Martyna Cieślik, Spencer D Strobel, Paweł Bryniarski, Hanna Twardowska, Adam Chmielowski, Michał Rudek, Dominik Felkle, Katarzyna Zięba, Konrad Kaleta, Mateusz Jarczyński, Bernadeta Nowak, Krzysztof Bryniarski, Katarzyna Nazimek
Nowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role. Thus, current comprehensive studies have investigated the impact of repeatedly administered hypotensive drugs (captopril, olmesartan, propranolol, carvedilol, amlodipine, verapamil) on macrophage functions in the innate and adaptive immunity, as well as if drug-induced effects are affected by a high-sodium diet (HSD), one of the key environmental risk factors of hypertension...
April 26, 2024: Biomedicine & Pharmacotherapy