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https://www.readbyqxmd.com/read/29158604/antiviral-cd8-t-cells-induce-zika-virus-associated-paralysis-in-mice
#1
Kellie A Jurado, Laura J Yockey, Patrick W Wong, Sarah Lee, Anita J Huttner, Akiko Iwasaki
Zika virus (ZIKV) is an emerging, mosquito-borne RNA virus. The rapid spread of ZIKV within the Americas has unveiled microcephaly (1) and Guillain-Barré syndrome (2,3) as ZIKV-associated neurological complications. Recent reports have also indicated other neurological manifestations to be associated with ZIKV, including myelitis (4) , meningoencephalitis (5) and fatal encephalitis (6) . Here, we investigate the neuropathogenesis of ZIKV infection in type I interferon receptor IFNAR knockout (Ifnar1 (-/-) ) mice, an infection model that exhibits high viral burden within the central nervous system...
November 20, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/29150828/vectors-hosts-and-control-measures-for-zika-virus-in-the-americas
#2
REVIEW
Sarah J Thompson, John M Pearce, Andrew M Ramey
We examine Zika virus (ZIKV) from an ecological perspective and with a focus on the Americas. We assess (1) the role of wildlife in ZIKV disease ecology, (2) how mosquito behavior and biology influence disease dynamics, and (3) how nontarget species and ecosystems may be impacted by vector control programs. Our review suggests that free-ranging, non-human primates may be involved in ZIKV transmission in the Old World; however, other wildlife species likely play a limited role in maintaining or transmitting ZIKV...
November 17, 2017: EcoHealth
https://www.readbyqxmd.com/read/29150641/repurposing-of-the-anti-malaria-drug-chloroquine-for-zika-virus-treatment-and-prophylaxis
#3
Sergey A Shiryaev, Pinar Mesci, Antonella Pinto, Isabella Fernandes, Nicholas Sheets, Sujan Shresta, Chen Farhy, Chun-Teng Huang, Alex Y Strongin, Alysson R Muotri, Alexey V Terskikh
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution. We demonstrate that the common anti-malaria drug chloroquine (CQ) extends the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice. However, the severity of ZIKV infection in these mice precludes the study of foetal (vertical) viral transmission...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29147884/ocular-flutter-following-zika-virus-infection
#4
Emely Karam, Jose Giraldo, Flor Rodriguez, Carlos E Hernandez-Pereira, Alfonso J Rodriguez-Morales, Gabriela M Blohm, Alberto E Paniz-Mondolfi
Zika virus (ZIKV) is an emerging flavivirus which has been linked to a number of neurologic manifestations such as Guillain-Barré syndrome (GBS), transverse myelitis, and meningo-encephalitis. Ophthalmologic manifestations are increasingly being reported; however, ocular dyskinesias have not been described in this context to date. Herein, we report a case of a 22-year-old female who presented with ocular flutter and associated Guillain-Barré syndrome following acute ZIKV infection. We speculate that although such symptoms may have originated from a direct viral insult, a post-infectious autoimmune mechanism may not be excluded...
November 16, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29147641/severity-of-acute-zika-virus-infection-a-prospective-emergency-room-surveillance-study-during-the-2015-2016-outbreak-in-suriname
#5
Pieter Vroon, Jimmy Roosblad, Fauzia Poese, Jan Wilschut, John Codrington, Stephen Vreden, Rens Zonneveld
Acute Zika virus (ZIKV) infection is usually mild and self-limiting. Earlier, we reported three cases of fatal acute ZIKV infection in patients without typical signs of ZIKV, but rather with criteria of systemic inflammation response syndrome (SIRS). To follow up these observations, we prospectively included patients at the emergency room with temperature instability and suspected to have acute ZIKV infection, SIRS, or both. A total of 102 patients were included of whom N = 21 (21%) were suspected of acute ZIKV infection, N = 56 (55%) of acute ZIKV infection with SIRS criteria, and N = 25 (24%) of SIRS alone...
2017: IDCases
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#6
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/29145400/zika-virus-an-updated-review-of-competent-or-naturally-infected-mosquitoes
#7
REVIEW
Yanouk Epelboin, Stanislas Talaga, Loïc Epelboin, Isabelle Dusfour
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) that recently caused outbreaks in the Americas. Over the past 60 years, this virus has been observed circulating among African, Asian, and Pacific Island populations, but little attention has been paid by the scientific community until the discovery that large-scale urban ZIKV outbreaks were associated with neurological complications such as microcephaly and several other neurological malformations in fetuses and newborns. This paper is a systematic review intended to list all mosquito species studied for ZIKV infection or for their vector competence...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29145171/host-target-based-approaches-against-arboviral-diseases
#8
Rebeca Froes Rocha, Juliana Lemos Del Sarto, Rafael Elias Marques, Vivian Vasconcelos Costa, Mauro Martins Teixeira
In the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reintroduction of mosquito-borne viral diseases and the dispersal of their causative agents in a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases of the last decade...
November 27, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/29141913/multiplexed-biomarker-panels-discriminate-zika-and-dengue-virus-infection-in-humans
#9
Guang Song, Hee-Sool Rho, Jianbo Pan, Pedro Ramos, Ki-Jun Yoon, Freddy A Medina, Emily M Lee, Daniel J Eichinger, Guo-Li Ming, Jorge L Muñoz-Jordan, Hengli Tang, Ignacio Pino, Hongjun Song, Jiang Qian, Heng Zhu
Zika virus (ZIKV) and dengue virus (DENV) are closely related flaviviruses that cause widespread, acute febrile illnesses, notably microcephaly for fetuses of infected pregnant women. Detecting the viral cause of these illnesses is paramount to determine risks to patients, counsel pregnant women, and help fight outbreaks. A combined diagnostic algorithm for ZIKV and DENV requires Reverse transcription polymerase chain reaction (RT-PCR) and IgM antibody detection. RT-PCR differentiates between DENV and ZIKV infections during the acute phases of infection, but differentiation based on IgM antibodies is currently nearly impossible in endemic areas...
November 15, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29141747/prevention-practices-among-the-united-states-pregnant-women-who-travel-to-zika-outbreak-areas
#10
Abbey B Berenson, Jacqueline M Hirth, Fangjian Guo, Erika L Fuchs, Scott C Weaver
We surveyed pregnant women from the United States to assess the prevention practices they used when traveling to countries with ongoing Zika virus (ZIKV) outbreaks. Of the 749 who agreed to participate, 710 completed the survey's travel questions and 59 of those had traveled to a ZIKV outbreak area in the past 12 months. Only 43% of the women who had traveled to ZIKV outbreak areas reported frequently using mosquito repellant with 32% stating they did not use it at all. They also did not frequently use other recommended methods to prevent mosquito bites...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141746/monitoring-and-control-of-aedes-albopictus-a-vector-of-zika-virus-near-residences-of-imported-zika-virus-patients-during-2016-in-south-korea
#11
Kyu-Sik Chang, Gi-Hun Kim, Young-Ran Ha, Eun Kyeong Jeong, Heung-Chul Kim, Terry A Klein, Seung Hwan Shin, Eun Jeung Kim, Seung Jegal, Se Jin Chung, Young-Ran Ju, Young Mee Jee
Zika virus (ZIKV) is an arthropod-borne virus mainly transmitted by Aedes species. A total of nine of the 16 imported ZIKV reported cases during the mosquito season in the Republic of Korea (ROK), following the return of local nationals from foreign ZIKV endemic countries, were surveyed for Aedes albopictus. Surveillance and vector control of Ae. albopictus, a potential vector of ZIKV, and related species are critical for reducing the potential for autochthonous transmission in the ROK. Surveillance and vector control were coordinated by Korean Centers for Disease Control & Prevention (KCDC) and conducted by local health authorities within 200 m of imported ZIKV patients' residences...
November 13, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140242/guillain-barr%C3%A3-syndrome-acute-disseminated-encephalomyelitis-and-encephalitis-associated-with-zika-virus-infection-in-brazil-detection-of-viral-rna-and-isolation-of-virus-during-late-infection
#12
Maria Lucia Brito Ferreira, Carlos Alexandre Antunes de Brito, Álvaro José Porto Moreira, Maria Íris de Morais Machado, Adélia Henriques-Souza, Marli Tenório Cordeiro, Ernesto Torres de Azevedo Marques, Lindomar José Pena
Zika virus (ZIKV) emerged in Brazil in 2015, which was followed by an increase of Guillain-Barre Syndrome (GBS) cases. We report the epidemiological, clinical, and laboratory findings of the first six neurological cases associated with ZIKV in Brazil seen in a reference neurology hospital in Pernambuco, Brazil. In all cases, ZIKV was detected in serum and/or cerebrospinal fluid (CSF) samples. In this case series, four cases were defined as GBS, one as acute disseminated encephalomyelitis (ADEM) and the other as encephalitis...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#13
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29136650/emerging-and-reemerging-arboviruses-a-new-threat-in-eastern-peru
#14
Carlos Alva-Urcia, Miguel Angel Aguilar-Luis, Carlos Palomares-Reyes, Wilmer Silva-Caso, Luis Suarez-Ognio, Pablo Weilg, Carlos Manrique, Fernando Vasquez-Achaya, Luis J Del Valle, Juana Del Valle-Mendoza
BACKGROUND: Arboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses. AIM: To assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru)...
2017: PloS One
https://www.readbyqxmd.com/read/29135369/t-cell-immunity-to-zika-and-dengue-viral-infections
#15
Jinsheng Wen, Sujan Shresta
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas has brought this relatively unknown flavivirus into the spotlight as the etiologic agent of congenital Zika syndrome in newborns and, potentially, of Guillain-Barré syndrome in adults. ZIKV shares a high degree of amino acid sequence homology with the closely related flavivirus Dengue virus (DENV). Due to the paucity of research investigating T cell-mediated immune responses to ZIKV, the precise roles of T cells in protection against and pathogenesis of ZIKV infection are unclear...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29133932/post-earthquake-zika-virus-surge-disaster-and-public-health-threat-amid-climatic-conduciveness
#16
Miguel Reina Ortiz, Nicole K Le, Vinita Sharma, Ismael Hoare, Edy Quizhpe, Enrique Teran, Eknath Naik, Hamisu M Salihu, Ricardo Izurieta
A recent major earthquake (M7.8), coupled with appropriate climatic conditions, led to significant destruction in Ecuador. Temperature variations, which may be induced by anthropogenic climate change, are often associated with changes in rainfall, humidity and pressure. Temperature and humidity are associated with ecological modifications that may favour mosquito breeding. We hypothesized that the disruptive ecological changes triggered by the earthquake, in the context of appropriate climatic conditions, led to an upsurge in Zika virus (ZIKV) infections...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#17
Mauricio Lacerda Nogueira, Nivison Ruy Rocha Nery Júnior, Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Georgia de Freitas Guimarães, Nathalia Zini, Rafael Alves da Silva, Gislaine Celestino Dutra Silva, Ligia Cosentino Junqueira Franco, Paula Rahal, Cintia Bittar, Bruno Carneiro, Pedro Fernando Vasconcelos da Costa, Daniele Freitas Henriques, Deusenia Machado Ulisses Barbosa, Patrícia Lopes Rombola, Luciana de Grande, Andréia Francesli Negri Reis, Sacha Ariane Palomares, Marcia Wakai Catelan, Lilian Elisa Arão Antonio Cruz, Silvia Helena Necchi, Rita de Cassia Vilella Mendonça, Izalco Nuremberg Penha Dos Santos, Suzimeiri Brigatti Alavarse Caron, Federico Costa, Fernando A Bozza, Antonio Soares de Souza, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Nikos Vasilakis, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Albert Icksang Ko
OBJECTIVE: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns' outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. METHODS: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV-positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29131357/zika-virus-what-we-need-to-know
#18
REVIEW
Farakh Javed, Khanzadi N Manzoor, Mubashar Ali, Irshad U Haq, Abid A Khan, Assad Zaib, Sobia Manzoor
Zika virus is one of the emerging viruses and is of significant threat to human health globally. It is a mosquito borne flavivirus similar to dengue, yellow fever, and West Nile viruses. It was reported about 5 decades ago and then it spreads to different parts of the world. Large outbreaks were reported on Yap Islands in 2007. Now it has gained wide attention globally by health communities. Major vector for virus transmission is Aedes aegypti mosquito. ZIKV infection is mostly asymptomatic but it is also responsible to cause mild influenza like illness to serious manifestations...
November 13, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29129917/dengue-virus-reactive-cd8-t-cells-mediate-cross-protection-against-subsequent-zika-virus-challenge
#19
Jinsheng Wen, Annie Elong Ngono, Jose Angel Regla-Nava, Kenneth Kim, Matthew J Gorman, Michael S Diamond, Sujan Shresta
Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 (-/-) or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8(+) T cells predominantly mediate cross-protective responses to ZIKV...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29127595/neurological-manifestations-of-congenital-zika-virus-infection
#20
Tania Saad, Alessandra Augusta PennaeCosta, Fernanda Veiga de Góes, Marcela de Freitas, Julia Valeriano de Almeida, Lúcio José de Santa Ignêz, Ana Paula Amancio, Renata Joviano Alvim, Ludmilla Athayde Antunes Kramberger
INTRODUCTION: In 2015, it was observed a rise in the number of microcephalic newborns associated with a history of non-specific febrile sickness and rash during pregnancy in Brazil. Since then, microcephaly has emerged as a public health concern. A few months after, the causal relation between congenital microcephaly and the Zika virus was discovered. Zika virus, an arbovirus, is a new TORCH member that leads to congenital infection through vertical transmission and harms the developing brain, disrupting synaptogenesis, and causing other central nervous system lesions...
November 10, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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