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https://www.readbyqxmd.com/read/29748700/myocardial-stress-perfusion-mri-experience-in-pediatric-and-young-adult-patients-following-arterial-switch-operation-utilizing-regadenoson
#1
Cory V Noel, Ramkumar Krishnamurthy, Prakash Masand, Brady Moffett, Tobiash Schlingmann, Benjamin Y Cheong, Rajesh Krishnamurthy
Dextro-transposition of the great arteries (D-TGA) is one of the most common cyanotic heart lesions. The arterial switch operation (ASO) is the preferred surgical palliation for D-TGA. One of the primary concerns following the ASO is complications arising from the coronary artery transfer. There is a need for myocardial perfusion assessment within ASO patients. There is no report on the utility of regadenoson as a stress agent in children following ASO. Our objective was to observe the safety and feasibility of regadenoson as a pharmacologic stressor for perfusion cardiac MR in a pilot cohort of pediatric and young-adult patients who have undergone ASO...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29724352/neonatal-brain-injury-and-timing-of-neurodevelopmental-assessment-in-patients-with-congenital-heart-disease
#2
Shabnam Peyvandi, Vann Chau, Ting Guo, Duan Xu, Hannah C Glass, Anne Synnes, Kenneth Poskitt, A James Barkovich, Steven P Miller, Patrick S McQuillen
BACKGROUND: Brain injury (BI) is reported in 60% of newborns with critical congenital heart disease as white matter injury (WMI) or stroke. Neurodevelopmental (ND) impairments are reported in these patients. The relationship between neonatal BI and ND outcome has not been established. OBJECTIVES: This study sought to determine the association between peri-operative BI and ND outcomes in infants with single ventricle physiology (SVP) and d-transposition of the great arteries (d-TGA)...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29701356/arterial-switch-how-to-predict-reoperation
#3
Carolina Rodrigues, Rui Cerejo
INTRODUCTION: Jatene surgery or arterial switch is performed at our institution since 1989. It is mandatory to submit our results to an evaluation that allow us to identify the main causes of reoperation and, more importantly, to determine what variables predict the need of reoperation. METHODS: In this retrospective analysis were included all the 91 patients with d-TGA who underwent an arterial switch operation at Santa Marta Hospital between 1999 and 2016. RESULTS: Mean follow-up was 6 years (range 1-21 years)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29675828/effect-of-prenatal-diagnosis-on-hospital-costs-in-complete-transposition-of-the-great-arteries
#4
Dipankar Gupta, Meredith E Mowitz, Dalia Lopez-Colon, Connie S Nixon, Himesh V Vyas, Jennifer G Co-Vu
OBJECTIVE: Prenatal diagnosis of congenital heart disease (CHD) is associated with improved clinical outcomes, yet its impact on the cost of hospitalization is not well described. We hypothesized that prenatal diagnosis of complete transposition of the great arteries (d-TGA) results in lower total hospital costs compared to postnatal diagnosis. METHODS: Retrospective analysis of infants with d-TGA repaired at our center from July 2006- 2014. Total charges from initial hospitalization until discharge were converted to costs using the cost-to-charge ratio, and then converted into 2016 dollars using the Consumer Price Index...
April 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29657908/a-rare-case-of-coronary-artery-embolism-in-a-patient-with-d-transposition-of-the-great-arteries-with-prior-mustard-repair
#5
Prince Sethi, Udit Bhatnagar, Kelly Steffen, Edgard Bendaly, Adam Stys
The dextro-transposition of great arteries (d-TGA) is a rare, congenital, cyanotic heart disease and there is a paucity of data regarding long-term cardiovascular outcomes. We present a rare case of non-ST-elevation myocardial infarction (NSTEMI) in a patient with surgically repaired d-TGA. A 43-year-old male who had previously undergone a Mustard atrial switch palliative procedure presented with chest pain and diaphoresis and was diagnosed with NSTEMI. A coronary angiogram revealed a small, underdeveloped, left anterior descending and a large, left circumflex coronary artery with an acute embolic lesion...
February 12, 2018: Curēus
https://www.readbyqxmd.com/read/29577005/transposition-of-great-arteries-with-left-main-coronary-artery-atresia-case-report
#6
Ahmed F Elmahrouk, Tamer Hamouda, Mohamed F Ismail, Ahmed Jamjoom
Background  The coronary artery anatomy in patients with transposition of the great artery (TGA) is a contributing factor for outcome in arterial switch procedure. Case Presentation  A full-term, 7-day-old baby boy diagnosed as dextro-TGA (dTGA) with intact ventricular septum. Intraoperatively, the left coronary sinus had a blind indentation from which a firm cord-like left main coronary artery originates. Procedure completed as usual for a routine arterial switch operation. Conclusion  About 5% of patients with D-TGA have a single coronary artery...
January 2018: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/29484251/graph-theory-analysis-of-cortical-thickness-networks-in-adolescents-with-d-transposition-of-the-great-arteries
#7
Christopher G Watson, Christian Stopp, Jane W Newburger, Michael J Rivkin
Objective: Adolescents with d-transposition of the great arteries (d-TGA) who had the arterial switch operation in infancy have been found to have structural brain differences compared to healthy controls. We used cortical thickness measurements obtained from structural brain MRI to determine group differences in global brain organization using a graph theoretical approach. Methods: Ninety-two d-TGA subjects and 49 controls were scanned using one of two identical 1...
February 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29444099/airway-ciliary-dysfunction-and-respiratory-symptoms-in-patients-with-transposition-of-the-great-arteries
#8
Maliha Zahid, Abha Bais, Xin Tian, William Devine, Dong Ming Lee, Cyrus Yau, Daniel Sonnenberg, Lee Beerman, Omar Khalifa, Cecilia W Lo
BACKGROUND: Our prior work on congenital heart disease (CHD) with heterotaxy, a birth defect involving randomized left-right patterning, has shown an association of a high prevalence of airway ciliary dysfunction (CD; 18/43 or 42%) with increased respiratory symptoms. Furthermore, heterotaxy patients with ciliary dysfunction were shown to have more postsurgical pulmonary morbidities. These findings are likely a reflection of the common role of motile cilia in both airway clearance and left-right patterning...
2018: PloS One
https://www.readbyqxmd.com/read/29433967/role-of-myocardial-collagen-degradation-and-fibrosis-in-right-ventricle-dysfunction-in-transposition-of-the-great-arteries-after-atrial-switch
#9
Magalie Ladouceur, Stephanie Baron, Valérie Nivet-Antoine, Gérard Maruani, Gilles Soulat, Helena Pereira, Anne Blanchard, Pierre Boutouyrie, Jean Louis Paul, Elie Mousseaux
BACKGROUND: Heart failure is a serious event in patients with transposition of the great arteries (D-TGA) after atrial redirection surgery. We aimed to determine the association between myocardial fibrosis and systolic and diastolic systemic right ventricle (sRV) dysfunction. METHODS: Diastolic and systolic function of sRV was prospectively assessed using echocardiography and cardiac magnetic resonance imaging (CMR) in 48 patients with atrially switched D-TGA and 26 healthy subjects...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29366495/cerebral-oximetry-monitoring-in-the-management-of-severe-hypoxaemia-associated-with-transposition-of-the-great-arteries-with-balloon-atrial-septostomy
#10
J C Pérez Moreno, D C Nájera Losada, P Sanabria Carretero, Á Paredes Lacave, F Benito Bartolomé
Transposition of the great arteries (D-TGA) is one of the most common congenital heart diseases requiring neonatal surgical intervention. In the desperately ill neonate with TGA and the resultant hypoxaemia, acidemia, and congestive heart failure, improvement is often obtained with balloon atrial septostomy (BAS). Current methods employed to evaluate oxygen delivery and tissue consumption are frequently nonspecific. Near infrared spectroscopy (NIRS) allows a continuous non-invasive measurement of tissue oxygenation which reflects perfusion status in real time...
January 21, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29336395/tricuspid-valve-straddling-an-uncommon-cause-of-left-ventricular-outflow-tract-obstruction-in-transposition-of-great-artery-with-ventricular-septal-defect
#11
Bhupesh Kumar, Aveek Jayant, Ganesh Kumar Munirathinam, Sachin Mahajan
Transposition of great arteries (TGA) can be associated with left ventricle outflow tract (LVOT) obstruction. In the presence of ventricular septal defect (VSD), septal leaflet of tricuspid valve may prolapse through perimembranous VSD or rarely tricuspid valve tissue may override to produce LVOT obstruction. Occasionally, this may be mistaken for vegetation due to associated pulmonary valve endocarditis. We report a case of d-TGA with presumptive pulmonary valve endocarditis and LVOT obstruction that was found to be due to tricuspid valve straddling on transesophageal echocardiography, resulting in change in the surgical plan and thus avoiding catastrophe...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29280178/relationship-between-cavum-septi-pellucidi-measurements-and-fetal-hypoplastic-left-heart-syndrome-or-dextro-transposition-of-the-great-arteries
#12
Michael Saadeh, Yili Zhao, Hadiza Galadima, Rabih Chaoui, Elena Sinkovskaya, Alfred Abuhamad
OBJECTIVES: The aim of this study was to compare the size and position of the cavum septi pellucidi (CSP) in fetuses with hypoplastic left heart syndrome (HLHS) or dextro-transposition of the great arteries (d-TGA) with healthy fetuses. METHODS: The CSP length, CSP width, and frontal lobe length were measured in 185 healthy fetuses (404 scans), 11 fetuses with HLHS (16 scans), and 11 fetuses with d-TGA (12 scans) between January 2005 and April 2016. Each measurement was compared between healthy fetuses and those with HLHS or d-TGA, controlling for the biparietal diameter...
December 27, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29274314/an-analysis-of-left-ventricular-retraining-in-patients-with-dextro-and-levo-transposition-of-the-great-arteries
#13
Richard D Mainwaring, William L Patrick, Ali N Ibrahimiye, Naruhito Watanabe, George K Lui, Frank L Hanley
BACKGROUND: Patients with dextro (D)-transposition of the great arteries (TGA) who have undergone a previous atrial switch and for some patients with levo (L)-TGA (ie, no ventricular septal defect or outflow tract obstruction), the left ventricle (LV) may require retraining before late arterial switch. The purpose of this study was to analyze the results of LV retraining for these two entities. METHODS: This was a retrospective review of 51 patients enrolled in an LV retraining program...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29261645/fetal-somatic-growth-trajectory-differs-by-type-of-congenital-heart-disease
#14
Kriti Puri, Carri R Warshak, Mounira A Habli, Amy Yuan, Rashmi D Sahay, Eileen C King, Allison Divanovic, James F Cnota
BackgroundThe growth trajectories of common measurements, including estimated fetal weight (EFW), head circumference (HC), and abdominal circumference (AC), in fetuses with congenital heart disease (CHD) have not been described for different cardiac lesions. We hypothesized that (i) fetuses with CHD have differential growth in utero, and (ii) different categories of CHD demonstrate different in utero growth curves.MethodsWe performed a retrospective observational cohort study of pregnancies with known fetal CHD seen from January 2000 to June 2013...
March 2018: Pediatric Research
https://www.readbyqxmd.com/read/29122798/impact-of-prenatal-diagnosis-on-survival-of-newborns-with-four-congenital-heart-defects-a-prospective-population-based-cohort-study-in-france-the-epicard-study
#15
Babak Khoshnood, Nathalie Lelong, Lucile Houyel, Damien Bonnet, Morgane Ballon, Jean-Marie Jouannic, François Goffinet
OBJECTIVES: (1) Assess the population-level probability of prenatal diagnosis and termination of pregnancy for fetal anomaly for four major congenital heart defects; (2) Examine, using population-based data, the relation between timing of (prenatal vs postnatal) diagnosis and risk of infant (ie, < 1 year) mortality for four major congenital heart defects (CHDs). DESIGN: Population-based cohort (the EPIdémiologie des CARDiopathies congénitales) study. SETTING: Greater Paris area (Paris and its surrounding suburbs)...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29057564/the-effect-of-fetal-hemodynamics-on-fetal-growth-in-single-ventricle-and-transposition-of-the-great-arteries
#16
Tarek Alsaied, Stephanie Tseng, Eileen King, Eunice Hahn, Allison Divanovic, Mounira Habli, James Cnota
INTRODUCTION: As birth weight is a critical predictor of neonatal congenital heart defect (CHD) outcomes, the common problem of poor fetal growth in this population is clinically important but not well understood. The impact of fetal hemodynamics on fetal growth and birth weight in CHD has not been assessed. Combined cardiac output (CCO) has been used to evaluate patients with structurally normal heart but rarely in CHD. Middle cerebral artery and umbilical artery pulsatility indices (PIs) have been used to evaluate the relative distribution of circulation in patients with CHD...
October 23, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29033017/neurocognitive-and-psychological-outcomes-in-adults-with-dextro-transposition-of-the-great-arteries-corrected-by-the-arterial-switch-operation
#17
Leïla Kasmi, Johanna Calderon, Michèle Montreuil, Nikoletta Geronikola, Virginie Lambert, Emrè Belli, Damien Bonnet, David Kalfa
BACKGROUND: Neurodevelopmental impairments have frequently been described in children and adolescents with dextro-transposition of the great arteries (d-TGA). The arterial switch operation (ASO) to correct d-TGA has been used for more than 30 years, and more than 90% of these patients now reach adulthood. However, very little is known about their long-term functional outcomes. The present study investigated neurocognitive outcomes and the prevalence of psychiatric disorders in adults with d-TGA corrected by ASO...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28925322/unusual-intramural-coronary-artery-with-vertical-course-complicating-an-arterial-switch-operation
#18
Lok Sinha, Richard A Jonas, Pranava Sinha
Intramural coronary arteries in patients with d-transposition of the great arteries (d-TGA) usually arise from the opposite sinus of Valsalva and traverse horizontally across the posterior/facing commissure before emerging externally from the appropriate sinus of Valsalva. Failure to make appropriate technical modifications during coronary transfer can result in an important risk of posttransfer ischemia. We report a case with an unusual course of an intramural left anterior descending (LAD) coronary artery in a patient with d-TGA, with origin at the mid ascending aorta and a vertical intramural course, increasing the susceptibility to injury during an arterial switch operation (ASO)...
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28818352/longitudinal-sequential-biventricular-assessment-in-adults-with-transposition-of-the-great-arteries-and-relationship-with-adverse-outcomes
#19
M Riahi, A Claman, M Kiess, M Orgad, D Human, S Chakrabarti, J Leipsic, J Grewal
BACKGROUND: In a cohort of congenitally corrected transposition of the great arteries (cc-TGA) and transposition of the great arteries after atrial switch procedure (d-TGA) the study objectives were: 1) to assess the change of quantitative systemic right ventricle (sRV) parameters over time and; 2) to examine the relationship of quantitative sRV parameters with adverse clinical outcomes. METHODS AND RESULTS: Single-center cohort study that included 49 (39%) cc-TGA and 76 (61%) d-TGA patients >18years who had at least one MUGA sRV assessment, 18/39 had more than one respectively...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28767656/collagen-turnover-biomarkers-and-systemic-right-ventricle-remodeling-in-adults-with-previous-atrial-switch-procedure-for-transposition-of-the-great-arteries
#20
Magdalena Lipczyńska, Piotr Szymański, Magdalena Kumor, Anna Klisiewicz, Piotr Hoffman
BACKGROUND: Myocardial fibrosis is a potential pathophysiological mechanism leading to systemic right ventricular (SRV) deterioration. We hypothesize that circulating levels of collagen deposition markers are elevated in patients with SRV remodeling and this elevation may have a predictive value. METHODS: We prospectively evaluated 56 patients with D-TGA after the atrial switch procedure (mean age 25.6 ± 4.8, range 18-37 years; 67% males). Serum levels of procollagen type III amino-terminal propeptide (PIIINP), collagen type I carboxy-terminal telopeptide (CITP), procollagen type I N-terminal propeptide (PINP), matrix metalloproteinase (MMP 1, MMP 9) and a tissue inhibitor of matrix metalloproteinase (TIMP 1) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were measured and compared with healthy controls...
2017: PloS One
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