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Pro- inflammatory diet

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https://www.readbyqxmd.com/read/28429171/sleeve-gastrectomy-alters-intestinal-permeability-in-diet-induced-obese-mice
#1
Claire Blanchard, François Moreau, Julien Chevalier, Audrey Ayer, Damien Garcon, Lucie Arnaud, Jean-Paul Pais de Barros, Thomas Gautier, Michel Neunlist, Bertrand Cariou, Cédric Le May
BACKGROUND: Increased lipopolysaccharide (LPS) translocation due to altered intestinal permeability has been suggested as a mechanism for obesity-associated insulin resistance. The goal of this study was to assess the effect of sleeve gastrectomy (SG) on intestinal barrier permeability in diet-induced obese mice. MATERIALS AND METHODS: Four weeks after surgery, the effects of SG on intestinal permeabilities were assessed ex vivo and in vivo in male C57Bl/6J mice fed a high-fat diet...
April 20, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28429080/effect-of-gpr84-deletion-on-obesity-and-diabetes-development-in-mice-fed-long-chain-or-medium-chain-fatty-acid-rich-diets
#2
Eugene Du Toit, Liam Browne, Helen Irving-Rodgers, Helen M Massa, Nicolette Fozzard, Michael P Jennings, Ian R Peak
PURPOSE: Although there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the pro-inflammatory, medium chain fatty acid receptor (GPR84) in the aetiology of obesity and glucose intolerance is not well characterised. We set out to determine whether GPR84 expression influences obesity and glucose intolerance susceptibility in MCFA and LCFA rich diet fed mice...
April 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28428059/the-decreased-growth-performance-and-impaired-immune-function-and-structural-integrity-by-dietary-iron-deficiency-or-excess-are-associated-with-tor-nf-%C3%AE%C2%BAb-p38mapk-nrf2-and-mlck-signaling-in-head-kidney-spleen-and-skin-of-grass-carp-ctenopharyngodon-idella
#3
Yan-Lin Guo, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Qiu Zhou, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Lin Feng
This study was conducted to investigate the effects of dietary iron on the growth, and immune function and structural integrity in head kidney, spleen and skin as well as the underlying signaling of young grass carp (Ctenopharyngodon idella). Total 630 grass carp (242.32 ± 0.58 g) were fed diets containing graded levels of iron at 12.15 (basal diet), 35.38, 63.47, 86.43, 111.09, 136.37 mg/kg (diets 2-6 were added with ferrous fumarate) and 73.50 mg/kg (diet 7 was added with ferrous sulfate) diet for 60 days...
April 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28427564/inflammation-in-epileptic-encephalopathies
#4
Oleksii Shandra, Solomon L Moshé, Aristea S Galanopoulou
West syndrome (WS) is an infantile epileptic encephalopathy that manifests with infantile spasms (IS), hypsarrhythmia (in ~60% of infants), and poor neurodevelopmental outcomes. The etiologies of WS can be structural-metabolic pathologies (~60%), genetic (12%-15%), or of unknown origin. The current treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhibitor vigabatrin, while ketogenic diet can be given as add-on treatment in refractory IS...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28424360/intermittent-hypoxia-in-obstructive-sleep-apnoea-mediates-insulin-resistance-through-adipose-tissue-inflammation
#5
Aoife M Murphy, Amandine Thomas, Sophie J Crinion, Brian D Kent, Murtaza M Tambuwala, Aurelie Fabre, Jean-Louis Pepin, Helen M Roche, Claire Arnaud, Silke Ryan
Obstructive sleep apnoea (OSA) is increasingly associated with insulin resistance. The underlying pathophysiology remains unclear but intermittent hypoxia (IH)-mediated inflammation and subsequent dysfunction of the adipose tissue has been hypothesised to play a key role.We tested this hypothesis employing a comprehensive translational approach using a murine IH model of lean and diet-induced obese mice, an innovative IH system for cell cultures and a tightly controlled patient cohort.IH led to the development of insulin resistance in mice, corrected for the degree of obesity, and reduced insulin-mediated glucose uptake in 3T3-L1 adipocytes, associated with inhibition of the insulin-signalling pathway and downregulation of insulin-receptor substrate-1 mRNA...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28414868/protective-effects-of-diallyl-sulphide-against-ethanol-induced-injury-in-rat-adipose-tissue-and-primary-human-adipocytes
#6
Venkata Harini Kema, Imran Khan, Reshma Jamal, Sandeep Kumar Vishwakarma, Chandrakala Lakki Reddy, Kirti Parwani, Farhin Patel, Dhara Patel, Aleem A Khan, Palash Mandal
BACKGROUND: Alcohol consumption is the fourth leading cause of death and disability worldwide. Several cellular pathways contribute to alcohol mediated tissue injury. Adipose tissue apart from being functioning as an endocrine organ secretes several hormones and cytokines known as adipokines that are known to play a significant role in alcohol induced tissue damage. OBJECTIVE: This study was designed to test the efficacy of diallyl sulphide (DAS) in regulating the alcohol induced outcomes on adipose tissue...
April 17, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28412693/feeding-angptl4-mice-trans-fat-promotes-foam-cell-formation-in-mesenteric-lymph-nodes-without-leading-to-ascites
#7
Antwi Boasiako Oteng, Asmita Bhattacharya, Susanne Brodesser, Ling Qi, Nguan Soon Tan, Sander Kersten
ANGPTL4 regulates plasma triglyceride levels by inhibiting lipoprotein lipase. Inactivation of ANGPTL4 decreases plasma triglycerides and reduces risk of coronary artery disease. Unfortunately, targeting ANGPTL4 for the therapeutic management of dyslipidemia and atherosclerosis is hampered by the observation that mice and monkeys in which ANGPTL4 is inactivated exhibit lipid accumulation in mesenteric lymph nodes. In mice these pathological events exclusively unfold upon feeding a high saturated fatty acid diet and are followed by an ultimately lethal pro-inflammatory response and chylous ascites...
April 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28412308/genistein-prevention-of-hyperglycemia-and-improvement-of-glucose-tolerance-in-adult-non-obese-diabetic-mice-are-associated-with-alterations-of-gut-microbiome-and-immune-homeostasis
#8
Guannan Huang, Joella Xu, Daniel E Lefever, Travis C Glenn, Tamas Nagy, Tai L Guo
Although studies have linked soy phytoestrogen 4,7,4-trihydroxyisoflavone genistein (GEN) to reduced type 1 diabetes (T1D) risk, the mechanism of dietary GEN on T1D remains unknown. In our studies, adult non-obese diabetic (NOD) mouse model was employed to investigate the effects of GEN exposure on blood glucose level (BGL), glucose tolerance, gut microbiome, and immune responses. Adult male and female NOD mice were fed with either soy-based or casein-based diet, and received GEN at 20mg/kg body weight by gavage daily...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28409336/dietary-docosahexaenoic-acid-and-trans-10-cis-12-conjugated-linoleic-acid-differentially-alter-oxylipin-profiles-in-mouse-periuterine-adipose-tissue
#9
Yuriko Adkins, Benjamin J Belda, Theresa L Pedersen, Dawn M Fedor, Bruce E Mackey, John W Newman, Darshan S Kelley
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, trans-10, cis-12-conjugated linoleic acid (CLA; 18:2n-6) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting...
April 13, 2017: Lipids
https://www.readbyqxmd.com/read/28407740/mu-opioid-receptor-and-delta-opioid-receptor-differentially-regulate-microglial-inflammatory-response-to-control-proopiomelanocortin-neuronal-apoptosis-in-the-hypothalamus-effects-of-neonatal-alcohol
#10
Pallavi Shrivastava, Miguel A Cabrera, Lucy G Chastain, Nadka I Boyadjieva, Shaima Jabbar, Tina Franklin, Dipak K Sarkar
BACKGROUND: Opioid receptors are known to control neurotransmission of various peptidergic neurons, but their potential role in regulation of microglia and neuronal cell communications is unknown. We investigated the role of mu-opioid receptors (MOR) and delta-opioid receptors (DOR) on microglia in the regulation of apoptosis in proopiomelanocortin (POMC) neurons induced by neonatal ethanol in the hypothalamus. METHODS: Neonatal rat pups were fed a milk formula containing ethanol or control diets between postnatal days 2-6...
April 14, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28394363/interleukin-18-mediates-cardiac-dysfunction-induced-by-western-diet-independent-of-obesity-and-hyperglycemia-in-the-mouse
#11
S Carbone, P J H Lee, A G Mauro, E Mezzaroma, R Buzzetti, B Van Tassell, A Abbate, S Toldo
Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized inflammatory mechanisms. We hypothesized that the detrimental cardiac effects of WD are mediated by interleukin-18 (IL-18), pro-inflammatory cytokine linked to cardiac dysfunction. C57BL/6J wild-type male mice and IL-18 knockout male mice were fed high-saturated fat and high-sugar diet for 8 weeks...
April 10, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28394002/supplementation-with-omega-3-acids-after-myocardial-infarction-and-modification-of-inflammatory-markers-in-light-of-the-patients-diet-a-preliminary-study
#12
Magdalena Makarewicz-Wujec, Gabriela Parol, Andrzej Parzonko, Małgorzata Kozłowska-Wojciechowska
BACKGROUND: Neuroendocrine activation, activation of proinflammatory cytokines and platelets, and endothelial dysfunction play a significant role in development of heart failure. AIM: The aim of the work was to assess the effect of supplementation with EPA and DHA in adaily dose of 1g on selected inflammatory markers and platelet activation in patients with heart failure after recent myocardial infarction in light of their diet. M ETHODS: This preliminary study was arandomised, double-blind trial involving 30patients with post-infarction heart failure...
April 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28388927/exposure-to-gestational-diabetes-mellitus-induces-neuroinflammation-derangement-of-hippocampal-neurons-and-cognitive-changes-in-rat-offspring
#13
Billy Vuong, Gary Odero, Stephanie Rozbacher, Mackenzie Stevenson, Stephanie M Kereliuk, Troy J Pereira, Vernon W Dolinsky, Tiina M Kauppinen
BACKGROUND: Birth cohort studies link gestational diabetes mellitus (GDM) with impaired cognitive performance in the offspring. However, the mechanisms involved are unknown. We tested the hypothesis that obesity-associated GDM induces chronic neuroinflammation and disturbs the development of neuronal circuitry resulting in impaired cognitive abilities in the offspring. METHODS: In rats, GDM was induced by feeding dams a diet high in sucrose and fatty acids. Brains of neonatal (E20) and young adult (15-week-old) offspring of GDM and lean dams were analyzed by immunohistochemistry, cytokine assay, and western blotting...
April 7, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28386616/molecular-adaptations-underlying-the-beneficial-effects-of-hydroxytyrosol-in-the-pathogenic-alterations-induced-by-a-high-fat-diet-in-mouse-liver-ppar-%C3%AE-and-nrf2-activation-and-nf-%C3%AE%C2%BAb-down-regulation
#14
Rodrigo Valenzuela, Paola Illesca, Francisca Echeverría, Alejandra Espinosa, Miguel Ángel Rincón-Cervera, Macarena Ortiz, María Catalina Hernandez-Rodas, Alfonso Valenzuela, Luis A Videla
SCOPE: Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by an increment in the liver fat content, with a concomitant reduction in the content of n-3-long chain polyunsaturated fatty acids (n-3 LCPUFAs), downregulation of PPAR-α activity, and upregulation of NF-κB activity, effects that induce pro-lipogenic and pro-inflammatory responses. Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28386236/metabolic-response-of-visceral-white-adipose-tissue-of-obese-mice-exposed-for-5-days-to-human-room-temperature-compared-to-mouse-thermoneutrality
#15
Inge van der Stelt, Femke Hoevenaars, Jitka Široká, Lidwien de Ronde, David Friedecký, Jaap Keijer, Evert van Schothorst
Housing of laboratory mice at room temperature (22°C) might be considered a constant cold stress, which induces a thermogenic program in brown adipose tissue (BAT). However, the early adaptive response of white adipose tissue (WAT), the fat storage organ of the body, to a change from thermoneutrality to room temperature is not known. This was investigated here for various WAT depots, focusing on epididymal WAT (eWAT), widely used as reference depot. Male adult diet-induced obese (DIO) C57BL/6JOlaHsd mice housed at thermoneutrality (29°C), were for 5 days either switched to room temperature (22°C) or remained at thermoneutrality...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28379213/energy-dense-diet-triggers-changes-in-gut-microbiota-reorganization-of-gut%C3%A2-brain-vagal-communication-and-increases-body-fat-accumulation
#16
Alexandra C Vaughn, Erin M Cooper, Patricia M DiLorenzo, Levi J O'Loughlin, Michael E Konkel, James H Peters, Andras Hajnal, Tanusree Sen, Sun Hye Lee, Claire B de La Serre, Krzysztof Czaja
Obesity is associated with consumption of energy-dense diets and development of systemic inflammation. Gut microbiota play a role in energy harvest and inflammation and can influence the change from lean to obese phenotypes. The nucleus of the solitary tract (NTS) is a brain target for gastrointestinal signals modulating satiety and alterations in gut-brain vagal pathway may promote overeating and obesity. Therefore, we tested the hypothesis that high-fat diet‑induced changes in gut microbiota alter vagal gut-brain communication associated with increased body fat accumulation...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28377725/gut-microbiota-dependent-metabolite-trimethylamine-n-oxide-contributes-to-cardiac-dysfunction-in-western-diet-induced-obese-mice
#17
Kui Chen, Xiaoqian Zheng, Mingchen Feng, Dongliang Li, Hongqi Zhang
Excessive consumption of diets high in sugars and saturated fat, frequently known as western diet (WD), may lead to obesity and metabolic syndrome. Recent evidence shows that WD-induced obesity impairs cardiac function, but the underlying mechanisms are not fully understood. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of specific dietary nutrients, has emerged as a key contributor to cardiovascular disease pathogenesis. We tested the hypothesis that elevated circulating TMAO levels contribute to cardiac dysfunction in WD-induced obesity...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28376869/differential-circulating-concentrations-of-adipokines-glucagon-and-adropin-in-a-clinical-population-of-lean-overweight-and-diabetic-cats
#18
Rizaldy C Zapata, Melissa D Meachem, Natalia Cavalca Cardoso, Susan O Mehain, Chantal J McMillan, Elisabeth R Snead, Prasanth K Chelikani
BACKGROUND: Dyslipidemia, dysregulated adipokine secretion and alteration in glucagon and adropin concentrations are important obesity-related factors in the pathophysiology of human Type 2 diabetes; however, their roles in the pathophysiology of feline diabetes mellitus are relatively unknown. Here, we determined the concentrations of circulating leptin, adiponectin, pro-inflammatory cytokines, glucagon, adropin, triglycerides, and cholesterol, in non-diabetic lean and overweight cats and newly diagnosed diabetic cats...
April 4, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28376792/dietary-inflammatory-index-and-risk-of-first-myocardial-infarction-a-prospective-population-based-study
#19
Stina Bodén, Maria Wennberg, Bethany Van Guelpen, Ingegerd Johansson, Bernt Lindahl, Jonas Andersson, Nitin Shivappa, James R Hebert, Lena Maria Nilsson
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up...
April 4, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28374780/inhibition-of-epidermal-growth-factor-receptor-attenuates-atherosclerosis-via-decreasing-inflammation-and-oxidative-stress
#20
Lintao Wang, Zhouqing Huang, Weijian Huang, Xuemei Chen, Peiren Shan, Peng Zhong, Zia Khan, Jingying Wang, Qilu Fang, Guang Liang, Yi Wang
Atherosclerosis is a progressive disease leading to loss of vascular homeostasis and entails fibrosis, macrophage foam cell formation, and smooth muscle cell proliferation. Recent studies have reported that epidermal growth factor receptor (EGFR) is involved vascular pathophysiology and in the regulation of oxidative stress in macrophages. Although, oxidative stress and inflammation play a critical role in the development of atherosclerosis, the underlying mechanisms are complex and not completely understood...
April 4, 2017: Scientific Reports
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