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Pro- inflammatory diet

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https://www.readbyqxmd.com/read/27909428/rapid-fermentable-substance-modulates-interactions-between-ruminal-commensals-and-toll-like-receptors-in-promotion-of-immune-tolerance-of-goat-rumen
#1
Hong Shen, Zhongyan Lu, Zhan Chen, Yufeng Wu, Zanming Shen
Whether dietary non-fiber carbohydrate (NFC), a rapid fermentable substance, affects immune homeostasis of rumen through the modulation of interactions of ruminal microbiota and epithelial toll-like receptors (TLRs) remains unclear. A combination of 16S rRNA amplicon sequencing and quantitative PCRs was applied to study the synergetic responses of ruminal microbiota and epithelial TLRs to the dietary NFC switch from 15 to 31% in the goat model. The results showed that the 31% NFC diet caused the radical increases on the richness and diversity of rumen microbiota...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27906427/the-role-of-diet-on-gut-microbiota-composition
#2
S Bibbò, G Ianiro, V Giorgio, F Scaldaferri, L Masucci, A Gasbarrini, G Cammarota
Gut microbiota is characterized by an inter-individual variability due to genetic and environmental factors. Among the environmental ones, dietary habits play a key role in the modulation of gut microbiota composition. There are main differences between the intestinal microbiota of subjects fed with prevalent Western diet and that of subjects with a diet rich in fibers. Specific changes in the composition of gut microbiota have been demonstrated among subjects according to a different dietary intake. A particular diet may promote the growth of specific bacterial strains, driving hosts to a consequent alteration of fermentative metabolism, with a direct effect on intestinal pH, which can be responsible for the development of a pathogenic flora...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27903745/inhibiting-microglia-expansion-prevents-diet-induced-hypothalamic-and-peripheral-inflammation
#3
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye, Daniela Cota
Cell proliferation and neuroinflammation in the adult hypothalamus may contribute to the pathogenesis of obesity. Here we tested whether the intertwining of these two processes has a role in the metabolic changes caused by three weeks of saturated high-fat diet (HFD) consumption.As compared to chow, HFD-fed mice rapidly increased body weight and fat mass, and specifically showed increased microglia number in the arcuate nucleus (ARC) of the hypothalamus. Microglia expansion required the adequate presence of fats and carbohydrates in the diet, since feeding mice a very high-fat, very low-carbohydrate diet did not affect cell proliferation...
November 30, 2016: Diabetes
https://www.readbyqxmd.com/read/27895640/%C3%AF-3-polyunsaturated-fatty-acids-as-immunomodulators-in-colorectal-cancer-new-potential-role-in-adjuvant-therapies
#4
REVIEW
Stefania Miccadei, Roberta Masella, Anna Maria Mileo, Sandra Gessani
Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabolic pathways. Colorectal cancer (CRC) is one of the leading causes of death worldwide. Antineoplastic drugs are widely used for CRC treatment, but drug resistance and/or off-target toxicity limit their efficacy...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27895415/factoring-the-intestinal-microbiome-into-the-pathogenesis-of-autoimmune-hepatitis
#5
EDITORIAL
Albert J Czaja
The intestinal microbiome is a reservoir of microbial antigens and activated immune cells. The aims of this review were to describe the role of the intestinal microbiome in generating innate and adaptive immune responses, indicate how these responses contribute to the development of systemic immune-mediated diseases, and encourage investigations that improve the understanding and management of autoimmune hepatitis. Alterations in the composition of the intestinal microflora (dysbiosis) can disrupt intestinal and systemic immune tolerances for commensal bacteria...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27894396/ellagic-acid-ameliorates-cuprizone-induced-acute-cns-inflammation-via-restriction-of-microgliosis-and-down-regulation-of-ccl2-and-ccl3-pro-inflammatory-chemokines
#6
N Sanadgol, F Golab, A Mostafaie, M Mehdizadeh, M Abdollahi, M Sharifzadeh, H Ravan
Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities. However, the efficacy of EA has not been examined in neuro-inflammatory conditions. Microglia making the innate immune system of the central nervous system (CNS) and are imperative cellular mediators of neuro-inflammatory processes. In this study, neuro-protective effects of EA on cuprizone (Cup)-induced acute CNS inflammation evaluated. C57BL/6J mice were fed with chow containing 0.2 % Cup for 3 weeks to induce acute neuro-inflammation predominantly in the corpus callosum (CC)...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27894064/dietary-gossypol-suppressed-postprandial-tor-signaling-and-elevated-er-stress-pathways-in-turbot-scophthalmus-maximus-l
#7
Fuyun Bian, Haowen Jiang, Mingsan Man, Kangsen Mai, Huihui Zhou, Wei Xu, Gen He
Gossypol is known to be a polyphenolic compound toxic to animals. However, its molecular targets are far from fully characterized. To evaluate the physiological and molecular effects of gossypol, we chose turbot (Scophthalmus maximus L.), a carnivorous fish as our model species. Juvenile turbots (7.83 ± 0.02 g) were fed with diets containing gradient levels of gossypol at 0 (G0), 600 (G1) and 1,200 (G2) mg/kg diets for 11 weeks. After the feeding trial, fish growth, body protein and fat contents were significantly reduced in G2 group compared with those of G0 group (P< 0...
November 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27878970/association-between-the-dietary-inflammatory-index-dii-and-telomere-length-and-c-reactive-protein-from-the-national-health-and-nutrition-examination-survey-1999-2002
#8
Nitin Shivappa, Michael D Wirth, Thomas G Hurley, James R Hébert
BACKGROUND: Leukocyte telomere length (LTL) is an important biomarker of aging. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory Index(TM) (DII) has an impact on telomere shortening in the National Health and Nutrition Examination Survey (NHANES). We also carried out validation of the DII with C-reactive protein (CRP). METHODS: Data came from NHANES 1999-2002. LTL and CRP were assayed from leukocyte DNA and serum specimens, respectively...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27870582/markers-of-islet-endothelial-dysfunction-occur-in-male-db-db-mice-and-may-contribute-to-reduced-insulin-release
#9
Meghan F Hogan, Amy W Liu, Michael J Peters, Joshua R Willard, Zaheen Rabbani, Erik C Bartholomew, Adam Ottley, Rebecca L Hull
Islet endothelial cells produce paracrine factors that support β-cell function and growth. Endothelial dysfunction underlies diabetic microvascular complications; thus we hypothesized that in diabetes, islet endothelial cells become dysfunctional and this may contribute to β-cell secretory dysfunction. Islets/islet endothelial cells were isolated from diabetic db/db mice, treated with or without the glucose-lowering agent phlorizin, or C57BL/6J mice fed a high fat diet for 18 weeks (and appropriate controls)...
November 21, 2016: Endocrinology
https://www.readbyqxmd.com/read/27865615/association-between-the-dietary-inflammatory-index-waist-to-hip-ratio-and-metabolic-syndrome
#10
Alexis Sokol, Michael D Wirth, Marta Manczuk, Nitin Shivappa, Katarzyna Zatonska, Thomas G Hurley, James R Hébert
Inflammation due to poor diet may contribute to the development of metabolic syndrome (MetSyn). The Dietary Inflammatory Index (DII) was created to characterize diet on a scale from anti- to pro-inflammatory. Our hypothesis was that higher (i.e., more pro-inflammatory) DII scores are associated with an increased prevalence of MetSyn compared to those with lower (i.e., more anti-inflammatory) DII scores. Data from the Polish-Norwegian (PONS) Study were analyzed using logistic and linear regression procedures in SAS (version 9...
April 19, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27861825/high-smad7-sustains-inflammatory-cytokine-response-in-refractory-celiac-disease
#11
Silvia Sedda, Veronica De Simone, Irene Marafini, Gerolamo Bevivino, Roberta Izzo, Omero Alessandro Paoluzi, Alfredo Colantoni, Angela Ortenzi, Paolo Giuffrida, Gino R Corazza, Alessandro Vanoli, Antonio Di Sabatino, Francesco Pallone, Giovanni Monteleone
Refractory celiac disease (RCD) is a form of celiac disease (CD) resistant to gluten-free diet and associated with elevated risk of complications. Many effector cytokines over-produced in the gut of RCD patients are supposed to amplify the tissue-destructive immune response, but it remains unclear if the RCD-associated mucosal inflammation is sustained by defects in counter-regulatory mechanisms. The aim of the present study was to determine whether RCD-related inflammation is marked by high Smad7, an intracellular inhibitor of transforming growth factor (TGF)-β1 activity...
November 14, 2016: Immunology
https://www.readbyqxmd.com/read/27860246/prospective-study-of-the-dietary-inflammatory-index-and-risk-of-breast-cancer-in-postmenopausal-women
#12
Nitin Shivappa, Cindy K Blair, Anna E Prizment, David R Jacobs, James R Hébert
SCOPE: Diet in relation to breast cancer etiology has been studied widely, but results have remained inconsistent. Various dietary components including fruits, vegetables, and meat have been implicated through their effects on inflammation. Using data from the Iowa Women's Health Study we examine prospectively the association between the dietary inflammatory index (DII) and breast cancer incidence. METHODS AND RESULTS: DII scores were computed based on baseline dietary intake assessed by a validated 121-item food frequency questionnaire in a cohort of 34,700 women, aged 55-69 years at recruitment in 1986 and followed for incident breast cancer...
November 10, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27859576/ccr5-deficiency-exacerbates-alcoholic-fatty-liver-disease-through-pro-inflammatory-cytokines-and-chemokines-induced-hepatic-inflammation
#13
Ju Ho Park, Dong Hun Lee, Mork Soon Park, Young Suk Jung, Jin Tae Hong
BACKGROUND AND AIM: Chemokines and chemokine receptors implicated with alcoholic liver disease. Studies have shown that inflammation and oxidative stress induce fat molecules aggregation in liver. We evaluated the relationship between alcoholic fatty liver disease and c-c chemokine receptor 5 and impact of inflammation and oxidative stress in fat molecule deposition. METHODS: Lieber-DeCarli diet containing ethanol or isocaloric control diets were fed to wildtype and CCR5 knockout mice for 10 days, and gavaged with a single dose of ethanol or isocaloric maltose dextrin at 11 day...
November 17, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27858942/interferon-beta-overexpression-attenuates-adipose-tissue-inflammation-and-high-fat-diet-induced-obesity-and-maintains-glucose-homeostasis
#14
M Alsaggar, M Mills, D Liu
The worldwide prevalence of obesity is increasing, raising health concerns regarding obesity-related complications. Chronic inflammation has been characterized as a major contributor to the development of obesity and obesity-associated metabolic disorders. The purpose of the current study is to assess whether the overexpression of interferon beta (IFNβ1), an immune-modulating cytokine, will attenuate high-fat diet-induced adipose inflammation and protect animals against obesity development. Using hydrodynamic gene transfer to elevate and sustain blood concentration of IFNβ1 in mice fed a high-fat diet, we showed that the overexpression of Ifnβ1 gene markedly suppressed immune cell infiltration into adipose tissue, and attenuated production of pro-inflammatory cytokines...
December 1, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27853810/inflammation-but-not-recruitment-of-adipose-tissue-macrophages-requires-signalling-through-mac-1-cd11b-cd18-in-diet-induced-obesity-dio
#15
Dennis Wolf, Nora Bukosza, David Engel, Marjorie Poggi, Felix Jehle, Nathaly Anto Michel, Yung-Chih Chen, Christian Colberg, Natalie Hoppe, Bianca Dufner, Louis Boon, Hermann Blankenbach, Ingo Hilgendorf, Constantin von Zur Muhlen, Jochen Reinöhl, Björn Sommer, Timoteo Marchini, Mark A Febbraio, Christian Weber, Christoph Bode, Karlheinz Peter, Esther Lutgens, Andreas Zirlik
Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, αMβ2) is a classic adhesion receptor critically regulating inflammatory cell recruitment. Here, we tested the hypothesis that a genetic deficiency and a therapeutic modulation of Mac-1 regulate adipose tissue inflammation in a mouse model of diet-induced obesity (DIO). C57Bl6/J mice genetically deficient (Mac-1(-/-)) or competent for Mac-1 (WT) consumed a high fat diet for 20 weeks. Surprisingly, Mac-1(-/-) mice presented with increased diet-induced weight gain, decreased insulin sensitivity in skeletal muscle and in the liver in insulin-clamps, insulin secretion deficiency and elevated glucose levels in fasting animals, and dyslipidaemia...
November 17, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27853291/a-high-fat-high-sucrose-diet-rapidly-alters-muscle-integrity-inflammation-and-gut-microbiota-in-male-rats
#16
Kelsey H Collins, Heather A Paul, David A Hart, Raylene A Reimer, Ian C Smith, Jaqueline L Rios, Ruth A Seerattan, Walter Herzog
The chronic low-level inflammation associated with obesity is known to deleteriously affect muscle composition. However, the manner in which obesity leads to muscle loss has not been explored in detail or in an integrated manner following a short-term metabolic challenge. In this paper, we evaluated the relationships between compromised muscle integrity, diet, systemic inflammatory mediators, adipose tissue, and gut microbiota in male Sprague-Dawley rats. We show that intramuscular fat, fibrosis, and the number of pro-inflammatory cells increased by 3-days and was sustained across 28-days of high-fat high-sugar feeding compared to control-diet animals...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27847215/grape-seed-and-skin-extract-reduces-pancreas-lipotoxicity-oxidative-stress-and-inflammation-in-high-fat-diet-fed-rats
#17
Faten Aloui, Kamel Charradi, Aziz Hichami, Selvakumar Subramaniam, Naim Akhtar Khan, Ferid Limam, Ezzedine Aouani
Obesity is related to an elevated risk of diabetes and the mechanisms whereby fat adversely affects the pancreas are poorly understood. We studied the effect of a high fat diet (HFD) on pancreas steatosis, oxidative stress and inflammation as well as the putative protection afforded by grape seed and skin extract (GSSE). HFD induced body weight gain, without affecting insulinemia, nor glycemia and dropped adiponectemia. HFD also provoked the ectopic deposition of cholesterol and triglyceride, and an oxidative stress characterized by increased lipoperoxidation and carbonylation, inhibition of antioxidant enzyme activities such as CAT, GPx and SOD, depletion of zinc and a concomitant increase in calcium and H2O2...
November 12, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27845068/combination-of-metformin-and-vsl-3-additively-suppresses-western-style-diet-induced-colon-cancer-in-mice
#18
Eun-Ju Chung, Eun-Ju Do, Sang-Yeob Kim, Eun A Cho, Dong-Hee Kim, Sehyung Pak, Sung Wook Hwang, Hyo Jeong Lee, Jeong-Sik Byeon, Byong Duk Ye, Dong Hoon Yang, Sang Hyoung Park, Suk-Kyun Yang, Jin-Ho Kim, Seung-Jae Myung
Western-style diet (WD) and dysbiosis are known to be associated with colonic inflammation, which contributes to carcinogenesis. Metformin (Met) exerts anti-inflammatory effects to induce AMP-activated protein kinase (AMPK), resulting in suppressed protein synthesis and reduced cell proliferation. Probiotic VSL#3 (V) modifies microbial composition. We investigated the chemopreventive mechanisms of Met and V in WD-induced colitis-associated colon carcinogenesis. Male BALB/c mice were randomly divided into five groups: a control diet (CD) group, WD group, WD+ Met (250mg/kg/day) group, WD+V (1...
November 12, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27832859/dietary-fat-drives-whole-body-insulin-resistance-and-promotes-intestinal-inflammation-independent-of-body-weight-gain
#19
Benjamin A H Jensen, Thomas S Nielsen, Andreas M Fritzen, Jacob B Holm, Even Fjære, Annette K Serup, Kamil Borkowski, Steve Risis, Simone I Pærregaard, Ida Søgaard, Audrey Poupeau, Michelle Poulsen, Tao Ma, Christian Sina, Bente Kiens, Lise Madsen, Karsten Kristiansen, Jonas T Treebak
BACKGROUND: The obesogenic potential of high-fat diets (HFD) in rodents is attenuated when the protein:carbohydrate ratio is increased. However, it is not known if intake of an HFD irrespective of the protein:carbohydrate ratio and in the absence of weight gain, affects glucose homeostasis and the gut microbiota. METHODS: We fed C57BL6/J mice 3 different HFDs with decreasing protein:carbohydrate ratios for 8weeks and compared the results to a LFD reference group...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27832159/a-novel-selective-inhibitor-of-delta-5-desaturase-lowers-insulin-resistance-and-reduces-body-weight-in-diet-induced-obese-c57bl-6j-mice
#20
Hiroaki Yashiro, Shuichi Takagahara, Yumiko Okano Tamura, Ikuo Miyahisa, Junji Matsui, Hideo Suzuki, Shota Ikeda, Masanori Watanabe
Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory eicosanoids) while decreasing AA (precursor to pro-inflammatory eicosanoids), and could result in synergistic improvement in the low-grade inflammatory state. Here, we demonstrate reduced insulin resistance and the anti-obesity effect of a D5D selective inhibitor (compound-326), an orally active small-molecule, in a high-fat diet-induced obese (DIO) mouse model...
2016: PloS One
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