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Malcolm Prentice
Diabetes Insipidus (DI) is a name given historically to two conditions, which result in 'diabetes', which is Greek for 'syphon' or polyuria. The "Insipidus" refers to urine being insipid. 'Cranial DI' is so called because it relates to a cause within the head characterised by deficiency of vasopressin [antidiuretic hormone (ADH)] secretion from the posterior pituitary. Treatment is with desmopressin, a synthetic long-acting analogue of vasopressin. In contrast 'Nephrogenic DI' is due to resistance of the renal tubules to vasopressin action...
February 20, 2018: Clinical Endocrinology
Hela Marmouch, Sondes Arfa, Saoussen Cheikh Mohamed, Tensim Slim, Ines Khochtali
Metastases of solid tumors to the pituitary gland are often asymptomatic or appereas as with diabetes insipid us. Pituitary metastases more commonly affect the posterior lobe and the infundibulum than the anterior lobe. The presentation with an acute adrenal insufficiency is a rare event. A 69-year-old men presented with vomiting, low blood pressure and hypoglycemia. Hormonal exploration confirmed a hypopituitarism. Appropriate therapy was initiated urgently. The hypothalamic-pituitary MRI showed a pituitary hypertrophy, a nodular thickening of the pituitary stalk...
2016: Pan African Medical Journal
N Benmostefa, F Z Boussekine, H Khabbat, R Zouaghi, R Malek
OBJECTIFS: L'intoxication au monoxyde de carbone est la première cause de décès par intoxication accidentelle dans le monde, les symptômes neurologiques sont les plus fréquents mais les évènements cardiovasculaires sont rares. Nous rapportons une observation particulière. MéTHODES: Un patient de 38, sans antécédent, était admis en ranimation pour un coma sur intoxication au monoxyde de carbone. Les explorations ont mis en évidence un accident vasculaire cérébral ischémique, un syndrome coronarien aigu et un diabète insipide...
December 2015: Annales de Cardiologie et D'angéiologie
Lidija Dokmanovic, Nada Krstovski, Srdja Jankovic, Dragana Janic
Langerhans cell histiocytosis (LCH) is characterized by the proliferation of clonal dendritic cells, while hemophagocytic lymphohistiocytosis (HLH) is an extreme inflammatory process sustained by the uncontrolled activation of macrophages. HLH can be primary or secondary, the latter arising in infectious, autoimmune or neoplastic disorders. We hereby present a young girl who developed secondary HLH while being treated for relapsed multisystem LCH under the LCH III Protocol. She fulfilled 5 of 8 HLH-2004 criteria (fever, splenomegaly, pancytopenia, ferritin level >500 μ/l and sIL-2R >2400 IU/ml) and was successfully treated by the HLH-2004 Protocol for secondary HLH...
July 2014: Turkish Journal of Pediatrics
Daniel R Moore
Sarcopenia is characterized by decreases in both muscle mass and muscle function. The loss of muscle mass, which can precede decrements in muscle function, is ultimately rooted in an imbalance between the rates of muscle protein synthesis and breakdown that favors a net negative balance (i.e., synthesis < breakdown). A preponderance of evidence highlights a blunted muscle protein synthetic response to dietary protein, commonly referred to as “anabolic resistance,” as a major underlying cause of the insipid loss of muscle with age...
September 2014: Advances in Nutrition
Roisin Mary Heaney
Gallstone ileus is a rare complication of cholelithiasis accounting for 1-4% of cases of intestinal obstruction with a predominance in the elderly population. Unfortunately, it has an insipid presentation and is associated with significant rates of morbidity and mortality. Controversy arises over the management of gallstone ileus, and while surgery remains the mainstay of treatment, the main point of contention surrounds the extent of surgery. We describe the case of an 85-year-old woman who presented with symptoms and signs of large bowel obstruction...
October 16, 2014: BMJ Case Reports
J G Wessels Boer
Environmental protection policy strives to maintain an environment favourable to human health, agriculture, and the preservation of natural heritage. Infringements upon the environment have been either by sudden deliberate action of man (construction, land reclamation, dams, etc.) or by gradual, insipid stress of chemical and physical agents (chemical substances, heat, noise, radiation, etc.). Indeliberate unwanted stress upon the environment may be measured either by observing biological effects on indicator organisms or by chemically analyzing contaminants in these organisms...
September 1983: Environmental Monitoring and Assessment
Harry S Paris, Marie-Christine Daunay, Jules Janick
BACKGROUND AND AIMS: The watermelon, Citrullus lanatus (Cucurbitaceae), is an important fruit vegetable in the warmer regions of the world. Watermelons were illustrated in Mediterranean Antiquity, but not as frequently as some other cucurbits. Little is known concerning the watermelons of Mediterranean Europe during medieval times. With the objective of obtaining an improved understanding of watermelon history and diversity in this region, medieval drawings purportedly of watermelons were collected, examined and compared for originality, detail and accuracy...
September 2013: Annals of Botany
J E Nagamani, K S Shivashankara, T K Roy
Spongy tissue formation in 'Alphonso' mangoes (Mangifera indica L) is a major national problem leading to loss for farmers and traders. Spongy tissue is whitish sponge like tissue formed near the seed with insipid taste and off odour. Lipid peroxidation of membranes as studied by malondialdehyde formation was significantly higher in spongy tissue. Activities of antioxidative enzymes like superoxide dismutase, catalase, peroxidase and polyphenol oxidase were lower in spongy tissue. Among the antioxidative enzymes, activities of catalase and peroxidases were severely reduced leading to membrane damage in spongy tissue...
June 2010: Journal of Food Science and Technology
Omar López-Arbolay, Justo González-González, Jorge Luis Rojas-Manresa
OBJECTIVE: Different approaches to the skull base have been developed through the sphenoidal sinus. Traditional boundaries of the trans-sphenoidal approach can be extended in antero-posterior and lateral plane. We review our experience with extended endoscopic endonasal approach in 127 cases. METHODS: We used the extended endoscopic endonasal approach in 127 patients with different lesions of the skull base. This study specifically focuses on: type of lesions, surgical approach, outcome and surgical complications...
November 2012: Neurocirugía
John I Glendinning, Jennifer Gillman, Haley Zamer, Robert F Margolskee, Anthony Sclafani
We examined the role of T1r3 and Trpm5 taste signaling proteins in carbohydrate-induced overeating and obesity. T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in taste cells. It is known that C57BL/6 wild-type (WT) mice are attracted to the tastes of both Polycose (a glucose polymer) and sucrose, whereas Tas1r3 KO mice are attracted to the taste of Polycose but not sucrose. In contrast, Trpm5 KO mice are not attracted to the taste of sucrose or Polycose...
August 20, 2012: Physiology & Behavior
Mbu Kalenga, N Collignon, C Andris, M Deprez, B Otto
PURPOSE: Third cranial nerve palsies are unfrequent in childhood and adolescence and are most often congenital. The association of sellar germ cell tumor and ophthalmoplegia is considered as being very rare at this age. CASE REPORT: A 11-year-old young girl was examined in emergency with a third left cranial nerve partial palsy associated with one- year duration history of hypopituitarism with insipid diabetes and growth retardation. Cerebral IRM revealed a tumor of the pituitary gland...
2011: Bulletin de la Société Belge D'ophtalmologie
Lorena Narvaez Ponce, Judith Carrio, Enrique R Soriano, Carlos D Santos, Patricia M Imamura, Luis J Catoggio
Wegener's granulomatosis is a granulomatous necrotizing vasculitis which predominantly affects the respiratory tract, kidney, and less frequently other organs such as the nervous system. The latter may occur in up to 54% of cases and when it does it is more frequently of the peripheral nerves. We present a 19 year old woman who commenced her disease with involvement of respiratory sinuses, lungs and kidney and who developed central insipid diabetes (CID) at onset. The CID persisted in spite of adequate response of the other organs and systems with immunosuppresor treatment...
2009: Revista de la Facultad de Ciencias Médicas
Garabed Eknoyan
Diabetes insipidus is an ancient disease considered under the rubric of diabetes, the Greek descriptive term for polyuria, which was unrecognized even after the sweetness of urine was reported as a characteristic of diabetes mellitus in the 17th century. It would be another century before diabetes insipidus was identified from the insipid rather than saccharine taste of urine in cases of polyuria. After its increased recognition, pathologic observations and experimental studies connected diabetes insipidus to the pituitary gland in the opening decades of the 20th century...
December 2010: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
A U Lekmanov, D K Azovskiĭ, S F Piliutik, E N Gegueva, V M Abramova, A S Chernova
The aim of the study was to elucidate a relationship between the development of hypernatremia and the frequency of poor outcomes in children with severe brain injury (SBI). The retrospective study enrolled 77 children (54 boys and 23 girls) aged 1 month to 18 years, who had SBI in the period of January 2008 to September 2009, and were divided into 3 groups after treatment termination. The admission injury severity criterion was Glasgow coma scale (8 scores or less) rating. Group A comprised 51 children with SBI without hypernatremia; Group B included 14 children with SBI and hypernatremia...
January 2010: Anesteziologiia i Reanimatologiia
E Gheorghita, O Rata, M Trifu
Organ transplantation is a multidisciplinary speciality that has undergone a remarkable development in the last two decades, saving the lives of patients in advanced failure of various organs. Medical management of organ donors is an essential component of achieving success in transplantation. It requires a good knowledge and understanding of the pathological changes caused by brain death, changes that usually require a diagnosis and a rapid treatment. In our study we intend to analyse the problems that we encountered during preparation of the donors...
March 2010: Chirurgia
D Ap Biasotto-Gonzalez, F Berzin, Joelma Magalhães da Costa, Tabajava Oliveira de Gonzalez
OBJECTIVE: The aim of this study was to compare the behavior of the major chewing muscles (anterior temporalis, masseter and suprahyoid muscles) by using two commercial chewing gums (A and B) and two insipid materials (cotton ball and Parafilm M) through analysis of electromyographic signals. METHOD: Ten female young adult subjects, aged from 18 to 27 years, with normal occlusion and no history of craniomandibular disorder were studied The masticatory activity was performed with the subjects comfortably sat so that the Frankfurt plane was parallel to the floor...
March 2010: Electromyography and Clinical Neurophysiology
F del Río-Gallegos, J L Escalante-Cobo, J R Núñez-Peña, E Calvo-Manuel
Brain death implies the complete cessation of activity in both cerebral hemispheres and in the brainstem; this leads to severe physiopathological disorders that make donor maintenance complex and involve the concomitant risk of rapid organ deterioration. The heart is one of the target organs in this process of multiple organ failure. Myocardial stunning occurs due to a "catecholamine storm" and subsequent release of many proinflammatory mediators, free oxygen radicals, and electrolyte imbalance secondary to insipid diabetes and hypothermia...
October 2009: Medicina Intensiva
Ranyse B Querino, Neusa Hamada
The tritrophic interaction Argia insipida Hagen in Selys, the Trichogrammatidae egg parasitoid Pseudoligosita longifrangiata (Viggiani) and the host plant Tonina fluviatilis (Eriocaulacea), which is a substrate for egg deposition of A.insipid, was investigated. The study locality was a stream with rapids where macrophytes such as T. fluviatilis grow. Information on aquatic egg parasitoids is scarce. This is the first record of egg parasitism of A. insipida by P. longifrangiata in Brazil, and the first record of occurrence of P...
May 2009: Neotropical Entomology
A Sayouti, R Benhaddou, R Khoumiri, L Gaboune, H Guelzim, N Benfdil, A Moutaoukil
Wolfram syndrome is a rare autosomal recessive neurodegenerative disease; it is characterized by the appearance of diabetes mellitus in childhood associated with bilateral optic atrophy that often leads to blindness. Insipid diabetes, deafness, psychiatric disorders, anosmia, anomalies of the urinary tract, nystagmus, ataxia, and myoclonias are less frequent. We report two cases of Wolfram syndrome, diagnosed in a 12-year-old girl and a 13-year-old boy. In each case, there was a history of diabetes mellitus; they consulted for a progressive loss of vision...
June 2007: Journal Français D'ophtalmologie
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