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https://www.readbyqxmd.com/read/28815643/early-intervention-with-non-ablative-fractional-laser-to-improve-cutaneous-scarring-a-randomized-controlled-trial-on-the-impact-of-intervention-time-and-fluence-levels
#1
Katrine E Karmisholt, Emily Wenande, Daniel Thaysen-Petersen, Peter A Philipsen, Uwe Paasch, Merete Haedersdal
BACKGROUND AND OBJECTIVES: Laser treatment in the early phases of wound healing may reduce scar formation. However, little is known on when in the early wound healing phases laser exposure most optimally should be provided and at which fluence levels. This study investigates the clinical effect of non-ablative-fractional-laser (NAFL) performed at three early time points at a range of fluence levels versus untreated control scars. MATERIALS AND METHODS: A randomized, controlled, intra-individual trial with erbium-glass 1,540 nm NAFL versus no laser treatment on sixteen subjects receiving 10 standardized full-thickness punch-biopsy wounds...
August 16, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28811000/a-case-of-cutaneous-leishmaniasis-guyanensis-mimicking-otitis-externa
#2
Eric S Goodrich, Stephen C Sears, Timothy Sorrells, James K Radike, Anis Miladi, Jonathan S Glass
Cutaneous leishmaniasis typically presents as a painless papule progressing to an ulcer or plaque. In this case study of the ear, the disease manifested as a small painful bump progressing into redness and swelling about the ear with purulent drainage. After multiple oral/intravenous antipseudomonal, antistaphylococcal, and antifungal treatments, there was no improvement. The skin progressed to an erythematous plaque and hemorrhagic ulcer; punch biopsy and speciation revealed Leishmaniasis guyanensis. The patient was switched to a seven-dose course of intravenous L-amphotericin B (visceral leishmaniasis protocol)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810813/newborn-thyroid-screening-influence-of-pre-analytic-variables-on-dried-blood-spot-tsh-measurement
#3
Allison M Butler, Wiyada Charoensiriwatana, Piamnukul Krasao, Rotjanapan Pankanjanato, Penpan Thong-Ngao, Randall C Polson, Gregory L Snow, Joel Ehrenkranz
BACKGROUND: Measuring thyroid stimulating hormone (TSH) eluted from a dried blood spot (DBS) is used to screen an estimated 30 million newborns annually for congenital hypothyroidism. Newborn thyroid screening has eliminated cretinism from the industrialized world and decreased the adverse effects of unrecognized congenital hypothyroidism on neurocognitive development. Hematocrit, a pre-analytic variable that affects the measurement of TSH from a DBS, contributes to the imprecision of DBS TSH measurement and could account for false negative and false positive DBS newborn screening test results...
August 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28802002/congenital-neurocristic-cutaneous-hamartoma-with-poliosis-a-case-report
#4
Lauren M Wilson, Knox J Beasley, Timothy C Sorrells, Viviana V Johnson
Neurocristic Cutaneous Hamartomas (NCH) are rare, pigmented skin lesions derived from the abnormal migration of neural crest cells. 1 2 We report the case of a 57-year-old female with a congenital localized area of poliosis and underlying pigmented patch on her scalp. Analysis of two punch biopsies yielded features consistent with NCH. Histopathology revealed schwannian-differentiated spindle cells and melanocytic components in the dermis. The spindle cells stained positively with S-100 and the stroma showed a prominent CD34 stain...
August 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28800004/sport-specific-repeated-sprint-training-improves-punching-ability-and-upper-body-aerobic-power-in-experienced-amateur-boxers
#5
Sigitas Kamandulis, Vidas Bruzas, Pranas Mockus, Alvydas Stasiulis, Audrius Snieckus, Tomas Venckunas
High-intensity interval training improves endurance and performance, but it is unclear whether sprint-type upper-body interval training is similarly effective. This study explored the effects of 4-week sport-specific sprint interval training on punch characteristics and endurance capacity in boxers. Experienced male amateur boxers (n = 18) participated in this 4-week training study, and were divided into an experimental group (EG) and a control group (CG) (n = 9 per group). Both groups completed standard low-intensity training...
August 9, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28799956/peripheral-blunt-dissection-using-a-microhoe-facilitated-method-for-descemet-membrane-endothelial-keratoplasty-donor-tissue-preparation
#6
Armand M Borovik, Mauricio Perez, Tova Lifshitz, Adi Einan-Lifshitz, Nir Sorkin, Tanguy Boutin, Mahmood Showail, Amir Rosenblatt, David S Rootman
PURPOSE: To describe a modified technique for Descemet membrane donor tissue preparation that facilitates the original Melles stripping technique. METHODS: Descemet membrane is prepared using a Rootman/Goldich modified Sloane microhoe, using a blunt instrument as opposed to a sharp blade or needle and begins dissection within the trabecular meshwork. The trabecular tissue is dissected for 360 degrees, and then Descemet membrane is stripped to approximately 50%. A skin biopsy punch is then used to create fenestration in the cornea, which is used to mark an "F...
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28799679/scanning-electron-microscope-investigation-on-the-process-of-healing-of-skin-wounds-in-cirrhinus-mrigala
#7
Neeraj Verma, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
Present scanning electron microscope study, reports healing of excised skin wounds in Cirrhinus mrigala. Healing process of wounds, inflicted on head skin, using biopsy punch was observed at intervals-0 hour (h), 1, 2, 4, 6, 12 h, 1 day (d) 2 and 4 d. Accumulation of mucus in wound region within 1h after infliction of wound has been considered an immediate measure to provide protection to injured skin from microbial invasion and other external environmental hazards. On infliction of wound, mobilization of epithelial cells at wound edge is associated with disturbance of coaptive relationship of epithelial cells till original coaptive stability is reached...
August 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28798967/effects-of-stretching-on-the-frictional-stress-of-rubber
#8
A Chateauminois, D T Nguyen, C Frétigny
In this paper, we report on new experimental results on the effects of in-plane surface stretching on the friction of poly(dimethylsiloxane) (PDMS) rubber with smooth rigid probes. Friction-induced displacement fields are measured at the surface of the PDMS substrate under steady-state sliding. Then, the corresponding contact pressure and frictional stress distributions are determined from an inversion procedure. Using this approach, we show that the local frictional stress τ is proportional to the local stretch ratio λ at the rubber surface...
August 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/28797990/marked-improvement-in-gastric-involvement-in-beh%C3%A3-et-s-disease-with-adalimumab-treatment
#9
Akira Sonoda, Ryo Ogawa, Kazuhiro Mizukami, Kensuke Fukuda, Mitsutaka Shuto, Kazuhisa Okamoto, Osamu Matsunari, Tadayoshi Okimoto, Kazunari Murakami
Gastric involvement is the least frequent manifestation of Behçet's disease, and effective treatment for it unknown. Here the case of a patient with gastric involvement in Behçet's disease that was markedly improved with adalimumab therapy is presented. A 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. Behçet's disease was suspected; then, prednisolone and colchicine were administered. Esophagogastroduodenoscopy showed a punched-out ulcer in the posterior wall of the gastric antrum...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28796900/punch-scoring-a-technique-that-facilitates-melanoma-diagnosis-of-clinically-suspicious-pigmented-lesions
#10
Judith Grogan, Caroline L Cooper, Tristan J Dodds, Pascale Guitera, Scott W Menzies, Richard A Scolyer
AIMS: Early recognition and accurate diagnosis underpins melanoma survival. Identifying early melanomas arising in association with pre-existing lesions is often challenging. Clinically suspicious foci, however small, must be identified and examined histologically. This study assessed the accuracy of punch biopsy "scoring" of suspicious foci in excised atypical pigmented skin lesions to identify early melanomas. METHODS AND RESULTS: Forty-one excised pigmented skin lesions with a clinically/dermoscopically focal area of concern for melanoma, with the suspicious focus marked prior to excision with a punch biopsy "score" (a partial incision into the skin surface), were analysed...
August 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28791686/the-role-of-dna-polymerase-chain-reaction-culture-and-histopathology-in-the-diagnosis-of-cutaneous-tuberculosis
#11
Puneet Agarwal, Elangbam Nelson Singh, Uma Shankar Agarwal, Ramsingh Meena, Saroj Purohit, Surendra Kumar
BACKGROUND: Cutaneous tuberculosis (TB) is re-emerging as a significant problem in India due to increased incidence of human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), other immunosuppressive states/factors like drugs, and emergence of multidrug resistance (MDR-TB). Proper diagnosis is warranted as there is varied clinical presentation and similarity with many other diseases. OBJECTIVE: To assess the sensitivities of DNA polymerase chain reaction (PCR), culture, and histopathology for the diagnosis of cutaneous TB in clinically suspected skin lesions...
August 9, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28783508/thoughts-after-marital-conflict-and-punch-biopsy-wounds-age-graded-pathways-to-healing
#12
Stephanie J Wilson, Rebecca Andridge, Juan Peng, Brittney E Bailey, William B Malarkey, Janice K Kiecolt-Glaser
Thoughts and emotions following marital conflict have received little attention but almost certainly contribute to marriage's long-term health effects. Consistent with emotion theories of aging, we expected the effects of post-conflict thoughts on important neuroendocrine and immune outcomes, cortisol levels and full-thickness wound healing, to differ by age. An age-diverse sample of married couples received a punch biopsy wound and discussed a marital problem, then privately recorded their thoughts and rated their mood...
July 29, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28783214/punch-and-scoop-technique-for-removing-pilomatricoma
#13
Eric L Maranda, Farhaad Riyaz, Tor Shwayder
Pilomatricomas are benign calcifying neoplasms derived from follicle matrix cells. Standard treatment for pilomatricomas involves complete surgical excision, with an overall low rate of recurrence. We discuss a simple alternative surgical technique that allows for removal of the lesion with less residual defect than complete excision.
August 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28782041/a-bimodal-activation-mechanism-underlies-scorpion-toxin-induced-pain
#14
Shilong Yang, Fan Yang, Bei Zhang, Bo Hyun Lee, Bowen Li, Lei Luo, Jie Zheng, Ren Lai
Venomous animals use peptide toxins for hunting and self-defense. To achieve these goals, toxins need to bind to their targets with high affinity due to the small amount that a single bite or sting can deliver. The scorpion toxin BmP01 is linked to sting-induced excruciating pain; however, the reported minimum concentrations for activating TRPV1 channel or inhibiting voltage-gated potassium (Kv) channels (both in the micromolar range) appear too high to be biologically relevant. We show that the effective concentration of BmP01 is highly pH-dependent-it increases by about 10-fold in inhibiting Kv channels upon a 1-U drop in pH but decreases more than 100-fold in activating TRPV1...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28779987/a-novel-technique-for-the-visualization-of-tablet-punch-surfaces-characterization-of-surface-modification-wear-and-sticking
#15
Claudia Al-Karawi, Thomas Kaiser, Claudia S Leopold
The surface quality of tablets is strongly related to the surface quality of the tablet punch. Therefore, regular control of the punch surfaces is needed to determine the surface properties, the wear status and sticking tendency of the punches. The aim of the present study was to develop and evaluate a new technique to visualize and evaluate tablet punch surfaces using high-resolution impression molding combined with 3D surface analysis. Standardized 3D surface texture parameters were analyzed by principal component analysis (PCA) to characterized differently surface-modified punches, punches with different wear status and the sticking pattern on the punch surfaces...
August 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28777264/feasibility-acceptability-and-adherence-with-short-term-hiv-pre-exposure-prophylaxis-in-female-sexual-partners-of-migrant-miners-in-mozambique
#16
Maria Lahuerta, Allison Zerbe, Rachel Baggaley, Joana Falcao, Laurence Ahoua, Pietro DiMattei, Fernando Morales, Isaias Ramiro, Wafaa M El-Sadr
BACKGROUND: Pre-exposure prophylaxis (PrEP) offers protection from HIV acquisition if taken as prescribed. We evaluated the feasibility, acceptability and adherence with short-term PrEP among female sexual partners of migrant miners in Mozambique. METHODS: HIV-negative female sexual partners of migrant miners were offered daily tenofovir/emtricitabine (TDF/FTC) for 6 weeks concurrent with miners' return home. Study visits occurred at baseline, Week 4, 6 and 8. Dried blood spots (DBS) were collected at Week 4 and 6...
August 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28776224/image-classification-for-die-punch-fracture-of-intermediate-column-of-the-distal-radius
#17
Yunhong Ma, Qudong Yin, Yongjun Rui, Sanjun Gu, Ying Yang
OBJECTIVE: The aim of the study was to analyze the imaging findings of Die-punch fracture of intermediate column of the distal radius, and to explore the clinical application value of image classification. METHODS: The clinical data of 45 patients who were admitted to our hospital from May 2010 to October 2016 were analyzed retrospectively. All patients met the inclusion criteria for Die-punch fracture. X-ray and CT scan were performed to examine the fracture, and the results were assessed by two doctors in a double blind method...
August 3, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28774182/annals-express-the-prediction-of-haematocrit-in-dried-blood-spots-from-the-measurement-of-haemoglobin-using-commercially-available-sodium-lauryl-sulphate
#18
Gareth Richardson, David John Marshall, Brian G Keevil
BACKGROUND: When preparing dried blood spots (DBS), the haematocrit (Hct) can affect the ability of the blood to spread through the filter paper, thus resulting in varying quantities of sample being measured when fixed sub- punches of the DBS are taken. It may be important to predict the sample Hct to correct for volume differences. METHODS: Blood (10 µL) was applied to Perkin Elmer 226® paper. The samples (n=165) were allowed to dry for 24 hrs and the entire blood spots were cut out...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28773917/correlation-factor-study-of-small-punch-creep-test-and-its-life-prediction
#19
Cheng Wen, Tong Xu, Kaishu Guan
A small punch test is one of the innovative methods that can be used to evaluate the properties of a material without destructive harm to the in-service component. Conventionally identifying material properties by a uniaxial test is widely applied to engineering. How the properties obtained from a small punch test can be applied with the same utility has been a goal. In 2006, European Code of Practice (CoP) of small punch tests was first released, in which the correlation factor, ksp, was introduced to bridge the gap between the above methods...
September 24, 2016: Materials
https://www.readbyqxmd.com/read/28773912/highly-absorbent-antibacterial-hemostatic-dressing-for-healing-severe-hemorrhagic-wounds
#20
Ting-Ting Li, Ching-Wen Lou, An-Pang Chen, Mong-Chuan Lee, Tsing-Fen Ho, Yueh-Sheng Chen, Jia-Horng Lin
To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel(®)/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. This study is the first to investigate the wicking and water-absorbing properties of a nonwoven base by measuring the vertical wicking height and water absorption ratio. Moreover, blood agglutination and hemostatic second tests were conducted to evaluate the hemostatic performance of the resultant wound dressing...
September 21, 2016: Materials
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