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Therapeutic Recreation

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https://www.readbyqxmd.com/read/28533043/-dementia-and-non-pharmacological-therapy-the-effectiveness-of-play
#1
Cédric Gueyraud, Marie Anaut, Stéphane Sanchez, Philippe Denormandie, Anthony Bathsavanis, Pierre Krolak-Salmon
A study was carried out to look into the effectiveness of play and the ways it can be used in the treatment of Alzheimer's disease. An intervention founded on the principal of a recreational setting, taking into account the choice of objects, the layout of the space and the role of the professional, could present itself as a form of therapeutic mediation adapted to this pathology. This study shows that play helps to reduce the behavioural problems of residents with Alzheimer's disease, and boosted their wellbeing and quality of life...
May 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28507726/adapting-tissue-engineered-in-vitro-cns-models-for-high-throughput-study-of-neurodegeneration
#2
Caitriona O'Rourke, Charlotte Lee-Reeves, Rosemary Al Drake, Grant Ww Cameron, A Jane Loughlin, James B Phillips
Neurodegenerative conditions remain difficult to treat, with the continuing failure to see therapeutic research successfully advance to clinical trials. One of the obstacles that must be overcome is to develop enhanced models of disease. Tissue engineering techniques enable us to create organised artificial central nervous system tissue that has the potential to improve the drug development process. This study presents a replicable model of neurodegenerative pathology through the use of engineered neural tissue co-cultures that can incorporate cells from various sources and allow degeneration and protection of neurons to be observed easily and measured, following exposure to neurotoxic compounds - okadaic acid and 1-methyl-4-phenylpyridinium...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28477247/why-psychiatry-needs-3-4-methylenedioxymethamphetamine-a-child-psychiatrist-s-perspective
#3
REVIEW
Ben Sessa
Since the late 1980s the psychoactive drug 3,4-methylenedioxymethamphetamine (MDMA) has had a well-known history as the recreationally used drug ecstasy. What is less well known by the public is that MDMA started its life as a therapeutic agent and that in recent years an increasing amount of clinical research has been undertaken to revisit the drug's medical potential. MDMA has unique pharmacological properties that translate well to its proposed agent to assist trauma-focused psychotherapy. Psychological trauma-especially that which arises early in life from child abuse-underpins many chronic adult mental disorders, including addictions...
May 5, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28454718/effects-of-co-administration-of-ketamine-and-ethanol-on-the-dopamine-system-via-the-cortex-striatum-circuitry
#4
Qing Liu, Tian-Yong Xu, Zhi-Bi Zhang, Chi-Kwan Leung, Ding-Yun You, Shang-Wen Wang, Shuai Yi, Qiang Jing, Run-Fang Xie, Huifang-Jie Li, Xiao-Feng Zeng
AIM: Ketamine and ethanol are increasingly being used together as recreational drugs in rave parties. Their effects on the dopamine (DA) system remain largely unknown. This study aimed to investigate the effects of consuming two different concentrations of ketamine with and without alcohol on the DA system. MATERIALS AND METHODS: We employed the conditioned place preference (CPP) paradigm to evaluate the rewarding effects of the combined administration of two different doses of ketamine (30mg/kg and 60mg/kg) with ethanol (0...
April 25, 2017: Life Sciences
https://www.readbyqxmd.com/read/28454538/transcriptomic-and-proteomic-insight-into-the-effects-of-a-defined-european-mistletoe-extract-in-ewing-sarcoma-cells-reveals-cellular-stress-responses
#5
M Twardziok, D Meierhofer, S Börno, B Timmermann, S Jäger, Sengül Boral, A Eggert, C I Delebinski, G Seifert
BACKGROUND: The hydrophobic triterpenes, oleanolic and betulinic acid as well as the hydrophilic mistletoe lectins and viscotoxins possess anticancer properties. They do all occur in combination in European mistletoe (Viscum album L.). Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We have previously shown that mistletoe lectins and triterpene acids are effective against Ewing sarcoma in vitro, ex vivo and in vivo. METHODS: We recreated a total mistletoe effect (viscumTT) by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilised with cyclodextrins and analysed the effects of viscumTT and the single extracts on TC-71 Ewing sarcoma cells in vitro by transcriptomic and proteomic profiling...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28440191/cannabis-a-neurological-remedy-or-a-drug-of-abuse-in-india
#6
Pronit Biswas, Pooja Mishra, Devasish Bose, Abhilasha Durgbanshi
Since ancient times it is well documented the use of cannabis as a medicine due to its potential therapeutic activity while subsequently its use as drug of abuse spread increasingly. The present review sought to give an insight in the history of medical and recreational use of cannabis in India. Indian use of cannabis dates back to Vedic time, mostly for the ritualistic and religious purposed, as documented in the ancient literature. It was India that introduced the medical use of cannabis to neighboring countries...
April 23, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28407798/utilization-of-defined-microbial-communities-enables-effective-evaluation-of-meta-genomic-assemblies
#7
William W Greenwald, Niels Klitgord, Victor Seguritan, Shibu Yooseph, J Craig Venter, Chad Garner, Karen E Nelson, Weizhong Li
BACKGROUND: Metagenomics is the study of the microbial genomes isolated from communities found on our bodies or in our environment. By correctly determining the relation between human health and the human associated microbial communities, novel mechanisms of health and disease can be found, thus enabling the development of novel diagnostics and therapeutics. Due to the diversity of the microbial communities, strategies developed for aligning human genomes cannot be utilized, and genomes of the microbial species in the community must be assembled de novo...
April 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28394016/integrative-intensive-retreats-for-veteran-couples-and-families-a-pilot-study-assessing-change-in-relationship-adjustment-posttraumatic-growth-and-trauma-symptoms
#8
J Kale Monk, Lauren M Oseland, Briana S Nelson Goff, Brian G Ogolsky, Kali Summers
We assessed a brief, systemic retreat-style intervention that was developed to address concerns about the utilization of services for veterans coping with traumatic stress. A total of 76 dyads (N = 152) were assessed before and after a 4-day retreat, which included psychoeducation, group and conjoint therapeutic sessions, and recreational relaxation components. Overall, participants reported a reduction in trauma symptoms, but only support persons experienced a significant increase in posttraumatic growth from pretest to posttest...
April 10, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28373851/exploring-musical-activities-and-their-relationship-to-emotional-well-being-in-elderly-people-across-europe-a-study-protocol
#9
Jennifer Grau-Sánchez, Meabh Foley, Renata Hlavová, Ilkka Muukkonen, Olatz Ojinaga-Alfageme, Andrijana Radukic, Melanie Spindler, Bodil Hundevad
Music is a powerful, pleasurable stimulus that can induce positive feelings and can therefore be used for emotional self-regulation. Musical activities such as listening to music, playing an instrument, singing or dancing are also an important source for social contact, promoting interaction and the sense of belonging with others. Recent evidence has suggested that after retirement, other functions of music, such as self-conceptual processing related to autobiographical memories, become more salient. However, few studies have addressed the meaningfulness of music in the elderly...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28373077/new-vistas-on-cannabis-use-disorder
#10
REVIEW
Miriam Melis, Roberto Frau, Peter W Kalivas, Sade Spencer, Vivian Chioma, Erica Zamberletti, Tiziana Rubino, Daniela Parolaro
Cannabis sativa preparations are the most consumed illicit drugs for recreational purposes worldwide, and the number of people seeking treatment for cannabis use disorder has dramatically increased in the last decades. Due to the recent decriminalization or legalization of cannabis use in the Western Countries, we may predict that the number of people suffering from cannabis use disorder will increase. Despite the increasing number of cannabis studies over the past two decades, we have gaps of scientific knowledge pertaining to the neurobiological consequences of long-term cannabis use...
March 31, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28346067/horseback-riding-therapy-for-a-deafblind-individual-enabled-by-a-haptic-interface
#11
Matjaž Ogrinc Ms, Ildar Farkhatdinov PhD, Rich Walker Ms, Etienne Burdet
We present a haptic interface to help deafblind people to practice horseback riding as a recreational and therapeutic activity. Horseback riding is a form of therapy which can improve self-esteem and sensation of independence. It has been shown to benefit people with various medical conditions-including autism. However, in the case of deafblind riders, an interpreter must stand by at all times to communicate with the rider by touch. We developed a simple interface that enables deafblind people to enjoy horseback riding while the instructor is remotely providing cues, which improves their independence...
March 27, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28340578/abcb1-and-abcg2-drug-transporters-are-differentially-expressed-in-non-small-cell-lung-cancers-nsclc-and-expression-is-modified-by-cisplatin-treatment-via-altered-wnt-signaling
#12
M Vesel, J Rapp, D Feller, E Kiss, L Jaromi, M Meggyes, G Miskei, B Duga, G Smuk, T Laszlo, I Karner, J E Pongracz
BACKGROUND: Lung cancer (LC) is still the most common cause of cancer related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of all LC cases but is not a single entity. It is now accepted that, apart from the characteristic driver mutations, the unique molecular signatures of adeno- (AC) and squamous cell carcinomas (SCC), the two most common NSCLC subtypes should be taken into consideration for their management. Therapeutic interventions, however, frequently lead to chemotherapy resistance highlighting the need for in-depth analysis of regulatory mechanisms of multidrug resistance to increase therapeutic efficiency...
March 24, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28303444/outcomes-of-a-therapeutic-fly-fishing-program-for-veterans-with-combat-related-disabilities-a-community-based-rehabilitation-initiative
#13
Jessie L Bennett, Jennifer A Piatt, Marieke Van Puymbroeck
The purpose of this study was to examine the outcomes of a therapeutic fly-fishing program for veterans with combat-related disabilities. A total of 40 veterans participated in the 4-day therapeutic fly-fishing program and this study. The outcomes examined included reducing symptoms of posttraumatic stress (PTS), depression, perceived stress, functional impairment (i.e., work, relationships, physical, and everyday life), increasing self-determination, and leisure satisfaction. Each research participant completed pretest, posttest, and 3-month follow-up questionnaires...
March 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28302577/methamphetamine-effects-on-the-brain-gut-and-immune-system
#14
REVIEW
Monica D Prakash, Kathy Tangalakis, Juliana Antonipillai, Lily Stojanovska, Kulmira Nurgali, Vasso Apostolopoulos
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates mood, alertness, energy levels and concentration in the short-term. However, chronic use and/or at higher doses METH use often results in psychosis, depression, delusions and violent behavior. METH was formerly used to treat conditions such as obesity and attention deficit hyperactivity disorder, but now is primarily used recreationally. Its addictive nature has led to METH abuse becoming a global problem. At a cellular level, METH exerts a myriad of effects on the central and peripheral nervous systems, immune system and the gastrointestinal system...
June 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28287530/open-tracheostomy-gastric-acid-aspiration-murine-model-of-acute-lung-injury-results-in-maximal-acute-nonlethal-lung-injury
#15
Ravi Alluri, Hilliard L Kutscher, Barbara A Mullan, Bruce A Davidson, Paul R Knight
Acid pneumonitis is a major cause of sterile acute lung injury (ALI) in humans. Acid pneumonitis spans the clinical spectrum from asymptomatic to acute respiratory distress syndrome (ARDS), characterized by neutrophilic alveolitis, and injury to both alveolar epithelium and vascular endothelium. Clinically, ARDS is defined by acute onset of hypoxemia, bilateral patchy pulmonary infiltrates and non-cardiogenic pulmonary edema. Human studies have provided us with valuable information about the physiological and inflammatory changes in the lung caused by ARDS, which has led to various hypotheses about the underling mechanisms...
February 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28263455/liver-disease-and-fibrosis-assessment-in-substance-use-related-disorders
#16
Marija Zeremski, Anthony Martinez
Substance users have the highest prevalence of hepatitis C virus (HCV) infection but have rarely been treated, largely because of their mistrust of the health care system, misconceptions about the consequences of the infection, and concerns regarding interferon-related side effects. With the development of highly efficacious, interferon-free therapeutic regimens without significant side effects, the concept of colocating HCV and substance use treatment would appear to be highly feasible. This process has been further facilitated by widespread clinical adaptation of noninvasive assays for fibrosis assessment, which could be performed routinely in substance use treatment facilities...
March 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28250739/platelet-rich-plasma-an-adjuvant-biological-therapy-to-assist-peripheral-nerve-repair
#17
REVIEW
Mikel Sánchez, Ane Garate, Diego Delgado, Sabino Padilla
Therapies such as direct tension-free microsurgical repair or transplantation of a nerve autograft, are nowadays used to treat traumatic peripheral nerve injuries (PNI), focused on the enhancement of the intrinsic regenerative potential of injured axons. However, these therapies fail to recreate the suitable cellular and molecular microenvironment of peripheral nerve repair and in some cases, the functional recovery of nerve injuries is incomplete. Thus, new biomedical engineering strategies based on tissue engineering approaches through molecular intervention and scaffolding offer promising outcomes on the field...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28246583/three-dimensional-bio-printing-a-new-frontier-in-oncology-research
#18
REVIEW
Nitin Charbe, Paul A McCarron, Murtaza M Tambuwala
Current research in oncology deploys methods that rely principally on two-dimensional (2D) mono-cell cultures and animal models. Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting. The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28242859/counseling-parents-and-teens-about-marijuana-use-in-the-era-of-legalization-of-marijuana
#19
Sheryl A Ryan, Seth D Ammerman
Many states have recently made significant changes to their legislation making recreational and/or medical marijuana use by adults legal. Although these laws, for the most part, have not targeted the adolescent population, they have created an environment in which marijuana increasingly is seen as acceptable, safe, and therapeutic. This clinical report offers guidance to the practicing pediatrician based on existing evidence and expert opinion/consensus of the American Academy of Pediatrics regarding anticipatory guidance and counseling to teenagers and their parents about marijuana and its use...
February 27, 2017: Pediatrics
https://www.readbyqxmd.com/read/28241493/neuronal-stress-and-injury-caused-by-hiv-1-cart-and-drug-abuse-converging-contributions-to-hand
#20
REVIEW
Ana B Sanchez, Marcus Kaul
Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus and recreational and therapeutic drugs on the brain is still incompletely understood...
February 23, 2017: Brain Sciences
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