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https://www.readbyqxmd.com/read/28726603/clinical-laboratory-values-as-early-indicators-of-ebola-virus-infection-in-nonhuman-primates
#1
Ronald B Reisler, Chenggang Yu, Michael J Donofrio, Travis K Warren, Jay B Wells, Kelly S Stuthman, Nicole L Garza, Sean A Vantongeren, Ginger C Donnelly, Christopher D Kane, Mark G Kortepeter, Sina Bavari, Anthony P Cardile
The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28723912/ginger-and-the-beetle-evidence-of-primitive-pollination-system-in-a-himalayan-endemic-alpine-ginger-roscoea-alpina-zingiberaceae
#2
Babu Ram Paudel, Mani Shrestha, Adrian G Dyer, Qing-Jun Li
The Himalayan endemic alpine genus Roscoea, like other members of ginger family, exhibits the combination of floral traits that would fit pollination by long distant foragers such as bees, birds or flies. We studied the pollination biology of Roscoea alpina, observed potential floral visitors and determined their foraging behaviour, visitation frequency and pollination efficiency, to seek evidence in support of the pollination syndrome hypothesis. We also measured the floral spectra of R. alpina flowers to evaluate if signals fit with the currently known framework for observed floral visitors...
2017: PloS One
https://www.readbyqxmd.com/read/28722023/potential-involvement-of-impaired-bkca-channel-function-in-sensory-defensiveness-and-some-behavioral-disturbances-induced-by-unfamiliar-environment-in-a-mouse-model-of-fxs
#3
Maria Isabel Carreno-Munoz, Fabienne Martins, Maria Carmen Medrano, Elisabetta Aloisi, Susanna Pietropaolo, Corentin Dechaud, Enejda Subashi, Guillaume Bony, Melanie Ginger, Abdelmalik Moujahid, Andreas Frick, Xavier Leinekugel
In Fragile X Syndrome (FXS), sensory-hypersensitivity and impaired habituation is thought to result in attention overload and various behavioral abnormalities in reaction to the excessive and remanent salience of environment-features that would normally be ignored. This phenomenon, termed sensory defensiveness, has been proposed as the potential cause of hyperactivity, hyperarousal, and negative reactions to changes in routine that are often deleterious for FXS patients. However, the lack of tools for manipulating sensory-hypersensitivity has not allowed the experimental testing required to evaluate the relevance of this hypothesis...
July 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28719419/in-reply
#4
David F Archer, Ginger D Constantine, James Simon, Harvey Kushner, Philip Mayer, Brian Bernick, Shelli Graham, Sebastian Mirkin
No abstract text is available yet for this article.
July 17, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28719139/identification-of-metabolites-in-human-and-rat-urine-after-oral-administration-of-xiao-qing-long-tang-granule-using-ultra-high-performance-liquid-chromatography-combined-with-quadrupole-time-of-flight-mass-spectrometry
#5
Lei Zhou, Qiang Zhang, Wen Qi, Shuai Yan, Jialin Qu, Toshiaki Makino, Dan Yuan
Xiao-Qing-Long-Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao-Qing-Long-Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was established for the detection and identification of the metabolites in human and rat urine after oral administration of Xiao-Qing-Long-Tang...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28708293/investigation-on-the-antimicrobial-activities-of-gingers-etlingera-coccinea-blume-s-sakai-nagam-and-etlingera-sessilanthera-r-m-sm-endemic-to-borneo
#6
Delhousie Daniel-Jambun, Jacky Dwiyanto, Yau Yan Lim, Joash Ban Lee Tan, Azira Muhamad, Sau Wai Yap, Sui Mae Lee
AIMS: To investigate the antimicrobial properties of E. coccinea and E. sessilanthera and to isolate and identify the antimicrobial compounds. METHODS AND RESULTS: Extracts were obtained via sequential solvent extraction method using hexane, dichloromethane, ethyl acetate, methanol and water. Antimicrobial activity testing was done using broth microdilution assay against 17 strains of bacteria. The leaf hexane extract of E. coccinea and rhizome hexane extract of E...
July 14, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28698459/dietary-natural-products-for-prevention-and-treatment-of-breast-cancer
#7
REVIEW
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang, Hua-Bin Li
Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28692848/modifications-of-fatty-acids-profile-lipid-peroxidation-and-antioxidant-capacity-in-raw-and-cooked-rabbit-burgers-added-with-ginger
#8
Simone Mancini, Giovanna Preziuso, Alessandro Dal Bosco, Valentina Roscini, Giuliana Parisi, Gisella Paci
Effects of ginger powder were evaluated on fatty acid (FA) profile, lipid peroxidation (TBARS) and antioxidant capacity (ABTS, DPPH and FRAP) of rabbit burgers. Burgers were manufactured as control samples (only meat) and two additions of ginger powder (1% and 2%) and stored raw at 4°C for 7days. At day 1, 4 and 7 of storage burgers were analysed both as raw and cooked. Ginger powder affected all the tested parameters; both PUFAω3 and PUFAω6 were incremented in raw and cooked samples leading to decreased atherogenicity and thrombogenicity indexes and increased hypo/hypercholesterolemic index and peroxidability index...
July 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28692788/watershed-versus-within-lake-drivers-of-nitrogen-phosphorus-dynamics-in-shallow-lakes
#9
Luke J Ginger, Kyle D Zimmer, Brian R Herwig, Mark A Hanson, William O Hobbs, Gaston E Small, James B Cotner
Research on lake eutrophication often identifies variables affecting amounts of phosphorus (P) and nitrogen (N) in lakes, but understanding factors influencing N:P ratios is important given its influence on species composition and toxin production by cyanobacteria. We sampled 80 shallow lakes in Minnesota (USA) for three years to assess effects of watershed size, proportion of watershed as both row crop and natural area, fish biomass, and lake alternative state (turbid versus clear) on total N: total P (TN:TP), ammonium, total dissolved phosphorus (TDP), and seston stoichiometry...
July 10, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28692754/rapid-sensory-profiling-and-hedonic-rating-of-whole-grain-sorghum-cowpea-composite-biscuits-by-low-income-consumers
#10
Koya A P Dovi, Constance Chiremba, John R N Taylor, Henriëtta L de Kock
BACKGROUND: The challenges of malnutrition and urbanization in Africa demand development of acceptable, affordable, nutritious complementary-type foods. Biscuits (cookies), a popular snack, from whole grain staples is an option. The objective was to relate check-all-that-applies (CATA) sensory profiles of sorghum-cowpea composite biscuits compared to economic commercial refined wheat biscuits with hedonic ratings by low income consumers. In addition, the nutritional composition and protein quality, L*a*b* colour and texture of the biscuits were determined...
July 10, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28692664/a-functional-approach-to-understanding-the-role-of-nckx5-in-xenopus-pigmentation
#11
Ruth M Williams, Robert J Winkfein, Rebecca S Ginger, Martin R Green, Paul P Schnetkamp, Grant N Wheeler
NCKX5 is an ion exchanger expressed mostly in pigment cells; however, the functional role for this protein in melanogenesis is not clear. A variant allele of SLC24A5, the gene encoding NCKX5, has been shown to correlate with lighter skin pigmentation in humans, indicating a key role for SLC24A5 in determining human skin colour. SLC24A5 expression has been found to be elevated in melanoma. Knockdown analyses have shown SLC24A5 to be important for pigmentation, but to date the function of this ion exchanger in melanogenesis has not been fully established...
2017: PloS One
https://www.readbyqxmd.com/read/28691127/selenium-nanoparticles-with-low-level-ionizing-radiation-exposure-ameliorate-nicotine-induced-inflammatory-impairment-in-rat-kidney
#12
Walid E Zahran, Sawsan M Elsonbaty, Fatma S M Moawed
Occupational exposure to low-level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. Nicotine, a major toxic component of cigarette smoke, is responsible for smoking-mediated renal dysfunction. The present study was therefore aimed to investigate the protective impact of ginger Zingiber officinale selenium nanoparticles (SeNPs) with whole-body low-dose gamma radiation (γ-R) against nicotine-induced nephrotoxicity in male albino rats. Nicotine intoxication was induced with 0...
July 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28690172/managing-colonic-inflammation-associated-gut-derangements-by-systematically-optimised-and-targeted-ginger-extract-lactobacillus-acidophilus-loaded-pharmacobiotic-alginate-beads
#13
Parneet Kaur Deol, Pragyanshu Khare, Dhirendra Pratap Singh, Girish Soman, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Indu Pal Kaur
Presently, we explore a cobiotic- ginger extract (GE; antioxidant-antiinflammatory) and Lactobacillus acidophilus (LAB, probiotic), for control of oxidative-stress, inflammation and dysbiosis mediated gut ailments. Since orally administered LAB looses viability while GE is a gastric irritant with poor ADME, we encapsulated them into calcium-alginate beads. Water-loving, viscolysing, and osmotic-building effects of polyethylene glycol were used to address poor probiotic encapsulation (≤10%) by effective sealing of numerous fine voids formed in the alginate gel...
July 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28683219/does-the-supplemental-nutrition-assistance-program-affect-hospital-utilization-among-older-adults-the-case-of-maryland
#14
Laura J Samuel, Sarah L Szanton, Rachel Cahill, Jennifer L Wolff, Pinchuan Ong, Ginger Zielinskie, Charles Betley
This study sought to examine whether Supplemental Nutrition Assistance Program (SNAP) participation and benefit levels are associated with reduced subsequent hospital and emergency department utilization in low-income older adults. Study participants were 68,956 Maryland residents aged ≥65 years who were dually enrolled in Medicare and Medicaid (2009-2012). Annual inpatient hospital days and costs and emergency department visits were modeled as a function of either 1-year lagged SNAP participation or lagged SNAP benefit amounts, controlling for sociodemographic characteristics, autoregressive effects, year, health status, and Medicaid participation...
July 6, 2017: Population Health Management
https://www.readbyqxmd.com/read/28678344/prebiotic-potential-and-chemical-composition-of-seven-culinary-spice-extracts
#15
Qing-Yi Lu, Paula H Summanen, Ru-Po Lee, Jianjun Huang, Susanne M Henning, David Heber, Sydney M Finegold, Zhaoping Li
The objective of this study was to investigate prebiotic potential, chemical composition, and antioxidant capacity of spice extracts. Seven culinary spices including black pepper, cayenne pepper, cinnamon, ginger, Mediterranean oregano, rosemary, and turmeric were extracted with boiling water. Major chemical constituents were characterized by RP-HPLC-DAD method and antioxidant capacity was determined by measuring colorimetrically the extent to scavenge ABTS radical cations. Effects of spice extracts on the viability of 88 anaerobic and facultative isolates from intestinal microbiota were determined by using Brucella agar plates containing serial dilutions of extracts...
July 5, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28675098/production-of-a-novel-wheat-gluten-hydrolysate-containing-dipeptidyl-peptidase-iv-inhibitory-tripeptides-using-ginger-protease
#16
Yuki Taga, Osamu Hayashida, Masashi Kusubata, Kiyoko Ogawa-Goto, Shunji Hattori
Wheat gluten is a Pro-rich protein complex comprising glutenins and gliadins. Previous studies have reported that oral intake of enzymatic hydrolysates of gluten has beneficial effects, such as suppression of muscle injury and improvement of hepatitis. Here, we utilized ginger protease that preferentially cleaves peptide bonds with Pro at the P2 position to produce a novel type of wheat gluten hydrolysate. Ginger protease efficiently hydrolyzed gluten, particularly under weak acidic conditions, to peptides with an average molecular weight of <600 Da...
July 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28672408/ginger-extract-modulates-the-expression-of-chemokines-ccl20-and-ccl22-and-their-receptors-ccr6-and-ccr4-in-the-central-nervous-system-of-mice-with-experimental-autoimmune-encephalomyelitis
#17
Abdollah Jafarzadeh, Zahra Arabi, Rayhaneh Ahangar-Parvin, Marziyeh Mohammadi-Kordkhayli, Maryam Nemati
Background Chemokines facilitate the leukocytes infiltration into the central nervous system (CNS) which is an essential step in the pathogenesis of multiple sclerosis. Ginger has also a broad anti-inflammatory properties. The aim was to evaluate the effects of ginger extract on the expression of CCL20 and CCL22 and their receptors (CCR6 and CCR4, respectively) in experimental autoimmune encephalomyelitis (EAE). Material and Methods Female C57BL/6 mice used for EAE induction by immunization with myelin oligodendroglial glycoprotein...
July 3, 2017: Drug Research
https://www.readbyqxmd.com/read/28666335/a-randomized-double-blind-placebo-controlled-multicenter-study-of-a-ginger-extract-in-the-management-of-chemotherapy-induced-nausea-and-vomiting-cinv-in-patients-receiving-high-dose-cisplatin
#18
P Bossi, D Cortinovis, S Fatigoni, M Cossu Rocca, A Fabi, P Seminara, C Ripamonti, S Alfieri, R Granata, C Bergamini, F Agustoni, P Bidoli, F Nolè, M A Pessi, F Macchi, L Michellini, F Montanaro, F Roila
Background: The activity of ginger in the management of chemotherapy-induced nausea and vomiting (CINV) has been suggested, but design inadequacies, heterogeneity of the population, small numbers and poor quality of tested products limit the possibility to offer generalizable results. Patients and methods: We conducted a randomized, double-blind, placebo-controlled, multicenter study in patients planned to receive ≥2 chemotherapy cycles with high dose (>50 mg/m 2 ) cisplatin...
June 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28665164/oral-administration-of-ginger-derived-nanolipids-loaded-with-sirna-as-a-novel-approach-for-efficient-sirna-drug-delivery-to-treat-ulcerative-colitis
#19
Mingzhen Zhang, Xiaoyu Wang, Moon Kwon Han, James F Collins, Didier Merlin
AIM: To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. MATERIALS & METHODS: Nanoparticles composed of edible ginger-derived lipid, termed ginger-derived lipid vehicles (GDLVs) were generated from ginger lipids through hydration of a lipid film, a commonly used method for a liposome fabrication. The morphology, biocompatibility and transfection efficiency of GDLVs loaded with siRNA-CD98 (siRNA-CD98/GDLVs) were characterized by standard methods...
June 30, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28659234/use-of-ginger-versus-stretching-exercises-for-the-treatment-of-primary-dysmenorrhea-a-randomized-controlled-trial
#20
Marjan Ahmad Shirvani, Narges Motahari-Tabari, Abbas Alipour
BACKGROUND: Dysmenorrhea is a common gynecologic problem. In some cases, non-medical treatments are considered to be more effective, with fewer side effects. Ginger and exercise are alternative treatments for dysmenorrhea, but in the present study they were not combined. OBJECTIVE: In this study, the effects of ginger and exercise on primary dysmenorrhea were compared. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This randomized controlled trial was performed in Mazandaran University of Medical Sciences, Iran...
July 2017: Journal of Integrative Medicine
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