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Therapeutic Recreation

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https://www.readbyqxmd.com/read/29161743/pharmacological-foundations-of-cannabis-chemovars
#1
Mark A Lewis, Ethan B Russo, Kevin M Smith
An advanced Mendelian Cannabis breeding program has been developed utilizing chemical markers to maximize the yield of phytocannabinoids and terpenoids with the aim to improve therapeutic efficacy and safety. Cannabis is often divided into several categories based on cannabinoid content. Type I, Δ(9)-tetrahydrocannabinol-predominant, is the prevalent offering in both medical and recreational marketplaces. In recent years, the therapeutic benefits of cannabidiol have been better recognized, leading to the promotion of additional chemovars: Type II, Cannabis that contains both Δ(9)-tetrahydrocannabinol and cannabidiol, and cannabidiol-predominant Type III Cannabis...
November 21, 2017: Planta Medica
https://www.readbyqxmd.com/read/29153631/human-abuse-potential-of-brivaracetam-in-healthy-recreational-central-nervous-system-depressant-users
#2
Kerri A Schoedel, Armel Stockis, Edward M Sellers
BACKGROUND: Brivaracetam is a new antiepileptic drug indicated for adjunctive treatment of focal seizures in adults at a dose of 50-200mg/day taken in two equal doses. The objective of this study was to evaluate the abuse potential of brivaracetam compared with alprazolam (positive control), placebo, and levetiracetam. METHODS: This was a randomized, double-blind, triple-dummy, crossover study in healthy male and female recreational central nervous system (CNS) depressant users aged 18-55years, who could distinguish between the subjective effects of alprazolam 2mg and placebo...
November 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29144997/examination-of-a-therapeutic-recreation-based-clinical-placement-for-undergraduate-nursing-students-a-self-determined-perspective
#3
Dana Perlman, Ellie Taylor, Lorna Moxham, Susan Sumskis, Christopher Patterson, Renee Brighton, Tim Heffernan
Nursing students across the globe are expected to undertake clinical placements. To date, there have been no studies that have examined the potential educational benefits for undergraduate nursing students engaged in a mental health clinical placement grounded in self-determination theory. The present study examined the experiences of undergraduate students engaged in a mental health clinical placement termed Recovery Camp. An ethnographic methodology within a case study approach was used. The researchers were immersed in the clinical placement, which took place at a YMCA camp facility...
November 10, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29132327/explaining-variance-in-self-directed-learning-readiness-of-first-year-students-in-health-professional-programs
#4
Craig E Slater, Anne Cusick, Jimmy C Y Louie
BACKGROUND: Self-directed learning (SDL) is expected of health science graduates; it is thus a learning outcome in many pre-certification programs. Previous research identified age, gender, discipline and prior education as associated with variations in students' self-directed learning readiness (SDLR). Studies in other fields also propose personality as influential. METHOD: This study investigated relationships between SDLR and age, gender, discipline, previous education, and personality traits...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29124947/activity-preferences-of-persons-with-dementia-an-examination-of-reports-by-formal-and-informal-caregivers
#5
Jiska Cohen-Mansfield, Rachel Gavendo, Erin Blackburn
Objectives The aims of this study are (1) to describe the types of leisure activities preferred by persons with dementia in the past and present, as reported by family members and therapeutic recreation staff members, and (2) to examine the influence of demographic and functional abilities variables on the perceived current interest of persons with dementia. Method Family members of persons with dementia and therapeutic recreation staff involved in the care of those persons completed an activities preference assessment concerning the persons with dementia...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29122279/stem-cell-based-bone-regeneration-in-diseased-microenvironments-challenges-and-solutions
#6
Bing-Dong Sui, Cheng-Hu Hu, An-Qi Liu, Chen-Xi Zheng, Kun Xuan, Yan Jin
Restoration of extensive bone loss and defects remain as an unfulfilled challenge in modern medicine. Given the critical contributions to bone homeostasis and diseases, mesenchymal stem cells (MSCs) have shown great promise to jumpstart and facilitate bone healing, with immense regenerative potential in both pharmacology-based endogenous MSC rescue/mobilization in skeletal diseases and emerging application of MSC transplantation in bone tissue engineering and cytotherapy. However, efficacy of MSC-based bone regeneration was not always achieved; particularly, fulfillment of MSC-mediated bone healing in diseased microenvironments of host comorbidities remains as a major challenge...
October 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/29119957/-the-psychological-security-in-the-framework-of-the-system-of-factors-responsible-for-the-effectiveness-of-spa-and-health-resort-based-rehabilitation
#7
T M Krasnyanskaya, V G Tylets
AIM: The present work was designed to address the problem of ensuring the psychological security in the framework of organization of the rehabilitative treatment based at the spa and health resort facilities. MATERIAL AND METHODS: We undertook the questionnaire study for which 650 subjects were recruited among those attending spa and health resort facilities of the cities of Essentuki and Kislovodsk. The participants were asked to estimate the level of their personal security and the quality of the provided means for the rehabilitative treatment and general health improvement...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29113936/reproducible-research-practices-are-underused-in-systematic-reviews-of-biomedical-interventions
#8
Matthew J Page, Douglas G Altman, Larissa Shamseer, Joanne E McKenzie, Nadera Ahmadzai, Dianna Wolfe, Fatemeh Yazdi, Ferrán Catalá-López, Andrea C Tricco, David Moher
OBJECTIVES: To evaluate how often reproducible research practices, which allow others to recreate the findings of studies, given the original data, are used in systematic reviews (SRs) of biomedical research. STUDY DESIGN AND SETTING: We evaluated a random sample of SRs indexed in MEDLINE® during February 2014, which focused on a therapeutic intervention and reported at least one meta-analysis. Data on reproducible research practices in each SR were extracted using a 26-item form by one author, with a 20% random sample extracted in duplicate...
November 4, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29107487/quantitatively-excessive-normal-tissue-toxicity-and-poor-target-coverage-in-postoperative-lung-cancer-radiotherapy-meta-analysis
#9
Yazan Abuodeh, Arash O Naghavi, Michelle Echevarria, MaryLou DeMarco, Brian Tonner, Vladimir Feygelman, Craig W Stevens, Bradford A Perez, Thomas J Dilling
BACKGROUND: A previous meta-analysis (MA) found postoperative radiotherapy (PORT) in lung cancer patients to be detrimental in N0/N1 patients and equivocal in the N2 setting. We hypothesized that treatment plans generated using MA protocols had worse dosimetric outcomes compared to modern plans. PATIENTS AND METHODS: We retrieved plans for 13 patients who received PORT with modern planning. A plan was recreated for each patient using the 8 protocols included in MA...
July 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29101174/dietary-nitrate-supplementation-in-cardiovascular-health-an-ergogenic-aid-or-exercise-therapeutic
#10
Mary N Woessner, Luke Colin McIlvenna, Joaquin Ortiz de Zevallos, Christopher Neil, Jason David Allen
Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which can be converted to NO in low oxygen conditions. The associated beneficial physiological effects include a reduction in blood pressure, modification of platelet aggregation and increases in limb blood flow. There have been numerous studies of nitrate supplementation in healthy recreational and competitive athletes, however, the ergogenic benefits are currently unclear due to a variety of factors including small sample sizes, different dosing regimens, variable nitrate conversion rates, the heterogeneity of participants' initial fitness levels and the types of exercise tests employed...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29090011/remodeling-the-human-adult-stem-cell-niche-for-regenerative-medicine-applications
#11
REVIEW
Silvana Bardelli, Marco Moccetti
The interactions between stem cells and their surrounding microenvironment are pivotal to determine tissue homeostasis and stem cell renewal or differentiation and regeneration in vivo. Ever since they were postulated in 1978, stem cell niches have been identified and characterized in many germline and adult tissues. Comprehensive studies over the last decades helped to clarify the critical components of stem cell niches that include cellular, extracellular, biochemical, molecular, and physical regulators. This knowledge has direct impact on their inherent regenerative potential...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29069360/mouse-models-of-primary-aldosteronism-from-physiology-to-pathophysiology
#12
Leticia Aragao-Santiago, Celso E Gomez-Sanchez, Paolo Mulatero, Ariadni Spyroglou, Martin Reincke, Tracy Ann Williams
Primary aldosteronism (PA) is a common form of endocrine hypertension that is characterized by the excessive production of aldosterone relative to suppressed plasma renin levels. PA is usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Somatic mutations have been identified in several genes that encode ion pumps and channels that may explain the aldosterone excess in over half of aldosterone-producing adenomas, whereas the pathophysiology of bilateral adrenal hyperplasia is largely unknown...
October 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/29057086/interprep-internet-based-pre-exposure-prophylaxis-with-generic-tenofovir-df-emtricitabine-in-london-an-analysis-of-outcomes-in-641-patients
#13
EDITORIAL
Isaac Aloysius, Anna Savage, Jey Zdravkov, Roxanna Korologou-Linden, Andrew Hill, Rachel Smith, Vicky Houghton-Price, Marta Boffito, Nneka Nwokolo
INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) is not available on the National Health Service (NHS) in England. People are buying generic versions of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) on the internet, which is legal under UK import laws. METHODS: HIV-negative individuals attending our clinic who reported purchasing generic PrEP online were provided with risk-reduction advice and were evaluated for HIV, hepatitis B and C, renal function and sexually transmitted infections (STIs)on their first visit...
October 1, 2017: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29051432/drug-vaping-from-the-dangers-of-misuse-to-new-therapeutic-devices
#14
V Varlet
Users of e-cigarettes are unwitting volunteers participating in a worldwide epidemiological study. Because of the obvious benefits of e-cigarettes compared with traditional cigarette smoking, these electronic devices have been introduced all around the world to support tobacco smoking cessation. Same potential harm reduction could be considered by cannabis vaping for marijuana smokers. However, the toxicities of liquids and aerosols remain under investigation because although the use of e-cigarettes is likely to be less harmful than traditional cigarette smoking, trace levels of contaminants have been identified...
December 16, 2016: Toxics
https://www.readbyqxmd.com/read/29046057/bile-duct-ligature-in-young-rats-a-revisited-animal-model-for-biliary-atresia
#15
Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastian San Martin, Sandra Montedónico
Biliary atresia leads to cirrhosis in the vast majority of patients and constitutes the first cause of paediatric liver transplantation. Animal models allow us to understand the molecular basis and natural history of diseases. The aim of this study is to describe a surgically created animal model of biliary atresia with emphasis in long-term liver function. Forty-two 3-week-old Sprague-Dawley rats were randomly divided into two groups: bile duct ligature (BDL) and control. The animals were sacrificed on the 2nd, 4th, and 6th postoperative weeks...
September 13, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29019274/effects-of-whole-body-vibration-on-balance-and-mobility-in-institutionalized-older-adults-a-randomized-controlled-trial
#16
Freddy Mh Lam, Philip Fl Chan, L R Liao, Jean Woo, Elsie Hui, Charles Wk Lai, Timothy Cy Kwok, Marco Yc Pang
OBJECTIVE: To investigate whether a comprehensive exercise program was effective in improving physical function among institutionalized older adults and whether adding whole-body vibration to the program conferred additional therapeutic benefits. DESIGN: A single-blinded randomized controlled trial was conducted. SETTING: This study was carried out in residential care units. PARTICIPANTS: In total, 73 older adults (40 women, mean age: 82...
October 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28926353/randomized-double-blind-placebo-and-active-comparator-controlled-crossover-study-evaluating-the-abuse-potential-of-the-antiepileptic-drug-lacosamide-in-healthy-recreational-drug-users
#17
Kerri A Schoedel, Jens-Otto Andreas, Pamela Doty, Klaus Eckhardt, Edward M Sellers
PURPOSE: This phase 1, randomized, double-blind, placebo- and active comparator-controlled crossover study assessed the abuse potential of the antiepileptic drug, lacosamide. METHODS: After a qualification phase, 38 healthy, recreational central nervous system-depressant users were randomized to treatment sequences comprising single oral therapeutic (200 mg) and supratherapeutic (800 mg) doses of lacosamide, alprazolam (1.5 and 3 mg), and placebo. Subjective effects were assessed for 24 hours following each dose using a range of scales, with a 5- to 9-day washout between treatments...
September 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28918193/psychedelic-pleasures-an-affective-understanding-of-the-joys-of-tripping
#18
Frederik Bøhling
BACKGROUND: This paper considers the pleasures of psychedelic drugs and proposes a Deleuzian understanding of drugged pleasures as affects. In spite of a large body of work on psychedelics, not least on their therapeutic potentials, the literature is almost completely devoid of discussions of the recreational practices and pleasures of entheogenic drugs. Yet, most people do not use psychedelics because of their curative powers, but because they are fun and enjoyable ways to alter the experience of reality...
September 13, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28899638/subpectoral-biceps-tenodesis-for-treatment-of-isolated-type-ii-slap-lesions-in-a-young-and-active-population
#19
Jonas Pogorzelski, Marilee P Horan, Zaamin B Hussain, Alexander Vap, Erik M Fritz, Peter J Millett
PURPOSE: The purpose of this study was to evaluate outcomes following open subpectoral biceps tenodesis for the treatment of isolated type II SLAP lesions in patients 45 years of age or younger and evaluate the rate of return to sport. METHODS: All patients included in the study were at least 2 years out from open subpectoral biceps tenodesis for treatment of an isolated type II SLAP lesion and were treated between December 2007 and March 2015. All patients older than 45, those who had prior surgery on the index shoulder, and those who had any concomitant reconstructive shoulder procedures were excluded...
September 9, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28898301/-notes-for-a-science-of-cannabis
#20
Diego A Golombek
The therapeutic and recreational use of cannabis and its derived products has been known since ancient times. The debate regarding its properties and legal status, which has recently changed in several states, has grown in recent years. However, scientifc evidence for or against its use, as well as for potential toxic effects in the short or long term, is scarce. In spite of the promising perspectives for its therapeutic use, in particular for neurological diseases such as refractory epilepsy or multiple sclerosis, which certainly aim for a controlled administration, this opinion article advocates for a greater incidence of basic and clinical scientifc research that may take this debate further away from matters of belief or prejudice and put it where it belongs, together with evidence and rationality...
November 2016: Vertex: Revista Argentina de Psiquiatriá
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