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https://www.readbyqxmd.com/read/29913526/tolerability-and-efficacy-of-ipragliflozin-in-the-management-of-inadequately-controlled-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#1
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29912998/safety-of-once-weekly-glucagon-like-peptide-1-receptor-agonists-in-patients-with-type-2-diabetes
#2
Juan P Frias
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been found efficacious in the treatment of type 2 diabetes (T2D), demonstrating the ability to lower HbA1c, and having the potential for inducing weight loss and reducing the risk of hypoglycemia, compared with other antihyperglycemic agents. Currently, 4 once-weekly (OW) GLP-1 RAs are approved: albiglutide, dulaglutide, exenatide ER, and recently, semaglutide. This review compares the relative safety of OW GLP-1 RAs, as well as their safety in comparison to other antihyperglycemic agents, using safety data reported in key sponsor-led phase 3 studies of the 4 OW GLP-1 RAs...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912997/clinical-efficacy-of-once-weekly-glucagonlike-peptide-1-receptor-agonists-in-patients-with-type-2-diabetes
#3
Timothy S Bailey
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are indicated for restoring normoglycemia in patients with type 2 diabetes (T2D). This review analyzed and compared the efficacy results from 30 trials with the once-weekly (OW) GLP-1 RAs albiglutide, dulaglutide, exenatide extended-release (ER) and semaglutide. The 4 OW GLP-1 RAs showed a higher reduction in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) and body weight, when compared to placebo. Semaglutide significantly reduced the HbA1c level (estimated treatment difference [ETD]: -0...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912879/polyclonal-human-antibodies-against-glycans-bearing-red-meat-derived-non-human-sialic-acid-n-glycolylneuraminic-acid-are-stable-reproducible-complex-and-vary-between-individuals-total-antibody-levels-are-associated-with-colorectal-cancer-risk
#4
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29912623/saxagliptin-upregulates-nesfatin-1-secretion-and-ameliorates-insulin-resistance-and-metabolic-profiles-in-type-2-diabetes-mellitus
#5
Kuanlin Chen, Tiejun Zhuo, Jian Wang, Qing Mei
BACKGROUND AND AIMS: Saxagliptin as one of dipeptidyl peptidase-4 (DPP-4) inhibitors can effectively improve glycaemic control in type 2 diabetes mellitus, and nesfatin-1 is regarded as a very important factor in regulating feeding behavior and energy homeostasis. In this trial, we observed the effect of saxagliptin on regulating nesfatin-1 secretion and ameliorating insulin resistance and metabolic profiles in type 2 diabetes mellitus. METHODS: One hundred two type 2 diabetes participants (M/F = 48/54) were investigated...
June 18, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29912386/impairment-of-the-akt-pathway-in-transplanted-type-1-diabetic-hearts-is-associated-with-post-transplant-graft-injury
#6
Sevil Korkmaz-Icöz, Shiliang Li, Sivakkanan Loganathan, Tamás Radovits, Mihály Ruppert, Paige Brlecic, Alex Ali Sayour, Gábor Veres, Thomas Fleming, Maik Brune, Patrick Most, Matthias Karck, Gábor Szabó
OBJECTIVES: The use of 'marginal' hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the diabetic myocardium. We hypothesized that DM-induced cardiac dysfunction in donors is further impaired after heart transplantation and that PI3K/Akt-pathway alterations may be one of the underlying pathomechanisms...
June 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29912237/-paclitaxel-coated-balloons-for-in-stent-restenosis-treatment-long-term-clinical-results-and-predictors-of-recurrent-target-lesion-revascularization
#7
Irene Bossi, Margherita D'Anna, Valentina Vaccaro, Maria Paola Caria, Paola Colombo, Federico De Marco, Jacopo Oreglia, Giacomo Piccalò, Emanuela Piccaluga, Francesco Soriano, Fabrizio Oliva, Silvio Klugmann
BACKGROUND: The aim of this study was to report clinical outcomes in patients treated with paclitaxel-coated balloons (PCB) for in-stent restenosis (ISR) in both bare metal (BMS) and drug-eluting stent (DES). METHODS: Between May 2009 and December 2015, we treated 155 ISR in 140 patients. At recruitment, 35% of patients had diabetes. Among the lesions, 125 were first occurrence (55 within BMS and 70 within DES) and 30 recurrent; 24 ISR were multi-metal layered. Mean reference diameter was 2...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911403/how-4-companies-became-one-co-development-under-an-outsourced-model-with-focus-on-phase-3-analysis-and-reporting-deliverables
#8
Susan Huyck, Gregory Golm, Sajda Ghani, James Mancuso, Tarra Irvin
With the growth in co-development deals between pharmaceutical companies and the increased use of contract research organizations (CROs) in drug development, more and more employees are encountering projects that require working across different companies. Navigating the mix of corporate cultures as well as variations in standards and procedures can lead to unanticipated challenges and delays. The development of ertugliflozin, a recently approved medicine for type 2 diabetes mellitus, involved both co-development and CRO engagement across 4 companies...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29911037/prevalence-pattern-of-key-polymorphisms-in-the-vitamin-d-receptor-gene-among-patients-of-type-2-diabetes-mellitus-in-northeast-india
#9
Dipti Sarma, Vikram Singh Chauhan, Kandarpa Kumar Saikia, Partha Sarma, Sukanta Nath
Aims: To investigate the association between Vitamin D receptor gene polymorphisms (BsmI, TaqI and FokI) and type 2 diabetes mellitus in patients in north eastern India. Settings and Design: This was a case control study with 40 cases of type 2 diabetes and 20 controls. Materials and Methods: Genomic DNA was extracted from blood and genotyped for the single nucleotide polymorphism (SNPs) of BsmI [rs1544410], TaqI [rs731236] and FokI [rs2228570] by polymerase chain reaction and gene sequencing...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911033/association-between-glycemic-gap-and-adverse-outcomes-in-critically-ill-patients-with-diabetes
#10
Sandeep Donagaon, Mala Dharmalingam
Objectives: Glycemic excursions are commonly seen in patients admitted to the Intensive Care Unit (ICU) and are related to adverse outcomes. Glycemic gap is a marker of this excursion in patients with diabetes. It can be used to predict adverse outcomes in patients with diabetes admitted to the ICU. It is calculated by subtracting A1C-derived average glucose (ADAG) = ([28.7 × HbA1c]-46.7) from plasma glucose at admission. Objective of this study was to correlate glycemic gap and adverse outcomes in patients with type 2 diabetes mellitus (DM) admitted to the ICU...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911032/assessment-and-evaluation-of-gustatory-functions-in-patients-with-diabetes-mellitus-type-ii-a-study
#11
Shriya Khera, Anjali Saigal
Introduction: The assessment of taste is critically important for an individual to enjoy life. This however, gets altered in various diseases. Diabetes Mellitus is one of the diseases in which person has dysgeusia. Objectives: This study was done to assess different taste sensations in patients suffering from Diabetes Mellitus Type II. Methods: A total of 120 subjects were taken in this study and were divided into 3 groups. One group consisted of patients who were uncontrolled diabetics ( n = 40), the second group of controlled diabetics ( n = 40) and 40 subjects who were normal healthy individuals (control group)...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911028/characterization-of-metabolic-parameters-in-responders-and-nonresponders-treated-with-canagliflozin-monotherapy-in-drug-naive-subjects-with-type-2-diabetes
#12
Eiji Kutoh, Asuka Wada, Teruma Murayama, Jyunka Hayashi
Objectives: The aim of this project is to compare the effect of canagliflozin monotherapy on metabolic parameters between responders and nonresponders with this drug. This study is a prospective, unblinded, observational study. Subjects and Methods: Drug-naïve patients with type 2 diabetes mellitus received only 50-100 mg/day canagliflozin for 3 months ( n = 39). They were divided into two groups according to the novel "A1c index" to assess glycemic efficacies; responders ( n = 24) and nonresponders ( n = 15)...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910773/characteristics-of-obstructive-sleep-apnea-across-the-spectrum-of-glucose-tolerance-in-obese-adolescents
#13
Tamara S Hannon, Sara E Watson, Hasnaa E Jalou, Sangeeta Chakravorty, Kieren J Mather, Silva A Arslanian
Background: It is not known if dysglycemia and sleep-disordered breathing are linked in adolescents, as in adults. Objective: To perform a pilot study evaluating measures of sleep-disordered breathing across the spectrum of glucose tolerance in obese adolescents. We hypothesized that dysglycemia would be associated with sleep-disordered breathing. Participants/methods: This was a prospective, cross-sectional clinical pilot study that included 57 adolescents [body mass index (BMI) 38...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29910159/nivolumab-induced-thyroid-dysfunction-in-patients-with-lung-cancer
#14
Ana M Ramos-Levi, Jacobo Rogado, Jose Miguel Sanchez-Torres, Ramón Colomer, Mónica Marazuela
BACKGROUND: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant. OBJECTIVE: To comprehensively evaluate the clinical presentation of endocrine IRAEs in patients with lung cancer treated with nivolumab...
June 14, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29910091/meal-derived-glucagon-responses-are-related-to-lower-hepatic-phosphate-concentrations-in-obesity-and-type-2-diabetes
#15
K S Weber, K Straßburger, M Fritsch, A Bierwagen, C Koliaki, E Phielix, G Pacini, J-H Hwang, D F Markgraf, V Burkart, K Müssig, J Szendroedi, M Roden
AIM: Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear. METHODS: In this observational study, lean insulin-sensitive control subjects (BMI: 23.2±1.5kg/m2 ), age-matched insulin-resistant obese subjects (BMI: 34.3±1.7kg/m2 ) and similarly obese elderly T2D patients (BMI: 32.0±2.4kg/m2 ) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic γATP, inorganic phosphate (Pi ) and lipids using 31 P/1 H magnetic resonance spectroscopy...
June 2, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#16
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29909196/bioelectronic-organ-based-sensor-for-microfluidic-real-time-analysis-of-the-demand-in-insulin
#17
R Perrier, A Pirog, M Jaffredo, J Gaitan, B Catargi, S Renaud, M Raoux, J Lang
On-line and real-time analysis of micro-organ activity permits to use the endogenous analytical power of cellular signal transduction algorithms as biosensors. We have developed here such a sensor using only a few pancreatic endocrine islets and the avoidance of transgenes or chemical probes reduces bias and procures general usage. Nutrient and hormone-induced changes in islet ion fluxes through channels provide the first integrative read-out of micro-organ activity. Using extracellular electrodes we captured this read-out non-invasively as slow potentials which reflect glucose concentration-dependent (3-15 mM) micro-organ activation and coupling...
June 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29908773/maternal-diabetes-mellitus-and-timing-of-pubertal-development-in-daughters-and-sons-a-nationwide-cohort-study
#18
Lea L B Lauridsen, Linn H Arendt, Andreas Ernst, Nis Brix, Erik T Parner, Jørn Olsen, Cecilia H Ramlau-Hansen
OBJECTIVE: To study the association between maternal diabetes and timing of pubertal development in daughters and sons. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29908078/ultrasound-detection-of-insulin-induced-lipohypertrophy-in-type-1-and-type-2-diabetes
#19
J E Kapeluto, B W Paty, S D Chang, G S Meneilly
AIMS: To define standard criteria for the detection of lipohypertrophy using ultrasonography and to determine the accuracy of this method. METHOD: Individuals using insulin therapy for ≥2 years with unknown lipohypertrophy status were enrolled at a diabetes education centre. A team of diabetes educator nurses performed a clinical examination for evidence of lipohypertrophy and a separate team of ultrasonographers examined participants in a blinded fashion. RESULTS: The echo signature for lipohypertrophy consisted of location in the subcutaneous layer and lesions that were 1) well circumscribed either by hyperechoic foci with defined borders or a nodular shape with a hypoechoic halo, 2) heterogeneous in echotexture compared with surrounding tissue, 3) associated with distortion of surrounding connective tissue with 4) absence of vascularity and 5) absence of capsule...
June 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29908010/rapamycin-improves-insulin-resistance-and-hepatic-steatosis-in-type-2-diabetes-rats-through-activation-of-autophagy
#20
Wan Zhou, Shandong Ye
Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This study aimed to explore the effects of rapamycin, a specific inhibitor of kinase mammalian target of rapamycin (mTOR), on IR in T2DM rats, and to validate whether the underlying mechanism was associated with autophagy. In this study, the model of T2DM rats was established by feeding the animals with a high-fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). Diabetic rats were randomly divided into model of T2DM control group (DM-C, n=15), metformin group (DM-M, n=15), rapamycin group (DM-Rapa, n=15), 3-methyladenine (3-MA) group (DM-3-MA, n=15), and rapamycin+3-MA group (DM-Rapa-3-MA, n=15)...
June 16, 2018: Cell Biology International
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