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https://www.readbyqxmd.com/read/28822991/aquatide-activation-of-sirt1-reduces-cellular-senescence-through-a-sirt1-foxo1-autophagy-axis
#1
Chae Jin Lim, Yong-Moon Lee, Seung Goo Kang, Hyung W Lim, Kyong-Oh Shin, Se Kyoo Jeong, Yang Hoon Huh, Suin Choi, Myungho Kor, Ho Seong Seo, Byeong Deog Park, Keedon Park, Jeong Keun Ahn, Yoshikazu Uchida, Kyungho Park
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822708/mrtf-a-mir-206-wdr1-form-feedback-loop-to-regulate-breast-cancer-cell-migration
#2
Yuan Xiang, Xing-Hua Liao, Ao Yao, Huan Qin, Li-Juan Fan, Jia-Peng Li, Peng Hu, Hui Li, Wei Guo, Jun-Yan Li, Chao-Jiang Gu, Le-Yuan Bao, Tong-Cun Zhang
Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. Our previous study has shown that MRTF-A promote the migration of MDA-MB-231 cells and WDR1 promotes breast cancer cell migration. But the exact molecular mechanism on metastasis is still not fully understood, we now report that WDR1 enhanced the effect of MRTF-A induced-MDA-MB-231 cell migration by promoting the expression of the EMT markers and migration markers via RhoA-MRTF-A signaling pathway. Importantly, WDR1 promoted the nuclear importion of MRTF-A by affecting the expression of nuclear transport protein importin...
August 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28821614/multiple-circadian-transcriptional-elements-cooperatively-regulate-cell-autonomous-transcriptional-oscillation-of-period3-a-mammalian-clock-gene
#3
Ritsuko Matsumura, Makoto Akashi
Cell-autonomous oscillation in clock gene expression drives circadian rhythms. The development of comprehensive analytical techniques, such as bioinformatics and ChIP-sequencing, has enabled the genome-wide identification of potential circadian transcriptional elements that regulate the transcriptional oscillation of clock genes. However, detailed analyses using traditional biochemical and molecular-biological approaches, such as binding and reporter assays, are still necessary to determine whether these potential circadian transcriptional elements are actually functional and how significantly they contribute to driving transcriptional oscillation...
August 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28820796/provider-approachability-an-all-staff-survey-approach-to-creating-a-culture-of-safety
#4
Mark E Deyo-Svendsen, Karl B Palmer, Jill K Albright, Michael R Phillips, Keith A Schilling, Matthew E Cabrera Svendsen
OBJECTIVES: A culture-of-safety survey of our hospital staff revealed fear-based reluctance to question those in authority. We aimed to examine provider approachability (words and actions that promote trust and reduce or eliminate fear of interaction). METHODS: Providers and staff completed an anonymous facility-wide survey (survey 1) regarding perceptions of provider approachability. Results were safely communicated to providers, and improvement resources were offered...
August 17, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28820754/sleep-apps-what-role-do-they-play-in-clinical-medicine
#5
Christopher P Lorenz, Adrian J Williams
PURPOSE OF REVIEW: Today's smartphones boast more computing power than the Apollo Guidance Computer. Given the ubiquity and popularity of smartphones, are we already carrying around miniaturized sleep labs in our pockets? RECENT FINDINGS: There is still a lack of validation studies for consumer sleep technologies in general and apps for monitoring sleep in particular. To overcome this gap, multidisciplinary teams are needed that focus on feasibility work at the intersection of software engineering, data science and clinical sleep medicine...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28820114/pseudonocardia-nigra-sp-nov-isolated-from-atacama-desert-rock
#6
Martha E Trujillo, Hamidah Idris, Raúl Riesco, Imen Nouioui, José M Igual, Alan T Bull, Michael Goodfellow
Eleven actinobacterial strains were isolated from a rock sample collected in the Atacama Desert. Molecular typing by BOX-PCR divided the strains into three clusters and showed that, although very similar, they were not clones. Three strains, ATK01, ATK03T and ATK17, each representing one of the defined BOX clusters, were chosen for further characterization. Phylogenetic analysis indicated that the strains were related to the genus Pseudonocardia and were recovered in a cluster together with Pseudonocardia bannensis YIM 63101T and Pseudonocardia xinjiangensis AS 4...
August 18, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28819881/resveratrol-induces-apoptosis-and-inhibits-adipogenesis-by-stimulating-the-sirt1-ampk%C3%AE-foxo1-signalling-pathway-in-bovine-intramuscular-adipocytes
#7
Xiaomu Liu, Hongbo Zhao, Qing Jin, Wei You, Haijian Cheng, Yifan Liu, Enliang Song, Guifen Liu, Xiuwen Tan, Xianglun Zhang, Fachun Wan
Sirtuin type 1 (SIRTl) and AMP-activated protein kinase (AMPK) play important roles in regulating energy metabolism, cell proliferation and differentiation, ageing, apoptosis, and metabolism. The effect of 100, 200, and 400 μm Resveratrol (RES), an activator of SIRT1, on apoptosis of bovine intramuscular adipocytes was investigated by nuclear staining, flow cytometry, quantitative real-time polymerase chain reaction, and western blotting. Results show that RES inhibited adipogenesis, decreased cell viability, and increased apoptotic rates in a dose-dependent way...
August 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28819579/dual-task-performance-in-gba-parkinson-s-disease
#8
Karin Srulijes, Kathrin Brockmann, Senait Ogbamicael, Markus A Hobert, Ann-Kathrin Hauser, Claudia Schulte, Jasmin Fritzen, Michael Schwenk, Thomas Gasser, Daniela Berg, Walter Maetzler
INTRODUCTION: Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. METHODS: Eleven GBA-PD patients (p...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28819440/microrna-204-5p-inhibits-invasion-and-metastasis-of-laryngeal-squamous-cell-carcinoma-by-suppressing-forkhead-box-c1
#9
Wei Gao, Yongyan Wu, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen, Binquan Wang
Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box C1 (FOXC1), in human LSCC and explore their roles in the malignant behaviors of LSCC Hep-2 and TU-177 cells. Methods: The regulatory effects of miR-204-5p on the 3' untranslated region of FOXC1 predicted by bioinformatics were tested by dual-luciferase reporter assay...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819388/role-of-y-box-protein-1-in-cancer-as-potential-biomarker-and-novel-therapeutic-target
#10
REVIEW
Pramod Kumar Maurya, Alok Mishra, Birendra Singh Yadav, Swati Singh, Prashant Kumar, Amit Chaudhary, Shweta Srivastava, Suriya Narayan Murugesan, Ashutosh Mani
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric cancer, oesophageal cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of cancer proliferation...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819355/box-office-forecasting-considering-competitive-environment-and-word-of-mouth-in-social-networks-a-case-study-of-korean-film-market
#11
Taegu Kim, Jungsik Hong, Pilsung Kang
Accurate box office forecasting models are developed by considering competition and word-of-mouth (WOM) effects in addition to screening-related information. Nationality, genre, ratings, and distributors of motion pictures running concurrently with the target motion picture are used to describe the competition, whereas the numbers of informative, positive, and negative mentions posted on social network services (SNS) are used to gauge the atmosphere spread by WOM. Among these candidate variables, only significant variables are selected by genetic algorithm (GA), based on which machine learning algorithms are trained to build forecasting models...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28819113/insights-into-the-role-of-endonuclease-v-in-rna-metabolism-in-trypanosoma-brucei
#12
Daniel García-Caballero, Guiomar Pérez-Moreno, Antonio M Estévez, Luis Miguel Ruíz-Pérez, Antonio E Vidal, Dolores González-Pacanowska
Inosine may arise in DNA as a result of oxidative deamination of adenine or misincorporation of deoxyinosine triphosphate during replication. On the other hand, the occurrence of inosine in RNA is considered a normal and essential modification induced by specific adenosine deaminases acting on mRNA and tRNA. In prokaryotes, endonuclease V (EndoV) can recognize and cleave inosine-containing DNA. In contrast, mammalian EndoVs preferentially cleave inosine-containing RNA, suggesting a role in RNA metabolism for the eukaryotic members of this protein family...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818882/neuropsychiatric-adverse-drug-reactions-in-children-initiated-on-montelukast-in-real-life-practice
#13
Brigitte Benard, Valérie Bastien, Benjamin Vinet, Roger Yang, Maja Krajinovic, Francine M Ducharme
Although montelukast is generally well tolerated, postmarketing studies have reported serious neuropsychiatric adverse drug reactions (ADRs) leading to a United States Food and Drug Administration black box warning. The objective of this study was to determine the incidence of neuropsychiatric ADRs leading to discontinuation of montelukast in asthmatic children.We conducted a retrospective cohort study in children aged 1-17 years initiated on montelukast. In a nested cohort study, children initiated on montelukast as monotherapy or adjunct therapy to inhaled corticosteroids (ICS) were matched to those initiated on ICS monotherapy...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28818793/cellular-adaptation-to-xenobiotics-interplay-between-xenosensors-reactive-oxygen-species-and-foxo-transcription-factors
#14
Lars-Oliver Klotz, Holger Steinbrenner
Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins involved in xenobiotic metabolism. This is achieved largely via activation of cellular xenosensors that modulate gene expression. Biotransformation of xenobiotics frequently comes with the generation of reactive oxygen species (ROS). ROS, in turn, are known modulators of signal transduction processes. FOXO (forkhead box, class O) transcription factors are among the proteins deeply involved in the cellular response to stress, including oxidative stress elicited by the formation of ROS...
August 3, 2017: Redox Biology
https://www.readbyqxmd.com/read/28818520/owlready-ontology-oriented-programming-in-python-with-automatic-classification-and-high-level-constructs-for-biomedical-ontologies
#15
Jean-Baptiste Lamy
OBJECTIVE: Ontologies are widely used in the biomedical domain. While many tools exist for the edition, alignment or evaluation of ontologies, few solutions have been proposed for ontology programming interface, i.e. for accessing and modifying an ontology within a programming language. Existing query languages (such as SPARQL) and APIs (such as OWLAPI) are not as easy-to-use as object programming languages are. Moreover, they provide few solutions to difficulties encountered with biomedical ontologies...
August 14, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28818419/a-school-based-brand-marketing-program-s-adherence-to-federal-nutrition-criteria
#16
Alyssa J Moran, Eric B Rimm, Elsie M Taveras
INTRODUCTION: The Healthy, Hunger-Free Kids Act of 2010 gave the U.S. Department of Agriculture authority to regulate school wellness policies, which include nutritional standards for foods advertised in schools. Brand marketing programs, which encourage students to purchase a company's products in exchange for money or rewards, were not explicitly prohibited. This study assesses the nutritional quality of products participating in "Box Tops for Education" ("Box Tops"), one of the largest national brand marketing programs in schools...
August 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818385/molecular-cloning-and-characterization-of-ptrzpt2-1-a-zpt2-family-gene-encoding-a-cys2-his2-type-zinc-finger-protein-from-trifoliate-orange-poncirus-trifoliata-l-raf-that-enhances-plant-tolerance-to-multiple-abiotic-stresses
#17
Dechun Liu, Li Yang, Man Luo, Qi Wu, Shanbei Liu, Yong Liu
In plants, most Cys2/His2 (C2H2) zinc finger proteins with two zinc finger domains (ZPT2) are involved in abiotic stress responses. In this study, a ZPT2 family gene PtrZPT2-1 was cloned from trifoliate orange (Poncirus trifoliata (L.) Raf.). PtrZPT2-1 is composed of 245 amino acids, has a putative molecular weight of 25.99kDa and an isoelectric point of 8.41. PtrZPT2-1 contained two C2H2 zinc finger domains, one nuclear localization signal (B-box), one transcription repression domain (DLN-box), and one protein-protein interaction domain (L-box)...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28818370/overexpression-of-vpeifp1-a-novel-f-box-kelch-repeat-protein-from-wild-chinese-vitis-pseudoreticulata-confers-higher-tolerance-to-powdery-mildew-by-inducing-thioredoxin-z-proteolysis
#18
Jie Wang, Wenkong Yao, Lei Wang, Fuli Ma, Weihuo Tong, Chen Wang, Rui Bao, Changyue Jiang, Yazhou Yang, Jianxia Zhang, Yan Xu, Xiping Wang, Chaohong Zhang, Yuejin Wang
An F-box protein (VpEIFP1) induced by Erysiphe necator was isolated from Vitis pseudoreticulata, a wild Chinese grapevine species naturally resistant to powdery mildew (PM). It contains an F-box domain and two Kelch-repeat motifs. Expression profiles indicate the VpEIFP1 is strongly induced at both transcriptional and translational levels by PM infection. A subcellular localisation assay showed that VpEIFP1 is predominantly located in the nucleus and cytoplasm. Overexpression of VpEIFP1 accelerated the accumulation of hydrogen peroxide (H2O2) and up-regulated the expressions of ICS2, NPR1 and PR1 involved in defence responses, resulting in suppression of PM germination and growth...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28818340/lps-binding-to-hmgb1-promotes-angiogenic-behavior-of-endothelial-cells-through-inhibition-of-p120-and-cd31-via-erk-p38-src-signaling
#19
Zhenguo Liu, Juan Wang, Wu Xing, Yingqiong Peng, Jun Quan, Xuegong Fan
Lipopolysaccharide (LPS) is known to mediate angiogenic effects in endothelial cells. The underlying mechanisms, however, remain largely unknown. In this study, we showed that LPS induced high motility group box protein 1 (HMGB1) secretion in human pulmonary microvascular endothelial cells (HPMECs). Knockdown and overexpression of HMGB1 by adenoviral vectors effectively inhibited and promoted LPS-induced HPMEC migration and capillary-like tube formation, respectively. On the other hand, HMGB1 exerted an inhibitory effect on LPS-suppressed expression of platelet-endothelial cell adhesion molecule (CD31) and p120 catenin (p120); HMGB1 knockdown reversed this effect...
August 9, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28818156/time-for-surgeons-to-think-outside-the-anatomical-box
#20
Raj C Dedhia
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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