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https://www.readbyqxmd.com/read/27933514/changes-in-cardiac-repolarisation-during-spontaneous-nocturnal-hypoglycaemia-in-subjects-with-type-1-diabetes-a-preliminary-report
#1
Minna L Koivikko, Tuomas Kenttä, Pasi I Salmela, Heikki V Huikuri, Juha S Perkiömäki
AIMS: Experimental studies have revealed that hypoglycaemia can result in morphological changes in electrocardiographic repolarisation in subjects with type 1 diabetes. However, the influence of spontaneous nocturnal hypoglycaemia on repolarisation morphology in a 'real life' situation is not clear. METHODS: Adults with type 1 diabetes (n = 11) underwent continuous glucose monitoring with a subcutaneous sensor and digital 12-lead ECG recording for three nights...
December 8, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27933508/patterns-of-diabetes-care-in-slovenia-croatia-serbia-bulgaria-and-romania-an-observational-non-interventional-cross-sectional-study
#2
Miro Cokolic, Nebojsa M Lalic, Dragan Micic, Gorana Mirosevic, Sanja Klobucar Majanovic, Ivaylo N Lefterov, Mariana Graur
BACKGROUND: National guidelines for treating type 2 diabetes in the Balkans generally follow European guidelines. The current study was undertaken to estimate the rate of glycated hemoglobin (HbA1c) measurements and level of HbA1c control in diabetic patients treated in regular clinical practice settings in the Balkans and to evaluate if providing HbA1c measurements improves adherence to treatment guidelines. METHODS: This cross-sectional study enrolled type 2 diabetic patients treated by 79 primary care physicians and 102 specialists...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27933334/improved-glycaemia-in-high-fat-fed-neprilysin-deficient-mice-is-associated-with-reduced-dpp-4-activity-and-increased-active-glp-1-levels
#3
Joshua R Willard, Breanne M Barrow, Sakeneh Zraika
AIM/HYPOTHESIS: Neprilysin, a widely expressed peptidase, is upregulated in metabolically altered states such as obesity and type 2 diabetes. Like dipeptidyl peptidase-4 (DPP-4), neprilysin can degrade and inactivate the insulinotropic peptide glucagon-like peptide-1 (GLP-1). Thus, we investigated whether neprilysin deficiency enhances active GLP-1 levels and improves glycaemia in a mouse model of high fat feeding. METHODS: Nep (+/+) and Nep (-/-) mice were fed a 60% fat diet for 16 weeks, after which active GLP-1 and DPP-4 activity levels were measured, as were glucose, insulin and C-peptide levels during an OGTT...
December 8, 2016: Diabetologia
https://www.readbyqxmd.com/read/27933189/insulin-resistance-of-protein-anabolism-accompanies-that-of-glucose-metabolism-in-lean-glucose-tolerant-offspring-of-persons-with-type-2-diabetes
#4
Sergio A Burgos, Vikram Chandurkar, Michael A Tsoukas, Stéphanie Chevalier, José A Morais, Marie Lamarche, Errol B Marliss
OBJECTIVE: To test whether protein anabolic resistance is an early defect in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Seven lean, normoglycemic T2D offspring (T2D-O) and eight matched participants without family history (controls; C) underwent a 3-hour hyperinsulinemic (40 mU/m(2)/min), euglycemic (5.5 mmol/L) and isoaminoacidemic clamp. Whole-body glucose and protein kinetics were measured with d-[3-(3)H]glucose and l-[l-(13)C]leucine, respectively...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27933185/circulating-serpinb1-levels-and-clinical-features-in-patients-with-type-2-diabetes
#5
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
OBJECTIVE: The main purpose of this study was to investigate the association of serum SerpinB1 levels and various parameters in patients with type 2 diabetes. The effect of canagliflozin (a sodium glucose cotransporter 2 (SGLT2) inhibitor), which can decrease circulating insulin levels, on serum SerpinB1 levels was also investigated. A recent study suggests that the serum levels of SerpinB1, also known as monocyte neutrophil elastase inhibitor, increase with insulin resistance, may have a protective effect for pancreatic β cells, and may decrease insulin resistance...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27933175/hyperinsulinemic-hypoglycemia-associated-with-insulin-antibodies-caused-by-exogenous-insulin-analog
#6
Chih-Ting Su, Yi-Chun Lin
: Insulin antibodies (IA) associated with exogenous insulin administration seldom caused hypoglycemia and had different characteristics from insulin autoantibodies (IAA) found in insulin autoimmune syndrome (IAS), which was first described by Dr Hirata in 1970. The characteristic of IAS is the presence of insulin-binding autoantibodies and related fasting or late postprandial hypoglycemia. Here, we report a patient with type 1 diabetes mellitus under insulin glargine and insulin aspart treatment who developed recurrent spontaneous post-absorptive hyperinsulinemic hypoglycemia with the cause probably being insulin antibodies induced by exogenous injected insulin...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27933093/long-term-consumption-of-an-obesogenic-high-fat-diet-prior-to-ischemia-reperfusion-mediates-cardioprotection-via-epac1-dependent-signaling
#7
F Edland, A Wergeland, R Kopperud, K S Åsrud, E A Hoivik, S L Witsø, R Æsøy, L Madsen, K Kristiansen, M Bakke, S O Døskeland, A K Jonassen
BACKGROUND: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the "obesity paradox". This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. METHODS: Wild type (wt), Epac1 (Epac1(-/-)) and Epac2 (Epac2(-/-)) deficient mice were fed a high fat (HFD) or normal chow diet (ND) for 33 ± 1 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27932675/the-effects-of-voluntary-exercise-and-prazosin-on-capillary-rarefaction-and-metabolism-in-streptozotocin-induced-diabetic-male-rats
#8
Emily C Dunford, Erwan Leclair, Julian Aiken, Erin R Mandel, Tara L Haas, Olivier Birot, Michael C Riddell
Type-1 diabetes mellitus (T1D) causes impairments within the skeletal muscle microvasculature. Both regular exercise and prazosin have been shown to improve skeletal muscle capillarization and metabolism in healthy rats, through distinct angiogenic mechanisms. The aim of this study was to evaluate the independent and additive effects of voluntary exercise and prazosin treatment on capillary-to-fiber ratio (C:F) in streptozotocin (STZ)-treated diabetic rats. STZ (65mg/kg) was intraperitoneally administered to male Sprague-Dawley rats (n=36) to induce diabetes, with healthy, non-diabetic, sedentary rats (n=10) as controls...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932366/sauna-bathing-is-inversely-associated-with-dementia-and-alzheimer-s-disease-in-middle-aged-finnish-men
#9
Tanjaniina Laukkanen, Setor Kunutsor, Jussi Kauhanen, Jari Antero Laukkanen
BACKGROUND: there are no previous studies linking repeated heat exposure of sauna and the risk of memory diseases. We aimed to investigate whether frequency of sauna bathing is associated with risk of dementia and Alzheimer's disease. SETTING: prospective population-based study. METHODS: the frequency of sauna bathing was assessed at baseline in the Kuopio Ischaemic Heart Disease population-based prospective cohort study of 2,315 apparently healthy men aged 42-60 years at baseline, with baseline examinations conducted between 1984 and 1989...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932091/octogenarian-donors-in-liver-transplantation
#10
M Gastaca, M Guerra, L Alvarez Martinez, P Ruiz, A Ventoso, I Palomares, M Prieto, A Matarranz, A Valdivieso, J Ortiz de Urbina
INTRODUCTION: Due to the disparity between the number of patients on the list for liver transplantation and the availability of organs, the use of older donors has become necessary. The aim of this study was to investigate the outcomes of liver transplantation using octogenarian donors. METHODS: From December 2003 to February 2016, 777 liver transplantations were performed at our institution, 33 of them (4.2%) with donors 80 years old and above. Our policy for the acceptance of these donors is based on preoperative liver function tests, donor hemodynamic stability, and intraoperative normal gross aspect...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930871/hepatitis-b-virus-infection-status-is-more-prevalent-in-patients-with-type-2-diabetes
#11
Jun Lu, Xuhong Hou, Hong Tu, Zhenghao Tang, Yongbing Xiang, Yuqian Bao, Jianren Gu, Weiping Jia
AIMS/INTRODUCTION: It has not been reported whether chronic hepatitis B virus (HBV) infection (CHB) is associated with a specific type of diabetes. We sought to investigate the prevalence of CHB status in different diabetes subtypes among Chinese population MATERIALS AND METHODS: This is a cross-sectional study. 381 cases with adult-onset autoimmune diabetes,1365 patients with type 2 diabetes, and 1365 non-diabetic controls were recruited from Jun 2005 to Feb 2014.The exclusion criteria included: (1) HCV-antibody positive, (2) hepatic cirrhosis, (3) malignant neoplasm and severe renal dysfunction (serum creatinine > 450 umol/L)...
December 8, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27930863/lessons-from-a-cardiovascular-outcome-trial-with-liraglutide-in-type-2-diabetes
#12
Hae Jin Kim, Dae Jung Kim
Cardiovascular disease (CVD) is the leading cause of death and one of common diabetes-related complications in patients with type 2 diabetes(1) . After the US Food and Drug Administration issued guidelines for assessing the CVD risk of all new glucose-lowering agents for type 2 diabetes in 2008(2) , randomized controlled CV outcome trials with new antidiabetic drugs, such as the dipeptidyl peptidase-4 inhibitors (saxagliptin, alogliptin, and sitagliptin) and the glucagon-like peptide-1 receptor agonist (GLP-1 RA), lixisenatide, showed CV safety in high CV risk patient populations with type 2 diabtes(3) ...
December 8, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27930690/structural-mapping-and-functional-characterization-of-zebrafish-class-b-g-protein-coupled-receptor-gpcr-with-dual-ligand-selectivity-towards-glp-1-and-glucagon
#13
Deena A Oren, Yang Wei, Luce Skrabanek, Billy K C Chow, Thomas Mommsen, Svetlana Mojsov
GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently being evaluated, while GLP-1 is already used in the treatment of type 2 diabetes and obesity. Development of a second generation of GLP-1 based therapeutics depends on a molecular and structural understanding of the interactions between the GLP-1 receptor (GLP-1R) and its ligand GLP-1...
2016: PloS One
https://www.readbyqxmd.com/read/27930591/weight-loss-before-a-diagnosis-of-type-2-diabetes-mellitus-is-a-risk-factor-for-diabetes-complications
#14
Shanshan Yang, Shuang Wang, Bo Yang, Jinliang Zheng, Yuping Cai, Zhengguo Yang
Our goal was to investigate the relationship between weight loss before a diagnosis of type 2 diabetes mellitus (T2DM) and diabetic complications among hospitalized patients with T2DM.We conducted a cross-sectional study and evaluated 347 and 642 hospitalized patients with T2DM who experienced and did not experienced weight loss before T2DM diagnosis, respectively. We used propensity score matching to reduce the confounding bias between the groups. In addition, a logistic regression analysis of the matched data was performed to evaluate the risk of diabetic complications...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930584/risk-of-infection-is-associated-more-with-drain-duration-than-daily-drainage-volume-in-prosthesis-based-breast-reconstruction-a-cohort-study
#15
Cheng-Feng Chen, Shou-Fong Lin, Chen-Fang Hung, Pesus Chou
In prosthesis-based breast reconstruction, drains are used to prevent seroma formation and to reduce the risk of infection. However, prolonged drainage increases the risk of ascending infection. Although the volume often accepted for drain removal is ≤30 mL per day, the optimal timing to remove the drain for best clinical outcome remains controversial.We did a retrospective cohort study of 569 patients of prosthesis-based breast reconstruction with infection rate as the outcome variable; drain duration and last daily drainage volume as the main independent variables...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930459/visual-function-correlates-of-foveal-slope-changes-on-optical-coherence-tomography-in-macular-telangiectasia-type-2
#16
Durgasri Jaisankar, Rajiv Raman, Harshal Gondhale, Jay Chhablani, Manisha Agarwal
PURPOSE: To evaluate changes in foveal and parafoveal thickness measured using optical coherence tomography across five stages of macular telangiectasia 2 (MacTel 2) and to correlate the foveal slope angle with best-corrected visual acuity (BCVA). METHODS: A multicentered, cross-sectional study of 90 patients with bilateral MacTel 2 was carried out. We reviewed medical records of patients who had undergone optical coherence tomography. Mean retinal thickness foveal and subfoveal were noted from ETDRS (Early Treatment Diabetic Retinopathy Study) mapping and later used for calculating foveal slope angle...
December 7, 2016: Retina
https://www.readbyqxmd.com/read/27929711/dual-effects-of-a-retn-single-nucleotide-polymorphism-snp-at-420-on-plasma-resistin-genotype-and-dna-methylation
#17
Hiroshi Onuma, Yasuharu Tabara, Ryoichi Kawamura, Jun Ohashi, Wataru Nishida, Yasunori Takata, Masaaki Ochi, Tatsuya Nishimiya, Yasumasa Ohyagi, Ryuichi Kawamoto, Katsuhiko Kohara, Tetsuro Miki, Haruhiko Osawa
CONTEXT: We previously reported that SNP (single nucleotide polymorphism) -420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of CpG dinucleotides. OBJECTIVE: To examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP-420. DESIGN AND METHODS: Genomic DNA was extracted from peripheral white blood cells in 2,078 Japanese subjects...
December 8, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27928991/mortality-in-patients-with-diabetes-mellitus-and-addison-s-disease-a-nationwide-matched-observational-cohort-study
#18
Dimitrios Chantzichristos, Anders Persson, Björn Eliasson, Mervete Miftaraj, Stefan Franzén, Ragnhildur Bergthorsdottir, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Gudmundur Johannsson
OBJECTIVE: Our hypothesis was that patients with diabetes mellitus obtain an additional risk of death if they develop Addison's disease (AD). DESIGN AND METHODS: Nationwide, matched, observational cohort study cross-referencing the Swedish National Diabetes Register with Inpatient, Cancer and Cause of Death Registers in patients with diabetes (type 1 and 2) and AD and matched controls with diabetes. Clinical characteristics at baseline, overall, and cause-specific mortality were assessed...
January 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27928958/short-and-long-term-effects-of-a-dpp-4-inhibitor-versus-bedtime-nph-insulin-as-add-on-therapy-in-patients-with-type-2-diabetes
#19
Giordana Maluf da Silva, Katia Camarano Nogueira, Rosa Tsuneshiro Fukui, Marcia Regina Soares Correia, Rosa Ferreira Dos Santos, Maria Elizabeth Rossi da Silva
BACKGROUND: We conducted a comparison between the dipeptidyl-peptidase-4(DPP-4) inhibitor sitagliptin versus NPH insulin as an add-on therapies in patients with type 2 diabetes mellitus (T2D) failing oral medications. The objective was to ascertain the better indication in long-duration diabetes. METHODS: thirty-five T2D patients inadequately controlled with metformin plus glyburide were randomized to receive sitagliptin (n=18) or bedtime NPH insulin (n=17) for 12 months...
December 8, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27928640/diabetes-as-a-risk-factor-in-patients-undergoing-groin-hernia-surgery
#20
Gustaf Hellspong, Ulf Gunnarsson, Ursula Dahlstrand, Gabriel Sandblom
BACKGROUND: Diabetes is a known risk factor for early postoperative complications. Even so, the incidence of acute postoperative complications following routine hernia surgery is seldom described, and the risk for reoperation for recurrence has hardly been studied. Our aim was to explore if diabetes is a significant risk factor for complications after inguinal hernia surgery. METHODS: All inguinal hernia repairs registered in the Swedish Hernia Register between 2002 and 2011 were identified...
December 7, 2016: Langenbeck's Archives of Surgery
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