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https://www.readbyqxmd.com/read/29299121/klf15-promotes-the-proliferation-and-metastasis-of-lung-adenocarcinoma-cells-and-has-potential-as-a-cancer-prognostic-marker
#1
Lihua Gao, Hongmei Qiu, Jian Liu, Yuzhen Ma, Jia Feng, Li Qian, Jianguo Zhang, Yifei Liu, Tingting Bian
Lung adenocarcinoma (LADC)is a general form of non-small cell lung cancer that represents a significant threat to public health worldwide. The 5-year-survival rate for LADC is currently below 15%. The transcription factor KLF15, also called kidney-enriched KLF (KKLF), has been proven to play a role in inhibiting proliferation and diversification of carcinoma cells, including those of the endometrium, pancreas and breast, but the involvement of KLF15 in LADC has not previously been studied. In this study, we compared the in vitro expression of KLF15 in human LADC tissues and adjacent normal lung tissues...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286255/mir-106b-responsive-gene-landscape-identifies-regulation-of-kruppel-like-factor-family
#2
Cody J Wehrkamp, Sathish Kumar Natarajan, Ashley M Mohr, Mary Anne Phillippi, Justin L Mott
MicroRNA dysregulation is a common feature of cancer and due to the promiscuity of microRNA binding this can result in a wide array of genes whose expression is altered. miR-106b is an oncomiR overexpressed in cholangiocarcinoma and its upregulation in this and other cancers often leads to repression of anti-tumorigenic targets. The goal of this study was to identify the miR-106b-regulated gene landscape in cholangiocarcinoma cells using a genome-wide, unbiased mRNA analysis. Through RNA-Seq we found 112 mRNAs significantly repressed by miR-106b...
December 29, 2017: RNA Biology
https://www.readbyqxmd.com/read/29273682/down-regulation-of-decidual-sp1-and-p300-is-associated-with-severe-preeclampsia
#3
Yachao Zhang, Jieqiong Yang, Shi-Jian Lv, Dong-Qin Zhao, Zi-Jiang Chen, Weiping Li, Cong Zhang
Preeclampsia is a pregnancy-induced disorder characterized by hypertension and proteinuria after 20 weeks of gestation, affecting 5-7% of pregnancies worldwide. So far, the etiology of PE remains poorly understood. Abnormal decidualization is thought to contribute to the development of preeclampsia. SP1 belongs to the Sp/KLF super family and can recruit P300 to regulate transcription of several genes. SP1 is also very important for decidualization as it enhances the expression of tissue factor. In this study, we investigated the expression of SP1 and P300 in deciduae and their relationship with PE...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29246575/development-of-one-control-and-one-tumor-specific-induced-pluripotent-stem-cell-line-from-laryngeal-carcinoma-patient
#4
Yamin Zhang, Jing Zhu, Yaozhang Dai, Liuzhong Wang, Rui Liu
Skin fibroblasts and tumor fibroblasts were extracted from a 64-year old male patient clinically diagnosed with laryngeal carcinoma. Control and tumor specific induced pluripotent stem cells were reprogrammed with 5 reprogramming factors, Klf-4, c-Myc, Oct-4, Sox-2, and Lin-28, using the messenger RNA reprogramming system. The transgene-free iPSC lines showed pluripotency, confirmed by immunofluorescence staining. The iPSC lines also showed normal karyotype, and could form embryoid bodies in vitro and differentiate into the 3 germ layers in vivo...
December 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29245984/kr%C3%A3-ppel-like-factor-2-suppresses-human-gastric-tumorigenesis-through-inhibiting-pten-akt-signaling
#5
Chunmei Wang, Liang Li, Qiuhui Duan, Qingqing Wang, Jinlian Chen
Krüppel-like factors (KLFs) are a large family of DNA-binding transcriptional regulators that affect basic cellular processes such as growth, survival, migration and differentiation and serve a complicated function in cancers. KLF2, one member of the KLF family, is dysregulated in many tumors. However, the specific role of KLF2 in human gastric tumorigenesis is unknown. Here we show that the expression of KLF2 protein was lower in gastric tumors when compared with adjacent normal tissue. Moreover, downregulated KLF2 expression in primary gastric tumor was closely correlated with patients' survival...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29198712/fbw7-targets-klf10-for-ubiquitin-dependent-degradation
#6
Su Yu, Feng Wang, Wei-Juan Pan, Yi Luan, Xin Ge
FBW7, a key component of SCFFBW7 E3 ubiquitin ligase, targets various proteins for degradation via the conserved Cdc4 phosphodegron (CPD) in substrates. In this study, we report that KLF10 is degraded by FBW7 via a conserved CPD. Through systematic analysis of the degradation of KLF transcription factors by FBW7, we identified KLF10 as a novel degradation target of FBW7. Ectopic expression of FBW7 markedly promoted the degradation of KLF10 while knockdown of endogenous FBW7 increased the protein levels of KLF10...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29196317/an-image-based-mirna-screen-identifies-mirna-135s-as-regulators-of-cns-axon-growth-and-regeneration-by-targeting-kr%C3%A3-ppel-like-factor-4
#7
Eljo Y van Battum, Marieke G Verhagen, Vamshidhar R Vangoor, Yuki Fujita, Alwin A H A Derijck, Eoghan O'Duibhir, Giuliano Giuliani, Thijs de Gunst, Youri Adolfs, Daphne Lelieveld, David Egan, Roel Q J Schaapveld, Toshihide Yamashita, R Jeroen Pasterkamp
During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian central nervous system (CNS) is limited, in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing CNS regeneration. Here, we performed one of the first miRNome-wide functional miRNA screens to identify microRNAs (miRNAs) with robust effects on axon growth. High-content screening identified miR-135a and miR-135b as potent stimulators of axon growth and cortical neuron migration in vitro and in vivo in male and female mice...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29179208/klf-15-works-as-an-early-anti-fibrotic-transcriptional-regulator-in-ang-ii-induced-renal-fibrosis-via-down-regulation-of-ctgf-expression
#8
Xiangchen Gu, Dechao Xu, Lili Fu, Yi Wang, Changlin Mei, Xiang Gao
BACKGROUND/AIMS: Angiotensin II (Ang II) has been regarded as an important profibrogenic cytokine in renal fibrosis. Krüppel-like factor 15 (KLF15) has been identified as an important negative transcription factor in renal fibrosis. However, little is known about the role of KLF15 in Ang II-induced renal fibrosis. METHODS: In this study, we randomized mice into a control group, Ang II group or Ang II plus losartan group. KLF15 expression was examined with real-time PCR and immunofluorescence in these groups...
November 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29165700/epigenetic-therapy-novel-translational-implications-for-arrest-of-environmental-dioxin-induced-disease-in-females
#9
Zaraq Khan, Ye Zheng, Tiffanny L Jones, Abigail A Delaney, Luiz F Correa, Chandra C Shenoy, Khashayarsha Khazaie, Gaurang S Daftary
Increased toxicant exposure and resultant environmentally-induced diseases are a tradeoff of industrial productivity. Dioxin (TCDD: 2,3,7,8 tetrachlorodibenzo-p-dioxin), a ubiquitous by-product is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytochrome p450 (CYP) metabolic enzymes, which alters organ function to cause disease. In contrast, the transcription factor, Krüppel-Like Factor (KLF) 11 represses these enzymes via epigenetic mechanisms...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29157672/kr%C3%A3-ppel-like-factors-family-expression-in-cervical-cancer-cells
#10
Daniel Marrero-Rodríguez, Hugo Arreola-De la Cruz, Keiko Taniguchi-Ponciano, Laura Gomez-Virgilio, Victor Huerta-Padilla, Gustavo Ponce-Navarrete, Sergio Andonegui-Elguera, Florinda Jimenez-Vega, Pablo Romero-Morelos, Miriam Rodriguez-Esquivel, Marco Meraz-Rios, Ma Del Pilar Figueroa-Corona, Alberto Monroy, Oscar Pérez-González, Mauricio Salcedo
BACKGROUND AND AIMS: Krüppel Like Factors (KLF) refers to a family of seventeen members of transcription factors. Involved in several cellular processes. As other cancer types, Cervical Cancer (CC) presents molecular deregulations in transcription factors, but especially Human Papilloma Virus (HPV) sequences. Here in this work we analyzed the mRNA expression of all KLF family members in CC-derived cell lines and CC tissues. METHODS: The cell lines used were HeLa, INBL, RoVa, C4-I, Ms751, ViPa, CaLo, SiHa, CaSki, C33a and ViBo and the non-tumorigenic HaCaT...
May 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29145494/global-analysis-of-gene-expression-mediated-by-ox1-orexin-receptor-signaling-in-a-hypothalamic-cell-line
#11
Eric Koesema, Thomas Kodadek
The orexins and their cognate G-protein coupled receptors have been widely studied due to their associations with various behaviors and cellular processes. However, the detailed downstream signaling cascades that mediate these effects are not completely understood. We report the generation of a neuronal model cell line that stably expresses the OX1 orexin receptor (OX1) and an RNA-Seq analysis of changes in gene expression seen upon receptor activation. Upon treatment with orexin, several families of related transcription factors are transcriptionally regulated, including the early growth response genes (Egr), the Kruppel-like factors (Klf), and the Nr4a subgroup of nuclear hormone receptors...
2017: PloS One
https://www.readbyqxmd.com/read/29084019/expression-of-klf6-sv2-in-colorectal-cancer-and-its-impact-on-proliferation-and-apoptosis
#12
Biao Zhang, Dan-Dan Guo, Jia-Ying Zheng, Yan-An Wu
Kruppel like factor 6 (KLF6), a member of KLF family, which has classic zinc finger structure, is broadly considered to have anticancer activity. The role of SV2 variant, one of KLF6 alternative splicing isoforms has not yet been definite in the colorectal cancer. This study aimed to detect the expression of the KLF6-SV2 in colorectal cancer and investigate its impact on cell proliferation and apoptosis. qRT-PCR was used to quantitatively determine KLF6-SV2 mRNA expression in colorectal cancer samples, corresponding normal tissue, normal colonic mucosal cell line FHC and seven colorectal cancer cell lines...
October 27, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29051189/klf-5-extends-its-fingers-to-desmosomes-the-next-frontier-for-enteric-epithelial-research
#13
Narek Israelyan, Kara Gross Margolis
n/a.
October 19, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29047116/novel-mutations-in-klf1-encoding-the-in-lu-phenotype-reflect-a-diversity-of-clinical-presentations
#14
Jessica Keller, Sunitha Vege, Trina Horn, Margaret A Keller, Regina M Leger, Judith Aeschlimann, Christine Lomas-Francis, Connie M Westhoff
BACKGROUND: Mutation in the KLF1 gene is the cause of the In(Lu) (Inhibitor of Lutheran) Lu(a-b-) phenotype and more than 60 alleles have been associated with this phenotype. Here we describe findings from investigation of seven cases: six presenting with a Lu(a-b-) phenotype including the historical index case and one referred from a patient with chronic anemia. STUDY DESIGN AND METHODS: Serologic testing was by standard methods. DNA testing included amplification and sequencing of KLF1 and LU coding regions...
October 19, 2017: Transfusion
https://www.readbyqxmd.com/read/29030550/a-conserved-klf-autophagy-pathway-modulates-nematode-lifespan-and-mammalian-age-associated-vascular-dysfunction
#15
Paishiun N Hsieh, Guangjin Zhou, Yiyuan Yuan, Rongli Zhang, Domenick A Prosdocimo, Panjamaporn Sangwung, Anna H Borton, Evgenii Boriushkin, Anne Hamik, Hisashi Fujioka, Ciaran E Fealy, John P Kirwan, Maureen Peters, Yuan Lu, Xudong Liao, Diana Ramírez-Bergeron, Zhaoyang Feng, Mukesh K Jain
Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are important regulators of autophagy and healthspan in C. elegans, and also modulate mammalian vascular age-associated phenotypes. Kruppel-like family of transcription factor deficiency attenuates autophagy and lifespan extension across mechanistically distinct longevity nematode models...
October 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28992202/kr%C3%A3-ppel-like-factors-and-vascular-wall-homeostasis
#16
Yanbo Fan, Haocheng Lu, Wenying Liang, Wenting Hu, Jifeng Zhang, Y Eugene Chen
Cardiovascular diseases (CVDs) are major causes of death worldwide. Identification of promising targets for prevention and treatment of CVDs is paramount in the cardiovascular field. Numerous transcription factors regulate cellular function through modulation of specific genes and thereby are involved in the physiological and pathophysiological processes of CVDs. Although Krüppel-like factors (KLFs) have a similar protein structure with a conserved zinc finger domain, they possess distinct tissue and cell distribution patterns as well as biological functions...
August 23, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28977783/kr%C3%A3-ppel-like-factor-7-is-a-marker-of-aggressive-gastric-cancer-and-poor-prognosis
#17
Zhonghua Jiang, Tingting Yu, Zhining Fan, Hongmei Yang, Xin Lin
BACKGROUND/AIMS: Krüppel-like factor (KLF) 7 protein is a member of the KLF transcription factor family, which plays important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation and metabolism. However, the role of KLF7 in gastric cancer (GC) is unknown. The aim of this study is to explore the role of KLF7 in GC and its correlation with clinicopathological characteristics and prognosis of GC patients. METHODS: We first systematically evaluated dysregulation of the KLF family in The Cancer Genome Atlas (TCGA) GC database...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28973855/autophagy-is-required-for-endothelial-cell-alignment-and-atheroprotection-under-physiological-blood-flow
#18
Anne-Clemence Vion, Marouane Kheloufi, Adel Hammoutene, Johanne Poisson, Juliette Lasselin, Cecile Devue, Isabelle Pic, Nicolas Dupont, Johanna Busse, Konstantin Stark, Julie Lafaurie-Janvore, Abdul I Barakat, Xavier Loyer, Michele Souyri, Benoit Viollet, Pierre Julia, Alain Tedgui, Patrice Codogno, Chantal M Boulanger, Pierre-Emmanuel Rautou
It has been known for some time that atherosclerotic lesions preferentially develop in areas exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent endothelial phenotype. Conversely, areas exposed to high SS are protected from plaque development, but the mechanisms have remained elusive. Autophagy is a protective mechanism that allows recycling of defective organelles and proteins to maintain cellular homeostasis. We aimed to understand the role of endothelial autophagy in the atheroprotective effect of high SS...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28963353/somatic-super-enhancer-duplications-and-hotspot-mutations-lead-to-oncogenic-activation-of-the-klf5-transcription-factor
#19
Xiaoyang Zhang, Peter S Choi, Joshua M Francis, Galen F Gao, Joshua D Campbell, Aruna Ramachandran, Yoichiro Mitsuishi, Gavin Ha, Juliann Shih, Francisca Vazquez, Aviad Tsherniak, Alison M Taylor, Jin Zhou, Zhong Wu, Ashton C Berger, Marios Giannakis, William C Hahn, Andrew D Cherniack, Matthew Meyerson
The Krüppel-like family of transcription factors (KLF) plays critical roles in human development and is associated with cancer pathogenesis. KLF5 has been shown to promote cancer cell proliferation and tumorigenesis, and to be genomically amplified in cancer cells. We recently reported that the KLF5 gene is also subject to other types of somatic coding and noncoding genomic alterations in diverse cancer types. Here we show that these alterations activate KLF5 by three distinct mechanisms. 1) Focal amplification of super-enhancers activates KLF5 expression in squamous cell carcinomas...
September 29, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28923246/klf15-regulates-in%C3%A2-vitro-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-targeting-sox9
#20
Zhuoyue Song, Xiaolei Lian, Yang Wang, Yong Xiang, Guangheng Li
Mesenchymal stem cells (MSCs) are multipotent stromal cells residing in the bone marrow. MSCs have the potential to differentiate into adipocytes, chondrocytes, and other types of cells. However, the mechanism underlying MSC differentiation is still not fully understood. Here we aimed to investigate the function of the Kruppel-like factor (KLF) transcriptional factor family in regulating chondrogenic differentiation from human MSCs. Among the KLF family members, KLF15 was activated during different models of chondrogenic differentiation in a time-dependent manner...
November 18, 2017: Biochemical and Biophysical Research Communications
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