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JOURNAL ARTICLE
Timothy R Rebbeck, Nandita Mitra, Fei Wan, Olga M Sinilnikova, Sue Healey, Lesley McGuffog, Sylvie Mazoyer, Georgia Chenevix-Trench, Douglas F Easton, Antonis C Antoniou, Katherine L Nathanson, Yael Laitman, Anya Kushnir, Shani Paluch-Shimon, Raanan Berger, Jamal Zidan, Eitan Friedman, Hans Ehrencrona, Marie Stenmark-Askmalm, Zakaria Einbeigi, Niklas Loman, Katja Harbst, Johanna Rantala, Beatrice Melin, Dezheng Huo, Olufunmilayo I Olopade, Joyce Seldon, Patricia A Ganz, Robert L Nussbaum, Salina B Chan, Kunle Odunsi, Simon A Gayther, Susan M Domchek, Banu K Arun, Karen H Lu, Gillian Mitchell, Beth Y Karlan, Christine Walsh, Jenny Lester, Andrew K Godwin, Harsh Pathak, Eric Ross, Mary B Daly, Alice S Whittemore, Esther M John, Alexander Miron, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Linda Steele, Susan L Neuhausen, Yuan Chun Ding, Bent Ejlertsen, Anne-Marie Gerdes, Thomas v O Hansen, Teresa Ramón y Cajal, Ana Osorio, Javier Benitez, Javier Godino, Maria-Isabel Tejada, Mercedes Duran, Jeffrey N Weitzel, Kristie A Bobolis, Sharon R Sand, Annette Fontaine, Antonella Savarese, Barbara Pasini, Bernard Peissel, Bernardo Bonanni, Daniela Zaffaroni, Francesca Vignolo-Lutati, Giulietta Scuvera, Giuseppe Giannini, Loris Bernard, Maurizio Genuardi, Paolo Radice, Riccardo Dolcetti, Siranoush Manoukian, Valeria Pensotti, Viviana Gismondi, Drakoulis Yannoukakos, Florentia Fostira, Judy Garber, Diana Torres, Muhammad Usman Rashid, Ute Hamann, Susan Peock, Debra Frost, Radka Platte, D Gareth Evans, Rosalind Eeles, Rosemarie Davidson, Diana Eccles, Trevor Cole, Jackie Cook, Carole Brewer, Shirley Hodgson, Patrick J Morrison, Lisa Walker, Mary E Porteous, M John Kennedy, Louise Izatt, Julian Adlard, Alan Donaldson, Steve Ellis, Priyanka Sharma, Rita Katharina Schmutzler, Barbara Wappenschmidt, Alexandra Becker, Kerstin Rhiem, Eric Hahnen, Christoph Engel, Alfons Meindl, Stefanie Engert, Nina Ditsch, Norbert Arnold, Hans Jörg Plendl, Christoph Mundhenke, Dieter Niederacher, Markus Fleisch, Christian Sutter, C R Bartram, Nicola Dikow, Shan Wang-Gohrke, Dorothea Gadzicki, Doris Steinemann, Karin Kast, Marit Beer, Raymonda Varon-Mateeva, Andrea Gehrig, Bernhard H Weber, Dominique Stoppa-Lyonnet, Olga M Sinilnikova, Sylvie Mazoyer, Claude Houdayer, Muriel Belotti, Marion Gauthier-Villars, Francesca Damiola, Nadia Boutry-Kryza, Christine Lasset, Hagay Sobol, Jean-Philippe Peyrat, Danièle Muller, Jean-Pierre Fricker, Marie-Agnès Collonge-Rame, Isabelle Mortemousque, Catherine Nogues, Etienne Rouleau, Claudine Isaacs, Anne De Paepe, Bruce Poppe, Kathleen Claes, Kim De Leeneer, Marion Piedmonte, Gustavo Rodriguez, Katie Wakely, John Boggess, Stephanie V Blank, Jack Basil, Masoud Azodi, Kelly-Anne Phillips, Trinidad Caldes, Miguel de la Hoya, Atocha Romero, Heli Nevanlinna, Kristiina Aittomäki, Annemarie H van der Hout, Frans B L Hogervorst, Senno Verhoef, J Margriet Collée, Caroline Seynaeve, Jan C Oosterwijk, Johannes J P Gille, Juul T Wijnen, Encarna B Gómez Garcia, Carolien M Kets, Margreet G E M Ausems, Cora M Aalfs, Peter Devilee, Arjen R Mensenkamp, Ava Kwong, Edith Olah, Janos Papp, Orland Diez, Conxi Lazaro, Esther Darder, Ignacio Blanco, Mónica Salinas, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Grzegorz Sukiennicki, Tomasz Huzarski, Tomasz Byrski, Cezary Cybulski, Aleksandra Toloczko-Grabarek, Elżbieta Złowocka-Perłowska, Janusz Menkiszak, Adalgeir Arason, Rosa B Barkardottir, Jacques Simard, Rachel Laframboise, Marco Montagna, Simona Agata, Elisa Alducci, Ana Peixoto, Manuel R Teixeira, Amanda B Spurdle, Min Hyuk Lee, Sue K Park, Sung-Won Kim, Tara M Friebel, Fergus J Couch, Noralane M Lindor, Vernon S Pankratz, Lucia Guidugli, Xianshu Wang, Marc Tischkowitz, Lenka Foretova, Joseph Vijai, Kenneth Offit, Mark Robson, Rohini Rau-Murthy, Noah Kauff, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Gschwantler-Kaulich, Georg Pfeiler, Muy-Kheng Tea, Andreas Berger, Mark H Greene, Phuong L Mai, Evgeny N Imyanitov, Amanda Ewart Toland, Leigha Senter, Anders Bojesen, Inge Sokilde Pedersen, Anne-Bine Skytte, Lone Sunde, Mads Thomassen, Sanne Traasdahl Moeller, Torben A Kruse, Uffe Birk Jensen, Maria Adelaide Caligo, Paolo Aretini, Soo-Hwang Teo, Christina G Selkirk, Peter J Hulick, Irene Andrulis
IMPORTANCE: Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE: To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN, SETTING, AND PARTICIPANTS: Observational study of women who were ascertained between 1937 and 2011 (median, 1999) and found to carry disease-associated BRCA1 or BRCA2 mutations. The international sample comprised 19,581 carriers of BRCA1 mutations and 11,900 carriers of BRCA2 mutations from 55 centers in 33 countries on 6 continents...
April 7, 2015: JAMA
#2
JOURNAL ARTICLE
Wilson Leung, Christopher D Shaffer, Laura K Reed, Sheryl T Smith, William Barshop, William Dirkes, Matthew Dothager, Paul Lee, Jeannette Wong, David Xiong, Han Yuan, James E J Bedard, Joshua F Machone, Seantay D Patterson, Amber L Price, Bryce A Turner, Srebrenka Robic, Erin K Luippold, Shannon R McCartha, Tezin A Walji, Chelsea A Walker, Kenneth Saville, Marita K Abrams, Andrew R Armstrong, William Armstrong, Robert J Bailey, Chelsea R Barberi, Lauren R Beck, Amanda L Blaker, Christopher E Blunden, Jordan P Brand, Ethan J Brock, Dana W Brooks, Marie Brown, Sarah C Butzler, Eric M Clark, Nicole B Clark, Ashley A Collins, Rebecca J Cotteleer, Peterson R Cullimore, Seth G Dawson, Carter T Docking, Sasha L Dorsett, Grace A Dougherty, Kaitlyn A Downey, Andrew P Drake, Erica K Earl, Trevor G Floyd, Joshua D Forsyth, Jonathan D Foust, Spencer L Franchi, James F Geary, Cynthia K Hanson, Taylor S Harding, Cameron B Harris, Jonathan M Heckman, Heather L Holderness, Nicole A Howey, Dontae A Jacobs, Elizabeth S Jewell, Maria Kaisler, Elizabeth A Karaska, James L Kehoe, Hannah C Koaches, Jessica Koehler, Dana Koenig, Alexander J Kujawski, Jordan E Kus, Jennifer A Lammers, Rachel R Leads, Emily C Leatherman, Rachel N Lippert, Gregory S Messenger, Adam T Morrow, Victoria Newcomb, Haley J Plasman, Stephanie J Potocny, Michelle K Powers, Rachel M Reem, Jonathan P Rennhack, Katherine R Reynolds, Lyndsey A Reynolds, Dong K Rhee, Allyson B Rivard, Adam J Ronk, Meghan B Rooney, Lainey S Rubin, Luke R Salbert, Rasleen K Saluja, Taylor Schauder, Allison R Schneiter, Robert W Schulz, Karl E Smith, Sarah Spencer, Bryant R Swanson, Melissa A Tache, Ashley A Tewilliager, Amanda K Tilot, Eve VanEck, Matthew M Villerot, Megan B Vylonis, David T Watson, Juliana A Wurzler, Lauren M Wysocki, Monica Yalamanchili, Matthew A Zaborowicz, Julia A Emerson, Carlos Ortiz, Frederic J Deuschle, Lauren A DiLorenzo, Katie L Goeller, Christopher R Macchi, Sarah E Muller, Brittany D Pasierb, Joseph E Sable, Jessica M Tucci, Marykathryn Tynon, David A Dunbar, Levent H Beken, Alaina C Conturso, Benjamin L Danner, Gabriella A DeMichele, Justin A Gonzales, Maureen S Hammond, Colleen V Kelley, Elisabeth A Kelly, Danielle Kulich, Catherine M Mageeney, Nikie L McCabe, Alyssa M Newman, Lindsay A Spaeder, Richard A Tumminello, Dennis Revie, Jonathon M Benson, Michael C Cristostomo, Paolo A DaSilva, Katherine S Harker, Jenifer N Jarrell, Luis A Jimenez, Brandon M Katz, William R Kennedy, Kimberly S Kolibas, Mark T LeBlanc, Trung T Nguyen, Daniel S Nicolas, Melissa D Patao, Shane M Patao, Bryan J Rupley, Bridget J Sessions, Jennifer A Weaver, Anya L Goodman, Erica L Alvendia, Shana M Baldassari, Ashley S Brown, Ian O Chase, Maida Chen, Scott Chiang, Avery B Cromwell, Ashley F Custer, Tia M DiTommaso, Jad El-Adaimi, Nora C Goscinski, Ryan A Grove, Nestor Gutierrez, Raechel S Harnoto, Heather Hedeen, Emily L Hong, Barbara L Hopkins, Vilma F Huerta, Colin Khoshabian, Kristin M LaForge, Cassidy T Lee, Benjamin M Lewis, Anniken M Lydon, Brian J Maniaci, Ryan D Mitchell, Elaine V Morlock, William M Morris, Priyanka Naik, Nicole C Olson, Jeannette M Osterloh, Marcos A Perez, Jonathan D Presley, Matt J Randazzo, Melanie K Regan, Franca G Rossi, Melanie A Smith, Eugenia A Soliterman, Ciani J Sparks, Danny L Tran, Tiffany Wan, Anne A Welker, Jeremy N Wong, Aparna Sreenivasan, Jim Youngblom, Andrew Adams, Justin Alldredge, Ashley Bryant, David Carranza, Alyssa Cifelli, Kevin Coulson, Calise Debow, Noelle Delacruz, Charlene Emerson, Cassandra Farrar, Don Foret, Edgar Garibay, John Gooch, Michelle Heslop, Sukhjit Kaur, Ambreen Khan, Van Kim, Travis Lamb, Peter Lindbeck, Gabi Lucas, Elizabeth Macias, Daniela Martiniuc, Lissett Mayorga, Joseph Medina, Nelson Membreno, Shady Messiah, Lacey Neufeld, San Francisco Nguyen, Zachary Nichols, George Odisho, Daymon Peterson, Laura Rodela, Priscilla Rodriguez, Vanessa Rodriguez, Jorge Ruiz, Will Sherrill, Valeria Silva, Jeri Sparks, Geeta Statton, Ashley Townsend, Isabel Valdez, Mary Waters, Kyle Westphal, Stacey Winkler, Joannee Zumkehr, Randall J DeJong, Arlene J Hoogewerf, Cheri M Ackerman, Isaac O Armistead, Lara Baatenburg, Matthew J Borr, Lindsay K Brouwer, Brandon J Burkhart, Kelsey T Bushhouse, Lejla Cesko, Tiffany Y Y Choi, Heather Cohen, Amanda M Damsteegt, Jess M Darusz, Cory M Dauphin, Yelena P Davis, Emily J Diekema, Melissa Drewry, Michelle E M Eisen, Hayley M Faber, Katherine J Faber, Elizabeth Feenstra, Isabella T Felzer-Kim, Brandy L Hammond, Jesse Hendriksma, Milton R Herrold, Julia A Hilbrands, Emily J Howell, Sarah A Jelgerhuis, Timothy R Jelsema, Benjamin K Johnson, Kelly K Jones, Anna Kim, Ross D Kooienga, Erika E Menyes, Eric A Nollet, Brittany E Plescher, Lindsay Rios, Jenny L Rose, Allison J Schepers, Geoff Scott, Joshua R Smith, Allison M Sterling, Jenna C Tenney, Chris Uitvlugt, Rachel E VanDyken, Marielle VanderVennen, Samantha Vue, Nighat P Kokan, Kwabea Agbley, Sampson K Boham, Daniel Broomfield, Kayla Chapman, Ali Dobbe, Ian Dobbe, William Harrington, Marwan Ibrahem, Andre Kennedy, Chad A Koplinsky, Cassandra Kubricky, Danielle Ladzekpo, Claire Pattison, Roman E Ramirez, Lucia Wande, Sarah Woehlke, Matthew Wawersik, Elizabeth Kiernan, Jeffrey S Thompson, Roxanne Banker, Justina R Bartling, Chinmoy I Bhatiya, Anna L Boudoures, Lena Christiansen, Daniel S Fosselman, Kristin M French, Ishwar S Gill, Jessen T Havill, Jaelyn L Johnson, Lauren J Keny, John M Kerber, Bethany M Klett, Christina N Kufel, Francis J May, Jonathan P Mecoli, Callie R Merry, Lauren R Meyer, Emily G Miller, Gregory J Mullen, Katherine C Palozola, Jacob J Pfeil, Jessica G Thomas, Evan M Verbofsky, Eric P Spana, Anant Agarwalla, Julia Chapman, Ben Chlebina, Insun Chong, I N Falk, John D Fitzgibbons, Harrison Friedman, Osagie Ighile, Andrew J Kim, Kristin A Knouse, Faith Kung, Danny Mammo, Chun Leung Ng, Vinayak S Nikam, Diana Norton, Philip Pham, Jessica W Polk, Shreya Prasad, Helen Rankin, Camille D Ratliff, Victoria Scala, Nicholas U Schwartz, Jessica A Shuen, Amy Xu, Thomas Q Xu, Yi Zhang, Anne G Rosenwald, Martin G Burg, Stephanie J Adams, Morgan Baker, Bobbi Botsford, Briana Brinkley, Carter Brown, Shadie Emiah, Erica Enoch, Chad Gier, Alyson Greenwell, Lindsay Hoogenboom, Jordan E Matthews, Mitchell McDonald, Amanda Mercer, Nicholaus Monsma, Kristine Ostby, Alen Ramic, Devon Shallman, Matthew Simon, Eric Spencer, Trisha Tomkins, Pete Wendland, Anna Wylie, Michael J Wolyniak, Gregory M Robertson, Samuel I Smith, Justin R DiAngelo, Eric D Sassu, Satish C Bhalla, Karim A Sharif, Tenzin Choeying, Jason S Macias, Fareed Sanusi, Karvyn Torchon, April E Bednarski, Consuelo J Alvarez, Kristen C Davis, Carrie A Dunham, Alaina J Grantham, Amber N Hare, Jennifer Schottler, Zackary W Scott, Gary A Kuleck, Nicole S Yu, Marian M Kaehler, Jacob Jipp, Paul J Overvoorde, Elizabeth Shoop, Olivia Cyrankowski, Betsy Hoover, Matt Kusner, Devry Lin, Tijana Martinov, Jonathan Misch, Garrett Salzman, Holly Schiedermayer, Michael Snavely, Stephanie Zarrasola, Susan Parrish, Atlee Baker, Alissa Beckett, Carissa Belella, Julie Bryant, Turner Conrad, Adam Fearnow, Carolina Gomez, Robert A Herbstsomer, Sarah Hirsch, Christen Johnson, Melissa Jones, Rita Kabaso, Eric Lemmon, Carolina Marques Dos Santos Vieira, Darryl McFarland, Christopher McLaughlin, Abbie Morgan, Sepo Musokotwane, William Neutzling, Jana Nietmann, Christina Paluskievicz, Jessica Penn, Emily Peoples, Caitlin Pozmanter, Emily Reed, Nichole Rigby, Lasse Schmidt, Micah Shelton, Rebecca Shuford, Tiara Tirasawasdichai, Blair Undem, Damian Urick, Kayla Vondy, Bryan Yarrington, Todd T Eckdahl, Jeffrey L Poet, Alica B Allen, John E Anderson, Jason M Barnett, Jordan S Baumgardner, Adam D Brown, Jordan E Carney, Ramiro A Chavez, Shelbi L Christgen, Jordan S Christie, Andrea N Clary, Michel A Conn, Kristen M Cooper, Matt J Crowley, Samuel T Crowley, Jennifer S Doty, Brian A Dow, Curtis R Edwards, Darcie D Elder, John P Fanning, Bridget M Janssen, Anthony K Lambright, Curtiss E Lane, Austin B Limle, Tammy Mazur, Marly R McCracken, Alexa M McDonough, Amy D Melton, Phillip J Minnick, Adam E Musick, William H Newhart, Joseph W Noynaert, Bradley J Ogden, Michael W Sandusky, Samantha M Schmuecker, Anna L Shipman, Anna L Smith, Kristen M Thomsen, Matthew R Unzicker, William B Vernon, Wesley W Winn, Dustin S Woyski, Xiao Zhu, Chunguang Du, Caitlin Ament, Soham Aso, Laura Simone Bisogno, Jason Caronna, Nadezhda Fefelova, Lenin Lopez, Lorraine Malkowitz, Jonathan Marra, Daniella Menillo, Ifeanyi Obiorah, Eric Nyabeta Onsarigo, Shekerah Primus, Mahdi Soos, Archana Tare, Ameer Zidan, Christopher J Jones, Todd Aronhalt, James M Bellush, Christa Burke, Steve DeFazio, Benjamin R Does, Todd D Johnson, Nicholas Keysock, Nelson H Knudsen, James Messler, Kevin Myirski, Jade Lea Rekai, Ryan Michael Rempe, Michael S Salgado, Erica Stagaard, Justin R Starcher, Andrew W Waggoner, Anastasia K Yemelyanova, Amy T Hark, Anne Bertolet, Cyrus E Kuschner, Kesley Parry, Michael Quach, Lindsey Shantzer, Mary E Shaw, Mary A Smith, Omolara Glenn, Portia Mason, Charlotte Williams, S Catherine Silver Key, Tyneshia C P Henry, Ashlee G Johnson, Jackie X White, Adam Haberman, Sam Asinof, Kelly Drumm, Trip Freeburg, Nadia Safa, Darrin Schultz, Yakov Shevin, Petros Svoronos, Tam Vuong, Jules Wellinghoff, Laura L M Hoopes, Kim M Chau, Alyssa Ward, E Gloria C Regisford, LaJerald Augustine, Brionna Davis-Reyes, Vivienne Echendu, Jasmine Hales, Sharon Ibarra, Lauriaun Johnson, Steven Ovu, John M Braverman, Thomas J Bahr, Nicole M Caesar, Christopher Campana, Daniel W Cassidy, Peter A Cognetti, Johnathan D English, Matthew C Fadus, Cameron N Fick, Philip J Freda, Bryan M Hennessy, Kelsey Hockenberger, Jennifer K Jones, Jessica E King, Christopher R Knob, Karen J Kraftmann, Linghui Li, Lena N Lupey, Carl J Minniti, Thomas F Minton, Joseph V Moran, Krishna Mudumbi, Elizabeth C Nordman, William J Puetz, Lauren M Robinson, Thomas J Rose, Edward P Sweeney, Ashley S Timko, Don W Paetkau, Heather L Eisler, Megan E Aldrup, Jessica M Bodenberg, Mara G Cole, Kelly M Deranek, Megan DeShetler, Rose M Dowd, Alexandra K Eckardt, Sharon C Ehret, Jessica Fese, Amanda D Garrett, Anna Kammrath, Michelle L Kappes, Morgan R Light, Anne C Meier, Allison O'Rouke, Mallory Perella, Kimberley Ramsey, Jennifer R Ramthun, Mary T Reilly, Deirdre Robinett, Nadine L Rossi, Mary Grace Schueler, Emma Shoemaker, Kristin M Starkey, Ashley Vetor, Abby Vrable, Vidya Chandrasekaran, Christopher Beck, Kristen R Hatfield, Douglas A Herrick, Christopher B Khoury, Charlotte Lea, Christopher A Louie, Shannon M Lowell, Thomas J Reynolds, Jeanine Schibler, Alexandra H Scoma, Maxwell T Smith-Gee, Sarah Tuberty, Christopher D Smith, Jane E Lopilato, Jeanette Hauke, Jennifer A Roecklein-Canfield, Maureen Corrielus, Hannah Gilman, Stephanie Intriago, Amanda Maffa, Sabya A Rauf, Katrina Thistle, Melissa Trieu, Jenifer Winters, Bib Yang, Charles R Hauser, Tariq Abusheikh, Yara Ashrawi, Pedro Benitez, Lauren R Boudreaux, Megan Bourland, Miranda Chavez, Samantha Cruz, GiNell Elliott, Jesse R Farek, Sarah Flohr, Amanda H Flores, Chelsey Friedrichs, Zach Fusco, Zane Goodwin, Eric Helmreich, John Kiley, John Mark Knepper, Christine Langner, Megan Martinez, Carlos Mendoza, Monal Naik, Andrea Ochoa, Nicolas Ragland, England Raimey, Sunil Rathore, Evangelina Reza, Griffin Sadovsky, Marie-Isabelle B Seydoux, Jonathan E Smith, Anna K Unruh, Vicente Velasquez, Matthew W Wolski, Yuying Gosser, Shubha Govind, Nicole Clarke-Medley, Leslie Guadron, Dawn Lau, Alvin Lu, Cheryl Mazzeo, Mariam Meghdari, Simon Ng, Brad Pamnani, Olivia Plante, Yuki Kwan Wa Shum, Roy Song, Diana E Johnson, Mai Abdelnabi, Alexi Archambault, Norma Chamma, Shailly Gaur, Deborah Hammett, Adrese Kandahari, Guzal Khayrullina, Sonali Kumar, Samantha Lawrence, Nigel Madden, Max Mandelbaum, Heather Milnthorp, Shiv Mohini, Roshni Patel, Sarah J Peacock, Emily Perling, Amber Quintana, Michael Rahimi, Kristen Ramirez, Rishi Singhal, Corinne Weeks, Tiffany Wong, Aubree T Gillis, Zachary D Moore, Christopher D Savell, Reece Watson, Stephanie F Mel, Arjun A Anilkumar, Paul Bilinski, Rostislav Castillo, Michael Closser, Nathalia M Cruz, Tiffany Dai, Giancarlo F Garbagnati, Lanor S Horton, Dongyeon Kim, Joyce H Lau, James Z Liu, Sandy D Mach, Thu A Phan, Yi Ren, Kenneth E Stapleton, Jean M Strelitz, Ray Sunjed, Joyce Stamm, Morgan C Anderson, Bethany Grace Bonifield, Daniel Coomes, Adam Dillman, Elaine J Durchholz, Antoinette E Fafara-Thompson, Meleah J Gross, Amber M Gygi, Lesley E Jackson, Amy Johnson, Zuzana Kocsisova, Joshua L Manghelli, Kylie McNeil, Michael Murillo, Kierstin L Naylor, Jessica Neely, Emmy E Ogawa, Ashley Rich, Anna Rogers, J Devin Spencer, Kristina M Stemler, Allison A Throm, Matt Van Camp, Katie Weihbrecht, T Aaron Wiles, Mallory A Williams, Matthew Williams, Kyle Zoll, Cheryl Bailey, Leming Zhou, Darla M Balthaser, Azita Bashiri, Mindy E Bower, Kayla A Florian, Nazanin Ghavam, Elizabeth S Greiner-Sosanko, Helmet Karim, Victor W Mullen, Carly E Pelchen, Paul M Yenerall, Jiayu Zhang, Michael R Rubin, Suzette M Arias-Mejias, Armando G Bermudez-Capo, Gabriela V Bernal-Vega, Mariela Colon-Vazquez, Arelys Flores-Vazquez, Mariela Gines-Rosario, Ivan G Llavona-Cartagena, Javier O Martinez-Rodriguez, Lionel Ortiz-Fuentes, Eliezer O Perez-Colomba, Joseph Perez-Otero, Elisandra Rivera, Luke J Rodriguez-Giron, Arnaldo J Santiago-Sanabria, Andrea M Senquiz-Gonzalez, Frank R Soto delValle, Dorianmarie Vargas-Franco, Karla I Velázquez-Soto, Joan D Zambrana-Burgos, Juan Carlos Martinez-Cruzado, Lillyann Asencio-Zayas, Kevin Babilonia-Figueroa, Francis D Beauchamp-Pérez, Juliana Belén-Rodríguez, Luciann Bracero-Quiñones, Andrea P Burgos-Bula, Xavier A Collado-Méndez, Luis R Colón-Cruz, Ana I Correa-Muller, Jonathan L Crooke-Rosado, José M Cruz-García, Marianna Defendini-Ávila, Francheska M Delgado-Peraza, Alex J Feliciano-Cancela, Valerie M Gónzalez-Pérez, Wilfried Guiblet, Aldo Heredia-Negrón, Jennifer Hernández-Muñiz, Lourdes N Irizarry-González, Ángel L Laboy-Corales, Gabriela A Llaurador-Caraballo, Frances Marín-Maldonado, Ulises Marrero-Llerena, Héctor A Martell-Martínez, Idaliz M Martínez-Traverso, Kiara N Medina-Ortega, Sonya G Méndez-Castellanos, Krizia C Menéndez-Serrano, Carol I Morales-Caraballo, Saryleine Ortiz-DeChoudens, Patricia Ortiz-Ortiz, Hendrick Pagán-Torres, Diana Pérez-Afanador, Enid M Quintana-Torres, Edwin G Ramírez-Aponte, Carolina Riascos-Cuero, Michelle S Rivera-Llovet, Ingrid T Rivera-Pagán, Ramón E Rivera-Vicéns, Fabiola Robles-Juarbe, Lorraine Rodríguez-Bonilla, Brian O Rodríguez-Echevarría, Priscila M Rodríguez-García, Abneris E Rodríguez-Laboy, Susana Rodríguez-Santiago, Michael L Rojas-Vargas, Eva N Rubio-Marrero, Albeliz Santiago-Colón, Jorge L Santiago-Ortiz, Carlos E Santos-Ramos, Joseline Serrano-González, Alina M Tamayo-Figueroa, Edna P Tascón-Peñaranda, José L Torres-Castillo, Nelson A Valentín-Feliciano, Yashira M Valentín-Feliciano, Nadyan M Vargas-Barreto, Miguel Vélez-Vázquez, Luis R Vilanova-Vélez, Cristina Zambrana-Echevarría, Christy MacKinnon, Hui-Min Chung, Chris Kay, Anthony Pinto, Olga R Kopp, Joshua Burkhardt, Chris Harward, Robert Allen, Pavan Bhat, Jimmy Hsiang-Chun Chang, York Chen, Christopher Chesley, Dara Cohn, David DuPuis, Michael Fasano, Nicholas Fazzio, Katherine Gavinski, Heran Gebreyesus, Thomas Giarla, Marcus Gostelow, Rachel Greenstein, Hashini Gunasinghe, Casey Hanson, Amanda Hay, Tao Jian He, Katie Homa, Ruth Howe, Jeff Howenstein, Henry Huang, Aaditya Khatri, Young Lu Kim, Olivia Knowles, Sarah Kong, Rebecca Krock, Matt Kroll, Julia Kuhn, Matthew Kwong, Brandon Lee, Ryan Lee, Kevin Levine, Yedda Li, Bo Liu, Lucy Liu, Max Liu, Adam Lousararian, Jimmy Ma, Allyson Mallya, Charlie Manchee, Joseph Marcus, Stephen McDaniel, Michelle L Miller, Jerome M Molleston, Cristina Montero Diez, Patrick Ng, Natalie Ngai, Hien Nguyen, Andrew Nylander, Jason Pollack, Suchita Rastogi, Himabindu Reddy, Nathaniel Regenold, Jon Sarezky, Michael Schultz, Jien Shim, Tara Skorupa, Kenneth Smith, Sarah J Spencer, Priya Srikanth, Gabriel Stancu, Andrew P Stein, Marshall Strother, Lisa Sudmeier, Mengyang Sun, Varun Sundaram, Noor Tazudeen, Alan Tseng, Albert Tzeng, Rohit Venkat, Sandeep Venkataram, Leah Waldman, Tracy Wang, Hao Yang, Jack Y Yu, Yin Zheng, Mary L Preuss, Angelica Garcia, Matt Juergens, Robert W Morris, Alexis A Nagengast, Julie Azarewicz, Thomas J Carr, Nicole Chichearo, Mike Colgan, Megan Donegan, Bob Gardner, Nik Kolba, Janice L Krumm, Stacey Lytle, Laurell MacMillian, Mary Miller, Andrew Montgomery, Alysha Moretti, Brittney Offenbacker, Mike Polen, John Toth, John Woytanowski, Lisa Kadlec, Justin Crawford, Mary L Spratt, Ashley L Adams, Brianna K Barnard, Martin N Cheramie, Anne M Eime, Kathryn L Golden, Allyson P Hawkins, Jessica E Hill, Jessica A Kampmeier, Cody D Kern, Emily E Magnuson, Ashley R Miller, Cody M Morrow, Julia C Peairs, Gentry L Pickett, Sarah A Popelka, Alexis J Scott, Emily J Teepe, Katie A TerMeer, Carmen A Watchinski, Lucas A Watson, Rachel E Weber, Kate A Woodard, Daron C Barnard, Isaac Appiah, Michelle M Giddens, Gerard P McNeil, Adeola Adebayo, Kate Bagaeva, Justina Chinwong, Chrystel Dol, Eunice George, Kirk Haltaufderhyde, Joanna Haye, Manpreet Kaur, Max Semon, Dmitri Serjanov, Anika Toorie, Christopher Wilson, Nicole C Riddle, Jeremy Buhler, Elaine R Mardis, Sarah C R Elgin
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25-50%) than euchromatic reference regions (3-11%)...
March 4, 2015: G3: Genes—Genomes—Genetics
#3
JOURNAL ARTICLE
Timothy R Rebbeck, Nandita Mitra, Susan M Domchek, Fei Wan, Tara M Friebel, Teo V Tran, Christian F Singer, Muy-Kheng Maria Tea, Joanne L Blum, Nadine Tung, Olufunmilayo I Olopade, Jeffrey N Weitzel, Henry T Lynch, Carrie L Snyder, Judy E Garber, Antonis C Antoniou, Susan Peock, D Gareth Evans, Joan Paterson, M John Kennedy, Alan Donaldson, Huw Dorkins, Douglas F Easton, Wendy S Rubinstein, Mary B Daly, Claudine Isaacs, Heli Nevanlinna, Fergus J Couch, Irene L Andrulis, Eitan Freidman, Yael Laitman, Patricia A Ganz, Gail E Tomlinson, Susan L Neuhausen, Steven A Narod, Catherine M Phelan, Roger Greenberg, Katherine L Nathanson
Inherited BRCA1 mutations confer elevated cancer risk. Recent studies have identified genes that encode proteins that interact with BRCA1 as modifiers of BRCA1-associated breast cancer. We evaluated a comprehensive set of genes that encode most known BRCA1 interactors to evaluate the role of these genes as modifiers of cancer risk. A cohort of 2,825 BRCA1 mutation carriers was used to evaluate the association of haplotypes at ATM, BRCC36, BRCC45 (BRE), BRIP1 (BACH1/FANCJ), CTIP, ABRA1 (FAM175A), MERIT40, MRE11A, NBS1, PALB2 (FANCN), RAD50, RAD51, RAP80, and TOPBP1, and was associated with time to breast and ovarian cancer diagnosis...
September 1, 2011: Cancer Research
#4
COMMENT
Tara J T Kennedy
No abstract text is available yet for this article.
December 2009: Medical Education
#5
JOURNAL ARTICLE
Tara J T Kennedy, Glenn Regehr, G Ross Baker, Lorelei A Lingard
CONTEXT: Medical trainees demonstrate a reluctance to ask for help unless they believe it is absolutely necessary, a situation which could impact on the safety of patients. This study aimed to develop a theoretical exploration of the pressure on medical trainees to be independent and to generate theory-based approaches to the implications for patient safety of this pressure towards independent working. METHODS: In Phase 1, 88 teaching team members from internal and emergency medicine were observed during clinical activities (216 hours), and 65 participants completed brief interviews...
July 2009: Medical Education
#6
MULTICENTER STUDY
Tara J T Kennedy, Glenn Regehr, G Ross Baker, Lorelei Lingard
OBJECTIVE: To develop a conceptual framework of the influences on medical trainees' decisions regarding requests for clinical support from a supervisor. DESIGN: Phase 1: members of teaching teams in internal and emergency medicine were observed during regular clinical activities (216 hours) and subsequently completed brief interviews. Phase 2: 36 in depth interviews were conducted using videotaped vignettes to probe tacit influences on decisions to request support...
February 9, 2009: BMJ: British Medical Journal
#7
JOURNAL ARTICLE
Tara J T Kennedy, Glenn Regehr, G Ross Baker, Lorelei Lingard
BACKGROUND: Clinical supervisors make frequent assessments of medical trainees' competence so they can provide appropriate opportunities for trainees to experience clinical independence. This study explored context-specific assessments of trainees' competence for independent clinical work. METHOD: In Phase One, 88 teaching team members from internal and emergency medicine were observed during clinical activities (216 hours), and 65 participants completed brief interviews...
October 2008: Academic Medicine
#8
JOURNAL ARTICLE
Tara J T Kennedy, Lorelei A Lingard
BACKGROUND: Attending physicians (APs) must constantly assess trainees' competence to act independently, to promote learning while ensuring quality of care. This study aimed to explore, through discourse analysis of case presentations, the process of competence assessment for case-specific clinical independence. METHOD: Twenty-six case presentations in emergency medicine were observed and audiorecorded. A discourse analysis was conducted, focusing on APs' use of questioning strategies...
October 2007: Academic Medicine
#9
JOURNAL ARTICLE
Tara J T Kennedy, Lorelei Lingard, G Ross Baker, Lisa Kitchen, Glenn Regehr
BACKGROUND: Concern about the link between clinical supervision and safe, quality health care has led to widespread increases in the supervision of medical trainees. The effects of increased supervision on patient care and trainee education are not known, primarily because the current multifacted and poorly operationalized concept of clinical supervision limits the potential for evaluation. OBJECTIVE: To develop a conceptual model of clinical supervision to inform and guide policy and research...
August 2007: Journal of General Internal Medicine
#10
JOURNAL ARTICLE
Tara J T Kennedy, Lorelei A Lingard
BACKGROUND: Grounded theory is a research methodology designed to develop, through collection and analysis of data that is primarily (but not exclusively) qualitative, a well-integrated set of concepts that provide a theoretical explanation of a social phenomenon. OBJECTIVE: This paper aims to provide an introduction to key features of grounded theory methodology within the context of medical education research. OVERVIEW: In this paper we include a discussion of the origins of grounded theory, a description of key methodological processes, a comment on pitfalls encountered commonly in the application of grounded theory research, and a summary of the strengths of grounded theory methodology with illustrations from the medical education domain...
February 2006: Medical Education
#11
REVIEW
Tara J T Kennedy, Glenn Regehr, G Ross Baker, Lorelei A Lingard
BACKGROUND: Progressive independence is a traditional premise of clinical training. Recently, issues such as managed care, work hours limitation, and patient safety have begun to impact the degree of autonomy afforded to clinical trainees. This article reviews empirical evidence and theory pertaining to the role of progressive autonomy in clinical learning. METHOD: A computerized literature search was performed using Medline, PsycINFO, Social Sciences Citation Index, and Educational Resources Information Center...
October 2005: Academic Medicine
#12
JOURNAL ARTICLE
C A Armstrong, N Murray, M Kennedy, S V Koppula, D Tara, J C Ansel
Malignant melanomas are capable of producing a wide range of cytokines with multiple biologic functions, including interleukin 6 (IL-6). We have observed an inverse relationship between IL-6 production of three B16-derived murine melanoma cell lines (NP133, HFH18, and HFH(M)) and the tumorigenicity of these melanoma cells in syngeneic mice. To further test the effect of IL-6 on melanoma growth, a non-IL-6-producing murine B16-derived melanoma cell line (HFH18) was transfected with a murine IL-6 expression vector, resulting in stable transfectants (HFH18/IL-6(+)) that expressed significant amounts of IL-6 mRNA and secreted high levels of bioactive IL-6...
March 1994: Journal of Investigative Dermatology
1
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