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Ana Isabel García-González, Zoraida Axtle-Serrano, Miriam López-Teros, Claudia Szlejf, Adrián Martínez-Ruiz, Oscar Rosas-Carrasco
Osteosarcopenic obesity (OSO) is a condition associated with adverse outcomes in older adults. Since it is a condition which includes three tissues (obesity, sarcopenia and osteopenia/osteoporosis), it requires simultaneous and multidisciplinary clinical interventions to revert it. Until this moment, there have been published review articles only focused on nutrition or physical activity. However, we believe that assembling the existing evidence on potential treatments (nutritional intervention with micro- and macronutrients), physical activity, farmacological treatment for osteopenia/osteoporosis, possible farmacological treatment for sarcopenia, and, finally, psychological interventions focused on the treatment of psychiatric comorbidities (such as anxiety or depression) will help healthcare providers to improve the body composition of older adults...
2018: Revista Médica del Instituto Mexicano del Seguro Social
Camilla Birgitte Sørensen, Nanette Mol Debes, Liselotte Skov, Maria J Miranda
Chronic tic disorder and Tourette syndrome are both chronic and impairing neurobiological disorders starting in childhood with a prevalence between 0.4 and 1.6%. Traditionally, pharmacological therapies have been first-line treatment but are often associated with adverse effects. Recently behavioural therapy has shown to be effective in treating tics and today both habit reversal (HR) and exposure and response prevention (ERP) are recommended as first-line treatments. HR and ERP are now available for Danish patients...
March 6, 2017: Ugeskrift for Laeger
G R Khakimova, T A Voronina, Yu L Dugina, I A Ertuzun, O I Epshtein
Antibodies to 5100 proteins (anti-5100) in release-active form (RA anti-5100) are an active component of some domestic drugs(tenoten, tenoten for children, divaza, brizantin, kolofort and proproten-100). The authors present the results of preclinical and clinical trials (with detailed consideration of experimental data) which demonstrated a wide spectrum of specific pharmacological activity and safety as well as mechanisms of anti-5100 action.
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Francesco Pelliccia, Francesco Romeo
Adherence to drug treatment is key to successful therapeutic intervention, especially in chronic conditions. This holds particularly true in the setting of cardiovascular diseases, because poor adherence may have serious adverse effects in terms of morbidity and mortality. Many factors may contribute to poor adherence, which can be either patient-related or dependent on the healthcare system, the physician and the environment. The identification and appropriate correction of these factors may result in both clinical and economic benefits...
January 2016: Recenti Progressi in Medicina
J Papík, H Procházka, L Šrámková, V Kňourek, M Pán
OBJECTIVE: To present a case of peripartal hemorrhage with a necessity to make a hysterectomy. DESIGN: Case Report. SETTING: Department of Obstetrics and Gynecology, Hospital Mladá Boleslav. CASE REPORT: We report a case of 34-year-old secundigravida secundipara in 40th week of pregnancy after caesarean section, when after an iterative caesarean section strong peripartal hemorrhage appeared with a necessity to make an urgent revision of an abdominal cavity...
January 2015: Ceská Gynekologie
María P Huertas-Vieco, Rafael Pérez-García, Marta Albalate, Patricia de Sequera, Mayra Ortega, Marta Puerta, Elena Corchete, Roberto Alcázar
BACKGROUND: The daily pill burden in hemodialysis patients is one of the highest reported to date in any chronic disease. The adherence to prescribed treatment has implications on the quality of life, the survival of patients, and the economic cost of their treatment, this being a priority public health issue. OBJECTIVE: To evaluate the adherence to pharmacological treatment examining, among the possible causes of non-adherence, psychosocial factors such as depression, anxiety, cognitive impairment and social support...
November 17, 2014: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
A G Petrov, S V Denisova, O V Odintseva, S N Raudina
To improve miners' health nowadays, effective application of available means and implication of economic management methods are necessary, as quality medical and pharmaceutic care for miners requires significant financial, material and working efforts both from the government and from every institution operating in health care.
2014: Meditsina Truda i Promyshlennaia Ekologiia
T A Obut, M V Ovsiukova, S A Egorova, T A Érdynieva, T Iu Dement'eva, E T Obut
The experiments were performed on male rats, which were subjected to single and multiply repeated vibrations (low-frequency, horizontal, high-amplitude) analogous to the action of motor transport vibrations. It is established that the administration of retabolil produces a hypotensive effect and blocks the vibration-induced increase in the level of hypertensive hormone aldosterone. Under conditions of the multiply repeated action of vibrations, both effects were realized via micro-opioid receptors. In the case of a single action, these receptors were only involved in a hypotensive effect but not mediated in aldosterone suppression...
2014: Eksperimental'naia i Klinicheskaia Farmakologiia
G Nosáľova, L Jureček, J Turjan, P Capek, L Prisenžňáková, S Fraňová
Hemicellulose polysaccharides represent a large group of natural renewable polymers, however, their application potency is still low. In our study a hardwood 4-O-methylglucuronoxylan was isolated by alkali peroxide extraction of Fagus sylvatica sawdust and modified into sulfated water soluble derivative (MGXS). Highly sulfated MGXS was characterized by HPLC, FTIR and NMR spectroscopies, and tested in vivo on chemically induced cough reflex and smooth muscles reactivity. Farmacological tests revealed an interesting antitussive activity of MGXS...
June 2014: International Journal of Biological Macromolecules
Rafał Nieckarz, Joanna Szaleniec, Patryk Hartwich, Agnieszka Wróbel, Karolina Hydzik-Sobocińska, Piotr Muszyński, Beata Markiewicz, Łukasz Turczynowski, Jacek Składzień, Paweł Strek
It is estimated that in Europe 10% of adults suffer from chronic sinusitis. Chronic sinusitis can be caused by many different diseases that share chronic inflammation of the sinuses as a common symptom. Rhinitis can be caused by stomach acid coming up from the stomach into the esophagus, which successively can result in chronic sinusitis. The current gold standard for diagnosing GERD is--bothersome for the patient--24 h esophageal pH monitoring. This method can be unpleasant for the patients, which makes it less acceptable...
2013: Przegla̧d Lekarski
Verónica Giubergia, Fernando Rentería, Gabriela Bauer, Hebe González Pena, Fernando Vila, Verónica Giubergia, Alicia Michelini, Verónica Aguerre, Conrado Llapur, Diana Fariña, Dora Haag, Virginia D'Alessandro
No abstract text is available yet for this article.
June 2013: Archivos Argentinos de Pediatría
Erika Paniago Guedes, Alexandre Hohl, Thais Gomes de Melo, Felipe Lauand
Type 2 diabetes mellitus (T2DM) has a high prevalence and incidence around the world. The complex pathophysiology mechanism is among the barriers for diabetes treatment. Type 2 diabetes patients have dysfunction in incretin hormones (as glucagon-like peptide-1 or GLP-1, and glucose-dependent insulinotropic polypeptide or GIP). By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, it is possible to slow the inactivation of GLP-1 and GIP, promoting blood glucose level reduction in a glucose-dependent manner...
May 22, 2013: Diabetology & Metabolic Syndrome
J Ferrís, O Berbel, J Alonso-López, J Garcia, J A Ortega
CONTEXT: Bladder carcinoma (BC), due its high morbidity and relapsing course, generates significant economic and health care costs. Accordingly, review the environmental nonoccupational risk factors (RF), more or less evidence-based, in the etiology and pathogenesis of BC, because the involvement of urologists is essential for prevention. ACQUISITION OF EVIDENCE: Review of the peer-reviewed literature (1987-2012) on nonoccupational environmental RF associated with BC retrieved from Medline, Embase and Science Citation Index...
October 2013: Actas Urologicas Españolas
Krystian Stachoń, Józefa Dabek, Daniel Jakubowski, Wojciech Rychlik
UNLABELLED: Calcium channel blockers are drugs often used in circulatory system diseases. Their overdose can cause asystoly, III grade of atrioventricular dissociation, heart insufficiency and cardiogenic shock. Due to wide availability of these drugs access to them for subjects who want commit suicide is easy. In a specialist literature predominantly you can find case reports about calcium channel blockers suicidal overdose. Our experience includes 12 such cases. The aim of the study was to analyze patients after suicidal calcium channel blockers overdose...
September 2011: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
M Rosa, A Pascarella, G Parenti, S Buono, A Romano, R Della Casa, G Andria, M Marino, M P Riccio, C Bravaccio
PURPOSE: evaluate the psychomotor evolution of a child with Multiple acyl-CoA dehydrogenase deficiency after treatment with L-carnitine, ubiquinone and riboflavin. METHODS: an assessment of psychomotor development was performed before the start of farmacological treatment using the Assessment Scale of Mental Development Griffiths (GMDS-R, 0-2 years). The same assessment was performed after a month and after six months of treatment to evaluate the possible benefits of treatment...
March 2012: European Journal of Paediatric Neurology: EJPN
M Brtko, J Vojácek, M Tuna, P Telekes
Bicuspid aortic valve is a disease with autosomal dominant inheritance with small penetration. The population of patients with bicuspid aortic valve is heterogenous. In the absence of dilatation of ascending aorta, valvular lesion or degenerative changes of valve leaflets patients are considered to belong to the low risk population. On the other hand patients with the above mentioned characteristics compose a high risk group. Dilatation of the ascending aorta in patients with bicuspid aortic valve has a progressive feature and continues even after replacement of the aortic valve...
February 2011: Vnitr̆ní Lékar̆ství
Jarbas Jakson Dinkhuysen, Reginaldo Cipullo, Carlos Contreras, Marco Aurélio Finger, Ricardo Manrique, Helio M Magalhães, Paulo Chaccur, João Rossi
BACKGROUND: Evaluation of pulmonary artery pressure just before transplanting with sodium nitroprusside may allow conversion to orthotopic technique. METHODS: Between 1992 and 2007, 228 transplants were performed systematically and this was used in seven patients with preoperative hemodynamic evaluation: Pre NP (mmHg) Post NP (mmHg) Systolic systemic blood pressure (PSAS) 108-78 (101.7 ± 10.9) 90-74 (79.5 ± 15.2) pulmonary arterial systolic pressure (PASP) 88-51 (69...
July 2010: Revista Brasileira de Cirurgia Cardiovascular
J Calls, Ma Rodríguez Calero, D Hernández Sánchez, Mj Gutiérrez Navarro, F Juan Amer, D Tura, Jj Torrijos
Pain in haemodialysis is very common, although frequently underdiagnosed. Chronic pain in dialysis has been scarcely evaluated, and intradialytic pain has not been specifically analyzed. Our aim was to compare intradialytic versus chronic pain characteristics in the same group of twenty-seven hemodialyzed patients, to investigate whether there were or not differences between them. Several validated scales were used: a) Analogical Visual Scale, defines pain intensity from 0, no pain, to 10, the worst pain; b) Pain Management Index, that results from subtracting pain level from analgesic use, ranging from - 3 (inadequate) to + 3 (adequate management); c) McGill Pain Questionnaire, which defines three items: pain related qualitative index, number of words chosen, and present pain intensity; and d) Brief Pain Inventory, which analyses influence of pain in patient's life, was only aplicable to evaluate chronic pain...
2009: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Andrzej Woyda-Płoszczyca, Wiesława Jarmuszkiewicz
Enormous interest in mitochondrial uncoupling proteins (UCPs) is caused by relevant impact of these energy-dissipating systems on cellular energy transduction. A key role of UCPs in regulation of mitochondrial metabolism is supported by existence of their different isoforms in various mammalian tissues. Recent studies have shown that UCPs have an important part in pathogenesis of various disorders, such as obesity, type-2 diabetes, cachexia, aging or tumor. The obscure roles of UCPs in normal physiology and their emerging role in pathophysiology, provide exciting potential for further investigation...
2008: Postepy Biochemii
Piotr Muszyński, Jacek Składzień, E Reroń, P Strek, L Popielski, M Dutsch-Wicherel, S Kocoń, J Bartnik
Juvenile idiopathic arthritis (JCA) is an inflammatory systemic disease of connective tissue which etiology is still unknown. Progressive arthritis is the basic symptom, with pain, oedema, stiffness and movement impediment are typical for. Chronic process of arthritis might be accompanied by rheumatoid nodes, pericarditis, myocarditis, changes in the lungs and kidney, which appear with various frequency and indicates on systemic form of disease. The incudo-malleolar and incudo-stapedial joints are synovial in type...
2007: Otolaryngologia Polska
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