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H Abdalla, A Abramowski, F Aharonian, F Ait Benkhali, A G Akhperjanian, T Andersson, E O Angüner, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, E Birsin, R Blackwell, M Böttcher, C Boisson, J Bolmont, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, T Bulik, M Capasso, J Carr, S Casanova, N Chakraborty, R Chalme-Calvet, R C G Chaves, A Chen, J Chevalier, M Chrétien, S Colafrancesco, G Cologna, B Condon, J Conrad, C Couturier, Y Cui, I D Davids, B Degrange, C Deil, J Devin, P deWilt, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, G Dubus, K Dutson, J Dyks, M Dyrda, T Edwards, K Egberts, P Eger, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, M Gajdus, Y A Gallant, T Garrigoux, G Giavitto, B Giebels, J F Glicenstein, D Gottschall, A Goyal, M-H Grondin, M Grudzińska, D Hadasch, J Hahn, J Hawkes, G Heinzelmann, G Henri, G Hermann, O Hervet, A Hillert, J A Hinton, W Hofmann, C Hoischen, M Holler, D Horns, A Ivascenko, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, T Jogler, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, U Katz, D Kerszberg, B Khélifi, M Kieffer, J King, S Klepser, D Klochkov, W Kluźniak, D Kolitzus, Nu Komin, K Kosack, S Krakau, M Kraus, F Krayzel, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, V Lefranc, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, I Lypova, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, K Morå, E Moulin, T Murach, M de Naurois, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, S Öttl, I Oya, M Padovani, M Panter, R D Parsons, M Paz Arribas, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, S Pita, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, C Romoli, S Rosier-Lees, G Rowell, B Rudak, C B Rulten, V Sahakian, D Salek, D A Sanchez, A Santangelo, M Sasaki, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Settimo, A S Seyffert, N Shafi, I Shilon, R Simoni, H Sol, F Spanier, G Spengler, F Spies, Ł Stawarz, R Steenkamp, C Stegmann, F Stinzing, K Stycz, I Sushch, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, M Tluczykont, C Trichard, R Tuffs, J van der Walt, C van Eldik, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, V Zabalza, D Zaborov, M Zacharias, A A Zdziarski, A Zech, F Zefi, A Ziegler, N Żywucka
: A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1...
October 7, 2016: Physical Review Letters
Ji-Youn Park, Ji-Hye Park, Sang Jin Kim, Ji Eun Kwon, Hee Young Kang, Eun-So Lee, You Chan Kim
BACKGROUND: Postinflammatory hyperpigmentation (PIH) commonly occurs, but the histopathological features are not well characterized. METHODS: Twenty-one PIH patients' medical charts were reviewed. Punch biopsies from lesional and perilesional normal skin were performed. Sections were stained with hematoxylin-eosin, Fontana-Masson, NKI/beteb, microphthalmia-associated transcription factor (MITF), CD68, c-kit, factor XIIIa, MMP-2, and MMP-9. RESULTS: Fontana-Masson stained sections suggested two obvious PIH groups: epidermal (13 cases) and dermal (8 cases) pigmentation...
October 21, 2016: Journal of Cutaneous Pathology
M Cascarino, Y Caron, C Butnaru, F Rongioletti, S Fraitag
BACKGROUND: Progressive mucinous histiocytosis is a very rare, benign, non-Langerhans' cell histiocytosis limited to the skin. This disorder has been observed solely in women, with the exception of three cases in male patients, and most cases are hereditary. The hereditary forms begin in childhood, with sporadic cases occurring later, and it is characterized by numerous papules of slow progression. The aetiology and mode of genetic transmission remain unclear. We report one sporadic case of progressive mucinous histiocytosis...
October 17, 2016: Annales de Dermatologie et de Vénéréologie
Jun Zhang, Xin Ran Ji, Ye Peng, Jian Tao Li, Li Hai Zhang, Pei Fu Tang
BACKGROUND: A die-punch fracture is a depression fracture of the lunate fossa of the distal radius. We propose a morphological classification of die-punch fractures that includes five types: center depression fractures, vertical depression fractures, volar depression fractures, dorsal depression fractures, and double die-punch fractures. METHODS: The radiographs of 112 die-punch fractures treated between January 2005 and January 2015 were retrospectively reviewed...
October 21, 2016: Journal of Orthopaedic Surgery and Research
Nehal Eldeeb, Samia Halileh, Khalid A Alyafei, Rula Ghandour, Soha Dargham, Rita Giacaman, Madeeha Kamal, Sawsan Imseeh, Mona Korayem, Shiraz Nasr, Ziyad Mahfoud, Niveen Abu-Rmeileh, Mohamed H Mahmoud, Hassan Tawfik, Margaret A Lynch, Marcellina Mian
To compare the nature and determinants of child discipline in Qatar and Palestine among young adults through retrospective survey to develop legislation, policies and interventions for effective prevention of child maltreatment, and educational materials to promote positive discipline among parents and caregivers. Cross-sectional random household surveys were conducted in each country (Qataris N=697, Palestinians N=2064) using ISPCAN Child Abuse Screening Tool-Retrospective (ICAST-R) for young adults (18-24 years), to investigate child discipline methods into the maltreatment range...
October 16, 2016: Child Abuse & Neglect
Hamilton C Tsang, Susan Mathew, Cynthia M Magro
Diffuse large cell B-cell lymphoma of the skin is most commonly represented by diffuse large cell variants of primary cutaneous follicle center lymphoma and the leg-type lymphoma. In a minority of cases, the infiltrates are an expression of stage 4 disease of established extracutaneous B-cell lymphoma. We describe 1 female patient 85 years of age with an aggressive form of primary cutaneous B-cell lymphoma manifesting in multiple firm erythematous indurated solid nodules 1-2 cm each symmetrically on the face periorbitally and on the upper extremities bilaterally...
October 18, 2016: American Journal of Dermatopathology
Sanusi Umar
: Hair transplantation involving patients with tightly curled Afro-textured hair using follicular unit extraction (FUE) employing conventional rotary punches frequently leads to unacceptably high transection rates. These patients are unsuitable candidates for FUE hair transplantation. Transection rates were observed during FUE in a case series of 18 patients with tightly curled Afro-textured hair using different punches. METHODS: Three different punches were sequentially used in patients to extract follicular units with several needle gauges until satisfactory transection rates occurred: conventional sharp and dull rotary punches, followed by a 2-pronged curved nonrotary punch...
September 2016: Plastic and Reconstructive Surgery. Global Open
Amaal Abrahams, Nicolas Mouchet, Nicolas Gouault, Françoise Lohézic Le Dévéhat, Myriam Le Roch, Isabelle Rouaud, David Gilot, Marie-Dominique Galibert
The stress-activated p38α MAP Kinase is an integral and critical component of the UV-induced inflammatory response. Despite the advances in recent years in the development of p38 kinase inhibitors, validation of these compounds in the diseased models remains limited. Based on the pharmacological profile of p38α inhibitor lead compound, SB203580, we synthesized a series of pyrrole-derivatives. Using UV-irradiated human skin punch-biopsies and cell cultures, we identified and validated the inhibitory activity of the derivatives by quantitatively measuring their effect on the expression of p38α target genes using real-time PCR...
October 17, 2016: Photochemical & Photobiological Sciences
Rafaela Mabile Ferreira Dos Santos, Claudia Paraguaçu Pupo Sampaio, Daniela Pache de Moraes, Rubianne Ligório de Lima
Introduction Bismuth subgallate (BS) is a yellow and odorless powder that has hemostatic astringent properties. Some otorhinolaryngologists and dentists currently use this substance to enhance wound healing. Objective The objective of this study is to evaluate the effects of bismuth subgallate on wound healing, through the analysis of inflammatory process, collagen production, and angiogenesis. Method A standard wound was made on the back of 60 male Wistar rats, using a biopsy punch. We created two groups: the experimental group, which underwent daily application of 0...
October 2016: International Archives of Otorhinolaryngology
Jung-In Kim, Young-Jun Choi, Hyun-Min Seo, Han-Saem Kim, Jae Yun Lim, Dong-Hoon Kim, Seoung Wan Chae, Ga-Young Lee, Won-Serk Kim
Pleomorphic dermal sarcoma (PDS) is a rare mesenchymal neoplasm sharing histopathological features with atypical fibroxanthoma (AFX), but has additional features of deep invasion of the superficial subcutis, tumor necrosis and vascular/perineural invasion. It is not well documented in the literature because of its rarity, and its clinical course has been debated due to the lack of homogenous criteria. We describe here the case of a 91-year-old female with a 6-month history of a solitary, asymptomatic, well-defined, 3...
October 2016: Annals of Dermatology
María-Luisa Martínez, Eduardo Escario, Enrique Poblet, David Sánchez, Fernando-Francisco Buchón, Ander Izeta, Francisco Jimenez
BACKGROUND: A prominent role of hair follicle-derived cells in epidermal wound closure is now well established but clinical translation of basic research findings is scarce. Although skin punch grafts have been used as a therapeutic intervention to improve healing of chronic leg ulcers, they are normally harvested from nonhairy areas, thus not taking advantage of the reported role of the hair follicle as a wound-healing promoter. OBJECTIVE: We sought to substantiate the role of hair follicles in venous leg ulcer healing by transplanting hair follicle-containing versus nonhairy punch grafts...
November 2016: Journal of the American Academy of Dermatology
Ali Said Durmus, Mehmet Tuzcu, Oguzhan Ozdemir, Cemal Orhan, Nurhan Sahin, Ibrahim Hanifi Ozercan, James Richard Komorowski, Shakir Ali, Kazim Sahin
Arginine silicate inositol (ASI) complex is a composition of arginine, silicon, and inositol that has been shown to have beneficial effects on vascular health. This study reports the effects of an ASI ointment on wound healing in rats. A full-thickness excision wound was created by using a disposable 5 mm diameter skin punch biopsy tool. In this placebo-controlled study, the treatment group's wound areas were covered by 4 or 10 % ASI ointments twice a day for 5, 10, or 15 days. The rats were sacrificed either 5, 10, or 15 days after the wounds were created, and biopsy samples were taken for biochemical and histopathological analysis...
October 14, 2016: Biological Trace Element Research
Aaron S Farberg, Darrell S Rigel
BACKGROUND: Guidelines exist for the management of cutaneous malignant melanoma, but their adoption, prevalence, and impact have not yet been determined. OBJECTIVE: To determine current melanoma clinical management practices of US dermatologists and the variance from guidelines that might exist. METHODS: A cross-sectional e-mail survey study assessing preferred biopsy methods for lesions suspicious for melanoma, margins used for excision, and recommended follow-up intervals were sent to 6177 US dermatologists (540 responding)...
October 11, 2016: Journal of the American Academy of Dermatology
Manuel P Pereira, Sebastian Mühl, Esther M Pogatzki-Zahn, Konstantin Agelopoulos, Sonja Ständer
In recent years, measurement of the intraepidermal nerve fiber (IENF) density has gained relevance in the diagnostics of chronic pruritus. This method allows the objectification and quantification of a small-fiber neuropathy, which may manifest clinically with pruritus, pain or dysesthetic sensory symptoms, such as burning, stinging and tingling sensations or numbness. Upon suspicion of a small-fiber neuropathy as a cause for chronic pruritus, targeted diagnostic procedures are essential for the early detection of the neuroanatomical changes...
October 11, 2016: Dermatology and Therapy
C Hernández-Ibáñez, N Blazquez-Sánchez, M Aguilar-Bernier, R Fúnez-Liébana, F Rivas-Ruiz, M de Troya-Martín
INTRODUCTION: Incisional biopsy may not always provide a correct classification of histologic subtypes of basal cell carcinoma (BCC). High-frequency ultrasound (HFUS) imaging of the skin is useful for the diagnosis and management of this tumor. OBJECTIVES: The main aim of this study was to compare the diagnostic value of HFUS compared with punch biopsy for the correct classification of histologic subtypes of primary BCC. We also analyzed the influence of tumor size and histologic subtype (single subtype vs...
October 5, 2016: Actas Dermo-sifiliográficas
Alain Goriely, Johannes Weickenmeier, Ellen Kuhl
When a swelling soft solid is rigidly constrained on all sides except for a circular opening, it will bulge out to expand as observed during decompressive craniectomy, a surgical procedure used to reduce stresses in swollen brains. While the elastic energy of the solid decreases throughout this process, large stresses develop close to the opening. At the point of contact, the stresses exhibit a singularity similar to the ones found in the classic punch indentation problem. Here, we study the stresses generated by swelling and the evolution of the bulging shape associated with this process...
September 23, 2016: Physical Review Letters
R Ledesma-Alonso, E Raphaël, L Léger, F Restagno, C Poulard
We report on the elastic contact between a spherical lens and a patterned substrate, composed of a hexagonal lattice of cylindrical pillars. The stress field and the size of the contact area are obtained by means of numerical methods: a superposition method of discrete pressure elements and an iterative bisection-like method. For small indentations, a transition from a Hertzian to a soft-flat-punch behaviour is observed when the surface fraction of the substrate that is covered by the pillars is increased. In particular, we present a master curve defined by two dimensionless parameters, which allows one to predict the stress at the centre of the contact region in terms of the surface fraction occupied by pillars...
September 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
Stuart J McCarter, Michael J Howell
Sleep disorders and neurodegenerative diseases are commonly encountered in primary care. A common, but underdiagnosed sleep disorder, rapid eye movement sleep behavior disorder (RBD), is highly associated with Parkinson disease and related disorders. Rapid eye movement sleep behavior disorder is common. It is estimated to affect 0.5% of the general population and more than 7% of individuals older than 60 years; however, most cases go unrecognized. Rapid eye movement sleep behavior disorder presents as dream enactment, often with patients thrashing, punching, and kicking while they are sleeping...
October 2016: Mayo Clinic Proceedings
Kanako Hosono, Risa Isonaka, Tadashi Kawakami, Shuh Narumiya, Masataka Majima
Lymphangiogenesis plays an important role in homeostasis, metabolism, and immunity, and also occurs during wound-healing. Here, we examined the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing processes. The hole-punch was made in the ears of male C57BL/6 mice using a metal ear punch. Healing process and lymphangiogenesis together with macrophage recruitment were analyzed in EP knockout mice. Lymphangiogenesis was up-regulated in the granulation tissues at the margins of punched-hole wounds in mouse ears, and this increase was accompanied by increased expression levels of COX-2 and microsomal prostaglandin E synthase-1...
2016: PloS One
Janne Gierthmühlen, Ralf Baron
Diagnosing neuropathic pain and distinguishing it from nociceptive pain can be challenging, but is essential because both forms of pain require different treatment strategies. The diagnosis of neuropathic pain is primarily based on clinical findings. Therefore, a careful, focused history and an examination of the signs characteristic of neuropathic pain are crucial. Imaging techniques and electrophysiological examinations, as well as punch skin biopsy can support the clinical diagnosis. Ideally, treatment should be individualized using a mechanism-based approach...
October 2016: Seminars in Neurology
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