolaji, Mercy Ojo, Tosin T Afolabi, Mary D Arowoogun, Darlinton Nwawolor, Ebenezer O Farombi
Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments. 6-Gingerol-rich fraction from Zingiber officinale (Ginger, 6-GRF) has been reported to possess potent anti-oxidative, anti-inflammatory and anti-apoptotic properties. Here, we investigated the protective properties of 6-GRF on CPF-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively...
March 31, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28316626/evaluation-of-phenolic-compounds-and-antioxidant-and-antimicrobial-activities-of-some-common-herbs
#12
Muhammad Abdul Qadir, Syeda Kiran Shahzadi, Asad Bashir, Adil Munir, Shabnam Shahzad
The study was designed to evaluate the phenolic, flavonoid contents and antioxidant and antimicrobial activities of onion (Allium cepa), garlic (Allium sativum), mint (Mentha spicata), thyme (Thymus vulgaris), oak (Quercus), aloe vera (Aloe barbadensis Miller), and ginger (Zingiber officinale). All extracts showed a wide range of total phenolic contents, that is, 4.96 to 98.37 mg/100 g gallic acid equivalents, and total flavonoid contents, that is, 0.41 to 17.64 mg/100 g catechin equivalents. Antioxidant activity (AA) was determined by measuring reducing power, inhibition of peroxidation using linoleic acid system, and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging activity...
2017: International Journal of Analytical Chemistry
https://www.readbyqxmd.com/read/28315822/protective-effect-of-zerumbone-reduces-lipopolysaccharide-induced-acute-lung-injury-via-antioxidative-enzymes-and-nrf2-ho-1-pathway
#13
Wai-Shing Leung, Ming-Ling Yang, Shiuan-Shinn Lee, Chi-Wen Kuo, Yung-Chyuan Ho, Rosa Huang-Liu, Hui-Wen Lin, Yu-Hsiang Kuan
Acute lung injury (ALI) is a serious disease with high morbidity and mortality rate. Although there are effective strategies for treatment of ALI; a widely accepted specific pharmacotherapy has not yet established. Zerumbone, the major active phytochemical compound from Zingiber zerumbet Smith, exhibits various beneficial biological and pharmacological activities, such as antioxidation, anti-inflammation, immunomodulation, and anti-cancer. We aimed to study the potential protective effects and mechanisms of zerumbone in mouse model of lipopolysaccharide (LPS)-induced ALI...
March 15, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28314171/improving-pork-burgers-quality-using-zingiber-officinale-roscoe-powder-ginger
#14
Simone Mancini, Gisella Paci, Filippo Fratini, Beatrice Torracca, Roberta Nuvoloni, Alessandro Dal Bosco, Valentina Roscini, Giovanna Preziuso
Pork burgers were evaluated for physical-chemical characteristics, fatty acids profile, lipid oxidation, antioxidant capacity, microbiological growth and sensory evaluation during storage time of seven days at 4°C as function of three formulations as only meat (control, B) and meat added with ginger powder at the percentage of 1 and 2% (BG1 and BG2). BG1 and BG2 were less redness than control ones with incremented yellow hue. These modifications in color parameters did not modify sensory characteristics of burgers...
March 8, 2017: Meat Science
https://www.readbyqxmd.com/read/28302020/olfactory-loss-management-in-view-of-avicenna-focus-on-neuroprotective-plants
#15
Farnaz Sinaei, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addressing useful remedies. Traditional Persian Medicine (TPM) has been practiced in Persia for more than 2000 years. Avicenna is the most eminent Persian physician. OBJECTIVE: To survey Avicenna's views on etiology and management of olfactory loss and to search for relevant modern pharmacological data...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28292010/the-anti-allergic-and-anti-inflammatory-effects-of-benjakul-extract-a-thai-traditional-medicine-its-constituent-plants-and-its-some-pure-constituents-using-in-vitro-experiments
#16
Sunita Makchuchit, Ruchilak Rattarom, Arunporn Itharat
Benjakul (BJK), a Thai traditional medicine preparation, has long been used for balanced health, controlled abnormal of element in the body, carminative, and relief of flatulence. It is composed of five plants: Piper interruptum Opiz., Piper longum L., Piper sarmentosum Roxb., Plumbago indica L., and Zingiber officinale Roscoe. The ethanolic extracts of BJK, its five individual plants, and pure constituents of BJK were investigated for their anti-allergic activity using immunoglobulin E (IgE)-sensitized β-hexosaminidase in the rat basophilic leukemia-2H3 (RBL-2H3) cells and anti-inflammatory activity using lipopolysaccharide (LPS)-induced nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) in the murine macrophage (RAW 264...
March 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28275210/phytomedicine-in-joint-disorders
#17
REVIEW
Dorin Dragos, Marilena Gilca, Laura Gaman, Adelina Vlad, Liviu Iosif, Irina Stoian, Olivera Lupescu
Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and efficiency frequently comparable with that of conventional drugs...
January 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28261954/screening-inhibitors-of-xanthine-oxidase-from-natural-products-using-enzyme-immobilized-magnetic-beads-by-high-performance-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#18
Ting Wang, Dapeng Li, Boyang Yu, Jin Qi
In this study, high-performance liquid chromatography coupled with tandem mass spectrometry was used to assess the results of bioactive compound screening from natural products using immobilized enzyme magnetic beads. We compared three commercial magnetic beads with modified amino, carboxy and N-hydroxysuccinimide groups, respectively. Amino magnetic beads performed best for immobilization and were selected for further experiments. Xanthine oxidase was immobilized on amino magnetic beads and applied to screen potential inhibitors in fresh Zingiber officinale Roscoe, extracts of Scutellaria baicalensis Georgi and Pueraria lobata Ohwi...
March 6, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28255816/morphological-analysis-of-vessel-elements-for-systematic-study-of-three-zingiberaceae-tribes
#19
Kathlyn Vasconcelos Gevú, Helena Regina Pinto Lima, John Kress, Maura Da Cunha
Zingiberaceae containing over 1,000 species that are divided into four subfamilies and six tribes. In recent decades, there has been an increase in the number of studies about vessel elements in families of monocotyledon. However, there are still few studies of Zingiberaceae tribes. This study aims to establish systematic significance of studying vessel elements in two subfamilies and three tribes of Zingiberaceae. The vegetative organs of 33 species processed were analysed by light and scanning electron microscopy and Principal Component Analysis was used to elucidate genera boundaries...
March 2, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28253877/neuroprotective-and-cognitive-enhancing-effects-of-the-combined-extract-of-cyperus-rotundus-and-zingiber-officinale
#20
Chatchada Sutalangka, Jintanaporn Wattanathorn
BACKGROUND: Currently, food supplements to improve age-related dementia are required. Therefore, we aimed to determine the effect of the combined extract of Cyperus rotundus and Zingiber officinale (CP1) on the improvement of age-related dementia in rats with AF64A-induced memory deficits. METHODS: Male Wistar rats weighing 180-200 g were orally given CP1 at doses of 100, 200 and 300 mg.kg(-1) BW for a period of 14 days after bilateral intracerebroventricular administration of AF64A...
March 3, 2017: BMC Complementary and Alternative Medicine
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