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https://www.readbyqxmd.com/read/29135893/inhibition-of-skin-wound-contraction-by-nanofibrillar-cellulose-hydrogel
#1
Kristo Nuutila, Antti Laukkanen, Andrew Lindford, Susanna Juteau, Markus Nuopponen, Jyrki Vuola, Esko Kankuri
BACKGROUND: Although wound contraction is an essential part of healing, excessive contraction can compromise healing through induction of scarring and fibrosis. This in turn leads to development of wound contractures that limit elasticity and function. Major research efforts have focused on development of novel therapeutic approaches to gain inhibitory control over wound contraction. Despite these efforts, the need for cost-effective, clinically feasible and effective agents to inhibit wound contraction remains...
November 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29133296/comparison-of-preservation-and-transportation-protocols-for-preloaded-descemet-membrane-endothelial-keratoplasty
#2
Vito Romano, Mohit Parekh, Alessandro Ruzza, Colin E Willoughby, Stefano Ferrari, Diego Ponzin, Stephen B Kaye, Hannah J Levis
BACKGROUND/AIMS: Descemet membrane endothelial keratoplasty (DMEK) preparation is technically demanding and is a limiting factor for uptake of this kind of surgery. Supply methods that simplify the procedure for surgeons are key to increasing uptake. This study compares two different shipping protocols for DMEK. METHODS: An 8.5 mm DMEK graft was punched, marked and loaded for transportation in two different conditions: (A) endothelium trifolded inwards in organ culture conditions (n=7) and (B) endothelium rolled outwards in hypothermic conditions (n=7)...
November 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118519/detection-of-tumor-necrosis-factor-alpha-in-nonlesional-tissues-of-alopecia-areata-patients-a-prove-for-a-systemic-disease
#3
Yasser Mostsfa Gohary, Dina Sabry Abdel Fattah
Introduction: The pathogenesis of alopecia areata (AA) remains incompletely understood. Different cytokines may play a role in AA. Tumor necrosis factor-alpha (TNF-α) has been shown to be inhibitory to hair follicle growth in in vitro studies suggesting that it may play an important role in AA. This study was conducted to assess the presence of TNF-α in lesional and nonlesional skin of AA, to review its possible role in AA, and to show whether AA is a systemic or localized disease by comparing the level of TNF-α between lesional and nonlesional skin biopsies of the patients...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29118370/all-materials-inclusive-flash-spark-plasma-sintering
#4
Charles Manière, Geuntak Lee, Eugene A Olevsky
A new flash (ultra-rapid) spark plasma sintering method applicable to various materials systems, regardless of their electrical resistivity, is developed. A number of powders ranging from metals to electrically insulative ceramics have been successfully densified resulting in homogeneous microstructures within sintering times of 8-35 s. A finite element simulation reveals that the developed method, providing an extraordinary fast and homogeneous heating concentrated in the sample's volume and punches, is applicable to all the different samples tested...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115558/bryostatin-1-causes-attenuation-of-tpa%C3%A2-mediated-tumor-promotion-in-mouse-skin
#5
Ning Zeng, Yi Xu, Yiping Wu, Tang Hongbo, Min Wu
The present study was designed to investigate the tumor inhibitory potential of bryostatin 1 in a 12‑O‑tetradecanoylphorbol‑13‑acetate (TPA)‑induced mouse model of skin cancer. The radical inhibition potential of various doses of bryostatin 1 was investigated against 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH) bleach in vitro. The DPPH radical potential was observed compared with treatment with 5, 10, 15, 20, 25 and 30 µM doses of bryostatin 1. In vivo, bryostatin 1 prevented the TPA‑mediated increase in the level of H2O2 and myeloperoxidase in mouse epidermal tissue...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29112898/development-and-validation-of-an-analytical-method-using-uplc-ms-ms-to-quantify-everolimus-in-dried-blood-spots-in-the-oncology-setting
#6
Lotte M Knapen, Yvo de Beer, Roger J M Brüggemann, Leo M Stolk, Frank de Vries, Vivianne C G Tjan-Heijnen, Nielka P van Erp, Sander Croes
While the therapeutic drug monitoring (TDM) of everolimus has been routinely performed for over 10 years in solid organ transplantation medicine, in order to optimize the balance between effectiveness and toxicity, it is yet uncommon in the treatment of malignancies. The aim of this study was to develop and validate a bioanalytical method to quantify everolimus in dried blood spots (DBS) to facilitate TDM for the oncology outpatient setting. The hematocrit effect of everolimus was investigated. An 7.5mm disk from the central part of the DBS was punched, followed by the extraction of everolimus from the DBS by methanol/acetonitrile (80/20%) spiked with deuterium-labelled everolimus as internal standard...
October 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29112053/concurrent-validity-and-reliability-of-a-linear-positional-transducer-and-an-accelerometer-to-measure-punch-characteristics
#7
Conor Lambert, Belinda R Beck, Benjamin K Weeks
Lambert, C, Beck, BR, and Weeks, BK. Concurrent validity and reliability of a linear positional transducer and an accelerometer to measure punch characteristics. J Strength Cond Res XX(X): 000-000, 2017-Punch speed is an important factor in the sport of boxing, and its measurement has important implications for monitoring training progression and outcomes. The aim of the current study was to establish the concurrent validity and reliability of a linear position transducer and an accelerometer for the quantification of punch characteristics in untrained adults...
November 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29111604/a-comparitive-study-with-a-755%C3%A2-nm-picosecond-alexandrite-laser-with-a-diffractive-lens-array-and-a-532%C3%A2-nm-1-064%C3%A2-nm-nd-yag-with-a-holographic-optic
#8
Emil Tanghetti, John Jennings
BACKGROUND AND OBJECTIVES: This study was performed to better understand the cutaneous effects of using a fractional picosecond laser at 755 nm with a diffractive lens array and a picosecond Nd:YAG laser at 532 mn and 1,064 nm with a holographic optic. We characterized the injuries created by these devices on skin clinically and histologically over 24 hours. With this information we modeled the effects of these devices on a cutaneous target. METHODS: Eight patients, representing Fitzpatrick skin types I-VI, were treated on their backs with a picosecond Alexandrite laser with a diffractive lens array, as well as a picosecond Nd:YAG laser at 532 nm and 1,064 nm with a holographic optic...
November 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29110565/impact-of-biopsy-modality-on-the-management-of-cutaneous-melanoma-of-the-head-and-neck
#9
Arya W Namin, Robert P Zitsch
Objective The purpose of this study was to examine how biopsy modality affects the treatment course and outcomes of patients with cutaneous melanoma of the head and neck. Specifically, we investigated if partial biopsy techniques are associated with positive margins on definitive wide local excision (DWLE), the need for early reoperation to obtain adequate margins or sentinel lymph node biopsy, and survival. Study Design Retrospective case series. Setting Tertiary care academic center. Subjects and Methods Subjects (N = 170) included all patients who were surgically treated for primary cutaneous melanoma of the head and neck at the University of Missouri-Columbia between January 1, 2000, and December 31, 2015...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29109739/a-case-of-polyarteritis-nodosa-presenting-as-rapidly-progressing-intermittent-claudication-of-right-leg
#10
Chathuranga Lakmal Fonseka, Sampath Rukshani Galappaththi, Dayakshi Abeyaratne, Nirmali Tissera, Lalith Wijayaratne
Background: Polyarteritis nodosa (PAN) is a medium vessel vasculitis which causes significant morbidity and mortality. Usually, it presents with constitutional symptoms with angiographic evidence of aneurysms or segmental stenosis of arteries of mesenteric or renal vasculature. It is exceedingly uncommon for PAN to present with symptomatic progressive intermittent claudication. Case Presentation: We describe a 60-year-old male who presented with rapidly progressive intermittent claudication of his right leg...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29108653/effect-of-asiaticoside-on-the-healing-of-skin-wounds-in-the-carp-cirrhinus-mrigala-an-immunohistochemical-investigation
#11
Neeraj Verma, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
In the present study effect of asiaticoside, on healing of skin wounds in Cirrhinus mrigala is reported. Skin wound, approx. 2mm in diameter was excised using sterile disposable biopsy punch. Immediately after infliction of the wound, epidermis from wound edge starts migrating as thin sheet toward wound gap. Fronts of migrating epidermis gradually advance, and results in complete epithelialization of wound. Experiments were conducted for 30days and fishes were divided into control, sham, vehicle control and asiaticoside treated groups...
October 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/29106076/rivaroxaban-reversal-with-prothrombin-complex-concentrate-or-tranexamic-acid-in-healthy-volunteers
#12
J H Levy, K T Moore, M D Neal, D Schneider, V S Marcsisin, J Ariyawansa, J I Weitz
BACKGROUND: Oral factor Xa inhibitors such as rivaroxaban are widely used, but specific reversal agents are lacking. Although 4-factor-prothrombin complex concentrate (4F-PCC) and tranexamic acid (TXA) are sometimes used to manage serious bleeding, their efficacy is unknown. Prior studies in healthy subjects taking rivaroxaban revealed that 4F-PCC partially reverses the prolonged prothrombin time (PT), and fully restores endogenous thrombin potential (ETP). The effect of TXA has not been evaluated...
November 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29102878/effects-of-horizontal-shoulder-abduction-and-adduction-on-the-activity-and-strength-of-the-scapular-protractors
#13
Sung-Hoon Jung, Ui-Jae Hwang, Jun-Hee Kim, Gyeong-Tae Gwak, Oh-Yun Kwon
Increased activity of the serratus anterior (SA) muscle combined with decreased activity of the pectoralis major (PM) muscle during scapular protraction exercise is a widely used method for selective strengthening of the former muscle. However, the role played by the PM during maximal scapular protraction remains unclear. The objective of our study was to investigate the effects of horizontal shoulder abduction (decreasing PM activity) and adduction (increasing activity) on the strength and activity of the scapular protractors (the SA and PM) during maximal protraction...
October 27, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29100029/validation-of-an-lc-ms-ms-assay-to-simultaneously-monitor-the-intracellular-active-metabolites-of-tenofovir-emtricitabine-and-lamivudine-in-dried-blood-spots
#14
Amanda P Schauer, Craig Sykes, Mackenzie L Cottrell, Heather Prince, Angela D M Kashuba
The ability to monitor adherence to antiretroviral therapy is critical for the interpretation of outcomes from clinical studies of HIV, and for optimizing patient care. The antiretrovirals tenofovir (TFV), emtricitabine (FTC), and lamivudine (3TC) are commonly included in drug regimens for HIV prevention and treatment. The active form of the drugs tenofovir diphosphate (TFVdp), emtricitabine triphosphate (FTCtp), and lamivudine triphosphate (3TCtp) are found intracellularly in erythrocytes and peripheral blood mononuclear cells (PBMCs)...
October 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29099672/rotational-and-linear-head-accelerations-from-taekwondo-kicks-and-punches
#15
Gabriel P Fife, David M O'sullivan, Sae Yong Lee
The purpose was to compare rotational and linear head accelerations as a result of taekwondo kicks and punches. Taekwondo athletes executed five repetitions of the turning kick, spinning hook kick, hook punch, straight punch, and jab punch to a Hybrid III Crash Test Dummy head-neck complex. A tri-axial accelerometer and an angular rate sensor were mounted inside the Hybrid III head to measure resultant linear (RLA) and rotational accelerations. The Hybrid III was fixed to a height-adjustable frame and fitted with protective taekwondo headgear...
November 3, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29098321/sugar-sweetened-beverage-intake-associations-with-fasting-glucose-and-insulin-concentrations-are-not-modified-by-selected-genetic-variants-in-a-chrebp-fgf21-pathway-a-meta-analysis
#16
Nicola M McKeown, Hassan S Dashti, Jiantao Ma, Danielle E Haslam, Jessica C Kiefte-de Jong, Caren E Smith, Toshiko Tanaka, Mariaelisa Graff, Rozenn N Lemaitre, Denis Rybin, Emily Sonestedt, Alexis C Frazier-Wood, Dennis O Mook-Kanamori, Yanping Li, Carol A Wang, Elisabeth T M Leermakers, Vera Mikkilä, Kristin L Young, Kenneth J Mukamal, L Adrienne Cupples, Christina-Alexandra Schulz, Tzu-An Chen, Ruifang Li-Gao, Tao Huang, Wendy H Oddy, Olli Raitakari, Kenneth Rice, James B Meigs, Ulrika Ericson, Lyn M Steffen, Frits R Rosendaal, Albert Hofman, Mika Kähönen, Bruce M Psaty, Louise Brunkwall, Andre G Uitterlinden, Jorma Viikari, David S Siscovick, Ilkka Seppälä, Kari E North, Dariush Mozaffarian, Josée Dupuis, Marju Orho-Melander, Stephen S Rich, Renée de Mutsert, Lu Qi, Craig E Pennell, Oscar H Franco, Terho Lehtimäki, Mark A Herman
AIMS/HYPOTHESIS: Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate positive associations between higher SSB intake and glycaemic traits...
November 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/29095179/barriers-to-research-recruitment-of-women-experiencing-a-pregnancy-loss-in-the-emergency-department
#17
Brittany E Punches, Kimberly D Johnson, Shauna P Acquavita, Dianne M Felblinger, Gordon L Gillespie
Women often come to the emergency department (ED) with signs and symptoms suggesting an early pregnancy loss; yet, little is known about their experience and how it relates to future outcomes. To improve patient outcomes and experiences of women seeking care for a pregnancy loss, research is required. However, recruitment of participants experiencing an event such as a pregnancy loss is challenging. The purpose of this article is to discuss the application of an electronic medical record (EMR)-based participant screening tool recruiting women seeking care for a pregnancy loss in the ED...
October 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29091491/management-of-intra-articular-distal-radius-fractures-volar-or-dorsal-locking-plate-which-has-fewer-complications
#18
Yoshihiro Abe, Susumu Tokunaga, Takuro Moriya
BACKGROUND: The aim of this study was to compare the functional outcomes and complications of volar and dorsal plating for the management of intra-articular distal radius fractures, with special regard to indications for dorsal plating. Furthermore, we examine the rationale for choosing dorsal plating and its frequency of use. METHODS: Clinical assessments included range of motion measurements at the wrist; grip strength; the Quick Disabilities of the Arm, Shoulder, and Hand score; and the Gartland and Werley score...
November 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29084422/histological-evaluation-of-experimentally-induced-critical-size-defect-skin-wounds-using-exosomal-solution-of-mesenchymal-stem-cells-derived-microvesicles
#19
Omar S El-Tookhy, Ashraf A Shamaa, Gehan G Shehab, Ahmed N Abdallah, Omnia M Azzam
Background and Objectives: The present study investigated whether MSCs derived microvesicles (MVs) or (Exosomes) can exert therapeutic effects on an experimental model of cutaneous injury and explored the underlying involving mechanisms. Methods and Results: Three bilateral full thickness circular wounds were created on the back of two groups of dogs using 2-cm dermal punch. The wounds were at least 2.5 cm apart. Saline was subcutaneously injected in 4 places around each wound area in group-I (control), whereas an equal volume of exosomal solution of MSCs derived MVs was similarly injected in group-II...
October 31, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/29083128/acute-neuromuscular-cognitive-and-physiological-responses-to-a-japanese-kickboxing-competition-in-semi-professional-fighters
#20
Giuseppe Cimadoro
BACKGROUND: Japanese kickboxing is a combat sport designed to accommodate fighters from different combat sports styles. However, the physiological profile of this discipline is unknown. Therefore, this study describes the neuromuscular, metabolic and cognitive responses to an official Japanese kickboxing (K-1) fight in 8 kickboxers. METHODS: Measurements before and after the competition involved a simple reaction time test (SRT), countermovement jump (CMJ), blood lactate (BLA) and rating of perceived exertion (RPE)...
October 27, 2017: Journal of Sports Medicine and Physical Fitness
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