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https://www.readbyqxmd.com/read/29350571/intimate-partner-violence-perpetration-corresponds-to-a-dorsal-ventral-gradient-in-medial-pfc-reactivity-to-interpersonal-provocation
#1
David S Chester, C Nathan DeWall
Intimate partner violence (IPV) perpetration is often preceded by perceived interpersonal provocations such as slights, insults, and rejections. Yet the neural mechanisms that link provocation to IPV remain unclear. In the context of interactions with strangers, the medial prefrontal cortex (MPFC) has been repeatedly shown to respond to provocation, with more dorsal activation associated with more aggressive reactions and more ventral activation associated with less aggressive reactions. We used functional brain imaging to test whether this dorsal-ventral MPFC reactivity gradient would also correlate with greater aggression towards an unexamined target: intimate partners...
January 19, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29342490/detection-of-early-neoplasia-in-barrett-s-esophagus-using-lectin-based-near-infrared-imaging-an-ex-vivo-study-on-human-tissue
#2
André A Neves, Massimiliano Di Pietro, Maria O'Donovan, Dale J Waterhouse, Sarah E Bohndiek, Kevin M Brindle, Rebecca C Fitzgerald
BACKGROUND AND STUDY AIMS:  Endoscopic surveillance for Barrett's esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting. METHODS:  Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited...
January 17, 2018: Endoscopy
https://www.readbyqxmd.com/read/29337668/solving-manufacturing-problems-for-l-carnitine-l-tartrate-to-improve-the-likelihood-of-successful-product-scale-up
#3
Aliaa A Badawi, Mahmoud M Hegazy, Dina Louis, Mohammed A Eldegwy
L-carnitine-L-tartrate, a non-essential amino acid, is hygroscopic. This causes a problem in tablet production due to pronounced adhesion of tablets to punches. A 33 full factorial design was adopted to suggest a tablet formulation. Three adsorbents were suggested (Aerosil 200, Aerosil R972, talc) to reduce stickiness at three concentrations (1, 3 and 5 %), and three fillers (mannitol, Avicel PH 101, Dibasic calcium phosphate) were chosen to prepare 27 formulations. Micromeritic properties of formulations were studied, and tablets were prepared by wet granulation...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29332930/bullosis-diabeticorum-a-rare-presentation-with-immunoglobulin-g-igg-deposition-related-vasculopathy-case-report-and-focused-review
#4
Hardik Sonani, Sohail Abdul Salim, Vishnu V Garla, Anna Wile, Venkataraman Palabindala
BACKGROUND Bullosis diabeticorum (BD) is a condition characterized by recurrent, spontaneous, and non-inflammatory blistering in patients with poorly controlled diabetes mellitus. While etiopathogenesis remains unclear, roles of neuropathy, vasculopathy and UV light are hypothesized. Most literature reports negative direct and indirect immunofluorescence findings in diabetics with bullous eruptions. Porphyria cutanea tarda, bullous pemphigoid, epidermolysis bullosa, and pseudoporphyria are other differential diagnoses of bullous lesions, and they must be excluded...
January 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29330224/vitamin-d-ameliorates-impaired-wound-healing-in-streptozotocin-induced-diabetic-mice-by-suppressing-nf-%C3%AE%C2%BAb-mediated-inflammatory-genes-expression
#5
Yifeng Yuan, Sushant K Das, MaoQuan Li
[Background] : Diabetic wounds are characterized by delayed wound healing due to persistent inflammation and excessive production of reactive oxygen species. Vitamin D, which is well acknowledged as enhanced intestinal calcium absorption and increase in plasma calcium level, has recently been shown to display beneficial effects in various vascular diseases by promoting angiogenesis and inhibiting inflammatory responses. However the role of Vitamin Din diabetic wound healing is still unclear. [Materials and Methods] : In the present study, we investigated the role of Vitamin D in cutaneous wound healing in streptozotocin (STZ) induced diabetic mice...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29329503/chemical-imaging-of-aggressive-basal-cell-carcinoma-using-time-of-flight-secondary-ion-mass-spectrometry
#6
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmäki, John Paoli, John S Fletcher
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface...
January 12, 2018: Biointerphases
https://www.readbyqxmd.com/read/29325051/dr-harrison-martland-and-the-history-of-punch-drunk-syndrome
#7
Abhinav R Changa, Robert A Vietrogoski, Peter W Carmel
No abstract text is available yet for this article.
January 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29324868/effects-of-pulsed-electromagnetic-field-pemf-on-the-tensile-biomechanical-properties-of-diabetic-wounds-at-different-phases-of-healing
#8
Harry M C Choi, Alex K K Cheing, Gabriel Y F Ng, Gladys L Y Cheing
The present study investigated the effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing. Two intensities of PEMF were adopted for comparison. We randomly assigned 111 10-week-old male streptozotocin-induced diabetic Sprague-Dawley rats to two PEMF groups and a sham control group. Six-millimetre biopsy punched full thickness wounds were made on the lateral side of their hindlimbs. The PEMF groups received active PEMF delivered at 25 Hz with intensity of either 2 mT or 10 mT daily, while the sham group was handled in a similar way except they were not exposed to PEMF...
2018: PloS One
https://www.readbyqxmd.com/read/29322537/comparative-evaluations-of-hypertrophic-scar-formation-in-in-vivo-models
#9
Myeongjin Kim, Hyejin Kim, Hyun Wook Kang
BACKGROUND AND OBJECTIVE: Hypertrophic scar (HTS) results from a connective tissue reaction to trauma, inflammation, surgery, or burn on skin. In spite of various techniques for wound generation, the degree of scar in animal models after healing is still unpredictable and less reproducible. The objective of the current study was to identify the appropriate method to create the maximal HTS tissue in a reliable manner by comparing three different methods in vivo. MATERIALS AND METHODS: A 27 ICR mice were tested for the in vivo evaluations...
January 11, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29316273/pilot-project-physiologic-responses-to-a-high-intensity-active-video-game-with-copd-patients-tools-for-home-rehabilitation
#10
Andrée-Anne Parent, Vincent Gosselin-Boucher, Marilyn Houle-Peloquin, Claude Poirier, Alain-Steve Comtois
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is a respiratory condition that causes a significant deterioration of the quality of life. However, exercise can improve the quality of life for COPD patients and it is for this reason previous study observed the effects of active video games to increase exercise. Using motion capture devices with short bursts of exercise never been tried with COPD patients. OBJECTIVES: The objective was to observe the feasibility of using this device safely and easily with COPD patients...
January 8, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29314297/wound-infection-after-inpatient-pediatric-skin-biopsy
#11
Hannah Song, Arash Mostaghimi, Jennifer T Huang
Punch and shave biopsies are important dermatologic procedures in the inpatient setting but have a risk of wound infection. Data on the incidence of infection in this setting are limited and conflicting. This retrospective study of 127 pediatric inpatients at two tertiary care centers who underwent biopsy demonstrated a low overall risk of infection (n = 1, 0.8%). Twenty-five (19.7%) were neutropenic, and 51 (40.2%) were not taking systemic antibiotics at the time of biopsy; none of these patients developed a wound infection...
January 4, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29303983/a-dipteran-s-novel-sucker-punch-evolution-of-arthropod-atypical-venom-with-a-neurotoxic-component-in-robber-flies-asilidae-diptera
#12
Stephan Holger Drukewitz, Nico Fuhrmann, Eivind A B Undheim, Alexander Blanke, Julien Giribaldi, Rosanna Mary, Guillaume Laconde, Sébastien Dutertre, Björn Marcus von Reumont
Predatory robber flies (Diptera, Asilidae) have been suspected to be venomous due to their ability to overpower well-defended prey. However, details of their venom composition and toxin arsenal remained unknown. Here, we provide a detailed characterization of the venom system of robber flies through the application of comparative transcriptomics, proteomics and functional morphology. Our results reveal asilid venoms to be dominated by peptides and non-enzymatic proteins, and that the majority of components in the crude venom is represented by just ten toxin families, which we have named Asilidin1-10...
January 5, 2018: Toxins
https://www.readbyqxmd.com/read/29295017/client-violence-against-youth-care-workers-findings-of-an-exploratory-study-of-workforce-issues-in-residential-treatment
#13
Yvonne Smith, Lex Colletta, Anna E Bender
Residential treatment centers (RTCs) for youth are plagued by high turnover of youth care workers who provide round-the-clock treatment and supervision to youth with severe affective and behavioral problems. This article presents findings from a 15-month ethnographic study of workforce issues in one RTC related to youth care workers' exposure to client violence (CV). Findings are based on 65 semistructured interviews and 490 hours of participant observation with consenting employees. Participants reported CV incidents, including punching, kicking, biting, hair pulling, choking, threats or assaults with a weapon, and other physical and sexualized violence...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294963/deconstructing-attitudes-about-intimate-partner-violence-and-bystander-intervention-the-roles-of-perpetrator-gender-and-severity-of-aggression
#14
Ashley E Ermer, Andrea L Roach, Marilyn Coleman, Lawrence Ganong
In this mixed methods study, we explored how gender of an aggressor and the levels of aggression (i.e., yelling, throwing a drink, slapping, and punching) influenced attitudes about (a) public displays of intimate partner violence (IPV) and (b) bystander intervention. A feminist-informed, social constructionist perspective guided the study. Participants ( N = 562) responded online to randomly assigned factorial vignettes. Participants ranged in age between 18 and 70 years. The majority were female, self-identified as heterosexual, and identified as White...
October 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291501/cutaneous-wound-healing-using-polymeric-surgical-dressings-based-on-chitosan-sodium-hyaluronate-and-resveratrol-a-preclinical-experimental-study
#15
Cristian Berce, Mihai-Stefan Muresan, Olga Soritau, Bobe Petrushev, Lucia Tefas, Isabella Rigo, Gheorghe Ungureanu, Cornel Catoi, Alexandru Irimie, Ciprian Tomuleasa
Wound healing is a complex and dynamic process that involves modifying the wound environment depending on the patient's health status. Scar formation depends on many factors that influence wound healing, are important to bear in mind because most of the negative factors involved can be stopped by implementing an adequate treatment. The consensus in wound therapy recommends dressings that should keep a moist and alkaline environment thus creating a protective barrier against mechanical stress and secondary infections, in view of promoting granulation...
December 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29290603/axial-load-transmission-through-the-elbow-during-forearm-rotation
#16
Jung-Taek Hwang, Youngbok Kim, Daniel R Bachman, Maegan N Shields, Lawrence J Berglund, Alessandro T Fitzsimmons, James S Fitzsimmons, Shawn W O'Driscoll
BACKGROUND: Forearm rotation is closely associated with the axiorotational force transmission through the elbow joint. A technique has been developed to study the transmission of force across the radiocapitellar and ulnotrochlear joints during forearm rotation. METHODS: Ten human cadaveric upper limbs were prepared on a custom-designed apparatus that permits the application of extrinsic axial loads across an intact cadaveric elbow joint. A force-sensitive transducer was inserted into the elbow joint of each cadaver...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29287064/human-behaviours-associated-with-dominance-in-elite-amateur-boxing-bouts-a-comparison-of-winners-and-losers-under-the-ten-point-must-system
#17
Emily C Dunn, Clare E Humberstone, K Fiona Iredale, David T Martin, Anthony J Blazevich
Humans commonly ascertain physical dominance through non-lethal fighting by participating in combat sports. However, the behaviours that achieve fight dominance are not fully understood. Amateur boxing competition, which is judged using the subjective "Ten Point Must-System", provides insight into fight dominance behaviours. Notational analysis was performed on 26 elite male competitors in a national boxing championship. Behavioural (guard-drop time; movement style [stepping/bouncing time]; clinch-time; interaction-time) and technical (total punches; punches landed [%Hit]; air punches [%Air]; defence) measures were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/29277361/ala-pdt-exerts-beneficial-effects-on-chronic-venous-ulcers-by-inducing-changes-in-inflammatory-microenvironment-especially-through-increased-tgf-beta-release-a-pilot-clinical-and-translational-study
#18
Vieri Grandi, Stefano Bacci, Alessandro Corsi, Maurizio Sessa, Elisa Puliti, Nicoletta Murciano, Francesca Scavone, Pietro Cappugi, Nicola Pimpinelli
A cohort of 19 patients affected by chronic venous ulcers was recruited from our centre. A 4-mm punch biopsy from wound bed was taken before application of ALA 20% gel and repeated one hour after the first PDT irradiation. We observed a significant and progressive reduction of wounds mean volumes right after three ALA-PDT sessions (once per week; 4479.9 +/- 345.5 mm3 vs 34599 +/- 190.3 mm3, p < 0.01). On immunofluorescence staining from biopsy specimens, we observed a change in all tested stains of post treatment specimens compared to pre-treatment ones...
December 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29274154/panoramic-and-skull-imaging-may-aid-in-the-identification-of-multiple-myeloma-lesions
#19
K-M Faria, T-B Brandao, W-G Silva, J Pereira, F-S Neves, M-C Alves, W-H Shintaku, M-A Lopes, C-P Ribeiro, C-A Migliorati, A-R Santos-Silva
BACKGROUND: The purpose of this study was to investigate the presence of punched-out lesions in craniofacial bones using three different radiographic protocols in a large cohort of patients. MATERIAL AND METHODS: One hundred fifty-five MM patients were evaluated using panoramic and skull (frontal and lateral) radiographs, which were performed in all patients at the time of MM diagnosis. The diagnostic potential for detecting punched-out lesions was compared among the radiographic techniques...
December 23, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29249796/atypical-presentation-of-radiation-associated-breast-angiosarcoma-a-case-report-and-review-of-literature
#20
Yvette Farran, Osvaldo Padilla, Karinn Chambers, Alexander Philipovskiy, Zeina Nahleh
BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma...
December 18, 2017: American Journal of Case Reports
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