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https://www.readbyqxmd.com/read/27754015/br-04-1management-of-treatment-resistant-hypertension
#1
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642926/br-04-1management-of-treatment-resistant-hypertension
#2
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27470506/reporting-quality-of-randomised-controlled-trial-abstracts-among-high-impact-general-medical-journals-a-review-and-analysis
#3
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/26434083/surviving-sepsis-puerto-rico-a-call-for-action
#4
Ronald Vigo, Miguel Laforet Matos, Tamid Turbay
There are 1.7 million sepsis-related hospitalizations each year making it the sixth most common cause for hospitalization in the United States. Not only are this hospitalizations common, they are expensive to our medical system with $15.3 billion spent yearly (3) and hospitalizations lasting 75% longer than for other conditions. In 2001, Rivers et al published in the NEJM the results of his study "Early Goal Directed Therapy (EGDT) in The Treatment of Severe Sepsis and Septic Shock". EGDT demonstrated a 16...
April 2015: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/26378905/arthroscopic-partial-meniscectomy-for-meniscal-tears-a-review-and-commentary-on-a-study-by-nejm
#5
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/24779345/immunocompetent-murine-models-for-the-study-of-glioblastoma-immunotherapy
#6
REVIEW
Taemin Oh, Shayan Fakurnejad, Eli T Sayegh, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Michael Safaee, Orin Bloch, Charles D James, Andrew T Parsa
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients...
2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24326015/cancer-immunotherapy-are-we-there-yet
#7
Zihai Li, Lieping Chen, Mark P Rubinstein
The immune system is the built-in host defense mechanism against infectious agents as well as cancer. Protective immunity against cancer was convincingly demonstrated in the 1940s with syngeneic animal models (JNCI 18:769-778, 1976; Cancer Immun 1:6, 2001). Since then, the last century's dream has been to effectively prevent and cure cancers by immunological means. This dream has slowly but surely become a reality (Nature 480:480-489, 2011). The successful examples of immunoprophylaxis and therapy against cancers include: (i) targeted therapy using monoclonal antibodies (Nat Rev Cancer 12:278-287, 2012); (ii) allogeneic hematopoietic stem cell transplantion to elicit graft-versus-cancer effect against a variety of hematopoietic malignancies (Blood 112:4371-4383, 2008); (iii) vaccination for preventing cancers with clear viral etiology such as hepatocellular carcinoma and cervical cancer (Cancer J Clin 57:7-28, 2007; NEJM 336:1855-1859, 1997); (iv) T cell checkpoint blockade against inhibitory pathways including targeting CTLA-4 and PD-1 inhibitory molecules for the treatment of melanoma and other solid tumors (NEJM 363:711-723, 2010; NEJM 366:2443-2454, 2012; NEJM 369:122-133, 2013; NEJM 366:2455-2465, 2012); (v) antigen-pulsed autologous dendritic cell vaccination against prostate cancer (NEJM 363:411-422, 2010); and (vi) the transfer of T cells including those genetically engineered with chimeric antigen receptors allowing targeting of B cell neoplasms (NEJM 365:725-733, 2011; NEJM 368:1509-1518, 2013; Blood 118:4817-4828, 2013; Sci Transl Med 5:177ra138, 2013)...
2013: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/23515174/the-influence-of-endoscopic-vein-harvesting-on-outcomes-after-coronary-bypass-grafting-a-meta-analysis-of-267-525-patients
#8
REVIEW
Priya Sastry, Rasmus Rivinius, Rebecca Harvey, Richard A Parker, Ann-Kathrin Rahm, Dierk Thomas, Sukumaran Nair, Stephen R Large
In recent times, practice in cardiac surgery has shifted towards using endoscopic techniques to harvest the saphenous vein from the leg for use as a bypass graft. A paper published in the New England Journal of Medicine (NEJM) in 2009 raised concerns over increased graft occlusion rates in veins harvested endoscopically. This NEJM paper has been criticized, but has nonetheless been influential in guiding practice. We have undertaken this meta-analysis to provide evidence on the clinical outcomes of endoscopic vein harvesting (EVH), so that clinicians can make an informed judgement about whether this technique, popular as it is with patients, should still be offered...
December 2013: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/21789717/differential-diagnosis-generators-an-evaluation-of-currently-available-computer-programs
#9
REVIEW
William F Bond, Linda M Schwartz, Kevin R Weaver, Donald Levick, Michael Giuliano, Mark L Graber
BACKGROUND: Differential diagnosis (DDX) generators are computer programs that generate a DDX based on various clinical data. OBJECTIVE: We identified evaluation criteria through consensus, applied these criteria to describe the features of DDX generators, and tested performance using cases from the New England Journal of Medicine (NEJM©) and the Medical Knowledge Self Assessment Program (MKSAP©). METHODS: We first identified evaluation criteria by consensus...
February 2012: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/16513694/nejm-stands-by-its-criticism-of-vioxx-study
#10
Janice Hopkins Tanne
No abstract text is available yet for this article.
March 4, 2006: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/16318095/-new-trends-in-the-management-of-common-solid-malignant-tumors
#11
J Klastersky, A Awada
Evidence-based medicine has become a requisite for novel therapies. It requires demonstration, in well performed clinical trials, that a benefit for the patients can be obtained by changing what is considered as a standard treatment. The present review deals with the clinical trials in the field of cancer therapy which have been published, during 2004, mainly in the New England Journal of Medicine (NEJM). We selected this mode of operation since the NEJM publishes highly selected papers after thoroughful peer review; moreover, the selection of the paper published by the NEJM is intended for general practionners in the different areas of medicine and critical editorial comments are offered for major contributions...
September 2005: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/16120409/the-neurological-presentations-of-childhood-and-adult-mitochondrial-disease-established-syndromes-and-phenotypic-variations
#12
Andrea L Gropman
Mitochondrial disorders are caused by mutations of nuclear or mitochondrial DNA encoded genes involved in oxidative phosphorylation (OXPHOS). Mutations in these critical genes are associated with specific clinical syndromes with diverse presentations (DiMauro and Schon, 2003. NEJM 348, 2656; Hart et al., 2002. Mitochondrial Disorders in Neurology). Since mitochondria are present in many of our organs and play a key role in energy metabolism, mitochondrial encephalomyopathies often present as multisystem disorders which may manifest with neurologic, cardiac, endocrine, gastrointestinal, hepatic, renal and/or hematologic involvement (DiMauro and Bonilla, 1997...
September 2004: Mitochondrion
https://www.readbyqxmd.com/read/2255376/-the-structured-summary-a-tool-for-reader-and-author
#13
M L Comans, A J Overbeke
OBJECTIVE: To determine and to compare the information contained in structured abstracts in original articles in Annals of Internal Medicine (AIM), British Medical Journal (BMJ), New England Journal of Medicine (NEJM) and of abstracts that have been published in Nederlands Tijdschrift voor Geneeskunde (NTvG). SETTING: Editorial office NTvG. DESIGN: Descriptive. MATERIAL AND METHOD: Critical reading of 15 original articles of AIM (5), BMJ (5) and NEJM (5) in 5 consecutive issues starting from 1 March 1990 and all original articles of 6 consecutive issues of NTvG starting from 7 april 1990...
December 1, 1990: Nederlands Tijdschrift Voor Geneeskunde
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