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Ginger R Fisher, Jeffrey T Olimpo, Thomas M McCabe, Ryan S Pevey
Evidence indicates that students who participate in scientific research during their undergraduate experience are more likely to pursue careers in the STEM disciplines and to develop increased scientific reasoning and literacy skills. One avenue to increase student engagement in research is via their enrollment in course-based undergraduate research experiences (CUREs), where they are able to conduct authentic research as part of the laboratory curriculum. The information presented herein provides an example of a CURE which was developed and implemented in an introductory cell and molecular biology course at the University of Northern Colorado...
2018: Journal of Microbiology & Biology Education: JMBE
Ginger E Nicol, Michael D Yingling, Karen S Flavin, Julia A Schweiger, Bruce W Patterson, Kenneth B Schechtman, John W Newcomer
Importance: Antipsychotic medications are commonly used to treat nonpsychotic disruptive behavioral disorders in youths. Objective: To characterize the metabolic effects of first exposure to antipsychotics in youths using criterion standard assessments of body composition and insulin sensitivity. Design, Setting, and Participants: This randomized clinical trial recruited antipsychotic-naive youths aged 6 to 18 years in the St Louis, Missouri, metropolitan area who were diagnosed with 1 or more psychiatric disorders and clinically significant aggression and in whom antipsychotic treatment was considered...
June 13, 2018: JAMA Psychiatry
Jane Harmer, Vyacheslav Yurchenko, Anna Nenarokova, Julius Lukeš, Michael L Ginger
Parasitic trypanosomatids diverged from free-living kinetoplastid ancestors several hundred million years ago. These parasites are relatively well known, due in part to several unusual cell biological and molecular traits and in part to the significance of a few - pathogenic Leishmania and Trypanosoma species - as aetiological agents of serious neglected tropical diseases. However, the majority of trypanosomatid biodiversity is represented by osmotrophic monoxenous parasites of insects. In two lineages, novymonads and strigomonads, osmotrophic lifestyles are supported by cytoplasmic endosymbionts, providing hosts with macromolecular precursors and vitamins...
June 13, 2018: Parasitology
Kenza A Mansoor, Fadi Qadan, Mathias Schmidt, Nidal A Qinna, Mujtaba Badr, Khalid Z Matalka
Background : Viral influenza infection causes serious health issues especially when an outbreak occurs. Although influenza virus vaccines are available and each year manufactures modify the vaccine depending on the expected mutated strain, it is still far from satisfactory, mainly in young children and older adults. Therefore, a product that can support and shape the immune system to protect against viral flu infections is highly essential. Methods : A functional food water-soluble mixture of pomegranate, red grape, dates, olive fruit, figs, and ginger extracts, termed herein “Protector”, was prepared and tested in stimulating/modulating the production of specific cytokines, and hemagglutinin inhibition (HAI) antibodies following viral flu vaccination in mice...
June 8, 2018: Nutrients
Rogerio A Lobo, David F Archer, Risa Kagan, Andrew M Kaunitz, Ginger D Constantine, James H Pickar, Shelli Graham, Brian Bernick, Sebastian Mirkin
OBJECTIVE: To evaluate efficacy, endometrial safety, and overall safety of a single-capsule 17β-estradiol-progesterone for treating menopausal moderate-to-severe vasomotor symptoms. METHODS: REPLENISH was a phase 3, 12-month, randomized, double-blind, placebo-controlled, multicenter trial. Women (aged 40-65 years) with vasomotor symptoms and a uterus were randomized to daily estradiol (mg)-progesterone (mg) (1/100, 0.5/100, 0.5/50, or 0.25/50), and women in the vasomotor symptoms substudy (women with moderate-to-severe hot flushes [seven or greater per day or 50 or greater per week]) to those estradiol-progesterone doses or placebo...
June 6, 2018: Obstetrics and Gynecology
Amit Kumar Singh, Anupam Bishayee, Abhay K Pandey
Cancer initiation and progression are the result of genetic and/or epigenetic alterations. Acetylation-mediated histone/non-histone protein modification plays an important role in the epigenetic regulation of gene expression. Histone modification is controlled by the balance between histone acetyltransferase and (HAT) and histone deacetylase (HDAC) enzymes. Imbalance between the activities of these two enzymes is associated with various forms of cancer. Histone deacetylase inhibitors (HDACi) regulate the activity of HDACs and are being used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy...
June 6, 2018: Nutrients
Richard A Stein, Kira Schmid, Jowell Bolivar, Andrew G Swick, Steven V Joyal, Steven P Hirsh
BACKGROUND: Sexual health positively correlates with overall wellbeing. Existing therapeutics to enhance male sexual health are limited by factors that include responsiveness, adherence and adverse effects. As the population ages, safe and effective interventions that preserve male sexual function are needed. Published research suggests that various preparations of Kaempferia parviflora, a plant in the Zingiberaceae (ginger) family, support cardiovascular health and may ameliorate erectile function...
May 26, 2018: Journal of Integrative Medicine
Parneet Kaur Deol, Pragyanshu Khare, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Indu Pal Kaur
Aim of the study was to evaluate a combination of ginger extract (GE; antioxidant, anti-inflammatory) and Lactobacillus acidophilus (LAB; probiotic), in DMH-DSS-induced inflammation-driven colon cancer, in Wistar rats. Effect of varying GE concentration on growth of LAB was assessed in vitro. Colonic histology and permeability, oxidative stress, serum proinflammatory cytokines, expression of selected genes, gut bacteria, and SCFA determination of gut content was monitored after treatment with agents alone or in combination, postdisease induction...
June 7, 2018: Phytotherapy Research: PTR
John W Newcomer, Ginger E Nicol
No abstract text is available yet for this article.
June 1, 2018: American Journal of Psychiatry
Nourhène Zammel, Nahed Amri, Rim Chaabane, Tarek Rebai, Riadh Badraoui
This study was assessed to examine whether Zingiber officinale (ZO) can prevent spine disorder and trabecular microarchitecture disruption in osteoporotic murin model. Three groups of male rats were selected: Controls (CTRL), combined model of osteoporosis (CMO), in which rats were orchidectomized and treated with cortisol, and CMO treated with ZO (CMO + ZO). One month after the surgical procedures, the rats were sacrificed. Lumbar curve of the spine has been evaluated using the kyphotic method. The spines were submitted to histological and histomorphometric analysis and mineral (calcium and phosphorus) metabolism assessment...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Alireza Shirpoor, Elaheh Heshmati, Fatemeh Kheradmand, Farzaneh Hosseini Gharalari, Leila Chodari, Roya Naderi, Farideh Nezami Majd, Mahrokh Samadi
The association between chronic alcohol consumption and the development of alcpholic liver disease is a very well known phenomenon, but the precise underlying molecular mediators involved in ethanol-induced liver disease remain elusive. This study aimed to characterize the lipid metabolism alterations and the molecular mediators which are related to lipid metabolism in liver under the heavy ethanol exposure alone or combined with ginger extract. Twenty-four male wistar rats were assigned into three groups, namely control, ethanol, and ginger extract treated ethanol (GETE) groups...
May 28, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Myung-Hee Lee, Ah-Ram Han, Mi Jang, Hyo-Kyoung Choi, Sung-Young Lee, Kyung-Tack Kim, Tae-Gyu Lim
Kaempferia parviflora (Krachaidum (KD)) is a traditional herbal medicine and has properties that are beneficial for human health. In the current study, we sought to investigate the anti-inflammatory properties of KD extract (KPE). In mouse skin tissue, UV light representing solar wavelengths (sUV) increased COX-2 expression, while treatment with KPE reduced this effect. The anti-inflammatory activity of KPE was confirmed in in vitro models. MAPK signaling pathways were activated by sUV irradiation, and this was also repressed in the presence of KPE treatment...
2018: Oxidative Medicine and Cellular Longevity
Jessica Kong, Rajiv Giridharagopal, Jeffrey S Harrison, David S Ginger
Correlating nanoscale chemical specificity with operational physics is a long-standing goal of functional scanning probe microscopy (SPM). We employ a data analytic approach combining multiple microscopy modes, using compositional information in infrared vibrational excitation maps acquired via photoinduced force microscopy (PiFM) with electrical information from conductive atomic force microscopy. We study a model polymer blend comprising insulating poly(methyl methacrylate) (PMMA) and semiconducting poly(3-hexylthiophene) (P3HT)...
May 31, 2018: Journal of Physical Chemistry Letters
Duan-Chao Wang, Hou-Yong Yu, Xuemeng Fan, Jiping Gu, Shounuan Ye, Juming Yao, Qing-Qing Ni
Charged nanocellulose (NC) with high aspect ratio (larger than 100) extracted from animal or bacterial cellulose and chemical crosslinked NC aerogels have great promising applicability in material science, but facile fabrication of such NC aerogels from plant cellulose by physical crosslinking still remains a major challenge. In this work, carboxylated cellulose nanofiber (CNF) with highest aspect ratio of 144 was extracted from wasted ginger fibers by a simple one-step acid hydrolysis. Our approach could easily make the carboxylated CNF assemble into robust bulk aerogels with tunable densities and desirable shapes on a large scale (3D macropores to mesopores) by hydrogen bonds...
May 30, 2018: ACS Applied Materials & Interfaces
Garth H Utter, Ginger L Cox, Oluseun O Atolagbe, Pamela L Owens, Patrick S Romano
OBJECTIVE: To convert the Agency for Healthcare Research and Quality's (AHRQ) Quality Indicators (QIs) from International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) specifications to ICD, 10th Revision, Clinical Modification and Procedure Classification System (ICD-10-CM/PCS) specifications. DATA SOURCES: ICD-9-CM and ICD-10-CM/PCS classifications, General Equivalence Maps (GEMs). STUDY DESIGN: We convened 77 clinicians and coders to evaluate ICD-10-CM/PCS codes mapped from ICD-9-CM using automated GEMs...
May 30, 2018: Health Services Research
Nadia M T Abu El Ezz, Noha M F Hassan, Amira H El Namaky, Faten Abo-Aziza
Nasopharyngeal myiasis is an important high incidence disease among camels in the Middle East and North of Africa caused by Cephalopina titillator ( C. titillator ) that results in sever economic losses in many camel breeding areas around the world. The current study was conducted to evaluate the efficacy of three essential oils; camphor, ginger and cinnamon oils and their histopathological effects on the 3rd larval instar of C. titillator, with special regard to the prevalence percentage of C. titillator infestation in slaughtered camels at Egyptian abattoirs in addition to investigate histopathological alterations of the infested animal's tissue...
June 2018: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Wirginia Kukula-Koch, Wojciech Koch, Lidia Czernicka, Kazimierz Głowniak, Yoshinori Asakawa, Akemi Umeyama, Zbigniew Marzec, Takashi Kuzuhara
BACKGROUND: In the search for novel antidepressive drug candidates, bioguided fractionation of nonpolar constituents present in the oleoresin from ginger rhizomes ( Zingiber officinale Roscoe, Zingiberaceae) was performed. This particular direction of the research was chosen due to the existing reports on the antidepressive properties of ginger total extract. The search for individual metabolites acting as MAO-A inhibitors, which correspond to the apparent effect of the total extract, is the subject of this work...
May 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Vivian Boesso Oriani, Izabela Dutra Alvim, Bruno Nicolau Paulino, Fernanda Ramalho Procópio, Glaucia Maria Pastore, Míriam Dupas Hubinger
Ginger oleoresin (GO) can be encapsulated within a protective lipid matrix in order to facilitate handling, provide protection against the external environment or promote the stability of GO compounds. The aim of this study was to verify the ability of solid lipid microparticles (SLMs) containing GO (10-20% w/w) to maintain or improve the stability of ginger compounds, by monitoring SLMs' characteristics during storage at different temperatures (25 and 40 °C). The lipids matrix of SLMs were composed by stearic acid (90, 80, 75, 65% w/w) and oleic acid (15% w/w), The crystalline structure of the particles after 84 days of storage did not present any polymorphic alterations, while presenting spherical form upon scanning by electron microscopy...
July 2018: Food Research International
Dongdong Wang, Verena Hiebl, Angela Ladurner, Simone L Latkolik, Franz Bucar, Elke H Heiß, Verena M Dirsch, Atanas G Atanasov
SCOPE: Ginger is reported to be used for the prevention and treatment of cardiovascular diseases (CVD). Cholesterol efflux from macrophage foam cells is an important process in reverse cholesterol transport, whose increase may help to prevent or treat CVD. In this study, we investigated the effects of 6-dihydroparadol from ginger on macrophage cholesterol efflux. METHODS AND RESULTS: We show that 6-dihydroparadol enhances concentration-dependently both apolipoprotein A1- and human plasma-mediated cholesterol efflux from cholesterol-loaded THP-1-derived macrophages using macrophage cholesterol efflux assay...
May 26, 2018: Molecular Nutrition & Food Research
Chelsea L Blankenchip, Dana E Michels, H Elizabeth Braker, Shana K Goffredi
The beetle genus Cephaloleia has evolved in association with tropical ginger plants and for many species their specific host plant associations are known. Here we show that the core microbiome of six closely related Costa Rican Cephaloleia species comprises only eight bacterial groups, including members of the Acinetobacter , Enterobacteriacea, Pseudomonas , Lactococcus, and Comamonas . The Acinetobacter and Enterobacteriacea together accounted for 35% of the total average 16S rRNA ribotypes recovered from all specimens...
2018: PeerJ
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