keyword
MENU ▼
Read by QxMD icon Read
search

Boxing

keyword
https://www.readbyqxmd.com/read/29031181/mdhy5-positively-regulates-cold-tolerance-via-cbf-dependent-and-cbf-independent-pathways-in-apple
#1
Jian-Ping An, Ji-Fang Yao, Xiao-Na Wang, Chun-Xiang You, Xiao-Fei Wang, Yu-Jin Hao
Cold stress is a major external stimulator that affects crop quality and productivity. The CBF cold regulatory pathway has been regarded as a master regulator in the response to cold stress. In this study, we found that the apple bZIP transcription factor, MdHY5, was responsive to cold treatment both at the transcriptional and at the post-translational levels. Moreover, overexpression of MdHY5 enhanced cold tolerance in apple calli and Arabidopsis. Subsequently, EMSA assay and transient expression assay demonstrated that MdHY5 positively regulated the transcript of MdCBF1 by binding to G-Box motif of its promoter...
September 7, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29028754/can-economic-model-transparency-improve-provider-interpretation-of-cost-effectiveness-analysis-a-response
#2
Joshua T Cohen, John B Wong
To enhance the credibility and the value of health economic analyses, we argue that the computer model source code underlying these analyses should be made publicly available. Only with open publication is it possible for others to assess whether alternative assumptions, beyond those examined by the model authors, alter the model's findings. Because reproducibility is critical for scientific acceptance and because computation increasingly permeates scientific inquiry, other fields have moved toward open publication of computer models, and health economics should avoid falling behind...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29028652/novel-dry-lab-training-method-for-totally-endoscopic-coronary-anastomosis-a-pilot-study
#3
Kosuke Ujihira, Akira Yamada
OBJECTIVE: We describe our original dry-lab training system for nonrobotic and beating heart endoscopic coronary artery anastomosis. METHODS: All the materials used for this training were commercially available. We selected a boxed machine, which can produce pulsatile movements of artificial vessels, and on its roof, we installed a two-dimensional home video camera and a monitor. A multiple-holed plate was placed in front of the machine, and through these holes, a trainee inserted endoscopic surgical instruments and anastomosed the artificial vessels by running fashion while watching the monitor...
October 13, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29028346/influence-of-hofmeister-i-on-tuning-optoelectronic-properties-of-ampholytic-polythiophene-by-varying-ph-and-conjugating-with-rna
#4
Radhakanta Ghosh, Dhruba P Chatterjee, Sujoy Das, Titas Kumar Mukhopadhyay, Ayan Datta, Arun K Nandi
A significant tuning of optoelectronic properties of polythiophene (PT) chains due to Hofmeister iodide (I-) ion is demonstrated in ampholytic polythiophene [polythiophene-g-poly{(N,N,N-trimethylamino iodide)ethyl methacrylate-co-methacrylic acid}, APT] at different pH. In acidic medium, the absorption and emission signals of PT chromophore exhibit appreciable blue shift in presence of I- as counter anion only. The co-operative effect of undissociated -COOH and quaternary ammonium groups immobilize I- near apolar PT chain causing threading of grafted chains and hence twisting of the backbone attributing to the blue shift...
October 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29028197/multi-task-vehicle-detection-with-region-of-interest-voting
#5
Wenqing Chu, Yao Liu, Chen Shen, Deng Cai, Xian-Sheng Hua
Vehicle detection is a challenging problem in autonomous driving systems, due to its large structural and appearance variations. In this paper, we propose a novel vehicle detection scheme based on multi-task deep convolutional neural networks (CNN) and region-of-interest (RoI) voting. In the design of CNN architecture, we enrich the supervised information with subcategory, region overlap, bounding-box regression and category of each training RoI as a multi-task learning framework. This design allows the CNN model to share visual knowledge among different vehicle attributes simultaneously, thus detection robustness can be effectively improved...
October 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29028100/zeb1-promotes-prostate-cancer-proliferation-and-invasion-through-erk1-2-signaling-pathway
#6
X-F Song, H Chang, Q Liang, Z-F Guo, J-W Wu
OBJECTIVE: Prostate cancer is a kind of malignancy with high occurrence in the male urogenital system. However, the mechanism of the occurrence, the progression, and the metastasis of prostate cancer are still unclear. Searching for the effective molecule target is of great significance to improve the curative effect on prostate cancer. Zinc finger E box binding protein-1 (ZEB1) protein is a member of the zinc finger transcription factor family that participates in the embryonic development and formation...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027422/-continual-improvement-of-quantitative-analytical-method-development-of-panax-notogineng-saponins-based-on-quality-by-design
#7
Sheng-Yun Dai, Bing Xu, Xin-Yuan Shi, Xiang Xu, Ying-Qiang Sun, Yan-Jiang Qiao
This study is aimed to propose a continual improvement strategy based on quality by design (QbD). An ultra high performance liquid chromatography (UPLC) method was developed to accomplish the method transformation from HPLC to UPLC of Panax notogineng saponins (PNS) and achieve the continual improvement of PNS based on QbD, for example. Plackett-Burman screening design and Box-Behnken optimization design were employed to further understand the relationship between the critical method parameters (CMPs) and critical method attributes (CMAs)...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027418/-optimization-of-ethanol-reflux-extraction-process-of-red-ginseng-using-a-design-space-approach-based-on-hazard-and-operability-analysis
#8
Fang Zhao, Xing-Chu Gong, Hai-Bin Qu
Quality by design principle was used as a guideline in this study to optimize ethanol reflux extraction of red ginseng. Firstly, hazard and operability analysis(HAZOP) was used as a risk assessment tool to evaluate the hazard degree of process parameters.Ethanol concentration, the ratio of alcohol and herbal material (A/M ratio), and extraction time were identified as the critical process parameters(CPPs) according to HAZOP method.Secondly, Box-Behnken experimental design was applied to establish theregression models between CPPs and the process indices...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027415/-application-of-quality-by-design-in-granulation-process-for-ginkgo-leaf-tablet-%C3%A2-%C3%AF-process-control-strategy-based-on-design-space
#9
Xiang-Long Cui, Bing Xu, Fei Sun, Sheng-Yun Dai, Xin-Yuan Shi, Yan-Jiang Qiao
In this paper, under the guidance of quality by design (QbD) concept, the control strategy of the high shear wet granulation process of the ginkgo leaf tablet based on the design space was established to improve the process controllability and product quality consistency. The median granule size (D50) and bulk density (Da) of granules were identified as critical quality attributes (CQAs) and potential critical process parameters (pCPPs) were determined by the failure modes and effect analysis (FMEA). The Plackeet-Burmann experimental design was used to screen pCPPs and the results demonstrated that the binder amount, the wet massing time and the wet mixing impeller speed were critical process parameters (CPPs)...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29027313/patient-experiences-with-care-across-various-types-of-mental-health-care-questionnaire-development-measurement-invariance-and-patients-reports
#10
Luk Bruyneel, Sabine Van Houdt, Ellen Coeckelberghs, Walter Sermeus, Else Tambuyzer, Peter Cosemans, Gert Peeters, Kris Van den Broeck, Ilse Weeghmans, Kris Vanhaecht
To describe the development, validation, and findings of a patient experience questionnaire across 7 types of residential and ambulatory mental health care services. Thirty-five items were hypothesized to cover information, participation, therapeutic relationship, personalized care, organization and collaboration, safety, patient rights, outcomes of care, and discharge preparation and after-care. Also included were 2 overall rating items (scoring and recommending the organization). This Dutch questionnaire was applied in 79 organizations in Belgium (N patients = 5,168)...
October 13, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29027232/immune-recognition-of-irradiated-cancer-cells
#11
REVIEW
Erik Wennerberg, Claire Vanpouille-Box, Sophia Bornstein, Takahiro Yamazaki, Sandra Demaria, Lorenzo Galluzzi
Ionizing irradiation has been extensively employed for the clinical management of solid tumors, with therapeutic or palliative intents, for decades. Until recently, radiation therapy (RT) was believed to mediate antineoplastic activity mostly (if not only) as a consequence of cancer cell-intrinsic effects. Indeed, the macromolecular damage imposed to malignant cells by RT initiates one or multiple signal transduction cascades that drive a permanent proliferative arrest (cellular senescence) or regulated cell death...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027228/high-mobility-group-box-1-protein-orchestrates-responses-to-tissue-damage-via-inflammation-innate-and-adaptive-immunity-and-tissue-repair
#12
REVIEW
Marco E Bianchi, Massimo P Crippa, Angelo A Manfredi, Rosanna Mezzapelle, Patrizia Rovere Querini, Emilie Venereau
A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage. HMGB1 is the best characterized damage-associated molecular pattern (DAMP), proteins that are normally inside the cell but are released after cell death, and allow the immune system to distinguish between antigens that are dangerous or not. Notably, cells undergoing severe stress actively secrete HMGB1 via a dedicated secretion pathway: HMGB1 is relocated from the nucleus to the cytoplasm and then to secretory lysosomes or directly to the extracellular space...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29026993/task-intentions-and-their-implementation-into-actions-cognitive-control-from-adolescence-to-middle-adulthood
#13
Edita Poljac, Rianne Haartsen, Renske van der Cruijsen, Andrea Kiesel, Ervin Poljac
Cognitive control processes involved in human multitasking arise, mature, and decline across age. This study investigated how age modulates cognitive control at two different levels: the level of task intentions and the level of the implementation of intentions into the corresponding actions. We were particularly interested in specifying maturation of voluntary task choice (intentions) and task-switching execution (their implementations) between adolescence and middle adulthood. Seventy-four participants were assigned to one of the four age groups (adolescents, 12-17 years; emerging adults, 18-22 years; young adults, 23-27 years; middle-aged adults, 28-56 years)...
October 13, 2017: Psychological Research
https://www.readbyqxmd.com/read/29026873/graft-growth-and-podocyte-dedifferentiation-in-donor-recipient-size-mismatch-kidney-transplants
#14
Janina Müller-Deile, Jan Hinrich Bräsen, Marion Pollheimer, Manfred Ratschek, Hermann Haller, Lars Pape, Mario Schiffer
BACKGROUND: Kidney transplantation is the treatment choice for patients with end-stage renal diseases. Because of good long-term outcome, pediatric kidney grafts are also accepted for transplantation in adult recipients despite a significant mismatch in body size and age between donor and recipient. These grafts show a remarkable ability of adaptation to the recipient body and increase in size in a very short period, presumably as an adaptation to hyperfiltration. METHODS: We investigated renal graft growth as well as glomerular proliferation and differentiation markers Kiel-67, paired box gene 2 and Wilms tumor protein (WT1) expression in control biopsies from different transplant constellations: infant donor for infant recipient, infant donor for child recipient, infant donor for adult recipient, child donor for child recipient, child donor for adult recipient, and adult donor for an adult recipient...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29025713/neutrophil-elastase-increases-airway-ceramide-levels-via-upregulation-of-serine-palmitoyltransferase
#15
Sophia Karandashova, Apparao B Kummarapurugu, Shuo Zheng, Charles Chalfant, Judith A Voynow
Altered sphingolipid metabolism is associated with increased inflammation; however, the impact of inflammatory mediators, including neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. Using a well-characterized mouse model of NE oropharyngeal aspiration, we investigated a potential link between NE-induced airway inflammation and increased synthesis of various classes of sphingolipids, including ceramide species. Sphingolipids in bronchoalveolar lavage fluids (BAL) were identified and quantified using reverse phase high-performance liquid chromatography/electrospray ionization tandem mass spectrometry analysis...
October 12, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29025122/software-application-profile-opal-and-mica-open-source-software-solutions-for-epidemiological-data-management-harmonization-and-dissemination
#16
Dany Doiron, Yannick Marcon, Isabel Fortier, Paul Burton, Vincent Ferretti
Motivation: Improving the dissemination of information on existing epidemiological studies and facilitating the interoperability of study databases are essential to maximizing the use of resources and accelerating improvements in health. To address this, Maelstrom Research proposes Opal and Mica, two inter-operable open-source software packages providing out-of-the-box solutions for epidemiological data management, harmonization and dissemination. Implementation: Opal and Mica are two standalone but inter-operable web applications written in Java, JavaScript and PHP...
September 2, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024700/high-ybx1-expression-indicates-poor-prognosis-and-promotes-cell-migration-and-invasion-in-nasopharyngeal-carcinoma
#17
Lei-Lei Zhou, Jie Ni, Wan-Ting Feng, Rong Yao, Shun Yue, Ya-Ning Zhu, Hai-Yan Tang, Ling-Yun Lv, Ji-Feng Feng, Wei-Guo Zhu
Y-box binding protein-1 (YBX1) is a multifunctional protein and often acts as an indicator of poor prognosis in cancers. Increasing evidence has shown that the levels of YBX1 protein were closely associated with multidrug resistance, relapse, metastasis and poor prognosis in cancers. However, its role in nasopharyngeal carcinoma (NPC) metastasis remains unknown. In our study, we discovered that the expression of YBX1 was increased in nasopharyngeal carcinoma tissues. YBX1 protein levels positively correlated with T stage and metastasis of NPC patients...
October 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29024517/germ-cell-migration-proliferation-and-differentiation-during-gonadal-morphogenesis-in-all-female-japanese-flounder-paralichthys-olivaceus
#18
Yang Yang, Qinghua Liu, Yongshuang Xiao, Xueying Wang, Hao An, Zongcheng Song, Feng You, Yanfeng Wang, Daoyuan Ma, Jun Li
In this study, all genetic female(XX)broods of Japanese flounder were produced artificially by mating the females with sex-reversed males. The proliferation and migration of primordial germ cells (PGCs), formation of ovary and oogenesis were described in detail. After hatching, around 20 individual PGCs migrated from the lateral to the dorsal of trunk region. At 15 days post hatching (dph), a part of PGCs were covered by a single layer somatic cells and formed the genital ridge. By 22 dph, the elongated gonadal primordia appeared under the ventral kidney, where the PGCs were totally enclosed by somatic cells...
October 10, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29023630/the-hmgb1-is-increased-in-csf-of-patients-with-an-anti-nmdar-encephalitis
#19
P Ai, X Zhang, Z Xie, G Liu, X Liu, S Pan, H Wang
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system (CNS). Interleukin (IL)-6 and IL-17A may play important roles in the pathogenesis of this disease. High-mobility group box protein 1 (HMGB1), a small but highly conserved ubiquitous protein, is recognized to be a potent innate inflammatory mediator that can activate the nuclear factor light chain enhancer of activated B cells and release cytokines such as IL-6 and IL-17A when released extracellularly...
October 12, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29023000/application-of-response-surface-methodology-for-optimization-of-extracellular-glucoamylase-production-by-candida-guilliermondii
#20
Lagzouli Mohamed, Youssfi El Kettani, Aitounejjar Ali, Elyachioui Mohamed, Jadal Mohamed
OBJECTIVE: Glucoamylase is among the most important enzymes in biotechnology. The present study aims to determine better conditions for growth and glucoamylase production by Candida guilliermondii and to reduce the overall cost of the medium using Box-Behnken design with one central point and response surface methodology. METHODOLOGY: Box-Behnken factorial design based on three levels was carried out to obtain optimal medium combination of five independent variables such as initial pH, soluble starch, CH4N2O, yeast extract and MgSO4...
2017: Pakistan Journal of Biological Sciences: PJBS
keyword
keyword
92304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"