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https://www.readbyqxmd.com/read/28214837/efficacy-of-glucosamine-sulphate-in-skin-ageing-results-from-an-ex-vivo-anti-ageing-model-and-a-clinical-trial
#1
Audrey Gueniche, Isabelle Castiel-Higounenc
BACKGROUND: Glucosamine sulphate (GS) is essential in the biosynthesis of glycolipids, glycoproteins, glycosaminoglycans (GAGs), hyaluronate, and proteoglycans. Connective tissues primarily contain collagen and proteoglycans and play an important role in skin ageing. OBJECTIVE: The objectives were to assess ex vivo the impact of GS on skin ageing parameters and in vivo the effect of GS on the skin physiology of mature healthy volunteers after oral intake. METHODS: The impact of GS on skin ageing was assessed ex vivo via different immunohistochemical assays and histology and via a clinical study using biopsies...
February 18, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28211759/gamma-tocopherol-supplementation-ameliorated-hyper-inflammatory-response-during-the-early-cutaneous-wound-healing-in-alloxan-induced-diabetic-mice
#2
Jihyun Shin, Soo Jin Yang, Yunsook Lim
Delayed wound healing is one of the major diabetic complications. During wound healing process, the early inflammatory stage is important for better prognosis. One of antioxidant nutrient, gamma-tocopherol (GT) is considered to regulate inflammatory conditions. This study investigated the effect of GT supplementation on mechanism associated with inflammation, oxidative stress, and apoptosis during early cutaneous wound healing in diabetic mice. Diabetes was induced by alloxan injection in ICR mice. All mice were divided into three groups: non-diabetic control mice (CON), diabetic control mice (DMC), and diabetic mice supplemented with GT (GT)...
March 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28205480/extensor-tendon-instability-due-to-sagittal-band-injury-in-a-martial-arts-athlete-a-case-report
#3
Andrew Kochevar, Ghazi Rayan
A Taekwondo participant sustained a hand injury from punching an opponent that resulted in painful instability of the ring finger extensor digitorum communis tendon due to sagittal band damage. His symptoms resolved after reconstructive surgery on the sagittal band (SB) with stabilization of the extensor tendon over the metacarpophalangeal joint.
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28195006/the-differential-effects-of-high-fat-and-high-fructose-diets-on-physiology-and-behavior-in-male-rats
#4
Lauren Woodie, Sarah Blythe
OBJECTIVES: The purpose of the current study is to directly compare a diet high in fat with a diet high in fructose. This side-by-side comparison will allow us to determine the physiological and behavioral effects resulting from the consumption of a diet dominated by one macronutrient. METHODS: Rats were fed pelletized food containing either 60% fat or 55% fructose diet, or control chow (5.8% kcal of fat, 44.3% kcal carb) for 9 weeks. Animals performed a classic Morris Water Maze (MWM) and a reversal MWM to assess spatial and working memory near the end of the feeding period...
February 14, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28194802/safe-treatment-of-ethmoid-sinusitis-utilizing-minimally-invasive-ethmoid-punch-sinusotomy-eps-in-chronic-rhinosinusitis-without-polyposis-crssnp-patients
#5
Nathalia Velasquez, Andrew Thamboo, Waleed M Abuzeid, Jayakar V Nayak
OBJECTIVES/HYPOTHESIS: Current rhinologic practice is devoid of minimally invasive procedures dedicated to the treatment of ethmoid sinusitis to improve ventilation and topical drug delivery. We have recently described a handheld spiral punch to create minimally invasive ethmoid punch sinusotomy (EPS) sites into the ethmoid bulla and basal lamella, which significantly increased irrigant access to the ethmoid sinuses in cadaver models. Here, we conducted a clinical feasibility study to determine the initial safety evaluation of EPS in chronic rhinosinusitis without polyposis (CRSsNP) patients with active ethmoid disease...
February 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28193007/enhanced-spatially-resolved-proteomics-using-on-tissue-hydrogel-mediated-protein-digestion
#6
David G Rizzo, Boone M Prentice, Jessica L Moore, Jeremy L Norris, Richard M Caprioli
The identification of proteins from tissue specimens is a challenging area of biological research. Many current techniques for identification forfeit some level of spatial information during the sample preparation process. Recently, hydrogel technologies have been developed that perform spatially localized protein extraction and digestion prior to downstream proteomic analysis. Regiospecific protein identifications acquired using this approach have thus far been limited to 1-2 mm diameter areas. The need to target smaller populations of cells with this technology necessitates the production of smaller diameter hydrogels...
February 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191716/clinical-efficacy-and-safety-evaluation-of-a-novel-fractional-unipolar-radiofrequency-device-on-facial-tightening-a-preliminary-report
#7
Dong Hye Suh, Eun Jung Byun, Sang Jun Lee, Kye Yong Song, Hei Sung Kim
BACKGROUND: Previous studies have shown that radiofrequency (RF) energy is safe and effective for improving skin laxity. Unlike monopolar and bipolar devices, little has been studied with the unipolar hand piece. OBJECTIVES: We sought to evaluate the safety and efficacy of a novel fractional unipolar RF device on facial tightening. PATIENTS AND METHODS: This was a retrospective, single-center study of 14 subjects with age-related facial laxity who underwent five sessions of fractional unipolar RF at an interval of 2 weeks, and then followed-up for 3 months...
February 13, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28187958/expression-of-oncogenic-mir-17-92-and-tumor-suppressive-mir-143-145-clusters-in-basal-cell-carcinoma-and-cutaneous-squamous-cell-carcinoma
#8
Michael Sand, Schapoor Hessam, Susanne Amur, Marina Skrygan, Michael Bromba, Eggert Stockfleth, Thilo Gambichler, Falk G Bechara
BACKGROUND: A variety of cancers are associated with the expression of the oncogenic miR-17-92 cluster (Oncomir-1) and tumor suppressor miR-143-5p/miR-145-5p. Epidermal skin cancer has not been investigated for the expression of miR-17-92 and miR-143-145 clusters, despite being extensively studied regarding global microRNA profiles. The goal of this study was to investigate the expression and possible correlation of expression of miR17-92 and miR-143-145 cluster members in epidermal skin cancer...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28185928/biologically-active-and-biomimetic-dual-gelatin-scaffolds-for-tissue-engineering
#9
P Sánchez, J L Pedraz, G Orive
We have designed, developed and optimized Genipin cross-linked 3D gelatin scaffolds that were biologically active and biomimetic, show a dual activity both for growth factor and cell delivery. Type B gelatin powder was dissolved in DI water. 100mg of genipin was dissolved in 10ml of DI water. Three genipin concentrations were prepared: 0.1%, 0.2% and 0.3% (w/v). Solutions were mixed at 40°C and under stirring and then left crosslinking for 72h. Scaffolds were obtained by punching 8 mm-cylinders into ethanol 70% solution for 10min and then freeze-drying...
February 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28181448/efficacy-of-bubaline-fibrin-glue-on-full-thickness-pinch-and-punch-skin-grafting-in-a-pig
#10
Krittee Dejyong, Theerayuth Kaewamatawong, Pasakorn Brikshavana, Sumit Durongphongtorn
Fibrin glue, which is formed from the action of thrombin (a serine protease) on fibrinogen, has been developed for use as an adhesive to increase the success of skin graft surgery. The objective of this study was to evaluate if bubaline fibrin glue would promote skin graft survival in pigs. The grafting was divided into two steps. First, granulation wound preparation was performed in a healthy swine by creating four full-skin depth wounds (3 × 12 cm(2)) at the dorsal part of the loin area on each side...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28177745/pre-and-within-meal-effects-of-fluid-dairy-products-on-appetite-food-intake-glycemia-and-regulatory-hormones-in-children
#11
Shirley Vien, Bohdan L Luhovyy, Barkha P Patel, Shirin Panahi, Dalia El Khoury, Rebecca C Mollard, Jill K Hamilton, G Harvey Anderson
The effect of beverages commonly consumed by children in-between or with meals on short-term food intake (FI) and glycemic control has received little attention. Therefore, two experiments were conducted in 9-14 y old children following a randomized repeated measures design. Experiment 1 (<i>n</i>=32) compared the effects of water (control) and isocaloric (130 kcal) amounts of 2% milk, chocolate milk, yogurt drink and fruit punch on subjective appetite and FI. Experiment 2 (<i>n</i>=20) compared the effects of isocaloric (130 kcal) amounts of 2% milk and fruit punch on subjective appetite, FI, glycemic and appetite hormone responses...
November 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28174654/breast-cancer-with-extensive-bone-metastasis-mimicking-myeloma
#12
Ya-Ting Hsu, Kung-Chao Chang
Punched-out lesions in skull film usually elicit consideration of myeloma. However, some other diseases cause similar clinical presentations. We describe an uncommon presentation of breast cancer, which mimics multiple myeloma. Therefore, in a broad spectrum of clinical settings, physicians should always consider differential diagnosis and await for definitive pathological diagnosis.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28169524/super-permeable-atomic-thin-graphene-membranes-with-high-selectivity
#13
Gaoliang Wei, Xie Quan, Shuo Chen, Hongtao Yu
Theoretical permeability of membrane is inversely proportional to its thickness, which indicates ultrathin membranes will be extremely permeable. Inspired by the atomic thickness of graphene, herein we report a four-layered graphene membrane with a thickness of about 2 nm. The ultrathin membrane is facilely fabricated by directly punching a complete graphene sheet through selective removal of some carbon atoms with metal oxide nanoparticles at high temperature. Their perpendicular pore channels spanning the whole thickness could, to a great extent, reduce hydrodynamic resistance for water transport...
February 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28157825/pain-sensation-during-colposcopy-and-cervical-biopsy-with-or-without-local-anesthesia-a-randomized-trial
#14
Mari Kiviharju, Ilkka Kalliala, Pekka Nieminen, Tadeusz Dyba, Annika Riska, Maija Jakobsson
OBJECTIVE: The aim of the study was to determine whether an injection of a local anesthetic is more painful than a cervical punch biopsy without local anesthesia. MATERIALS AND METHODS: The study was a randomized controlled trial, conducted at the Helsinki University Central Hospital. It consisted of 204 women referred for colposcopic assessments. Half of them were randomized to receive local anesthesia before their cervical punch biopsies. After the injection of the local anesthetic, the cervical punch biopsy, and the endocervical curettage, the women scored their actual pain using a 10-cm visual analog scale (VAS)...
February 3, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28153626/contralateral-interlaminar-keyhole-percutaneous-endoscopic-surgery-in-patients-with-unilateral-radiculopathy-technical-notes
#15
Jae Ha Hwang, Cheul Woong Park
OBJECTIVE: Percutaneous endoscopic surgery is increasingly used as an alternative to open microsurgery for treating lumbar spinal diseases. The purpose of this study was to determine the feasibility and efficacy of contralateral keyhole endoscopic surgery (CKES) for treating unilateral radiculopathy. METHODS: We performed percutaneous endoscopic sublaminar decompression via the contralateral interlaminar approach in 14 patients with unilateral radiculopathy. All procedures were performed under epidural anesthesia...
January 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28152546/a-phase-1-dose-escalation-and-expansion-study-of-binimetinib-mek162-a-potent-and-selective-oral-mek1-2-inhibitor
#16
Johanna C Bendell, Milind Javle, Tanios S Bekaii-Saab, Richard S Finn, Zev A Wainberg, Daniel A Laheru, Colin D Weekes, Benjamin R Tan, Gazala N Khan, Mark M Zalupski, Jeffrey R Infante, Suzanne Jones, Kyriakos P Papadopoulos, Anthony W Tolcher, Renae E Chavira, Janna L Christy-Bittel, Emma Barrett, Amita Patnaik
BACKGROUND: Binimetinib (MEK162; ARRY-438162) is a potent and selective oral MEK 1/2 inhibitor. This phase 1 study determined the maximum tolerated dose (MTD), safety, pharmacokinetic and pharmacodynamic profiles, and preliminary anti-tumour activity of binimetinib in patients with advanced solid tumours, with expansion cohorts of patients with biliary cancer or KRAS- or BRAF-mutant colorectal cancer. METHODS: Binimetinib was administered twice daily. Expansion cohorts were enroled after MTD determination following a 3+3 dose-escalation design...
February 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28148813/climate-change-delivers-a-punch-to-the-gut
#17
Oana Birceanu
No abstract text is available yet for this article.
February 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28145942/clinical-pathologic-correlation-of-sarcoidosis-associated-multifocal-chorioretinitis-in-an-elderly-patient
#18
Mohamed G A Saleh, John L OʼDonnell, Ronald P Davis, David Wilson, Phoebe Lin
BACKGROUND/PURPOSE: To describe a case of histopathologic clinical correlation of sarcoidosis-related multifocal chorioretinitis in an elderly individual. METHODS: This is a single case report and review of the pertinent literature. A 72-year-old white woman with a history of asthma was referred with bilateral asymmetric low-grade chronic panuveitis with advancing peripheral punched-out chorioretinal lesions despite systemic corticosteroid treatment. RESULTS: Coalescent chorioretinal punched-out lesions on fundus examination in the more severely affected right eye did not respond to corticosteroid treatment, and the refractory nature resulted in a suspicion of intraocular lymphoma despite a previous inconclusive diagnostic vitrectomy result...
January 31, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28145776/fibroblast-senescence-and-apoptosis-one-two-punch-to-slow-down-lung-fibrosis
#19
Annie Pardo, Moises Selman
No abstract text is available yet for this article.
February 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28138402/construction-and-analysis-of-tissue-microarrays-in-the-era-of-digital-pathology-a-pilot-study-targeting-cdx1-and-cdx2-in-a-colon-cancer-cohort-of-612-patients
#20
Sarah Nolte, Inti Zlobec, Alessandro Lugli, Werner Hohenberger, Roland Croner, Susanne Merkel, Arndt Hartmann, Carol I Geppert, Tilman T Rau
CDX1 and CDX2 are possibly predictive biomarkers in colorectal cancer. We combined digitally-guided (next generation) TMA construction (ngTMA) and the utility of digital image analysis (DIA) to assess accuracy, tumour heterogeneity and the selective impact of different combined intensity-percentage levels on prognosis.CDX1 and CDX2 immunohistochemistry was performed on ngTMAs covering normal tissue, tumour centre and invasive front. The percentages of all epithelial cells per staining intensity per core were analysed digitally...
January 2017: Journal of Pathology. Clinical Research
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