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https://www.readbyqxmd.com/read/27912885/tetrandrine-an-alkaloid-from-s-tetrandra-exhibits-anti-hypertensive-and-sleep-enhancing-effects-in-shr-via-different-mechanisms
#1
Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
BACKGROUND: Sleep disorders have been found to be associated with hypertension in both cross-sectional and longitudinal epidemiological studies. Tetrandrine, a major component of Stephania tetrandra, is well known as an antihypertensive agent. The anti-hypertension mechanism mainly relies on its L-type calcium channel blocking property. In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). PURPOSE: This study aims to elucidate whether the antihypertensive mechanism of tetrandrine in SHRs is relevant to its hypnotic effect...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912882/tenuifolin-a-saponin-derived-from-radix-polygalae-exhibits-sleep-enhancing-effects-in-mice
#2
Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported that tenuifolin was a major constituent of polygalasaponins. PURPOSE: The currently study aims to investigate the hypnotic effect and possible mechanism of tenuifolin in freely moving mice...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27875126/epileptogenic-source-imaging-using-cross-frequency-coupled-signals-from-scalp-eeg
#3
Chunsheng Li, Daniel Jacobs, Trevor Hilton, Martin Del Campo, Yotin Chinvarun, Peter L Carlen, Berj L Bardakjian
OBJECTIVE: The epileptogenic zone (EZ) is a brain region containing the sources of seizure genesis. Removal of the EZ is associated with cessation of seizures after resective surgical procedures, as measured by Engel Class I score. This study describes a novel EEG (electroencephalography) source imaging (ESI) method which uses cross-frequency coupled potential signals (SCFC) derived from scalp EEG. METHODS: Scalp EEG were recorded from ten patients (20 seizures) suffering from epilepsy...
December 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27826247/modulations-of-heart-rate-ecg-and-cardio-respiratory-coupling-observed-in-polysomnography
#4
REVIEW
Thomas Penzel, Jan W Kantelhardt, Ronny P Bartsch, Maik Riedl, Jan F Kraemer, Niels Wessel, Carmen Garcia, Martin Glos, Ingo Fietze, Christoph Schöbel
The cardiac component of cardio-respiratory polysomnography is covered by ECG and heart rate recordings. However, their evaluation is often underrepresented in summarizing reports. As complements to EEG, EOG, and EMG, these signals provide diagnostic information for autonomic nervous activity during sleep. This review presents major methodological developments in sleep research regarding heart rate, ECG, and cardio-respiratory couplings in a chronological (historical) sequence. It presents physiological and pathophysiological insights related to sleep medicine obtained by new technical developments...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27799694/the-effect-of-intervention-according-to-muscle-contraction-type-on-the-cerebral-cortex-of-the-elderly
#5
Jeong-Il Kang, Dae-Keun Jeong, Hyun Choi
[Purpose] Here we investigated the activity of the cerebral cortex after resistance training in the elderly. We evaluated the clinical neuropsychological basis of 2 contractile types, and determined the usefulness of a movement-related cortical potential (MRCP) from an electroencephalography (EEG). [Subjects and Methods] The subjects were 11 females and 11 males aged between 65 and 70 years. The subjects were randomly assigned into a group that performed an eccentric contraction exercise (experimental group I, n=11) and a group that performed a concentric contraction exercise (experimental group II, n=11)...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27788128/reduction-hybrid-artifacts-of-emg-eog-in-electroencephalography-evoked-by-prefrontal-transcranial-magnetic-stimulation
#6
Yang Bai, Xiaohong Wan, Ke Zeng, Yinmei Ni, Lirong Qiu, Xiaoli Li
OBJECTIVE: When prefrontal-transcranial magnetic stimulation (p-TMS) performed, it may evoke hybrid artifact mixed with muscle activity and blink activity in EEG recordings. Reducing this kind of hybrid artifact challenges the traditional preprocessing methods. We aim to explore method for the p-TMS evoked hybrid artifact removal. APPROACH: We propose a novel method used as independent component analysis (ICA) post processing to reduce the p-TMS evoked hybrid artifact...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27771371/rem-sleep-disorder-following-general-anesthesia-in-rats
#7
Katarina Lazic, Jelena Petrovic, Jelena Ciric, Aleksandar Kalauzi, Jasna Saponjic
Postoperative sleep disorders, particularly the REM sleep disorder, may have a significant deleterious impact on postoperative outcomes and may contribute to the genesis of certain delayed postoperative complications. We have followed the effect of distinct anesthesia regimens (ketamine/diazepam vs. pentobarbital) over 6days following the induction of a stable anesthetized state in adult male Wistar rats, chronically instrumented for sleep recording. In order to compare the effect of both anesthetics in the physiological controls vs...
January 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27760892/investigation-of-sleep-wake-rhythm-in-non-human-primates-without-restraint-during-data-collection
#8
Akiyoshi Ishikawa, Keita Sakai, Takehiro Maki, Yuri Mizuno, Kimie Niimi, Yasuhiro Oda, Eiki Takahashi
To understand sleep mechanisms and develop treatments for sleep disorders, investigations using animal models are essential. The sleep architecture of rodents differs from that of diurnal mammals including humans and non-human primates. Sleep studies have been conducted in non-human primates; however, these sleep assessments were performed on animals placed in a restraint chair connected via the umbilical area to the recording apparatus. To avoid restraints, cables, and other stressful apparatuses and manipulations, telemetry systems have been developed...
October 18, 2016: Experimental Animals
https://www.readbyqxmd.com/read/27710806/sleep-related-changes-in-cardiovascular-autonomic-regulation-in-left-coronary-artery-ligation-rats-neural-mechanism-facilitating-arrhythmia-after-myocardial-infarction
#9
Wei-Lun Lin, Li-Wei Lo, Hau-Ruey Chen, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Yu-Hui Chou, Shih-Ann Chen, Yun-Ching Fu, Terry B J Kuo
BACKGROUND: Autonomic imbalance with increased sympathetic and decreased parasympathetic activities is observed in patients after myocardial infarction (MI). We aimed to investigate sleep-related changed in autonomic regulation in left coronary artery (LCA) ligation rats. METHODS: Wireless transmission of polysomnographic recording was performed in sham and LCA ligation male rats during normal daytime sleep with and without atenolol treatment. Spectral analyses of the electroencephalogram (EEG) and electromyogram (EMG) were evaluated to define active waking (AW), quiet and paradoxical sleeps (QS, PS)...
September 30, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27702708/neurophysiology-of-myoclonus-and-progressive-myoclonus-epilepsies
#10
Giuliano Avanzini, Hiroshi Shibasaki, Guido Rubboli, Laura Canafoglia, Ferruccio Panzica, Silvana Franceschetti, Mark Hallett
The high temporal resolution of neurophysiological recordings makes them particularly suited to faithfully describing the time course of rapid events such as myoclonus and to precisely measure its time relationship with other related activities. In progressive myoclonus epilepsies (PMEs) polygraphy with simultaneous EMG-EEG recordings is a crucial tool for defining the characteristic of myoclonic jerks their topography over different muscles (namely antagonists), their time course and relationship with vigilance muscle activation and stimulations...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27702643/electroencephalographic-correlates-of-states-of-concentrative-meditation
#11
Dylan DeLosAngeles, Graham Williams, John Burston, Sean P Fitzgibbon, Trent W Lewis, Tyler S Grummett, C Richard Clark, Kenneth J Pope, John O Willoughby
Meditative techniques aim for and meditators report states of mental alertness and focus, concurrent with physical and emotional calm. We aimed to determine the electroencephalographic (EEG) correlates of five states of Buddhist concentrative meditation, particularly addressing a correlation with meditative level. We studied 12 meditators and 12 pair-matched meditation-naïve participants using high-resolution scalp-recorded EEG. To maximise reduction of EMG, data were pre-processed using independent component analysis and surface Laplacian transformed data...
October 1, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27692059/cntnap2-knockout-rats-and-mice-exhibit-epileptiform-activity-and-abnormal-sleep-wake-physiology
#12
Alexia M Thomas, Michael D Schwartz, Michael D Saxe, Thomas S Kilduff
STUDY OBJECTIVES: Although recent innovations have enabled modification of the rat genome, it is unclear whether enhanced utility of rodents as human disease models will result. We compared EEG and behavioral phenotypes of rats and mice with homozygous deletion of Cntnap2, a gene associated with cortical dysplasia-focal epilepsy (CDFE) and autism spectrum disorders (ASD). METHODS: Male Cntnap2 knockout (KO) and wild-type (WT) rats and male Cntnap2 KO and WT mice were implanted with telemeters to record EEG, EMG, body temperature and locomotor activity...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27658486/trace-amine-associated-receptor-1-regulates-wakefulness-and-eeg-spectral-composition
#13
Michael D Schwartz, Sarah W Black, Simon P Fisher, Jeremiah B Palmerston, Stephen R Morairty, Marius C Hoener, Thomas S Kilduff
Trace amine-associated receptor 1 (TAAR1) agonists have been shown to have procognitive, antipsychotic-like, anxiolytic, weight-reducing, glucose-lowering, and wake-promoting activities. We used Taar1 knockout (KO) and overexpressing (OE) mice and TAAR1 agonists to elucidate the role of TAAR1 in sleep/wake. EEG, EMG, body temperature (Tb), and locomotor activity (LMA) were recorded in Taar1 KO, OE, and WT mice. Following a 24 h recording to characterize basal sleep/wake parameters, mice were sleep deprived (SD) for 6 h...
October 26, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27628205/functional-connectivity-in-the-neuromuscular-system-underlying-bimanual-coordination
#14
Ingmar E J de Vries, Andreas Daffertshofer, Dick F Stegeman, Tjeerd W Boonstra
Neural synchrony has been suggested as a mechanism for integrating distributed sensorimotor systems involved in coordinated movement. To test the role of corticomuscular and intermuscular coherence in bimanual coordination, we experimentally manipulated the degree of coordination between hand muscles by varying the sensitivity of the visual feedback to differences in bilateral force. In 16 healthy participants, cortical activity was measured using EEG and muscle activity of the flexor pollicis brevis of both hands using high-density electromyography (HDsEMG)...
December 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27619737/the-middle-aged-ovariectomized-marmoset-callithrix-jacchus-as-a-model-of-menopausal-symptoms-preliminary-evidence
#15
Nicole J Gervais, Shaun S Viechweg, Jessica A Mong, Agnès Lacreuse
Menopausal women often suffer from hot flashes and sleep disturbances that significantly impact their quality of life. Both human and animal studies suggest that loss of estrogens during menopause contribute to these symptoms. In the female rat, both core body temperature (CBT) and sleep are sensitive to 17β-estradiol (E2) levels, but important differences between the rat and the human patterns limit the interpretation of the results. The sleep and thermoregulation of the common marmoset (Callithrix jacchus) more closely resemble human patterns...
September 9, 2016: Neuroscience
https://www.readbyqxmd.com/read/27581084/ataxia-dystonia-and-myoclonus-in-adult-patients-with-niemann-pick-type-c
#16
L H Koens, A Kuiper, M A Coenen, J W J Elting, J J de Vries, M Engelen, J H T M Koelman, F J van Spronsen, J M Spikman, T J de Koning, M A J Tijssen
BACKGROUND: Niemann-Pick type C (NP-C) is a rare autosomal recessive progressive neurodegenerative disorder caused by mutations in the NP-C 1 or 2 gene. Besides visceral symptoms, presentation in adolescent and adult onset variants is often with neurological symptoms. The most frequently reported presenting symptoms of NP-C in adulthood are psychiatric symptoms (38 %), cognitive decline (23 %) and ataxia (20 %). Myoclonus can be present, but its value in early diagnosis and the evolving clinical phenotype in NP-C is unclear...
September 1, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27573669/%C3%AE-pinene-a-major-constituent-of-pine-tree-oils-enhances-non-rapid-eye-movement-sleep-in-mice-through-gabaa-benzodiazepine-receptors
#17
Hyejin Yang, Junsung Woo, Ae Nim Pae, Min Young Um, Nam-Chul Cho, Ki Duk Park, Minseok Yoon, Jiyoung Kim, C Justin Lee, Suengmok Cho
α-Pinene is a major monoterpene of the pine tree essential oils. It has been reported that α-pinene shows anxiolytic and hypnotic effects upon inhaled administration. However, hypnotic effect by oral supplementation and the molecular mechanism of α-pinene have not been determined yet. By combining in vivo sleep behavior, ex vivo electrophysiological recording from brain slices, and in silico molecular modeling, we demonstrate that (-)-α-pinene shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site...
November 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/27568798/sleep-is-critical-for-remote-preconditioning-induced-neuroprotection
#18
Allison J Brager, Tao Yang, J Christopher Ehlen, Roger P Simon, Robert Meller, Ketema N Paul
STUDY OBJECTIVES: Episodes of brief limb ischemia (remote preconditioning) in mice induce tolerance to modeled ischemic stroke (focal brain ischemia). Since stroke outcomes are in part dependent on sleep-wake history, we sought to determine if sleep is critical for the neuroprotective effect of limb ischemia. METHODS: EEG/EMG recording electrodes were implanted in mice. After a 24 h baseline recording, limb ischemia was induced by tightening an elastic band around the left quadriceps for 10 minutes followed by 10 minutes of release for two cycles...
November 1, 2016: Sleep
https://www.readbyqxmd.com/read/27568007/reductions-in-co-contraction-following-neuromuscular-re-education-in-people-with-knee-osteoarthritis
#19
Stephen J Preece, Richard K Jones, Christopher A Brown, Timothy W Cacciatore, Anthony K P Jones
BACKGROUND: Both increased knee muscle co-contraction and alterations in central pain processing have been suggested to play a role in knee osteoarthritis pain. However, current interventions do not target either of these mechanisms. The Alexander Technique provides neuromuscular re-education and may also influence anticipation of pain. This study therefore sought to investigate the potential clinical effectiveness of the AT intervention in the management of knee osteoarthritis and also to identify a possible mechanism of action...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27513629/long-term-training-with-a-brain-machine-interface-based-gait-protocol-induces-partial-neurological-recovery-in-paraplegic-patients
#20
Ana R C Donati, Solaiman Shokur, Edgard Morya, Debora S F Campos, Renan C Moioli, Claudia M Gitti, Patricia B Augusto, Sandra Tripodi, Cristhiane G Pires, Gislaine A Pereira, Fabricio L Brasil, Simone Gallo, Anthony A Lin, Angelo K Takigami, Maria A Aratanha, Sanjay Joshi, Hannes Bleuler, Gordon Cheng, Alan Rudolph, Miguel A L Nicolelis
Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated that long-term BMI training could induce any type of clinical recovery. Eight chronic (3-13 years) spinal cord injury (SCI) paraplegics were subjected to long-term training (12 months) with a multi-stage BMI-based gait neurorehabilitation paradigm aimed at restoring locomotion. This paradigm combined intense immersive virtual reality training, enriched visual-tactile feedback, and walking with two EEG-controlled robotic actuators, including a custom-designed lower limb exoskeleton capable of delivering tactile feedback to subjects...
2016: Scientific Reports
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